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Study directly compares Zepbound and Wegovy for weight-loss results

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Study directly compares Zepbound and Wegovy for weight-loss results

Weight-loss medications continue to grow in popularity as an anti-obesity tool — but are some more effective than others?

The question was explored in a new study published this month in The New England Journal of Medicine.

Researchers compared the safety and efficacy of tirzepatide (brand name Zepbound) and semaglutide (brand name Wegovy) in a 72-week clinical trial.

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The randomized, controlled trial — called SURMOUNT-5 — included 751 people throughout the U.S. and Puerto Rico who had obesity but not type 2 diabetes.

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“Doctors, insurance companies and patients are always asking, ‘Which drug is more effective?’” said Dr. Louis Aronne, director of the Comprehensive Weight Control Center and the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medicine, in the release. “This study allowed us to do a direct comparison.” 

Researchers compared the safety and efficacy of tirzepatide (brand name Zepbound) and semaglutide (brand name Wegovy) in a 72-week clinical trial. (iStock)

“The results are consistent with — in fact, almost identical to — what we’ve seen in trials in which these drugs were evaluated independently,” added Aronne, who was a principal investigator in the trial.

The study found that tirzepatide achieved greater weight loss, with participants shedding about 50 pounds (20.2% of their body weight).

“Doctors, insurance companies and patients are always asking, ‘Which drug is more effective?’”

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The group taking semaglutide lost an average of 33 pounds or 13.7% of their baseline weight, according to a press release summarizing the study outcome.

Overall, 32% of the people taking tirzepatide lost at least 25% of their body weight; semaglutide users lost around 16%.

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Tirzepatide users also reported a “greater reduction in waist circumference” than those on semaglutide.

The likely reason for tirzepatide’s greater effectiveness is that it uses a “dual mechanism of action,” according to Aronne.

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The randomized, controlled trial — called SURMOUNT-5 — included 751 people in the U.S. and Puerto Rico who had obesity but not type 2 diabetes. (Steve Christo – Corbis/Corbis via Getty Images)

“Whereas semaglutide works by activating receptors for a hormone called glucagon-like peptide 1, or GLP-1, tirzepatide mimics not only GLP-1, but also an additional hormone, glucose-dependent insulinotropic peptide (GIP),” the release stated.

“Together, these actions reduce hunger, lower blood-glucose levels and affect fat cell metabolism.”

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Additional trials are actively exploring whether tirzepatide also reduces the risk of heart attack and stroke, a benefit that has been linked to semaglutide.

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The study was led by an investigator at Weill Cornell Medicine and NewYork-Presbyterian. It was also conducted with the University of Texas McGovern Medical School, the David Geffen School of Medicine at the University of California, Los Angeles, the University College Dublin and Eli Lilly (maker of Zepbound).

The study found that tirzepatide achieved greater weight loss, with participants shedding about 50 pounds (20.2% of their body weight). (iStock)

The participants all received guidance regarding nutrition and exercise.

The reported side effects were very similar for the two drugs, with 44% of people experiencing nausea and 25% having abdominal pain.

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Dr. Ada Londono, M.D., a board-certified obesity and internal medicine primary care physician with PlushCare — a virtual health platform offering primary care, therapy and weight management services — said she was not surprised by the study’s findings.

“The results are consistent with prior trials, confirming tirzepatide’s advantage over semaglutide’s single GLP-1 action,” Londono, who is based in New York City, told Fox News Digital.

Beyond weight loss, semaglutide has also shown potential benefits for cardiovascular health, sleep apnea and kidney disease. (iStock)

Beyond weight loss, semaglutide has also shown potential benefits for cardiovascular health, sleep apnea and kidney disease, she noted. 

“These findings highlight the need for continued research to understand tirzepatide’s broader health impacts,” she said. “It’s encouraging to see ongoing studies exploring the full potential of GLP-1 medications beyond weight management.”

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Londono said these treatments can come with side effects. 

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“Most people on these medications only report mild symptoms, but some have experienced more serious reactions, such as pancreatitis,” she told Fox News Digital. 

“This underscores the importance of reviewing your medical history and discussing any concerns with your healthcare provider.”

Potential limitations

The study did have some limitations — chiefly that it was not a blinded analysis and participants knew which medication they were receiving. This could introduce some level of bias, the researchers acknowledged.

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Londono pointed out that while the study’s findings are “promising,” it was funded by Eli Lilly, the manufacturer of Zepbound.

“This may raise questions about potential conflicts of interest,” she said. “Additionally, the open-label design and 72-week duration may limit objectivity and long-term insight.”

An expert emphasized that people should work with a physician to choose a weight-loss medication that matches personal goals and health status. (iStock)

While the study primarily looked at the impact of the medications, experts agreed there are other factors that play a role in successful weight management.

