Science
Hantavirus strikes a cruise ship, Californians at risk: Is this the start of something much worse?
The voyage was marketed for explorers eager to venture to “the edges of the map,” from Antarctica to some of the most remote islands in the world.
It would be a tantalizing trip for tourists with an appetite for adventure — less about trips to the spa and lounging by the pool than a chance to see landscapes few humans have ever laid eyes upon.
But this call of the wild was ultimately among the factors that turned the MV Hondius into the epicenter of the first-ever deadly outbreak of hantavirus aboard a modern cruise ship. Eleven cases have been linked to the outbreak so far. Three people are dead, and two others are in intensive care.
The incident — with a few uncomfortable echoes of the onset of the COVID-19 pandemic — has sparked concerns and questions. Chief among them: Was this a freak occurrence, or a sign of things to come?
“I think it’s both,” said Dr. Peter Chin-Hong, an infectious diseases expert at UC San Francisco.
Hantavirus had previously been an obscure illness. Typically spread through exposure to infected rodents’ urine and droppings, it’s notoriously difficult to diagnose and has no specified antiviral treatment. It was definitively identified relatively recently, in a field rodent near the Hantan River in South Korea in 1978, and finally explained the mystery cause of the “Korean hemorrhagic fever” that infected thousands of United Nations troops during the Korean War.
Though rare, the disease has drawn attention in the U.S. over the decades due to its incredibly high case-fatality rate: up to 50% among the strains that circulate in the Americas.
Western Hemisphere hantavirus strains are so deadly because they can attack the lungs and make them leak. The strains that circulate in Asia and Europe — where hantavirus is more common, and generally less deadly — attack the kidneys.
Those who are severely ill can only be treated by putting them on life-support machines that directly add oxygen to their blood.
Despite its severity, the overall impact of the disease in the Americas has remained muted for two main reasons. First, most strains of hantavirus do not spread directly from person to person. And second, many people will not come into contact with rodents carrying the virus during their daily lives.
Excursions that attract people like those aboard the MV Hondius, however, blur the second line. Launched in 2019, the ice-strengthened vessel offered passengers opportunities for “maximum contact with the nature and wildlife you traveled so far to see,” according to its operator, Oceanwide Expeditions.
“The broader pattern is definitely not random,” Chin-Hong said, “which is more expedition tourism visiting remote areas.” Climate change, he added, is also increasing the range of certain infectious diseases.
“The hantavirus in the cruise ship is unprecedented, and reflects kind of like a perfect storm of the expedition cruise through a remote area, environmental exposure potentially during a short excursion, and the hantavirus — this particular Andes virus — being capable of going from person to person,” he said.
The Andes virus, which circulates in Argentina and Chile and is mainly spread among the long-tailed pygmy rice rat, is the only hantavirus strain known to be able to transmit from human to human.
Such inter-person spread occurred previously in a deadly outbreak in Argentina. From November 2018 through February 2019, the Andes virus infected 34 people there, killing 11, according to a study in the New England Journal of Medicine.
There were 149 passengers and staff aboard the MV Hondius when the ship publicly disclosed that three of its passengers had died. Of the 18 U.S. citizens on the ship, one passenger initially tested positive for hantavirus overseas but also got a negative test result; a follow-up test is now being done in the U.S., and results are expected in a day or so, Dr. David Fitter, incident manager for the Centers for Disease Control and Prevention’s hantavirus response, told reporters in a briefing Wednesday.
That patient, who is not ill, is being monitored at a biocontainment unit at the University of Nebraska Medical Center.
Five California residents have been potentially exposed to the virus — four aboard the cruise ship, and the fifth while on a plane with an infected person in South Africa. All five are asymptomatic and appear healthy, the California Department of Public Health said Wednesday.
Most infected people actually don’t seem to spread the Andes virus, Chin-Hong said. But some do end up being “superspreaders,” infecting others at exceptional rates.
That’s what happened in 2018-19. A single person got the Andes virus from a rodent, and the outbreak was spread mainly by three sick people who attended crowded social events, the medical journal study said — including a birthday party and a wake for one of the hantavirus victims.
In the case of the MV Hondius, the first person believed to have contracted the hantavirus was a man from the Netherlands who was possibly exposed to rodents while bird-watching prior to boarding the ship before it left for its transatlantic journey, according to authorities. He had spent the prior three months traveling through Argentina, Chile and Uruguay, the World Health Organization said. The man boarded the ship on April 1, developed symptoms on April 6 and died on board on April 11.
“At present, the thought is that it was an ornithologist who was visiting a dump, where many rare birds congregate, and was exposed to a rodent that was in the garbage dump,” said Dr. Elizabeth Hudson, regional physician chief of infectious diseases for Kaiser Permanente Southern California.
