NFL Week 2 scouting report: Denver Broncos players to watch vs Indianapolis Colts

The Indianapolis Colts host the Denver Broncos in NFL Week 2 action, and this matchup is unlikely to look much like the Colts’ opener. Indianapolis overwhelmed the Miami Dolphins in all areas in Week 1, while the Broncos overcame a sluggish offensive performance with dominant defense to beat the Tennessee Titans.

“I don’t know how many games I’ve called but that was one of those where I came away from it and said, ‘Man, I’ve got to be a lot better,’” Broncos coach Sean Payton told the media Sept. 10.

Here’s what Colts fans should know about the Broncos.

Denver Broncos stats from Week 1

• Bo Nix: 25-of-40 for 176 yards, 1 touchdown and 2 interceptions. He rushed 8 times for 18 yards and was sacked once. He lost a fumble.
• J.K. Dobbins: 16 carries, 63 yards, 1 TD; 2 catches for 5 yards
• R.J. Harvey: 6 carries for 70 yards, with a long of 50
• Courtland Sutton: 6 catches for 61 yards, 1 TD, 9 targets
• Talanoa Hufanga: 10 tackles
• The Broncos allowed the Titans 133 total yards and 7 first downs, both the fewest in the NFL. They sacked Titans quarterback Cam Ward 6 times, the most in the league.
• The Broncos had 4 turnovers, the most in the NFL.

Who are the Denver Broncos’ best players? Denver Broncos players to watch in NFL Week 2 on Sunday, Sept. 14

The quarterback who led Denver to the playoffs as a rookie had a shaky start to his second season, going 25-of-40 for 176 yards, 1 touchdown and 2 interceptions. His primary target is Courtland Sutton (6 catches, 61 yards, 1 TD in Week 1). The Colts held Miami to 133 passing yards with 2 INTs in Week 1, and would love a similar result this weekend.

Denver had trouble running the ball until the fourth quarter, when Harvey’s 50-yard run set up Dobbins’ 19-yard touchdown carry. The Broncos finished with 151 rushing yards.

The 2024 second-team All-Pro linebacker got a four-year contract extension worth up to $106 million in the week leading up to the opener. He spent a lot of time in the Titans backfield with 2 tackles for a loss, 1 sack and 3 quarterback hits. Indy’s offensive line should be on notice.

The defensive end who signed a four-year contract extension worth up to $102 million in training camp also spent a lot of time in Tennessee’s backfield, getting a sack and 3 quarterback hits. That’s another reason for the Colts O-line to be wary.

The Titans largely avoided throwing toward the 2024 NFL Defensive Player of the Year, and he compiled no stats. Will the Colts do the same? If so, which wide receiver gets left out? They threw to their four regular wide receivers at least twice each against the Dolphins.

Denver Broncos injury report

Linebacker Dre Greenlaw (quad) did not practice Wednesday and tight end Evan Engram (calf) was a limited participant.

The Colts have two significant injuries coming out of Week 1, both at cornerback: Charvarius Ward (concussion), Jaylon Jones (hamstring).

The Denver Broncos and Indianapolis Colts will play at 4:05 p.m. ET Sunday, Sept. 14, 2025, at Lucas Oil Stadium in Indianapolis.

What channel is Denver Broncos vs Indianapolis Colts game on TV Sunday, Sept. 14, 2025? How to watch NFL Week 2 football game live

TV: CBS, with Kevin Harlan (play-by-play) and Trent Green (analysis)

Watch Colts vs. Broncos in Week 2 on Fubo (free trial)

How to stream Colts vs Broncos NFL football game Sunday, Sept. 14, 2025. Where to watch Broncos-Colts Week 2

NFL+, Paramount+, NFL Sunday Ticket and YouTube TV, Fubo

Watch the Colts with a free Fubo trial

NFL Week 2 predictions: Are the Indianapolis Colts favored over the Denver Broncos on Sept. 14, 2025? Indianapolis Colts betting odds vs Denver Broncos in NFL Week 2

• via BetMGM
• Favorite: Broncos by 2 points
• Over/under: 42.5 total points
• Moneyline: Colts +110, Broncos -130
• ESPN’s matchup predictor gives the Colts a 51.5% chance of winning

(all times ET)

• Thursday, Sept. 11: Washington Commanders at Green Bay Packers, 8:15 p.m., Amazon (summary, box score)
• Sunday, Sept. 14: Cleveland Browns at Baltimore Ravens, 1 p.m., CBS (summary, box score)
• Sunday, Sept. 14: Jacksonville Jaguars at Cincinnati Bengals, 1 p.m., CBS (summary, box score)
• Sunday, Sept. 14: New York Giants at Dallas Cowboys, 1 p.m., Fox (summary, box score)
• Sunday, Sept. 14: Chicago Bears at Detroit Lions, 1 p.m., Fox (summary, box score)
• Sunday, Sept. 14: New England Patriots at Miami Dolphins, 1 p.m., CBS (summary, box score)
• Sunday, Sept. 14: San Francisco 49ers at New Orleans Saints, 1 p.m., Fox (summary, box score)
• Sunday, Sept. 14: Buffalo Bills at New York Jets, 1 p.m., CBS (summary, box score)
• Sunday, Sept. 14: Seattle Seahawks at Pittsburgh Steelers, 1 p.m., Fox (summary, box score)
• Sunday, Sept. 14: Los Angeles Rams at Tennessee Titans, 1 p.m., CBS (summary, box score)
• Sunday, Sept. 14: Carolina Panthers at Arizona Cardinals, 4:05 p.m., CBS (summary, box score)
• Sunday, Sept. 14: Denver Broncos at Indianapolis Colts, 4:05 p.m., CBS (summary, box score)
• Sunday, Sept. 14: Philadelphia Eagles at Kansas City Chiefs, 4:25 p.m., Fox (summary, box score)
• Sunday, Sept. 14: Atlanta Falcons at Minnesota Vikings, 8:20 p.m., NBC, Peacock, Telemundo (summary, box score)
• Monday, Sept. 15: Tampa Bay Buccaneers at Houston Texans, 7 p.m., ABC, ESPN (summary, box score)
• Monday, Sept. 15: Los Angeles Chargers at Las Vegas Raiders, 10 p.m., ESPN (summary, box score)

Watch NFL action with a free Fubo trial

• Week 1: Indianapolis Colts 33, Miami Dolphins 8, box score, stats
• Week 2: Sunday, Sept. 14, vs. Denver Broncos, 4:05 p.m., CBS
• Week 3: Sunday, Sept. 21, at Tennessee Titans, 1 p.m., CBS
• Week 4: Sunday, Sept. 28, at Los Angeles Rams, 4:05 p.m., Fox
• Week 5: Sunday, Oct. 5, vs. Las Vegas Raiders, 1 p.m., Fox
• Week 6: Sunday, Oct. 12, vs. Arizona Cardinals, 1 p.m., Fox
• Week 7: Sunday, Oct. 19, at Los Angeles Chargers, 4:05 p.m., CBS
• Week 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBS
• Week 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBS
• Week 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL Network
• Week 11: Bye
• Week 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBS
• Week 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBS
• Week 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBS
• Week 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBS
• Week 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN’s “Monday Night Football”
• Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., Fox
• Week 18: Date TBD, at Houston Texans, time TBD, TBD

Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.