South Carolina vs. Indiana prediction, picks for 2025 women’s basketball NCAA Tournament

It’s South Carolina vs. Indiana in the 2025 NCAA Tournament first round. See our expert picks and predictions for the women’s March Madness bracket, along with betting odds and game time.

The 2025 NCAA women’s Tournament rolls into the second round on Sunday.

Defending national champ South Carolina, which holds a No. 1 seed, hosts No. 9 Indiana, a rematch of a Sweet 16 contest last season.

The Gamecocks (31-3) are aiming to make their 11th consecutive appearance in the Sweet 16, while the Hoosiers are looking to make the Sweet 16 for the fourth time ever and third time in the last four years.

Here’s how our experts see Sunday’s second-round game playing out. Be sure to check out USA TODAY’s complete March Madness bracket breakdown for in-depth analysis. While you’re at it, don’t forget to read our tournament upset picks and players who could make a splash.

South Carolina vs. Indiana picks and predictions

South Carolina vs. Indiana date, start time, how to watch

• Game Day: Sunday, March 23, 2025
• Game Time: 3 p.m. ET
• Location: Colonial Life Arena, Columbia, S.C.
• TV Channel: ABC
• Live Stream: Fubo – Watch Now!

Watch South Carolina vs. Indiana on Fubo

South Carolina vs. Indiana odds

Odds via BetMGM as of Saturday.

• Spread: South Carolina -22.5
• Moneyline Favorite: South Carolina -25000
• Moneyline Underdog: Indiana +3000
• Total: 136.5