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Parkinson’s disease risk is linked to gut health, researchers say

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Parkinson’s disease risk is linked to gut health, researchers say

Gut health has been linked to a common neurological disorder in a new study.

Those who have sustained damage to the upper lining of their gastrointestinal (GI) tract are 76% more likely to develop Parkinson’s disease, according to research led by Beth Israel Deaconess Medical Center (BIDMC) in Boston.

The findings were published in JAMA Network Open on Sept. 5.

THE EFFECTS OF PARKINSON’S DISEASE ON THE BRAIN AND COMMON WAYS THOSE IMPACTED SUBDUE SYMPTOMS

The study included 9,350 patients (averaging 52 years of age) who underwent an upper endoscopy — a procedure that examines the esophagus, stomach and first portion of the small intestine — between 2000 and 2005 within the Mass General Brigham system.

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Gut health has been linked to a common neurological disorder in a new study. (iStock)

Those who had “mucosal damage” were shown to have an elevated risk, the researchers found.

Parkinson’s disease was diagnosed an average of 14.2 years after the damage was detected, the study showed.

Mucosa, also called the mucous membrane, is the “soft tissue that lines the body’s canals and organs in the digestive, respiratory and reproductive systems,” according to Cleveland Clinic. 

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“When asked, many of my patients with Parkinson’s disease will say, ‘Come to think of it, yeah, I started to get bad constipation or nausea, years before anyone diagnosed me with Parkinson’s,’” lead study author Trisha Pasricha, MD, a gastroenterologist at Massachusetts General Hospital and an instructor of medicine at Harvard Medical School, told Fox News Digital.

“We now know that gut symptoms like these herald a future diagnosis of Parkinson’s disease.”

The study included 9,350 patients who underwent an upper endoscopy, a procedure that examines the esophagus, stomach and first portion of the small intestine. (iStock)

Dr. Earnest Lee Murray, a board-certified neurologist at Jackson-Madison County General Hospital in Jackson, Tennessee, was not involved in the study, but confirmed that gastrointestinal dysfunction is very common in patients with Parkinson’s. 

“Motor symptoms, such as stiffness, tremors and difficulty walking, are the stereotypical features of Parkinson’s,” Murray said. 

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NEW PARKINSON’S DRUG COULD SLOW OR REVERSE PROGRESSION OF DISEASE, RESEARCHERS SAY: ‘BIG STEP FORWARD’

“However, there are several non-motor symptoms that are often seen, the most common being gastrointestinal dysfunction, especially constipation and difficulty swallowing.”

These gastrointestinal symptoms can appear years before the motor symptoms, the neurologist added.

Patients who had “mucosal damage” were shown to have an elevated risk, the researchers found. (iStock)

“Given the prominence of early gastrointestinal issues in Parkinson’s, there has been a theory suggesting that the pathology that causes Parkinson’s can originate in the GI tract and travel to the brain via the vagus nerve,” Murray said. 

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“This study gives additional evidence to the ‘gut-first’ theory.” 

Causes and prevention of upper GI damage

Many factors can cause damage to the mucosal lining, Pasricha said. 

“Those include taking NSAIDs like ibuprofen, drinking alcohol, stress or bacteria like H. pylori,” she said.

“Our study only examined people whose stomach symptoms were so severe that they sought an upper endoscopy to investigate the etiology, but we all experience small amounts of damage to our gut lining throughout our lives for various reasons.”

Gastrointestinal symptoms can appear years before the motor symptoms, such as tremors and stiffness, a neurologist said. (iStock)

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It is not clear how those frequent, smaller amounts of damage impact the risk of Parkinson’s, the doctor noted. 

“Nonetheless, I advise my patients — regardless of their risk of any neurological disease — that minimizing NSAIDs, reducing stress and cutting down on alcohol will only help their gut health,” she added.

      

As Murray noted, Parkinson’s is caused by a depletion of the neurotransmitter dopamine — which leads to slowed muscle movements, stiffness and tremors — and is also involved in the integrity of the GI tract. 

Parkinson’s is caused by a depletion of the neurotransmitter dopamine — which leads to slowed muscle movements, stiffness and tremors — and is also involved in the integrity of the GI tract, a neurologist said. (iStock)

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“As the study authors point out, we don’t know if the injury to the GI tissue triggers a depletion in dopamine or if the destruction of the GI tissue is the earliest sign of an issue with dopamine that eventually leads to more stereotypical Parkinson’s symptoms,” he told Fox News Digital.

