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The Top 5 drugs fueling the overdose crisis in Indianapolis

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The Top 5 drugs fueling the overdose crisis in Indianapolis


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If you or a loved one is struggling with mental health or substance abuse problems, contact the Substance Abuse and Mental Health Services Administration at 1-800-662-HELP (4357) for help. Anyone grieving the loss of someone to overdose can text ‘mental’ to 317-435-5281 to get connected with mental health resources.

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INDIANAPOLIS — Drugs are continuing their deadly grip on the Circle City, keeping overdose deaths at concerning levels.  

Illicit fentanyl is the driving force behind the crisis, carrying a fatal dose small enough to fit on the tip of a pencil.

Beyond fentanyl, other drugs remain a concern in overdose cases seen by the Marion County Coroner’s Office.  

Here are the top drugs seen in overdose deaths in the Indianapolis area:  

Overdose alerts: Get texts to know when a bad batch of drugs is in your neighborhood

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Where are overdoses happening the most in Indianapolis?

Seven ZIP codes in Marion County were identified as “hot spots” for overdose, accounting for 46% of deaths so far this year.

What is fentanyl?

Fentanyl is a synthetic opioid that’s 100 times more potent than morphine and 50 times more potent than heroin, according to the U.S. Drug Enforcement Administration.

Where to get fentanyl test strips

Overdose Lifeline offers to anonymously send fentanyl test strips to Indiana residents through its website. Those interested must fill out a form with their contact info.

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Strips are also available 24/7 inside one of thousands of “NaloxBox” kits stationed throughout the state. Find a kit online at overdoselifeline.org/naloxone-indiana-distribution/.

Fentanyl overdose symptoms and side effects

Overdose causes someone to fall into a stupor state. Their pupil size may change, their skin may become clammy and their lips, nail beds and skin may turn blue. Someone who is overdosing may have respiratory failure that leads to death.

What does fentanyl look like?

Fentanyl is typically a powder or liquid. In recent years, the powder has become a common additive to heroin, methamphetamine or other street drugs, often without the user knowing.

Illicit fentanyl has also been pressed into fake pills to mimic drugs such as oxycodone or Adderall.

Where can I get Narcan?

Narcan, the common name brand for the opioid reversal agent naloxone, can be requested through Overdose Lifeline website. The supplies can be delivered anonymously.  

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Medetomidine What to know about the latest sedative found in Indianapolis street drugs

Contact reporter Sarah Nelson at sarah.nelson@indystar.com



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Pirates farm report for April 18, 2026: Rafael Flores Jr. hits 1st homer in Indianapolis win

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Pirates farm report for April 18, 2026: Rafael Flores Jr. hits 1st homer in Indianapolis win


INDIANAPOLIS (Triple A, 6-14) thumped Omaha (Royals), 11-3. 1B Rafael Flores Jr. (.206) went 2 for 3 with a double, his first home run, two runs scored and three RBIs. LF Tyler Callihan (.239) went 3 for 4 with a double and his first homer, a two-run shot. DH Enmanuel Valdez (.273) went 2 for 4 with his first homer and three runs scored. RF Esmerlyn Valdez (.258) went 2 for 5 with two doubles and a run scored. SS Davis Wendzel (.269) went 1 for 3 with a double, two walks, two runs scored and two RBIs. RHP Carson Fulmer (2-0, 5.51) started, gave up three runs on three hits in five innings and earned the win. RHP Chris Devenski (1.50) and LHP Joe La Sorsa (3.24) each pitched two scoreless innings.

Next: Sunday at Omaha (Royals), 3:05 p.m.

ALTOONA (Double-A, 2-12) had two hits – both solo home runs – and beat Portland (Red Sox), 2-0. LHP Dominic Perachi (1-0, 1.80) started and went six innings, allowing three hits and two walks with three strikeouts. RHP Landon Tomkins (3.38) followed with two scoreless. RHP Jaycob Deese (3.00) worked the ninth for his first save. LF Titus Dumitru (.146) went 1 for 3 with his second homer. C Shawn Ross (.182) went 1 for 3 with his second homer.

