Rhode Island
3 Medical Breakthroughs in Rhode Island – Rhode Island Monthly
Pressure Point
Brown scientists have discovered a key driver of preeclampsia, which causes high blood pressure during pregnancy. By Dana Laverty
Photograph: Getty Images/Petrunjela.
Researchers at Brown University have identified a protein in cerebrospinal fluid that’s a driver in preeclampsia, a dangerous pregnancy condition that affects between 5 to 8 percent of pregnancies and is a leading cause of maternal and fetal death.
Research led by Surendra Sharma and Sukanta Jash at Brown University and Kun Ping Lu and Xia Zhen Zhou at Western University in Canada found the protein, cis P-tau, in the blood and placentas of people with preeclampsia. They also found that depleting cis P-tau prevented mice from developing the condition.
“Our study identifies cis P-tau as a culprit and biomarker for preeclampsia,” says Sharma, who until recently was a Brown professor of pathology and laboratory medicine and professor of pediatrics. “It can be used for early diagnosis of the complication and is a crucial therapeutic target.” (Sharma is now a professor of obstetrics and gynecology at the University of Texas Medical Branch in Galveston.)
Preeclampsia is a complication that results in high blood pressure during pregnancy. Untreated, it can lead to serious complications for both the mother and baby, and often leads to preterm labor and birth.
The protein cis P-tau has mainly been associated with Alzheimer’s disease, traumatic brain injuries and stroke. Lu and Zhou discovered the association in 2015.
Screening tests for the cis P-tau biomarker, combined with therapies involving the cis P-tau antibody, could change the outlook for pregnant people with preeclampsia, Jash says. The root cause of preeclampsia has so far remained unknown, Sharma says, and without a known cause there has been no cure.
The team at Brown is currently working on developing a lab test that can detect preeclampsia.
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Bridging the Gap
Researchers from Brown University and Lifespan are partnering on a device that could restore function for individuals with a spinal cord injury. By Lauren Clem
A clinician works with a participant in the trial. Photo courtesy of Lifespan
In an unassuming building on Allens Avenue in Providence, research is underway that could change the future of spinal cord injury treatment.
The Intelligent Spine Interface, led by researchers from Brown University and surgeons from Rhode Island Hospital, aims to restore limb motor function, sensation, autonomic function and bladder control for individuals paralyzed following a spinal cord injury. According to principal investigator David Borton, an associate professor of engineering and brain science at Brown University and biomedical engineer with the Department of Veterans Affairs, no technology currently exists to bridge the gap created by such an injury.
“There’s no tool or a magic fix that we have for someone who has a complete spinal cord injury,” he says. “There’s nothing available to help them regain functions that they have lost.”
Working with Dr. Jared Fridley, director of the Spinal Outcomes Laboratory at Lifespan and an associate professor of neurosurgery at Brown, the team is creating a device that would carry signals across the injury site and restore the connection between brain and limbs. The device uses artificial intelligence to interpret signals from the spinal cord and adapt to the needs of the wearer over time.
“These devices enable the person’s spinal cord and nervous system to modulate over time to hopefully recover function,” Fridley says. “For most people, we’re talking about weeks to months of rehabilitation, plus the device, to see if there’s recovery of function.”
David Borton and Dr. Jared Fridley, right, present their research to Yunyan “Jennifer” Wang and Jean-Paul Chretien of the Defense Advanced Research Projects Agency in Washington, D.C. Photo courtesy of DARPA.
The study, funded by the Defense Advanced Research Projects Agency and the Department of Veterans Affairs at the Providence VA Medical Center, has the potential to restore movement to those with spinal cord injuries, including veterans paralyzed in combat situations. A clinical trial is underway at Lifespan’s Center for Innovative Neurotechnology for Neural Repair, where the researchers have enlisted two individuals to participate in phase one of the trial.
“This is a first in human clinical study for this type of technology,” Borton says. “No one’s ever done this before.”