Potential study limitations

While the study reveals a “strong link” between injury to the upper gastrointestinal tract and later development of Parkinson’s disease, Pasricha noted that the mechanisms leading to this effect are not yet known. 

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The study did not include cases of Parkinson’s that were diagnosed outside the Mass General Brigham system, the researchers noted.

“The brain-gut connection is really a two-way street.”

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Due to the small sample sizes in the study — and the risk of “confounding variables” that could introduce a measure of bias — the research team called for additional studies to confirm the association.

“The brain-gut connection is really a two-way street,” said Pasricha.

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“The gut can exert an enormous influence on the brain in ways we are still only beginning to understand — but when we do,​ we might be able to open new avenues for early intervention and treatment strategies for many diseases.”

The study was funded by grants from the National Institute on Aging, the American Gastroenterological Association and Harvard University.

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The ‘1776 Diet’: What Americans really ate during the nation’s founding

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The ‘1776 Diet’: What Americans really ate during the nation’s founding

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Many of the American colonists’ eating habits have made a comeback in recent years. They ate minimally processed, locally sourced whole foods and regularly incorporated organ meats into their meals.

Livestock and many Old World crops had already been introduced to North America by European explorers and settlers during the centuries before the nation’s founding.

Early settlers adapted European cooking traditions using ingredients available in North America, the Center for the Study of the Presidency and Congress (CSPC) reported.

Indigenous peoples introduced corn to the colonists, and it became a core ingredient in many of their recipes. Beans, squash, and potatoes were among the other crops that became incorporated into colonial cooking, according to the CSPC.

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“Cornmeal appeared in dishes such as hasty pudding — a thick porridge similar to polenta — and johnnycakes, simple griddle cakes that were popular from New England to the South,” History Facts reported.

Cornmeal Johnnycakes, roast pork and cream cheese are distinctly early-American foods the CSPC has recipes for on its website.

Corn became a staple of early colonists’ diets after Indigenous peoples introduced the crop to the settlers and taught them how to cultivate it. (iStock)

Regional customs and crops greatly influenced what the colonists ate. Rice and okra grew well and were plentiful in the South, where French and African influences also shaped eating habits. 

Dutch, English and German immigrants largely settled in the north and established the region’s culinary traditions.

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Seafood such as rockfish and crab dominated the diets of early Maryland settlers, NPR reported.

Meat was a status symbol, local food historian Joyce White told the publication. Beef was prized, and chicken was often saved for egg production.

“If it’s your pig or cow coming from your plantation, you don’t want to waste it,” White said.

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Thomas Jefferson was known for his decadent tastes and a fondness for French wine and macaroni and cheese. Records show that black-eyed peas, turnip greens and ham were also part of the Founding Father’s diet.

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Salted and preserved fish and meats, including bacon, sausage, liver pudding and offal, were staples of working-class people’s diets, while the upper classes indulged in such luxuries as white flour and sugar.

Interest in these traditional foods has resurfaced in recent years as some Americans seek diets centered on whole, minimally processed ingredients.

Founding Father Thomas Jefferson was known for his continental tastes and enjoyed French wine and macaroni and cheese. (iStock)

Advocates of the Make America Healthy Again movement, for instance, have promoted organ meats, or offal, as some of the cheapest and most nutrient-dense foods people can eat.

Stews that evolved as ingredients became available were also common an America’s early days.

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The amount of alcohol the colonists consumed was “staggering,” Adrian Miller, author of “The President’s Kitchen Cabinet,” told NPR.

“They were very open about how much they were drinking,” he said.

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George Washington wrote a recipe for “small beer” in a journal he kept as a young colonel in charge of the Virginia militia during the Seven Years’ War, Fox News Digital previously reported. The New York Public Library houses the journal.

“Small beer,” according to the library, derives its name from the small amount of alcohol it contains. It was quick to make, safer to drink because the brewing process helped eliminate bacteria in the water — and it was an “everyday, mainstay beverage,” the library reported.

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“While the 1776 Diet has some positives — such as emphasizing whole foods, home cooking and fewer ultra-processed foods — it’s not one I’d recommend following too literally,” registered dietician Lisa R. Young, adjunct professor of nutrition at New York University, told Fox News Digital.

