Arizona Cardinals vs San Francisco 49ers picks, predictions: Who wins NFL Week 5 game?

The Arizona Cardinals and San Francisco 49ers play on Sunday, Oct. 6, at Levi’s Stadium in a game on the NFL Week 5 schedule.

Which team will win the NFL Week 5 game?

Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 1:05 p.m. MST on FOX (stream with free trial from FUBO).

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.

San Francisco is -375 on the moneyline, while Arizona is +300.

The over/under (point total) is set at 49.5 points.

Watch Cardinals at 49ers live with FUBO (free trial)

Jeremy Cluff writes: “The 49ers are the biggest favorite of the week. Can the Cardinals shock San Francisco? Can they even keep this game close? Not the way they are playing.”

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Bill Speros writes: “The 49ers active roster remains in flux. But their defense will be enough to win this one at home. But a full TD cover might be too much to ask, especially given how the Cardinals can score big-yardage-play TDs with Kyler Murray and Marvin Harrison Jr. Especially in garbage time.”

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The site’s formula predicts that the Cardinals will win the NFL Week 5 game against the 49ers.

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ESPN: 49ers have a 70.5% chance to beat Cardinals on Sunday

The site gives the Cardinals a 29.2% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.

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Dimers: 49ers 26, Cardinals 19

It writes: “After extensive simulations, our model gives the Cardinals a win probability of 23%, while the 49ers have a win probability of 77%.”

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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