Health
‘Smart mask’ could detect asthma, COPD and other medical conditions, researchers say
Your breath could hold clues to your health, researchers say — and they have developed a “smart mask” to tap into them.
Wei Gao, professor of medical engineering at the California Institute of Technology (Caltech) in Pasadena, led the team that created the EBCare, a mask that analyzes the chemicals in someone’s breath to detect any existing health issues.
The mask is designed to screen for medical conditions like respiratory infections, COPD (chronic obstructive pulmonary disease), asthma and post-COVID infections, according to a press release from Caltech.
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EBCare works by cooling the breath to convert it into a liquid, then transports it to sensors to be analyzed for specific biomarkers.
Researchers have developed a “smart mask” (pictured at left) to detect signs of medical conditions. (Caltech/Wei Gao and Wenzheng Heng; iStock)
In an email to Fox News Digital, lead researcher Gao noted the mask’s ability to enable “continuous, real-time monitoring of exhaled breath condensate (EBC) in a non-invasive and wearable format.”
“This technology has the potential to revolutionize the way we monitor respiratory health by providing valuable insights into conditions like asthma, COPD and other metabolic disorders,” Gao said, noting that it could be a path to more personalized health care.
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“It can also be applied to pandemic management by monitoring respiratory infections on a wide scale,” he added.
The ultimate goal is for the EBCare technology to go beyond respiratory diseases, Gao noted.
“As research progresses, we envision that the smart mask can be adapted to detect a wider range of biomarkers, including those related to metabolic, cardiovascular and infectious diseases,” he said.
This schematic shows the process by which the smart mask can detect chemicals in the breath, such as nitrite, which is an indicator of airway inflammation. (Caltech/Wei Gao and Wenzheng Heng)
A study of the mask’s capabilities included 31 healthy adults who wore the EBCare in real-life settings over a 14-hour span, according to Caltech. They only removed the mask for three-minute intervals to eat.
Ten of the participants were smokers, 10 had asthma, nine had COPD and 12 had recently recovered from COVID-19.
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The masks accurately detected the biomarker for asthma and COPD in participating patients. They also successfully detected signs of kidney disease.
EBCare also produced accurate readings of blood alcohol levels.
“Monitoring alcohol levels in real time offers a non-invasive and continuous alternative to breathalyzers or blood tests,” Gao said.
“We would need to see at least a few clinical studies demonstrating that the masks can diagnose better — or more rapidly or with more sensitivity — than the standard of care.”
The research — which was funded by the National Institutes of Health, the National Science Foundation, the Tobacco Related Disease Research Program, and the U.S. Army Medical Research Acquisition Activity — was published in the journal Science on Aug. 29.
The idea is not for the smart mask to replace traditional medical diagnosis, but to provide “early warning” through continuous health monitoring during daily activities and to “bridge the gap” between doctor’s visits, Gao said.
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“The goal is to identify subtle physiological changes before they develop into more severe conditions, giving individuals the opportunity to take proactive steps in managing their health,” he said.
This is especially important for those who need regular monitoring, such as patients with chronic conditions or those recovering from respiratory infections like COVID-19, according to Gao.
The mask (not pictured) is designed to screen for medical conditions like respiratory infections, COPD (chronic obstructive pulmonary disease), asthma and post-COVID infections. (iStock)
“I recommend that health care providers consider integrating real-time EBC analysis technology into their diagnostic and monitoring practices, especially for chronic conditions like asthma and COPD,” he said.
“For individuals, the ability to monitor one’s health non-invasively through a wearable device offers the opportunity to be more proactive in managing personal health, which can lead to early intervention and better health outcomes.”
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MarkAlain Déry, DO, MPH, infectious disease doctor and chief innovation officer at Access Health Louisiana, who was not involved with the development of the smart mask, agreed that it is an “exciting concept.”
“Could it work? Sure,” he told Fox News Digital.
Wei Gao, professor of medical engineering at the California Institute of Technology in Pasadena, led the team that created the EBCare mask. (Caltech)
“However, we would need to see at least a few clinical studies demonstrating that the masks can diagnose better — or more rapidly or with more sensitivity — than the standard of care,” he went on.
“Then, we would need studies that demonstrate clinical improvement.”
Potential limitations
Some external doctors not involved in the mask’s development questioned whether this mode of data collection is beneficial.
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“While the mask introduces an innovative method to monitor exhaled breath condensate (EBC), we need to ask an important question: Do these continuous, real-time measurements genuinely make a difference in everyday life?” said Dr. Brett Osborn, a Florida neurosurgeon, in a conversation with Fox News Digital.
“For the average person, the biomarkers it detects — ammonium, pH, nitrite and alcohol — do not need constant monitoring, especially when routine blood tests can provide this information more accurately and with greater relevance.”
“For the average person, the biomarkers it detects … do not need constant monitoring, especially when routine blood tests can provide this information more accurately and with greater relevance,” a doctor said. (iStock)
Osborn believes that the concept of the EBCare mask is better suited for “specific, high-stakes environments,” such as real-time monitoring of toxic gases in military or industrial settings.
“However, for the average person, especially in a post-pandemic world, the idea of wearing a mask like this is counterproductive,” he said.
Dr. John W. Ayers, PhD, vice chief of innovation in the Division of Infectious Diseases and Global Public Health at the University of California San Diego, also questioned the idea of having patients with asthma or COPD — who already experience breathing difficulties — wear the masks.
“For the average person, especially in a post-pandemic world, the idea of wearing a mask like this is counterproductive.”
The lead researcher, Gao, responded to some of these comments.
“While routine blood tests are indeed reliable, they are typically periodic and require a clinical setting, which limits their ability to capture dynamic, day-to-day physiological changes,” he told Fox News Digital.
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“The real innovation of the EBCare mask lies in its ability to continuously monitor health in real time, offering insights that might not be detectable with intermittent tests.”
For individuals managing chronic conditions like asthma, COPD or metabolic disorders, fluctuations in certain biomarkers can provide early warning signs, according to the researchers. (iStock)
For individuals managing chronic conditions like asthma, COPD or metabolic disorders, fluctuations in certain biomarkers can provide early warning signs before symptoms worsen, allowing for timely intervention, according to the researcher.
Gao, however, did acknowledge some limitations with the EBCare device.
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“One limitation was the relatively small sample size in some of the clinical trials, particularly for conditions like COPD and asthma,” he told Fox News Digital.
“Future studies with larger and more diverse populations will help to further validate the device’s performance across a broader range of conditions and environments.”
Health
New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
Health
One extra serving of processed meat a day linked to higher cancer risk
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
Health
The Surprising Hormone That Could Make Menopause Weight Loss Easier
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