Working-class colonists would often save chickens for their eggs, rather than consuming their meat. (iStock)

“Colonial Americans often ate foods like salted ham, organ meats and other preserved meats out of necessity,” she said. “Today, we know it’s best to limit processed and cured meats because they’re high in sodium and saturated fat, and organ meats, while nutrient-dense, are best eaten in moderation due to their high cholesterol content.”

Focus on the healthiest aspects of the 1776 diet, Young recommended. That includes plenty of fruits and vegetables, beans, whole grains, fish and lean proteins.

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“Of course, you can emulate the Founding Fathers’ diet for the week of the 250th anniversary,” she said. “What you eat for a day or a week won’t matter much in the scheme of things.”

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Some of the Founding Fathers drank a lot of ale, often in the morning, Young noted.

“We shouldn’t emulate that,” she said.

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Fourth of July fireworks pose hidden health risk for certain Americans, experts warn

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Fourth of July fireworks pose hidden health risk for certain Americans, experts warn

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Fireworks have been a quintessential part of Fourth of July celebrations across the nation for generations.

But as Independence Day festivities light up the night sky, the colorful displays can also pose serious health risks — especially to the lungs.

Nearly 300 million pounds of fireworks are released into the atmosphere each year in the U.S., according to the American Lung Association. This creates smoke filled with tiny particles, as well as gases like sulfur dioxide, carbon dioxide and carbon monoxide, which are “very harmful to our lungs.”

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The smoke from fireworks can also release harmful metals, like aluminum, manganese and cadmium, into the air.

Some illegal fireworks may contain lead, which the association describes as “extremely dangerous” due to its potential to cause lasting health damage.

Attendees watch the Independence Day fireworks display along the National Mall in Washington, D.C. (Probal Rashid/LightRocket via Getty Images)

“Inhaling any of these chemicals can irritate the lungs, making it hard to breathe and causing serious health problems, which is why it is important to avoid firework smoke whenever possible,” the group said in a public advisory.

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Air pollution levels increase by an average of 42% on the Fourth of July, according to a 2015 study.

Smoke from fireworks can worsen symptoms and cause flare-ups in those who have asthma or chronic obstructive pulmonary disease (COPD).

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Fine particle pollution has also been linked to more serious health consequences, including heart attacks, stroke, lung cancer and premature death, according to the American Lung Association.

The organization warned that children, older adults and pregnant women, as well as people with lung and heart disease, are especially vulnerable.

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Smoke from fireworks can worsen symptoms and cause flare-ups in those who have asthma or chronic obstructive pulmonary disease. (iStock)

Dr. Afif El-Hasan, member of the Lung Association’s board of directors, shared some advice for high-risk fireworks spectators in an interview with Fox News Digital.

Instead of using fireworks at home, El-Hasan recommends watching them from a distance.

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People with asthma who use a rescue inhaler should keep it close at hand in case fireworks trigger wheezing or other symptoms, the expert advised. Wearing a well-fitting N95 mask can also help reduce exposure to fine particles from fireworks smoke and debris.

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“If you are familiar with the area and the wind patterns, try to be upwind from the fireworks display and avoid areas where smoke may accumulate,” he said.

An expert recommends watching fireworks from a distance to avoid exposure to air pollution. (iStock)

The expert also recommends attending fireworks events with friends or family, so someone is available to help if a medical emergency arises.

“Make sure you have taken all of your preventative medication before a fireworks show,” El-Hasan advised. “If possible, take a car to the fireworks display. Try to park as close as possible to the event in case you have to get to the car quickly.”

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The expert also recommends drinking water immediately after the show to clear the upper airway. Changing and washing clothes upon returning home can also help to prevent smoke particles from accumulating in the home.

If case of shortness of breath or chest pain, it’s important to seek medical care immediately.

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Scientists discover possible link between 9/11 and accelerated aging

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Scientists discover possible link between 9/11 and accelerated aging

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A study of World Trade Center responders found that PTSD is associated with molecular changes linked to accelerated biological aging and a higher risk of chronic disease.

The study, led by Stony Brook University in New York, could offer new clues to the long-term physical health effects of post-traumatic stress disorder.

The researchers tested blood samples from 393 WTC responders, collected approximately 18 years after the September 11, 2001, attacks, according to a university press release.

