Indianapolis Colts at Jacksonville Jaguars predictions, odds: Who wins NFL Week 6 game?

The Indianapolis Colts and Jacksonville Jaguars play on Sunday, Oct. 15 at EverBank Stadium in a game on the NFL Week 6 schedule.

Which team will win the Week 6 NFL game?

Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with free trial from FUBO).

The Jaguars are a 4.5-point favorite over the Colts in NFL Week 6 odds for the game.

Jacksonville is -225 on the moneyline, while Indianapolis is +180.

The over/under (point total) is set at 45.5 points.

The Colts are coming off a 23-16 win against the Tennessee Titans in their NFL Week 5 game.

The Jaguars are coming off a 25-20 win against the Buffalo Bills.

NFL Week 6 picks, predictions: Who wins Seahawks-Bengals, Cowboys-Chargers, other games?

Jeremy Cluff writes: “The winner of this game will lead the AFC South. We did not think the Colts would be in that position entering the season, but Trevor Lawrence and company will bring Indianapolis a little bit back to earth in this one.”

NFL power rankings Week 6: San Francisco 49ers quarterback Brock Purdy joins MVP race

Bookies.com: Take the Jaguars to cover vs. Colts

Bill Speros writes: “Winner gets first place alone in the AFC South. Both teams are 3-2 outright and ATS. These teams split last season but the Jaguars beat the Colts at home 24-0. This number has tightened from Jacksonville -6.5 to -4. The Jaguars rolled to back-to-back wins in their home-away-from-home London. Trevor Lawrence & Co. impressed with a hard-fought 25-20 win over the Bills. The Colts upended Tennessee at home, and have RB Jonathan Taylor back in the lineup. But they lost Anthony Richardson – again. This could be the Gardner Minshew homecoming. The Jaguars will be ready.”

NFL Week 6 predictions: ESPN matchup predictor’s picks, win probabilities for games

The site’s formula predicts that the Colts will win the NFL Week 6 game against the Jaguars.

NFL Week 6 odds: Point spreads, moneylines, over/unders for betting on games

ESPN: Jaguars have a 67.1% chance to beat Colts on Sunday

The site gives the Colts a 32.7% shot at winning the Week 6 NFL game.

NFL Week 6 schedule: Television channels, how to watch, stream games

CBS Sports: Odds favor Colts on road vs. Jaguars

Tyler Sullivan writes: “The status of Anthony Richardson is worth monitoring here. Indy’s rookie quarterback reportedly suffered an AC joint sprain in his throwing shoulder on Sunday, which could keep him out of this matchup. If so, that’d thrust Gardner Minshew into the starting lineup under center. The Jaguars are starting to find their rhythm after posting back-to-back wins in London, including an upset victory over the Bills. Both of these teams are 3-2 ATS on the year, but the Colts are 2-0 ATS on the road.”

STREAM THE GAME: Watch Colts at Jaguars live with FUBO (free trial)

NFL Week 6 announcers: Television broadcasters, announcing crews for Week 6 NFL schedule

We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. USA TODAY Network newsrooms operate independently, and this doesn’t influence our coverage.

NFL’s highest paid players in 2023: Quarterbacks | Running backs | Wide receivers | Tight ends | Cornerbacks | Safeties | Linebackers | O-linemen | D-linemen | Edge rushers | Highest paid players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to azcentral.com today.