South Carolina vs Southern University predictions, picks, odds for NCAA Tournament First Round

The First Round of the women’s 2026 NCAA Tournament continues Saturday with a slate featuring No. 1 South Carolina vs. No. 16 Southern University on the 16-game schedule.

Here is the latest on Saturday’s March Madness matchup, including expert picks from reporters across the USA TODAY Sports Network.

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No. 1 South Carolina vs No. 16 Southern University prediction

• Heather Burns: South Carolina
• Mitchell Northam: South Carolina
• Nancy Armour: South Carolina
• Cydney Henderson: South Carolina
• Meghan Hall: South Carolina

No. 1 South Carolina vs No. 16 Southern University odds

• Opening Moneyline: N/A
• Opening Spread: South Carolina (-52.5)
• Opening Total: 130.5

How to Watch South Carolina vs Southern University on Saturday

No. 1 South Carolina takes on No. 16 Southern University at Colonial Life Arena in Columbia on at 1:00 p.m. (ET). The game is airing on ABC.

Stream March Madness on Fubo

2026 Women’s NCAA Tournament full schedule

• March 18-19: First Four
• March 20-21: First Round
• March 22-23: Second Round
• March 27-28: Sweet 16
• March 29-30: Elite 8
• April 3: Final Four
• April 5: National Championship