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Out of the sampled responders, 232 were diagnosed with PTSD and 161 were not. Between the two groups, 114 proteins and seven metabolites were significantly different.

Firefighter Gerard McGibbon, of Engine 283 in Brownsville, Brooklyn, prays after the World Trade Center buildings collapsed on September 11, 2001. (Mario Tama/Getty Images)

In particular, the researchers detected changes in blood markers linked to brain function, immune activity, energy metabolism, protection against cell damage and how cells communicate and repair tissues.

Also reported were signs of accelerated biological aging in multiple organs — including the heart, kidneys, liver and lungs — among responders with PTSD.

COMMON VITAMIN MAY INFLUENCE BRAIN AGING IN WAYS SCIENTISTS DIDN’T EXPECT

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These discoveries could help explain why people with long-term PTSD are at greater risk for chronic conditions such as heart disease, lung disease, cognitive decline and other age-related illnesses.

“This study found that chronic PTSD is associated with long-lasting biological changes throughout the body, affecting multiple organs and biological systems decades after their traumatic exposure,” lead study author Benjamin Luft, director and principal investigator at the Stony Brook WTC Wellness Program, told Fox News Digital.

“Traumatic experiences can produce lasting biological changes that persist for decades.”

The study reinforces the view that PTSD is a “whole-body illness” rather than simply a mental health disorder, he noted.

“Traumatic experiences can produce lasting biological changes that persist for decades,” Luft said. “These changes appear to accelerate aspects of biological aging and may increase the risk of many chronic diseases.”

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Several proteins that are critical for healthy brain function were also altered in those with PTSD, the researchers found.

“Many of these proteins play critical roles in helping brain cells communicate with one another, repair damage and maintain healthy connections that support memory and thinking,” Luft said.

A New York firefighter is pictured amid the rubble of the World Trade Center following the 9/11 attacks in 2001. (Universal History Archive/Universal Images Group via Getty Images)

The study – which was funded in part by the CDC, the National Institute for Occupational Safety and the National Institutes of Health – was published in Nature Communications.

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Luft said the findings should be viewed with “cautious optimism.”

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“The research provides compelling evidence that PTSD is associated with long-lasting biological changes throughout the body, including signs of accelerated aging, altered metabolism and changes in proteins involved in brain health,” he said.

“These findings strengthen the growing recognition that PTSD is not simply a mental health disorder, but a condition that can have lasting effects on physical health as well.”

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Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the study but called the results “fascinating.”

“This speaks to the complex reality that PTSD is not an isolated psychiatric event due to emotional trauma alone, but that it is also tied in with physical trauma,” he told Fox News Digital. “The stress is both emotional and physical, and leads directly to immune dysregulation and aging processes.”

“These findings strengthen the growing recognition that PTSD is not simply a mental health disorder, but a condition that can have lasting effects on physical health as well,” the researcher said. (iStock)

“The chronic diseases that resulted from high exposure in the aftermath of the 9/11 World Trade Center attacks were conjoined in terms of the impact on physical and emotional well-being, longevity and effects on multiple organ systems, as well as core metabolic and immunological processes,” the doctor added.

Study limitations

There were some limitations to the findings, the researchers noted.

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“Because all measurements were taken at one point in time, the research can only show an association — not that PTSD directly caused the changes,” Luft noted.

“We are currently doing studies in these patients examining multiple time points to see whether the changes in specific proteins and metabolites precede clinical changes.”

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Also, because the study was done on a unique population – World Trade Center responders who experienced very specific trauma and environmental exposures – the findings may not apply to everyone with PTSD, “such as combat veterans, survivors of abuse or people who experienced other types of trauma.”

Several proteins that are critical for healthy brain function were also altered in those with PTSD, the researchers found. (iStock)

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Women are not well-represented in the study, comprising only 10% of responders.

“Blood tests cannot tell us exactly what is happening inside the brain,” Luft said. “Although many of the altered proteins are related to brain function, blood measurements are only an indirect reflection of processes occurring in the brain.”

Looking ahead

Additional studies are needed to determine whether these blood markers can predict disease progression or treatment response.

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“From a public health and policy perspective, the study reinforces the importance of recognizing PTSD as a chronic medical condition with significant long-term health implications,” Luft said.

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“Investing in early diagnosis, comprehensive treatment and long-term follow-up for trauma survivors, including our first responders and veterans, may improve quality of life while reducing the burden of chronic disease.”

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