San Francisco 49ers vs. Cleveland Browns 2025 odds, tips and betting trends | Week 13

The San Francisco 49ers (8-4) face the Cleveland Browns (3-8) on Sunday, November 30, 2025 at Huntington Bank Field. The 49ers are listed as favorites in this one, with the spread sitting at 5.5 points. An over/under of 35.5 points has been set for the outing.

The 49ers won versus the Carolina Panthers in their last game, 20-9.

In that matchup against the Panthers, Niners quarterback Brock Purdy completed 23 of 32 attempts for 193 yards, with one touchdown and three interceptions.

Last time around, the Browns defeated the Las Vegas Raiders, with 24-10 being the final score.

49ers vs Browns betting information

NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

• Spread favorite: San Francisco (-5.5)
• Moneyline: San Francisco (-246), Cleveland (+201)
• Total: 35.5 points

49ers betting insights

• In away games, San Francisco is 5-2 against the spread and 5-2 overall.
• The 49ers have covered the spread seven times over 12 games with a set spread.
• In games they have played as 5.5-point favorites or more, the 49ers have a perfect ATS record of 1-0.
• San Francisco has gone over the total in five of seven away games this season.
• 49ers games have finished with a final combined score above the over/under seven times this season.

49ers leaders

• Purdy: 979 PASS YDS / 244.8 YPG / 68.7% / 8 TD / 7 INT
• Christian McCaffrey: 217 CAR / 796 YDS / 66.3 YPG / 7 TD / 81 REC / 785 YDS / 65.4 YPG / 5 TD
• Brian Robinson Jr.: 64 CAR / 302 YDS / 25.2 YPG / 2 TD / 7 REC / 19 YDS / 1.6 YPG / 0 TD
• Kendrick Bourne: 31 REC / 482 YDS / 53.6 YPG / 0 TD
• Jauan Jennings: 37 REC / 419 YDS / 41.9 YPG / 4 TD

49ers vs Browns game info

• Date: Sunday, November 30, 2025
• Time: 1 p.m. ET
• City: Cleveland, Ohio
• Venue: Huntington Bank Field
• TV channel: CBS
• Live stream: Watch on Fubo (Regional restrictions may apply)
• Live stream: Watch on Paramount+ (Regional restrictions may apply)

Watch San Francisco 49ers vs. Cleveland Browns on Fubo! (Regional restrictions may apply)