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Jacksonville Jaguars at Indianapolis Colts odds, picks and predictions

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The Jacksonville Jaguars square off against the Indianapolis Colts Sunday in Week 1 NFL action. Kickoff from Lucas Oil Stadium is scheduled for 1 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Jaguars vs. Colts odds, and make our expert NFL picks and predictions.

The Jaguars are looking to build off of a 9-8 campaign in 2022 that saw them advance to the AFC Divisional Round before losing to the Kansas City Chiefs. With the addition of WR Calvin Ridley this offseason, QB Trevor Lawrence is expected take another step forward in his 3rd season.

The Colts finished with a dismal 4-12-1 record in 2022, which led to them replacing former head coach Frank Reich with Shane Steichen from the Philadelphia Eagles. After cycling through veteran quarterbacks in recent years, Indianapolis will now give the keys to the offense to rookie 1st-round QB Anthony Richardson, who they selected 4th overall.

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Jaguars at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9 a.m. ET.

  • Moneyline (ML): Jaguars -225 (bet $225 to win $100) | Colts +180 (bet $100 to win $180)
  • Against the spread (ATS): Jaguars  -4.5 (-110) | Colts +4.5 (-110)
  • Over/Under (O/U): 46 (O: -110 | U: -110)

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Jaguars at Colts key injuries

Jaguars

Colts

  • DT DeForest Buckner (forearm) questionable
  • LB Shaquille Leonard (concussion) questionable
  • RB Zack Moss (forearm) questionable

Jaguars at Colts picks and predictions

Prediction

Jaguars 30, Colts 20

Moneyline

The Jaguars (-225) are favored to win Sunday’s season opener, but I’ll AVOID their moneyline at the current odds and look for better value on the spread.

Against the spread

BET JAGUARS -4.5 (-110).

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The Colts don’t seem to have much to look forward to this season outside the arrival of Richardson under center. Indianapolis will be without its star RB Jonathan Taylor after he was placed on the PUP list to start a season.

The Jaguars tallied a 7-2-1 record ATS in their final 10 games last season and should pick back from where they left off in Week 1.

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Over/Under

OVER 46 (-110) is how I’d wager on the total in this divisional bout as the Jaguars are poised to have an even better offense in 2023 upon adding Ridley to an already-talented receiver room.

The Colts are going to have a new-look defense that will be littered with inexperienced players, which will lead to more scoring opportunities for the Jaguars.

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Meanwhile, Richardson’s rushing ability is enough to give Jacksonville’s defense a little trouble to begin the season.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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