The Clemson Tigers close out the 2025 college football regular season with their annual matchup against the in-state rival South Carolina Gamecocks from the SEC.

Clemson (6-5) clinched bowl eligibility with a 45-10 win over Furman from the Football Championship Subdivision last week at Memorial Stadium. Cade Klubnik threw for 159 yards and two touchdowns before receiving one last ovation from the Clemson faithful after being taken out of the game midway through the second quarter.

Antonio Williams caught both touchdown passes from Klubnik and finished the day with 57 yards, and the Tigers ran for 219 yards, with freshman quarterback Chris Denson turning in a stellar performance in his first meaningful action.

The freshman from Plant City, Florida completed all four passes for 22 yards and a touchdown while running for 106 yards and a touchdown on six carries. Denson suffered an injury in practice this week, coach Dabo Swinney announced Tuesday.

South Carolina (4-7) cruised past Coastal Carolina, 51-7, last week. LaNorris Sellers threw for two touchdowns and rushed for two others. Sellers accounted for 356 all-purpose yards (274 passing, 82 rushing). The Gamecocks had lost seven of their last eight games after starting the season 2-0.

Clemson has won eight of the last 10 meetings in the series vs. South Carolina dating back to 2014, including five straight at Williams-Brice Stadium. The Tigers defeated the Gamecocks, 16-7, in the last meeting in Columbia in 2023. South Carolina has won two of the past three head-to-head matchups, both at Clemson.

Will Clemson football beat South Carolina in Columbia again? ESPN makes ‘prediction’

Ahead of Clemson-South Carolina, ESPN’s Bill Connelly tried to predict who will win using his popular SP+ metrics. But even Connelly isn’t sure, it seems.

His score “prediction”: Clemson 24, South Carolina 24.

Clemson and South Carolina have never played in overtime since ties in college football were abandoned in 1995. Nevertheless, Connelly gives the Tigers a win probability of 51%.

What are ESPN SP+ rankings?

According to Connelly, SP+ is “simply a measure of the most sustainable and predictable aspects of football. If you’re lucky or unimpressive in a win, your rating will probably fall. If you’re strong and unlucky in a loss, it will probably rise.”

“SP+ is not a résumé ranking, so it does not automatically give credit for big wins or particularly brave scheduling — no good predictive system does,” he adds.

Clemson vs South Carolina football start time, channel

Clemson-South Carolina is scheduled for a noon ET kickoff Saturday from Williams-Brice Stadium in Columbia. The game will be televised on SEC Network. Taylor Zarzour and Matt Stinchcomb will have the TV call of the game. Alyssa Lang will report from the sidelines.

The radio broadcast of Saturday’s game can be heard on the Clemson Tigers app via the Clemson Athletic Network. Don Munson, Tim Bourret and Reggie Merriweather will have the call of the game on the radio. Additionally, the Tigers’ radio broadcast can be heard on SiriusXM channel 193.