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Vasectomy Victor
There may be a faster and easier way to perform a vasectomy. By Jamie Coelho
Imagine if men could get a vasectomy in five seconds. There may be a new, minimally invasive way to conduct the procedure in our near future. On the heels of its five-year anniversary, Providence-based Signati Medical earned FDA approval for clinical trials for a study of a minimally invasive surgical device to perform a sealed vasectomy procedure (SVP).
Photo courtesy of Signati Medical.
Signati Medical is a medical device company working to advance men’s health. Signati CEO William Prentice says the study kicked off this April with its first patient at Louisiana State University Medical Center, and they plan to have an additional seven people undergo the procedure by the end of the month. The device obstructs the vas deferens by sending a shock through the skin that seals the tubes, rather than a surgeon cutting and fusing.
Prentice wants to undergo SVP on live TV to gain support, but he must wait until the procedure is fully approved. “I agreed to do it,” he says. “We should be doing this for women. There’s no reason women need to go in for tubal ligations and have major surgery, take birth control pills or get IUDs. Men think because they have a vasectomy, they are not going to get an erection. It really shouldn’t be that way.”
Prentice says this is the first innovation in vasectomy in more than twenty years.
“About twenty years ago, one thing changed and that was that they went from scalpel to no scalpel,” he says. “This procedure takes about five seconds. Bipolar sealing in the body is the best sealing you can get.” signatimed.com
Rhode Island
Rhode Island women’s basketball wins A-10 regular-season championship
WATCH: URI women’s basketball clinches A-10 regular-season championship
The Rhode Island women’s team beat George Washington University 72-48 on Saturday, Feb. 28, clinching the Atlantic 10 regular-season championship
SOUTH KINGSTOWN – What was a peerless achievement in University of Rhode Island women’s basketball history now has some company just four short years later.
The Rams are Atlantic 10 regular-season champions again after a special Saturday afternoon in Kingston, a coronation more than a contest against visiting George Washington.
The Revolutionaries never had a chance after the hosts got off to a sharp start at the Ryan Center. URI left no doubt in front of its best crowd of the season, and a significant portion of that gathering stuck around long after the final whistle to see the nets cut down again.
It was all Rams in this 72-48 cruise, a result that matched what was a first in 2022-23 and handed URI a No. 1 seed in the upcoming conference tournament. George Mason dropped to the No. 2 spot despite posting the same 16-2 league record as the Rams, and that came thanks to a comprehensive 79-63 defeat in a Valentine’s Day matchup.
“There’s nothing more satisfying as a coach than to have the confetti fall and to cut down nets with this group of young women,” URI coach Tammi Reiss said. “I’ve never been prouder.”
URI scored on each of its first five offensive possessions and authored a masterpiece through the opening three quarters. It was only in the fourth when Reiss emptied her bench that George Washington showed any semblance of being able to keep pace. Palmire Mbu led three in double figures with 23 points, and Sophia Vital played yet another complete all-around game to help the Rams run roughshod.
“We were just extra motivated today,” Mbu said. “We wanted to do great for our crowd.
“Just trying my best. Trying to be aggressive and to give solutions on offense and defense. It felt good.”
URI owned a 21-point lead entering the final 10 minutes, thanks to 18 assists, just two turnovers and 63.4% shooting from the field. The Rams buried the offensive struggles they experienced in road losses to La Salle and Richmond with what had been a typical display of crisp execution. URI closed 26-for-35 from 2-point range, collected 48 points in the paint and racked up another 17 off Revolutionaries turnovers.
“I do believe the last four years we had talented teams – we had talented players,” URI guard Ines Debroise said. “But I think it’s also how we can put all the pieces of the puzzle together. This year that’s what we were going to do from day one.”
Mbu’s bucket off a Vanessa Harris steal gave the Rams a 25-10 lead and forced a George Washington timeout with 6:38 left in the second quarter. It seemed just a matter of time before this one was out of reach, and Brooklyn Gray followed a Debroise 3-pointer with a pair of layups to make it a 32-12 cushion. URI’s lead never dipped under 12 points again, and Mbu’s hook in the lane capped an 8-0 run that took it back to 58-38 with 1:00 left in the third.
