Missouri State vs. FIU: Week 10 College Football Betting Odds, Prediction, Pick

Week 10 of the 2025 college football season continues on Wednesday night when the Missouri State Bears host the FIU Panthers in a Conference USA battle.

The Bears come into Wednesday on a two-game winning streak, and it has pushed their record to 4-3 overall and 2-1 in the CUSA. They are near the top of the conference in their first year in the FBS.

The Panthers have been going the other direction as they have lost three of their last four games and it has dropped them to 3-4 overall and 1-2 in the conference.

Stream Missouri State vs. FIU

If you’re looking to get back in the swing of football season and need some betting advice for Wednesday’s matchup in Springfield, we’ve got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Missouri State vs FIU game odds:

All college football odds via BetMGM

• Spread: Missouri State -3.5 (-115), FIU +3.5 (-105)
• Money Line: Missouri State -190, FIU +155
• Over-Under: Over 50.5 (-110), Under 50.5 (-110)

Missouri State vs FIU prediction, pick:

The Bears have been finding ways to win over the last two weeks, while the Panthers have been getting blown out. The Panthers have been struggling on defense, giving up 28 or more points in five of their last six games. The Bears haven’t exactly been putting up a ton of points, but their defense has played well. They are also at home, and that will make the difference. They hold down the Panthers and do enough offensively to cover and get their third straight win.

Prediction: Missouri State 27, FIU 17

Best Bet: Missouri State -3.5, Under 50.5

Missouri State vs FIU channel, start time, streaming:

Time: 8 p.m. ET

TV Channel: CBS Sports Network

Live Stream: Paramount+

Get more betting analysis and predictions at Sportsbook Wire.

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