From there, she said, the realities of cruising at sea set the stage.
“Cruise ships are a perfect environment for the spread of infectious diseases, unfortunately,” Hudson said. “You have a population of people who are living together in a relatively small and confined space, with most folks spending a good part of their time indoors eating and socializing. This means that if there’s an infection that can spread easily from person to person, the very nature of the cruise ship allows this to happen more readily.”
It can also be difficult to isolate sick people aboard a cruise ship. The MV Hondius’ doctor fell ill with hantavirus, as did another crew member who was working as a guide. Among the symptoms people reported were gastrointestinal illness, fever, general malaise, pneumonia, fatigue, aches and respiratory symptoms.
Extensive spread of the hantavirus outbreak is not expected, health experts say. Unlike COVID-19, the Andes virus is much harder to transmit from person to person.
In past outbreaks of the Andes virus, taking steps like isolating people who are sick — and asking those who aren’t sick but have been exposed to stay away from others — have brought outbreaks to an end.
It can take up to six weeks from the time a person has been exposed to the virus to the onset of illness. That “takes us to the 21st of June,” WHO Director-General Tedros Adhanom Ghebreyesus said at a news briefing Tuesday. “WHO’s recommendation is that they should be monitored actively at a specified quarantine facility or at home for 42 days from the last exposure.”
One Californian who was on the MV Hondius, but left the ship before the hantavirus outbreak was discovered, is back home in Santa Clara County and remains healthy. That person is being asked to limit trips outside the home during the 42-day period to see if they become ill, according to Dr. Erica Pan, director of the California Department of Public Health.
Another Californian, from Sacramento County, is also back at home after sitting within a couple of seats of a hantavirus-infected passenger who was briefly on a flight from South Africa to the Netherlands before being asked to deplane due to her illness. The Californian remains healthy, but is also being asked to limit activities with others.
“They’re not to share a bed with someone else. … They shouldn’t attend social events, and they should not visit any crowded venues,” Pan said.
Two other Californians who were on board the MV Hondius are healthy and are being observed at the University of Nebraska Medical Center’s National Quarantine Unit, the only federally funded quarantine unit in the U.S. Thirteen others are also being observed there, while two are at Emory University in Atlanta.
The California Department of Public Health said it didn’t know when the Californians in Nebraska would return home.
California health officials Wednesday said that there was a fifth state resident who was potentially exposed to the hantavirus. That person left the cruise ship, returned briefly to California, then left for additional travel, all before the outbreak was announced.
That person, who remains healthy, is now in the remote Pitcairn Islands in the south Pacific Ocean — halfway between Peru and New Zealand.
Despite concerns surrounding this latest outbreak, the Andes virus is considered a poor candidate to become the next pandemic. One thing that makes COVID spread so easily is that people can infect others even if they’re not personally experiencing symptoms.
With COVID, people could get sick just by breathing in aerosolized viral particles floating around and pushed across an entire room by an air conditioning vent.
With the Andes virus, by contrast, people probably need to be symptomatic to spread illness.
The 2018-19 Andes virus outbreak in Argentina also showed that close contact is needed for transmission, including “being seated very close” to the sick person, Chin-Hong said.
Those at highest risk of getting hantavirus from another human have “some direct exposure to bodily fluids,” Pan said.
The first U.S. case of Andes virus actually occurred in January 2018, in a woman who had stayed in cabins and youth hostels in the Andes region of Argentina and Chile. She did not infect anyone else after her return despite taking two commercial flights in the U.S. when sick and before she was hospitalized in Delaware. She eventually recovered at home.
More morbidly, health experts note, the Andes virus is also too deadly for it to spread rapidly in a pandemic situation.
So why are we seeing this outbreak now?
Hantavirus appears to be expanding its range in Argentina. A report published in December noted that hantavirus’ range in that country was moving southward.
“This redistribution indicates either ecological shifts affecting rodent reservoir populations, increased human encroachment into previously untouched habitats, or improved surveillance detecting cases in areas with lower historical awareness,” said the report, published by the Biothreats Emergence, Analysis and Communications Network, or BEACON, based at Boston University’s Center on Emerging Infectious Diseases.
From mid-June through early November, there were 23 confirmed cases in the country, with nine deaths. No human-to-human transmission was reported during that time period.
Another report suggested changing temperatures and rainfall also affected hantavirus transmission in Argentina.
Another well-documented example of that phenomenon is the rise of dengue viruses in Argentina, which are spread by mosquitoes. Rising temperatures are making the climate more suitable for transmission, one study suggested.