Video of URI coach Tammi Reiss speaking postgame on Feb. 28
URI women’s basketball beats George Washington to win the Atlantic 10 regular-season championship
“They were sharing the ball in a championship game,” Reiss said. “It wasn’t 1-on-1. That’s what makes this team special.”
The Rams (25-4, 16-2 Atlantic 10) set a new program best for conference wins in a season and are now one shy from a new overall mark – they collected 26 while making a run to the WNIT Round of 16 in 2022-23. URI shared the league crown with rival Massachusetts that year before suffering a semifinal upset against Saint Louis and missing out on a third meeting with the Minutewomen.
“Their job is to show up and be us,” Reiss said. “Execute our game plan with discipline and ferocity for 40 minutes. Our job is to manage them – their health, their minutes.”
The Revolutionaries (15-16, 7-11 Atlantic 10) dropped to the No. 10 seed in the upcoming conference tournament and will play No. 7 Saint Louis in the second round on Thursday, March 5. The Rams will open Friday’s quarterfinals in an 11 a.m. tip on the USA Network against either No. 8 Loyola Chicago or No. 9 St. Bonaventure. No. 4 Davidson and No. 5 Saint Joseph’s are in URI’s half of the bracket, while the second-seeded Patriots and third-seeded Spiders could be on a semifinal collision course in the other half at Henrico Sports & Events Center.
“It’s going to be tough for everybody – probably three games in three days,” Mbu said. “We’ve got to push to the end and play like we’ve been doing.”
GEORGE WASHINGTON (48): Sara Lewis 2-10 2-2 6, Gabby Reynolds 7-13 2-2 17, Tanah Becker 1-2 1-1 3, Mia James 2-6 0-0 4, Kamari Sims 2-4 0-0 4, Emma Theodorsson 0-6 2-2 2, Jaeda Wilson 1-2 0-0 2, Filipa Calisto 2-2 0-0 4, Colleen Phiri 0-0 0-0 0, Caia Loving 2-2 0-0 4, Payton Dulin 1-1 0-2 2. Totals 20-48 7-9 48.
RHODE ISLAND (72): Palmire Mbu 9-14 3-4 23, Albina Syla 5-6 0-0 10, Brooklyn Gray 5-6 0-0 11, Sophia Vital 3-6 1-2 7, Ines Debroise 4-7 0-0 9, Vanessa Harris 3-7 0-0 7, Aimee Michel 2-2 0-0 4, Valentina Ojeda 0-2 0-0 0, Ta’Viyanna Habib 0-0 0-0 0, Eva Agba 0-1 1-2 1. Totals 31-51 5-8 72.
Halftime – RI, 40-25. 3-point FG – GW 1-8 (Reynolds 1-2, Becker 0-1, James 0-2, Sims 0-1, Theodorsson 0-2), RI 5-16 (Mbu 2-4, Gray 1-1, Vital 0-2, Debroise 1-4, Harris 1-2, Ojeda 0-2, Agba 0-1). Rebounds – GW 23 (Sims 5), RI 26 (Vital 6). Assists – GW 7 (Sims 2, Loving 2), RI 21 (Vital 7). Turnovers – GW 13 (Sims 4), RI 7 (Gray 2, Harris 2). Blocked shots – GW 2 (James 1, Loving 1), RI 3 (Mbu 2). Steals – GW 3 (Lewis 1, James 1, Sims 1), RI 6 (Vital 3). Attendance – 6,580.
bkoch@providencejournal.com
On X: @BillKoch25
Rhode Island
Frostbitten lizard found in Rhode Island is healing
While shoveling his driveway during yet another winter storm, a man in Providence, Rhode Island found something rather unexpected—a very cold giant lizard. Fortunately, the animal rehabilitation experts at the New England Wildlife Center found that besides being very dehydrated and having frostbite on its tongue and toes, the female tegu named Frankie was doing okay.
