Tennessee
New synthetic opioid ‘cychlorphine’ linked to 16 overdose deaths across East Tennessee
KNOX COUNTY, Tenn. (WZTV) — A newly identified synthetic opioid has been linked to at least 16 overdose deaths in East Tennessee, according to preliminary toxicology tests from the Knox County Regional Forensic Center.
Officials say the drug, N-propionitrile chlorphine, also known as cychlorphine, appeared in nine overdose deaths between late October and December. As of mid-January, the substance had been associated with seven additional deaths.
Authorities say the drug has been detected primarily in cases where other substances were present, including methamphetamine and fentanyl.
Chris Thomas, chief administrative officer and director of the Knox County Regional Forensic Center, said the drug has been appearing more frequently in toxicology reports, though officials are still working to understand how widely it has spread.
“It’s showing up at an exponential rate and at this point, we don’t know if it’s a single batch and done with or if it’s the new future,” Thomas said.
Initial cases were identified in Knox County before spreading to several nearby counties, including Roane, McMinn, Campbell, Union, Anderson, Claiborne, and Sevier counties, according to forensic officials.
Dr. Darinka Mileusnic-Polchan, the center’s chief medical examiner, said cychlorphine is not approved for clinical use and has never been authorized for sale on the medical market.
“This isn’t a drug that has been approved for clinical use, and it’s never been clinically approved to be sold on the market,” said Dr. Darinka Mileusnic-Polchan, chief medical examiner at Knox County Regional Forensic Center. “We do know it’s more powerful than fentanyl and that naloxone, or Narcan, does not completely block the effects of the drug and multiple doses may be needed to prevent an overdose.”
She said early findings suggest the substance may be more potent than fentanyl. Mileusnic-Polchan also said naloxone, commonly known by the brand name Narcan, may require multiple doses to counteract overdoses involving the drug.
Researchers say cychlorphine is part of a group known as new synthetic opioids, or NSOs, laboratory-made opioids that differ structurally from fentanyl and its analogues.
According to the Center for Forensic Science Research and Education, the drug may have first appeared in China in 2024 before spreading to Europe, Canada, and the United States by mid-2025.
The Knox County Regional Forensic Center first identified the substance in Tennessee in late November 2025 after it appeared in an overdose death in Roane County. Investigators later determined an earlier case in Knox County dated back to October.
Officials say the findings remain preliminary as investigators continue to study the substance and its role in overdose deaths.
The Tennessee Lottery offers several draw games for those aiming to win big.
Here’s a look at June 25, 2026, results for each game:
Winning Cash 3 numbers from June 25 drawing
Morning: 9-1-6, Wild: 3
Midday: 5-6-7, Wild: 5
Evening: 8-0-9, Wild: 2
Check Cash 3 payouts and previous drawings here.
Winning Cash 4 numbers from June 25 drawing
Morning: 1-0-7-7, Wild: 5
Midday: 0-1-3-6, Wild: 0
Evening: 4-0-9-0, Wild: 2
Check Cash 4 payouts and previous drawings here.
Winning Daily Tennessee Jackpot numbers from June 25 drawing
03-04-09-12-28
Check Daily Tennessee Jackpot payouts and previous drawings here.
Winning Millionaire for Life numbers from June 25 drawing
03-13-14-34-45, Bonus: 01
Check Millionaire for Life payouts and previous drawings here.
Feeling lucky? Explore the latest lottery news & results
Are you a winner? Here’s how to claim your lottery prize
All Tennessee Lottery retailers will redeem prizes up to $599.
For prizes over $599, winners can submit winning tickets through the mail or in person at Tennessee Lottery offices. By mail, send a winner claim form, winning lottery ticket, a copy of a government-issued ID and proof of social security number to P.O. Box 290636, Nashville, TN 37229. Prize claims less than $600 do not require a claim form. Please include contact information on prizes claimed by mail in the event we need to contact you.