“Climate change has definitely had an impact on Argentina,” Chin-Hong said. “As it gets warmer, you potentially have more rats.”
Science
After bold pledge, EPA shelves microplastics testing in U.S. drinking water
For the next five years, the Environmental Protection Agency has indicated it will not require public water utilities to test for microplastics or pharmaceuticals in drinking water, according to a proposed rule published in the Federal Register.
On Friday, the EPA submitted a list of chemicals it plans to test for under the Unregulated Contaminant Monitoring Rule, a mandatory testing program used to collect information about concerning chemicals in drinking water that could be harming human health. It did not include microplastics or pharmaceuticals.
The omissions come after announcements by EPA Administrator Lee Zeldin earlier this year that his agency was designating microplastics and pharmaceuticals priority contaminants for testing.
“This is a direct response to the concern of millions of Americans who have long demanded answers about what they and their families are drinking every day,” he said at an April news conference with Health and Human Secretary Robert F. Kennedy Jr. at EPA headquarters.
Zeldin’s announcement was seen at the time as a move to placate the increasingly disgruntled Make America Healthy Again contingent of Trump supporters.
Now the agency says it has no validated or standardized method to test for the plastic particles in drinking water, and wouldn’t be able to develop one before December, when testing is required to begin.
Among the 33 chemicals the EPA will require water utilities to test for are seven PFAS, or forever chemicals, and three pesticide residues.
It will be five years before the EPA proposes another list.
The EPA did not respond to a request for comment.
The agency noted in its proposed rule that it will collaborate with other federal agencies to “evaluate risks and exposures” of microplastics for future monitoring.
Environmentalists reacted with frustration and resignation. They pointed out that the European Union has developed methods to test for the tiny plastic particles, which have been found in people’s blood, brains and lung tissue. California has one in the works.
“The California water board has spent a lot of time and money on how to measure in drinking water,” said Judith Enck, a former EPA regional administrator and president of the anti-plastic environmental group Beyond Plastics. “EPA should give them a call.”
California was required by a 2018 state law to establish a protocol for local water utilities to test for the particles in drinking water. The state has not yet begun reporting its results, but protocols were established in 2021. Blair Robertson, a spokesman for the State Water Resources Control Board, said it’s not “a fully validated, end-to-end regulatory method” yet.
At the April meeting, Zeldin announced that he would place microplastics on what is known as the Contaminant Candidate List, which acts as a preliminary “watch list” of unregulated, priority contaminants in drinking water. Like the mandatory monitoring list, it is updated only every five years. The most recent list was published on April 2 — the day he made his announcement.
“Americans have been ignored as they sound the alarm about plastics in their drinking water,” Zeldin said during the announcement. “That ends today by placing microplastics on the contaminant candidate list for the first time ever. EPA will follow the science, will pursue answers and will hold ourselves to the highest standards to protect the health of Americans.”
There appears to be no clear association between these two lists, although the contaminant list is supposed to inform the monitoring list. Seventy-five chemicals and four chemical groups (microplastics, pharmaceuticals, PFAS chemicals, and disinfection byproducts) were listed on the 2026 contaminant list. Only seven of those chemicals were also on the proposed monitoring list (as well as seven PFAS chemicals).
When Zeldin announced microplastics as “‘a priority contaminant for regulation,’ and called it ‘a historic action on microplastics,’ he made it seem like the administration was going to take microplastics seriously,” said Mary Grant, water policy director for the environmental group Food & Water Watch.
“By not including them, they made it clear they don’t actually have plans to immediately address this crisis by getting the real-world monitoring data that we need right now to really start correcting ourselves,” she said.
Craig Davis, senior director of plastics chemistry at the American Chemistry Council — the nation’s largest trade group for chemical companies — said that while his organization supports microplastic research, it also agrees with the EPA’s decision not to include them in the monitoring list.
“National drinking water monitoring should be based on validated, standardized methods that can produce reliable and comparable data,” said Davis in a statement. He said “limited” national monitoring resources should be focused where data can produce “actionable public health information.”
The public has 60 days to comment once the plan is published in the Federal Register.
Science
Hospital visits for smoke inhalation spiked during Boyle Heights warehouse fire
The number of Angelenos who went to the hospital with throat pain and concerns about smoke inhalation spiked as a fire burned through the massive Lineage cold storage warehouse in Boyle Heights this month, The Times has learned.
The blaze burned for eight days beginning June 17 and involved solar panels, insulation foam and other industrial materials.
During that time, more than three times as many people went to emergency departments within 10 miles of the warehouse mentioning the fire or smoke inhalation compared with the two weeks prior, according to data from the Los Angeles County Department of Public Health obtained through a public records request.