Tegus are large South American reptiles, so how did Frankie end up in the middle of a snowstorm in New England? Tess Gannaway, a veterinarian at the wildlife center who treated Frankie, tells Popular Science that she was probably someone’s pet.
“Given their size they often roam folk’s homes like dogs or cats and there is a chance that in warmer months Frankie escaped and was surviving on her own outside until the weather got too cold for her to manage,” Gannaway explains. There’s also the more unfortunate possibility that the lizard was recently abandoned.
Either way, Frankie was likely unable to pull her tongue back into her mouth at the start of the storm, which caused the frostbite on both her tongue and her toes. The tongue frostbite is particularly notable because known cases of animals with mucus membrane related frostbite are exceedingly unusual. Because of the frostbite, Frankie no longer has the iconic reptilian V-shape in her tongue.
In fact, veterinary medicine as a whole didn’t have any published accounts of such an affliction. As such, Gannaway and her veterinary student turned to human medical literature to decide on Frankie’s best treatment option, and ultimately identified what they were looking for.
This “is really cool and an example of something in veterinary medicine and other fields we call one health, so the intersection between human and animal health,” Gannaway explained in a New England Wildlife Center video.
In the human report, a portion of a patient’s tongue had unintentionally frozen because of a medical intervention in the mouth. Doctors then removed the dead external tissue a number of times, healing the injury within three weeks.
Similarly, the team at the New England Wildlife Center aims to remove part of Frankie’s dead tongue tissue every two or three weeks. Hopefully, the tongue will heal on its own, but the good news is that tongues are rapid healers.
Gannaway says that the team is “cautiously optimistic” about Frankie’s future.
“She did great during her first debridement [the tissue removal] and has moved on from liquid to solid food. New England Wildlife Centers’ Veterinarians will keep checking her tongue every 2 weeks to see if she needs further sedation to remove more superficial tissue,” she adds.“Until then she is on pain medications and an antibiotic. Tegus can live normal lives with only part of their tongue so as long as we can get her tongue to stabilize she should be ready to live a warmer although slightly less adventurous life.”
Rhode Island
Bodycam footage shows moments police respond to Pawtucket shooting
Police bodycam footage shows the moments officers arrived to the scene of a deadly mass shooting in Pawtucket, Rhode Island.
The shooting on Feb. 16 at the Dennis M. Lynch Arena killed Rhonda Dorgan and Aidan Dorgan, the ex-wife and son of the shooter, who died by suicide.
If you or someone you know is in crisis, call or text 988 to reach the Suicide and Crisis Lifeline or chat live at 988lifeline.org. You can also visit SpeakingOfSuicide.com/resources for additional support.
Gerald Dorgan, Rhonda’s father, died from his injuries this week. His wife, Linda Dorgan, and family friend Thomas Geruso remain hospitalized.
Around five minutes after the first officer arrives, he beings helping paramedics with a man who identifies himself as Aidan. Twelve minutes in, Aidan Dorgan is transported to the hospital, where he would later die from his injuries.
If you or someone you know is experiencing domestic violence, contact the National Domestic Violence Hotline by calling 1-800-799-SAFE (7233), visiting www.thehotline.org or texting LOVEIS to 22522.
For the last 10 minutes of the footage, the officer then begins helping paramedics transport the other three gunshot victims.
The video ends with police prepping witness interviews.
The shooting rocked the Pawtucket community. Chris Librizzi, head coach of the Blackstone Valley Schools hockey team impacted by the shooting, said the players and coaching staff “are devastated over the events that took place at Lynch Arena on Monday and intimately affected one of our teammates.”
As authorities continue investigating the shooting in Pawtucket, three patients remain in critical condition.
“We will lean on each other and support one another, as we have always done as a team,” he added.
Pawtucket police said two handguns were found at the scene after the shooting, a Sig Sauer P226 and Glock. Other weapons have been seized at the suspect’s storage unit in Maine.
Investigators continue reviewing all video evidence from before, during and after the shooting, including surveillance footage from the Dennis M. Lynch Arena, police body-worn camera footage and other records — a high school sports livestream captured the shooting from a distance — police said.
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