To submit in person, sign the back of your ticket, fill out a winner claim form and deliver the form, along with the ticket and government-issued ID and proof of social security number to any of these locations:
Nashville Headquarters & Claim Center: 26 Century Blvd., Nashville, TN 37214, 615-254-4946 in the (615) and (629) area, 901-466-4946 in the (901) area, 865-512-4946 in the (865) area, 423-939-7529 in the (423) area or 1-877-786-7529 (all other areas in Tennessee). Outside Tennessee, dial 615-254-4946. Hours: 9 a.m. to 4 p.m. Monday through Friday. This office can cash prizes of any amount.
Knoxville District Office: Cedar Springs Shopping Center, 9298 Kingston Pike, Knoxville, TN 37922, (865) 251-1900. Hours: 9 a.m. to 4 p.m. Monday through Friday. This office can cash prizes up to $199,999.
Chattanooga District Office: 2020 Gunbarrel Rd., Suite 106, Chattanooga, TN 37421, (423) 308-3610. Hours: 9 a.m. to 4 p.m. Monday through Friday. This office can cash prizes up to $199,999.
Memphis District Office: Chiles Plaza, 7424 U.S. Highway 64, Suite 104, Memphis, TN 38133, (901) 322-8520. Hours: 9 a.m. to 4 p.m. Monday through Friday. This office can cash prizes up to $199,999.
Check previous winning numbers and payouts at https://tnlottery.com/.
When are the Tennessee Lottery drawings held?
- Powerball: 9:59 p.m. CT Monday, Wednesday, and Saturday.
- Mega Millions: 10:00 p.m. CT Tuesday and Friday.
- Cash 3, 4: Daily at 9:28 a.m. (Morning) and 12:28 p.m. CT (Midday), except for Sunday. Evening game daily, seven days a week, at 6:28 p.m. CT.
- Daily Tennessee Jackpot: 9:00 p.m. CT daily.
- Tennessee Cash: 10:34 p.m. CT Monday, Wednesday, and Friday.
- Powerball Double Play: 10:30 p.m. CT Monday, Wednesday and Saturday.
- Millionaire for Life: 10:15 p.m. CT daily.
This results page was generated automatically using information from TinBu and a template written and reviewed by a Tennessean editor. You can send feedback using this form.
GREENBRIER, Tenn. (WSMV) – A Middle Tennessee man is facing a 64-count indictment involving child sex crime charges, according to the Greenbrier Police Department.
GPD reports that James Mackenzie Gay was indicted by a Robertson County grand jury following an investigation by the department’s Criminal Investigations Division.
Investigators arrested Gay on Wednesday and he’s now being held at the Robertson County Jail.
Gay has been indicted on the following charges, according to GPD:
- 20 counts of aggravated sexual battery involving a child under 13
- 36 counts of sexual exploitation of a minor, possession
- 5 counts of especially aggravated sexual exploitation of a minor, production
- 1 count of solicitation of a minor for rape of a child
- 1 count of sexual exploitation of a minor by electronic means
- 1 count of criminal attempted sexual exploitation of a minor by electronic means
GPD expressed its gratitude to the 19th Judicial District Attorney’s Office and the Robertson County Child Advocacy Center for their assistance in this case.
No other information has been released at this time.
Copyright 2026 WSMV. All rights reserved.
NASHVILLE, Tenn. (WZTV) — On the fourth anniversary of the U.S. Supreme Court’s decision to overturn Roe v. Wade, Tennessee Republicans unveiled a new monument at the State Capitol honoring unborn children.
The Roe v. Wade decision allowed states to set their own abortion laws and triggered Tennessee’s Human Life Protection Act, which bans nearly all elective abortions in the state. The law has saved about 10,000 lives each year since taking effect, according to Tennessee Right to Life.
The Tennessee Monument to Unborn Children is located on the southeast side of the Capitol grounds. Lawmakers say it recognizes unborn children whose lives ended through abortion and serves as a place for reflection and remembrance.
The monument was approved by the General Assembly in 2018 and was paid for entirely through private donations.
Republican leaders said the monument reflects Tennessee’s commitment to protecting unborn children and honoring the value of human life.
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