“Weight loss is biological, but it’s also emotional, and whole-person support can make the difference between short-term results and sustainable health,” Dr. Rekha Kumar, chief medical officer at the weight care program Found and a practicing endocrinologist in New York City, told Fox News Digital.

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Kumar emphasized the importance of working with a physician to choose a weight-loss medication that matches the patient’s personal goals and health status.

“Both Wegovy and Zepbound have demonstrated clinically significant weight reduction.”

“For example, if a patient has fatty liver, we will choose the GLP-1 that is proven to work best for liver disease,” she said. 

Looking ahead, the researchers plan to investigate new versions of weight-loss drugs, including retatrutide, which mimics the hormones GLP-1, GIP and glucagon, according to the release.

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“Even though drugs like tirzepatide and semaglutide work really well, better than anything we have ever seen, we still have people who don’t respond to them,” said Aronne. 

“So, moving forward, we want to keep trying to do better.”

“Across the respective clinical trial programs and in SURMOUNT-5, both Wegovy and Zepbound have demonstrated clinically significant weight reduction,” Novo Nordisk, maker of Wegovy, said in a statement. (iStock)

A spokesperson from Novo Nordisk, the company that makes Wegovy (semaglutide), sent a statement to Fox News Digital.

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“Across the respective clinical trial programs and in SURMOUNT-5, both Wegovy and Zepbound have demonstrated clinically significant weight reduction,” the company said. “It is important to recognize that the comprehensive management of obesity goes beyond weight reduction alone.”

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The spokesperson also pointed out that in a previous trial, adults who were obese or overweight and who took Wegovy along with diet and exercise lost an average of 15.2% of their weight (~35 pounds) at the two-year mark, compared with 2.6% (~6 pounds) for patients taking a placebo.

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take


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I Tried the Viral Gelatin Weight-Loss Recipe: Does It Really Work?




















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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Medicare fraud is a multibillion-dollar problem that government officials say threatens both taxpayer dollars and Americans’ personal identities.

In a July 6 interview with Fox News Digital at the Great American State Fair in Washington, D.C., Dr. Mehmet Oz warned that every dollar stolen through Medicare fraud is a dollar taxpayers lose – a problem that has worsened since the COVID pandemic.

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz, who is the administrator of the Centers for Medicare & Medicaid Services. “And just to put this in perspective, we think it’s about $100 billion a year.”

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Medicare fraud can include billing for services that were never provided, overcharging for medical equipment, using stolen patient or doctor information, or performing unnecessary procedures, according to the U.S. Government Accountability Office.

CMS administrator Dr. Mehmet Oz is pictured on stage at the Great American State Fair in Washington, D.C., on July 6, 2026. (Angelica Stabile/Fox News Digital)

As the Trump administration ramped up efforts to combat fraud, CMS reported $41.9 billion in Medicare program integrity savings in 2025, up 59% from $26.3 billion in 2024.

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Medicare fraud not only harms the federal budget and steals from taxpayers, but exposes seniors to identity theft, unnecessary care, higher premiums and reduced access, Oz cautioned.

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Removing corruption from the healthcare system will have the greatest impact among seniors, since “so much of the fraud is perpetrated against them,” the administrator said.

“I’m talking about people tricking seniors to give up their Medicare beneficiary numbers, which is like a credit card basically,” he said. “These scammers can take those numbers and use them for all kinds of illegitimate purposes.”

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz. (Fox News Digital)

“People are stealing from you by pretending to send you drugs you don’t want, wheelchairs you don’t need, [and] services you never asked for or don’t benefit from,” Oz added.

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To prevent this, he shared his top advice for seniors: Do not give your Medicare beneficiary number to anybody, do not answer questions on a phone call from an unknown person and do not give away personal information.

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“These scammers are calling seniors, tricking them, and once they have key information, they can steal it,” he said. “And I won’t know it and you won’t know it.”

“We want to protect people who need these programs the most,” Oz went on. “You do that by making sure scoundrels don’t corrupt the systems and steal money out of the till that is designed to help folks in dire straits when they’re vulnerable and in need of services.”

Seniors should never share their Medicare information with unknown people, the administrator advised. (iStock)

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Removing fraud could “double the life expectancy of the trust fund that makes all this possible,” Oz predicted.

“If you’re worried about Medicare being there when you’re ready to retire in a couple decades, depending on how old you are, and you’re concerned that it might not last because of all the fraud that’s hitting it … you’ve got a good [reason to] worry,” he said.

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“If we take the fraud out, we could double the life expectancy, which means you, your kids, your kids’ kids … they could all benefit from this beautiful safety net program.”

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