The agency also noted a near doubling of patients mentioning throat pain within five miles of the fire June 21 — 1.9 times the baseline levels.
Usually, fewer than 50 people go to the emergency room each day for throat pain, and fewer than 20 people for smoke inhalation, the department said.
The hospitalization data was tracked through the department’s syndromic surveillance project, which monitors trends in what people report when they come to emergency departments in L.A. County, as well as diagnosis codes noted by providers. The system is not as comprehensive as full patient health records, and clinicians may not always include key words about “fire,” “smoke” or other circumstantial information in their diagnoses, the public health department said.
As such, it “cannot capture the true number of [emergency department] visits related to symptoms from the fire and likely underestimates the true burden of fire related symptoms,” the department said.
Perhaps unexpectedly, the department said it did not note a substantial increase in asthma, acute respiratory symptoms or chronic obstructive pulmonary disease-related emergency department visits during the fire.
But even these preliminary findings are concerning, experts said. The fire is believed to have started on the solar array on the roof of the 500,000 square-foot building, which housed 85 million pounds of frozen food. It then reached an ammonia line, prompting two brief shelter-in-place orders for nearby residents.
Over the next week, the fire continued to burn through dense insulation foam within the building’s walls and other unknown industrial materials, blanketing much of L.A. in acrid smoke. Residents in downtown L.A., northeast L.A., Burbank, the San Gabriel Valley and many other parts of the city and county reported seeing and smelling the fumes.
The South Coast Air Quality Management District issued multiple warnings about unhealthy levels of PM 2.5, or fine particulate matter. The city and county opened two smoke respite shelters in the immediate area so that people could breath cleaner air.
It is still unclear what exactly was in the smoke that people breathed in. Industrial fires release far more materials than the burned wood smoke that is emitted during wildfires.
“The makeup of the smoke can include toxic chemicals, fine particles and other serious risks to lung health depending on fire conditions and what is burned,” Will Barrett, assistant vice president for nationwide clean air policy at the American Lung Assn., said as the fire was burning. Children and elderly people are particularly at risk.
David Eisenman, director of the UCLA Center for Public Health and Disasters, said urban industrial fires also can represent a hazard that standard PM 2.5 warnings don’t always address. Those advisories are “blunt instruments” that don’t adequately capture emissions from burning man-made goods — or convey that the source of pollution may include burning batteries or toxic refrigerants, he said.
The fact that initial numbers don’t show a spike in asthma attacks is “somewhat reassuring,” Eisenman said. But “people may have gone to their primary care doctors, which this would not capture. This data deserves follow up.”
The air district and the U.S. Environmental Protection Agency deployed air monitors to assess particulate matter, airborne toxic metals and other harmful compounds during the early days of the blaze. The air district said it didn’t find significant levels of air toxics during the first two days of the fire, although it did record significantly elevated concentrations of particulate matter within the plume downwind.
Some of the measurements it took with mobile monitors, which are five-minute snapshots, also showed increased bromine and chlorine, which often are found when buildings burn and were at levels “below short-term health-based exposure thresholds,” the air district said. It began continuous PM 2.5. monitoring at two nearby elementary schools on the third day.
The L.A. Fire Department said it detected low-levels of toxic hydrogen fluoride on the second day of the fire, which can be a byproduct of burning lithium-ion batteries.
Lineage, the tenant-operator of the warehouse, said no concentrations of ammonia were detected in the air at any time.
“There’s no doubt this fire has had a huge impact on the local community, and we are committed to showing up in every way we can,” company officials wrote in a statement last week. They said Lineage worked closely with the Fire Department during the blaze and delivered masks, air purifiers and other supplies to the community, and will work to ensure the fastest cleanup possible.
The long-term health effects of the fire and its smoke probably won’t be known unless researchers conduct a follow-up study, said Eisenman of UCLA.
For example, there may have been delayed pulmonary effects from the hydrogen fluoride and burning insulation foam that — when combined with the elevated PM 2.5 levels in a dense urban environment — produced health effects that didn’t show up in the emergency room data.
“They will show up in increased primary care office visits and exacerbations of chronic disease over the next few weeks,” he said. “So from a public health standpoint, this fire is not over.”
Science
Water from Boyle Heights warehouse fire carries foam into L.A. River, sparks testing
LOS ANGELES — All the water unleashed onto the warehouse fire in Boyle Heights — some of it 480 gallons at a time by helicopter — had to end up somewhere.
That somewhere is the Los Angeles River.