Next: Sunday vs. Portland (Red Sox), 1 p.m.

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GREENSBORO (High-A, 10-4) lost 8-3 to Brooklyn (Mets). C Easton Carmichael (.273) went 2 for 4 with an RBI. RF Shalin Polanco (.250) went 1 for 3 with a stolen base and an RBI. 1B Jared Jones (.277) went 2 for 5 with a run scored. RHP Carlson Reed (0-1, 7.36) started, recorded one out and gave up four runs on two hits and four walks. RHP Jose Garces (3.60) pitched two scoreless innings.

Next: Sunday at Brooklyn (Mets), 2 p.m.

BRADENTON (Low-A, 5-9) allowed seven stolen bases in its 6-5 loss to Tampa (Yankees). CF Edward Florentino, starting a rehab assignment as he recovers from an ankle injury, went 1 for 3 with a walk, double and run scored. LHP Reinold Navarro (6.43) started and gave up three hits, four walks and two earned runs over three innings while striking out five. SS/1B Eddie Rynders (.128) went 2 for 4 with a double and an RBI. DH Edgleen Perez (.238) went 1 for 4 and drove in two runs. LF/CF Josh Tate (.208) went 2 for 5 with an RBI. 2B/SS Antonio Pimentel (.154) went 2 for 4 with a double. RHP Greiber Mendez (5.40) and RHP Noah Murdock (0-1, 9.00), who took the loss, each gave up two hits and one run in one inning. RHP Treyson Peters pitched the final three innings, allowing five hits, one earned run and one walk while striking out two.

Next: Sunday at Tampa (Yankees), noon

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The Zone Extra | April 18, 2026

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The Zone Extra | April 18, 2026


INDIANAPOLIS (WISH) — It was another busy week in high school sports in central Indiana and ‘The Zone Extra’ has it all covered.

Athlete of the week and Guerin Catholic senior outfielder Ian Taylor is off to a scorching hot start to the young season. Check out his interview as well as Guerin Catholic head coach Dave Schrage talk about Taylor’s success.

The Johnson County baseball tournament came to a close. See highlights from Center Grove’s tournament victory.

The 4A baseball coaches poll was released as well as the 3A softball coaches poll.

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The former Columbus North gymnastics coach, John Hinds, passed away at 88 years old.

Center Grove head softball coach Alyssa Coleman joins the show for a coaches corner conversation.

See highlights from the Colts Local Pro Day, featuring several former Hoosiers and Purdue’s Devin Mockobee.

Girls lacrosse is in the first season as an IHSAA emerging sport.

All of that, and more, can be found in the full The Zone Extra show above.

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Tornado watches issued for counties north and west of Indianapolis

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Tornado watches issued for counties north and west of Indianapolis


(WISH) — A tornado watch was issued until 3 a.m. EDT Saturday for counties northwest and west of Indianapolis, and into Illinois.

Indiana counties in the watch area are Boone, Carroll, Cass, Clay, Clinton, Elkhart, Fountain, Fulton, Howard, Kosciusko, La Porte, Marshall, Miami, Montgomery, Parke, Pulaski, Putnam, St. Joseph, Starke, Tippecanoe, Vermillion, Vigo, Wabash, Warren and White. The watch area includes the cities of Crawfordsville, Elkhart, Lafayette, Lebanon, South Bend, Terre Haute, and West Lafayette.

The National Weather Service Storm Prediction Center has issued two watches in Indiana. The other one until midnight EDT Friday includes the Indiana counties of Benton, Jasper, Lake, Newton and Porter. That includes the city of Gary. That watch also extends into Illinois.

Storms on Friday night in central Illinois, Iowa, Missouri and Minnesota led to dozens of confirmed tornado warnings. The storms in central Illinois has gusts up to 80 mph, and tornadoes embedded in heavy rain.

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An alert issued after 10:30 p.m. Friday from the National Weather Service at Indianapolis said, “A line of strong thunderstorms is nearing the state line with a history of widespread damaging winds and tornadoes. The line is expected to continue to produce damaging winds as it moves into Indiana with the potential for additional tornadoes. The line is then expected to gradually weaken as it moves further into the state.”



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