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49ers vs. Saints Final Score Prediction for NFL Week 2 (Fade San Francisco?)

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49ers vs. Saints Final Score Prediction for NFL Week 2 (Fade San Francisco?)


Brock Purdy (toe, left shoulder) is banged up for the San Francisco 49ers, and it’s caused some massive line movement for their Week 2 matchup against the New Orleans Saints.

San Francisco is favored by just three points against Spencer Rattler and company, a four-point difference from where this line opened up earlier this week. San Fran did win in Week 1 over the Seattle Seahawks, but it could be an upset candidate with Mac Jones likely under center in Week 2.

Spencer Rattler and the Saints had a chance to tie their game with the Arizona Cardinals in Week 1 on the final drive, but they came up short in a seven-point loss. Could the Saints pull out a shocking win with San Francisco banged up at quarterback (Purdy), tight end (George Kittle) and wide receiver (Brandon Aiyuk and Jauan Jennings)?

All season long, the SI Betting team is going to share score predictions using the latest odds and analysis to attempt to get a score right – and give bettors our thoughts on both the spread and total.

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Here’s how I’d bet on this Week 2 matchup. 

Odds via DraftKings Sportsbook

Spread

Moneyline

Total

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Purdy’s injury has caused some massive line movement in this game, as the 49ers went from seven-point favorites in the opening odds on Sunday night to three-point favorites after Kyle Shanahan shared that Purdy may miss multiple weeks. 

Now, bettors have to decide whether or not their willing to trust Mac Jones in this matchup. 

Based on the odds for this game, oddsmakers are expecting a close matchup – and a low-scoring one – in New Orleans.

The 49ers won in Week 1 on a comeback drive from Purdy, but now bettors have to put their faith in Mac Jones in this game. I just can’t do it.

San Francisco may win this game, but I don’t see it being by much, especially since the Saints were able to hang around with the Arizona Cardinals in Week 1. Two bad quarterbacks are facing off in this game, but Rattler has the benefit of playing behind his home crowd.

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This game is likely a stay away when it comes to what I’m betting on Sunday, but I wouldn’t mind taking the points with the Saints. If San Fran wins, it’s going to be a slug fest of a game.  

Final Score Prediction: 49ers 16, Saints 14

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $200 in bonus bets plus over $200 off NFL Sunday TicketRegardless of the outcome of your wager,DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.

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San Francisco, CA

Yes, an $8 Burger Exists in Downtown San Francisco

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Yes, an  Burger Exists in Downtown San Francisco


Sometimes life requires an easy hang, without the need for reservations and dressing up, and preferably with food that’s easy to rally folks behind. The newish Hamburguesa Bar is just such a place, opening in December 2025 and serving a tight food menu of smash and tavern burgers (made with beef ground in-house), along with hand-cut duck fat fries, poutine, and Caesar salad. The best part? Nothing here costs more than $20. Seriously, this spot has so much going for it, including solid cocktails and boozy shakes. It’s become a homing beacon for post-work hangs, judging by a recent weekday crowd.

Hamburguesa Bar’s drinks are the epitome of unfussy: Cocktail standards, four beers on tap, two choices of wine (red or white), boozy and non-boozy shakes, plus 21 beers by the can or bottle. Standards on the cocktail menu are just that, a list of drinks you’ve heard before — such as an Old Fashioned, daiquiri, gin or vodka martini, or Harvey Wallbanger — with no special tinctures or fat-washed liquors to speak of (that we know of, at least). I’m typically split on whether boozy shakes are ever worth it, but the Fruity Pebbles option ($14) makes a convincing case, mixed with a just-right amount of vodka and some cereal bits. (I’ll leave the more adventurous Cinnamon Toast shake made with Fireball to others with more positive experiences with that liquor.)

Downtown and SoMa has a reputation for restaurants closing early, but Hamburguesa Bar keeps later hours, closing at midnight from Monday through Saturday (closed Sundays). It’s also open for lunch at noon during those days, with the exception of Saturdays when it opens at 5 p.m.



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San Francisco, CA

Iran conflict disrupts flights out of SFO

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Iran conflict disrupts flights out of SFO


SAN FRANCISCO (KRON) — Attacks on Iran by U.S. and Israeli forces have disrupted air travel across the Middle East, leading to thousands of flight cancellations and delays worldwide. The instability has reached the Bay Area, where international flights at San Francisco International Airport have been canceled or grounded. The travel disruptions followed retaliatory strikes […]



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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED

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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED


She acknowledged that Iranian Americans hold a range of political views, including some who support U.S. intervention, but said she believes the future of Iran should be determined by its people.

“The Iranian people in Iran can decide the future of their country,” she said. “War, I don’t think, is going to help.”

Speaking to the crowd, Mortazavi challenged what she described as a narrative that Iranians broadly support U.S. and Israeli military action.

“They want you to believe that every Iranian … is cheering on the United States and Israel,” she said. “That is unequivocally false.”

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She urged attendees to continue organizing beyond the rally and announced plans for additional demonstrations.

A demonstrator holds an Iranian flag as protesters gather outside the San Francisco Federal Building during a “Hands Off Iran” rally Feb. 28, 2026, in San Francisco. The demonstration called for an end to U.S. involvement in the strikes on Iran. (Gustavo Hernandez/KQED)

Dina Saadeh, an organizer with the Palestinian Youth Movement, said multiple groups mobilized quickly in response to the strikes.

“I’m angered today,” Saadeh told KQED. “People here don’t want to see our country engaged in more endless war.”

Saadeh described the protest as part of a broader effort to oppose sanctions, military escalation and what she called U.S. imperialism. She said participants were calling on elected officials to redirect public funds toward domestic needs.

“People want money for jobs and education, not for war and occupation,” she said.

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KQED’s María Fernanda Bernal contributed to this story.



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