Los Angeles Fire Department crews ripped through 50-foot walls filled with foam insulation to get to the building’s steel skeleton and its storage racks.
Charred chunks of foam have been floating from the burn site, partially blocking storm drains. Now organizers from East Yard Communities for Environmental Justice are teaming up with scientists from UCLA and Columbia University to find out more about what’s in the runoff.
“The community here is really interested in knowing, ‘Are there any contaminants that are potentially making their way down to the L.A. River?’” said Yoshira “Yoshi” Ornelas Van Horne, UCLA assistant professor in environmental health sciences. “We really can’t answer that unless we actually have measures and samples analyzed.”
Water samples collected directly from the warehouse fire runoff have been shipped to Columbia‘s Multi-Element Trace Analysis Laboratory in New York, which has a spectrometer that can identify trace levels of elements. The lab also has relationships with researchers in Southern California.
1. Emmanuel Carrera Ruedas, left, and Casey Cooper prep containers to take water samples from the L.A. River. 2. Casey Cooper holds a water sample. (Christina House / Los Angeles Times)
The data will then come back to UCLA for analysis. For now, the scientists and community advocates only have the money to test for copper, lead and arsenic, Ornelas Van Horne said. Residents have expressed interest in testing for more contaminants.
As the water from the firefighting efforts trickles through the warehouse in rivulets, it forms a stream at the corner of S. Indiana and Noakes streets, that gushed into the storm drain. On a recent visit, the water traversed a smoky 10-foot canyon of charred foam and twisted wall panels on its way to the drain.
From there, the water flows to the L.A. River. Despite the fact that its concrete design is intended to whisk water out of the city as fast as possible, life stubbornly persists in the river and nearby. Recreational swimming is not permitted, yet anglers fishing for tilapia, largemouth bass and carp are a common sight along the rocky sides of the soft-bottom areas.
The L.A. River, and all it carries with it, meets the ocean in Long Beach.
The L.A. County Public Works Department said it has deployed three containment booms — floating barriers — on the L.A. River, and is continuing to monitor the water as it makes its way to the ocean.
Emmanuel Carrera Ruedas takes a water sample.
(Christina House / Los Angeles Times)
Before it gets there, the river passes through the Dominguez wetlands, where Public Works is removing some number of dead fish. The wetland has absorbed toxic runoff from a warehouse fire before, resulting in a fish die-off.
“For so long, the L.A. River has been used as a dumping ground for all kinds of chemicals,” said Emmanuel Carrera Ruedas, a community scientist and member of East Yard Communities for Environmental Justice.
Pollution has plagued the L.A. River, but it does have allies. In the 1980s, the Friends of the LA River pushed to address street runoff and trash that had made the water body infamous. Significant progress from advocacy and government initiatives improved water conditions, but these efforts have not been equally distributed.
Carrera said the samples represent “proof of what’s actually going on, and accountability, too, for the city, of not just what’s happening in our air, but what’s actually happening in our waterways.”
The first samples for the project were taken last Friday, the second day of the fire.
They were the first of 20 samples the research groups have agreed to test at no cost to see if any exceed regulatory standards and could pose a risk to people nearby.
The warehouse fire represents the latest environmental disaster for people in Boyle Heights and East L.A. Just four weeks ago, a telecommunications crew accidentally struck one of the many oil pipelines beneath the L.A. area, spilling 25,000 gallons of crude oil near Eastern and Cesar Chavez avenues — including into storm drains feeding to the L.A. River.
“I think it really is difficult to see disaster after disaster hit the communities here, with not a lot of talk about how we can move through these disasters together,” said Casey Cooper, a volunteer community scientist involved in the sampling. They were inspired, they said, by the response of neighbors, and how people were supporting one another.
Results from the laboratory analysis could be back to Ornelas Van Horne within a month.
-
Los Angeles, Ca58 minutes agoMan dies after violent solo crash in Sherman Oaks
-
Detroit, MI1 hour agoPriority Waste CEO shares progress on plan to fix disruptions, delays across Metro Detroit
-
San Francisco, CA1 hour agoThe San Francisco Church That Holds America’s Secrets
-
Dallas, TX2 hours agoCrews battle large fire at Pilates studio in Uptown Dallas, officials say
-
Miami, FL2 hours agoalaïa clads first miami boutique in pink mosaic tiles, from interior to facade
-
Boston, MA2 hours ago
Looking for a lodging adventure? Beat the heat at a floating B&B. – The Boston Globe
-
Denver, CO2 hours agoLavender festival, Tennyson Street Fair and more free and cheap things to do in July
-
Seattle, WA2 hours agoSeattle’s solution for the middle-class housing squeeze: government housing | CNN Business