Health
'The White Lotus' characters taking lorazepam: What is it and why are they in danger by abusing it?
Those watching HBO’s “The White Lotus” may be familiar with matriarch Victoria’s long southern drawl, sweeping silk robes — and her affinity for lorazepam.
Searches for the anti-anxiety drug spiked, according to Google Trends, following an episode of the hit show that heavily featured its use — or, more accurately, its abuse.
Victoria Ratliff, played by actress Parker Posey, is seen tossing back a pill or two at all hours of the day.
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She cites its use for anxiety when questioned by her family.
But when Ratliff finds herself suddenly without her medication, she utters the memorable quote: “I don’t even have my lorazepam. I’m going to have to drink myself to sleep.”
Actress Parker Posey is shown at the Season 3 premiere of HBO’s “The White Lotus” in Bangkok on Feb. 14, 2025. (CHANAKARN LAOSARAKHAM/AFP via Getty Images; iStock)
What is lorazepam?
The drug, which is in a class of medications called benzodiazepines, works by slowing activity in the brain to allow for relaxation, according to MedlinePlus.
Lorazepam is used to relieve anxiety as well as insomnia caused by temporary situational stress (or, in Mrs. Ratliff’s case, a stressful family vacation).
Lorazepam is used to relieve anxiety as well as insomnia caused by temporary situational stress. (iStock)
The medication is also sometimes used in hospital environments to help patients relax and fall asleep prior to surgery, according to Healthline.
It may also be used to treat certain types of seizures.
Potential risks and side effects
Some side effects of lorazepam include dizziness, confusion, memory issues and slowed breathing, especially when combined with other sedating substances, such as alcohol or opioids, according to Chelsie Rohrscheib, a neuroscientist and sleep specialist at Wesper in New York.
“This class of drug is extremely habit-forming, which means a patient taking it may become dependent and experience withdrawal symptoms once it’s discontinued,” she told Fox News Digital.
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Lorazepam has also been found to negatively impact mood and may raise a patient’s risk of depression, Rohrscheib warned.
“There is also clinical evidence that long-term use of these medications is associated with certain diseases, like neurodegenerative disorders, such as dementia,” she added.
Mixing lorazepam with other pain-relieving medications, including opiates, could heighten the risk of serious or life-threatening problems, experts warn. (iStock)
Some studies have shown that long-term use of the medication can result in memory loss or difficulty forming new memories, alongside impairments in problem-solving, focus and attention.
Lorazepam may increase the risk of serious or life-threatening breathing problems, sedation or coma if combined with certain medications, according to MedlinePlus.
“This class of drug is extremely habit-forming, which means a patient taking it may become dependent and experience withdrawal symptoms once it’s discontinued.”
Medications that may interact with lorazepam include cough medicines or pain medicines that contain opiates, such as codeine, hydrocodone, morphine, oxycodone or tramadol.
While the characters in “The White Lotus” appear to use lorazepam predominantly as a sleep aid, it’s important to note that their on-screen use mixed with alcohol can be quite dangerous.
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In the show, alcohol of every variety is flowing, with Mrs. Ratliff swigging glasses of wine in almost all of her scenes.
Experts advise against taking lorazepam after drinking alcohol, as the combination can lead to breathing issues or difficulty waking.
The cast of HBO’s “The White Lotus” is pictured at Paramount Studios in Los Angeles on Feb. 10, 2025. (CHRIS DELMAS/AFP via Getty Images)
The drug cannot be purchased over the counter. In the show, Mrs. Ratliff refilled her prescription immediately before vacation.
Those interested in taking lorazepam should see a medical professional to determine whether it is suitable and safe and to obtain a prescription.
Safer sleep alternatives
Patients suffering from insomnia and other sleep issues should try making lifestyle changes and cognitive behavioral therapy before being placed on lorazepam, Rohrscheib advised.
“Doctors may consider alternatives, such as over-the-counter, non-benzodiazepine medications or supplements that promote sleep, such as melatonin,” she told Fox News Digital.
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“Additionally, it’s critical to rule out other sleep disorders, such as sleep apnea, which can mimic insomnia, as benzodiazepines may make sleep apnea worse.”
People can improve their quality of rest by adopting several good sleep hygiene practices, Clémence Cavaillès, Ph.D., a researcher at University of California San Francisco, previously told Fox News Digital.
Maintaining a consistent sleep schedule and creating an ideal sleep environment can help alleviate insomnia, according to experts. (iStock)
“They can start by maintaining a consistent sleep schedule, going to bed and waking up at the same time every day,” he said.
“Creating an ideal sleep environment — keeping the bedroom dark, quiet and at a cool temperature — also helps.”
Regular exercise and exposure to natural sunlight can also improve sleep quality.
Cavaillès also suggested avoiding screens and blue light, as well as stimulants like caffeine and alcohol.
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“Incorporating relaxation techniques before bed, such as deep breathing or meditation, can also help prepare the body for sleep,” the researcher added.
Fox News Digital reached out to the maker of a branded lorazepam medication requesting comment.
Health
New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
Health
One extra serving of processed meat a day linked to higher cancer risk
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
Health
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