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Pittsburgh doctor hopes FDA-approved colon cancer blood tests boosts screening rates

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Pittsburgh doctor hopes FDA-approved colon cancer blood tests boosts screening rates


PITTSBURGH (KDKA) — A simple blood test to screen for colorectal cancer was approved by the U.S. Food and Drug Administration.

According to the American Cancer Society, 53,000 people will die of colorectal cancer this year and less than 60 percent follow screening guidelines. Doctors are hoping the newly approved screening tool will help change that.

“I’m very happy that we have an additional tool in our toolbox to help people get screened for colon cancer,” said Dr. James McCormick, chief of colon and rectal surgery at Allegheny Health Network.

Dr. McCormick is excited about the FDA-approved first-of-its-kind blood test. It’s meant for people 45 and older with an average risk for the disease.

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“You just get your blood drawn. What they’re doing is looking in the blood for circulating tumor DNA. So, DNA that the tumor will have released into the blood, and it would be able to detect that,” Dr. McCormick said.

In Guardant Health’s clinical trials, the blood test was 83 percent accurate in detecting cancer that’s already formed.

“That’s someone who’s already has a cancer. For the precancer solutions, unfortunately, it’s down in the 13 to 20% range that it can pick that up. So, it’s not going to pick up those polyps before they become cancer,” he said.

The Shield test is not a replacement for colonoscopies. Any positive blood test result would then require a colonoscopy.

“It’s different from a colonoscopy, which is the traditional screening test that we offer people, where we can take precancerous tumors at the time of the colonoscopy and remove them before they can become cancerous tumors. That’s still the best screening test, and really the only test that you should have if you have any symptoms at any age,” Dr. McCormick said.

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McCormick reiterated that people who get symptoms at any age should get screened and that everyone should be screened for colon cancer at age 45. He said despite efforts to spread the word, 20 or 25 percent of people never get screened.

He hopes the blood test will help boost the rate of screenings and save more lives.

“If there’s a reason that they’re not getting screened that is solved by the Shield test, then we’ll take it. We’ll get them in that way,” Dr. McCormick said.

This approval comes at a time when more people have been developing colon cancer at younger ages.

“We’re even seeing patients in their 20s and 30s with colon cancer, even with no family history. And we have no idea why or who is going to be affected by this,” Dr. McCormick said.

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He said never to ignore symptoms. If something is different with your bowel, fight for yourself and make sure you get the test you need.

“Anytime there’s bleeding, there’s abdominal pain, anytime there’s a change in the way your bowels work that persists more than just a few weeks, definitely call your doctor and insist upon getting a colonoscopy,” Dr. McCormick said.

The Shield test has been used by doctors for high-risk surveillance after treatment. A stool test is another screening tool that’s available.

Dr. McCormick said if a blood test and a stool test are negative, those would probably be repeated every three years. Negative colonoscopies only need to be done every 10 years.

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Pittsburgh natives Joe Manganiello and Caitlin O’Connor move to Mt. Lebanon

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Pittsburgh natives Joe Manganiello and Caitlin O’Connor move to Mt. Lebanon



Pittsburgh-area natives Joe Manganiello and Caitlin O’Connor are returning to their roots. 

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Manganiello, from Mt. Lebanon, and O’Connor, from Uniontown, have bought a home in the South Hills after getting engaged this summer

On Pittsburgh Today Live on Thursday, O’Connor talked about the couple’s move from Hollywood to Mt. Lebanon. 

“It’s so nice to be home,” she said. 

While Manganiello and O’Connor are happy to be back in southwestern Pennsylvania, O’Connor said it’ll be a bigger adjustment for the beloved chihuahua Bubbles. From the Pittsburgh Steelers fashion show to the gala celebrating the new airport terminal, the tiny dog is seemingly always in Manganiello’s arms.

“Bubbles is a California girl. She really doesn’t like the cold. We wrap her in a blanket and she has many, many puffy coats. I bought her a Steelers puffy to put in her stocking, so we’re going to see how she does over the next few months. But it’s not that long. It’s not forever. Winter will come and go,” O’Connor said. 

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And they all got quite the Pittsburgh welcome. O’Connor said it snowed when they were moving in, and Manganiello was outside shoveling for over two hours. She said she’s getting him a snowblower for Christmas.

The couple won’t be braving the Pittsburgh winter for too long. O’Connor said they’ll soon be off to South Africa, where Manganiello will film “One Piece” for Netflix. He’ll star as the villain Crocodile in the popular Japanese manga series. 

“Bubbles will be in a better state,” O’Connor joked, saying it’s currently summer in South Africa. “I just bring Bubbles to set and hang out. It’s really the best job.” 



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Police investigating late-night shooting at Irwin apartment complex

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Police investigating late-night shooting at Irwin apartment complex



Police in Westmoreland County are investigating a late-night shooting that happened at an apartment complex in Irwin Borough.

Irwin Police Chief Daniel Wensel confirmed to KDKA-TV that the department, along with Westmoreland County detectives are investigating a shooting that happened at the Bevington Building along Sweetbriar Drive within the Villages of Easton Apartment Complex.

Dispatchers said the first call related to the incident came in around 11:30 p.m. on Wednesday.

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Details are limited but Chief Wensel said there is no danger to the public.

Police are investigating a late-night shooting that happened at an apartment complex in Irwin Borough, Westmoreland County.

KDKA Photojournalist Brian Smithmyer


It’s unclear if any injuries have been reported or if any arrests have been made.

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Chief Wensel said that more information is expected to be released once detectives and the department get further along in the investigation. 



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Steelers re-sign veteran running back

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Steelers re-sign veteran running back


The Pittsburgh Steelers are re-signing veteran running back Trey Sermon, the team announced today. Sermon has had multiple on-and-off stints with the Steelers since signing with the team rookie mini-camp. He’s appeared in three games for the Steelers in 2025.

Sermon was drafted in the third round of the 2021 NFL Draft by the San Francisco 49ers. In 46 career games, Sermon has 505 yards on 134 carries and three touchdowns with the 49ers, Philadelphia Eagles, Indianapolis Colts, and Steelers.

The Steelers have the chance to put the Baltimore Ravens on the ropes this Sunday. If they defeat the Detroit Lions, the Ravens would have to defeat one of the New England Patriots or Green Bay Packers for the Week 18 matchup between the Steelers and Ravens to have any stakes. The Steelers can also clinch the division before Week 18 if they win their next two games and the Ravens go 1-1 or 0-2.

Be sure to bookmark Behind the Steel Curtain for all the latest news, breakdowns, and more!

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