Arizona State vs Iowa State picks, predictions for college football Week 10 game Saturday

The Iowa State Cyclones and Arizona State Sun Devils play on Saturday, Nov. 1, at Iowa State football’s Jack Trice Stadium in a game on the college football Week 10 schedule.

Which team will win the college football Week 10 game?

Check out these college football Week 10 picks and college football Week 10 predictions for the Big 12 game, which can be seen at 10 a.m. MST on TNT (stream with Sling).

Iowa State is a 5.5-point favorite over Arizona State in college football Week 10 odds for the game, according to BetMGM Sportsbook.

The Cyclones are -210 on the moneyline, while the Sun Devils are +170. The over/under (point total) for the game is set at 50.5 points.

Big 12 football Week 10 picks: West Virginia at Houston | UCF at Baylor | Arizona State at Iowa State | Texas Tech at Kansas State | Oklahoma State at Kansas | Arizona at Colorado | Cincinnati at Utah | The Republic’s predictions

Watch Arizona State at Iowa State live on Sling

Jeremy Cluff writes: “Iowa State has had this game circled since the Big 12 schedule was released. Rocco Becht and the Cyclones will be ready for this game, eager to get some revenge for their loss to Arizona State in the Big 12 title game last season.”

Big 12 football Week 10 picks: Predictions for every game on conference schedule this week

Dimers.com: Iowa State 27, Arizona State 24

It writes: “After extensive simulations, our model gives Arizona State a win probability of 41%, while Iowa State has a win probability of 59%.”

College football rankings: Big 12 teams after BYU, Cincinnati, Houston wins in Week 9

ESPN: Iowa State has a 66.5% chance to defeat Arizona State on Saturday

The site gives the Sun Devils a 33.5% shot at winning the college football Week 10 game over the Cyclones on Nov. 1, 2025.

Bookies.com: Bet Iowa State to cover vs Arizona State

Bill Speros writes: “Perhaps the most notable thing about this game has it landing on TNT. This slot was set aside for the Big 12 games ESPN gave to TNT and TBS in exchange for the rights to air ‘Inside the NBA’ this season. Shaq, Ernie, Kenny and Charles for ASU at Iowa State? Both teams stand 5-3 outright, 3-2 in the Big 12, have covered just 3 times this season, are coming off home Big 12 losses at home, and have failed to be meet their lofty conference expectations this season. ISU dropped its third-straight conference game Saturday, losing 41-27 to BYU on Homecoming Weekend. Ouch. The Sun Devils exited the Top 25 following a 24-16 home loss to Houston. The home team here gets a slight edge due to the early start and temperatures in the 40s come kickoff time.”

Big 12 football Week 10 odds: Point spreads, moneylines, over/unders

The site’s formula predicts that the Cyclones will beat the Sun Devils in the Big 12 football game this week.

Big 12 football Week 10 schedule: TV channels, how to watch, stream games

Eddie Kline writes: “Arizona State QB Sam Leavitt was forced to leave Saturday’s loss with a lower leg injury and his status for this game is uncertain. With Leavitt and Tyson banged up, it is hard to imagine the Sun Devils finding a way to win in this spot.”

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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