Health
Pancreatic cancer patient survival doubled with high dose of common vitamin, study finds
High doses of vitamin C could be a new breakthrough in treating cancer.
The University of Iowa Health Care Carver College of Medicine has shared results from a randomized, phase 2 trial testing the impact of adding high-dose vitamin C to intravenous chemotherapy treatments for pancreatic cancer patients.
The researchers found that administering 75 grams of vitamin C three times a week doubled overall survival rates of patients with late-stage metastatic pancreatic cancer from eight months to 16 months.
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The study, published in the journal Redox Biology, also found that progression-free survival was extended from four to six months.
The researchers found that vitamin C in high doses generates hydrogen peroxide, which “kills the cancer cells.” (iStock)
Lead researcher Joseph Cullen, MD, University of Iowa professor of surgery and radiation oncology, shared in an interview with Fox News Digital that the “groundbreaking” findings are the result of 20 years of research on vitamin C.
After testing vitamin C in the lab, Iowa researchers found that using vitamin C in much higher doses “worked great” in killing cancer cells.
“Vitamin C, which is inexpensive and well-tolerated, may improve the efficacy of chemotherapy with a good quality of life.”
“We found that at these high doses, ascorbate [vitamin C] actually generates hydrogen peroxide,” Cullen said. “And the hydrogen peroxide is what kills the cancer cells.”
The patients who received vitamin C in the phase 2, FDA-approved trial also seemed to “better tolerate the chemotherapy they were given,” according to the researcher.
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“Therefore, they got more chemotherapy for longer periods of time and larger doses of chemotherapy, which also would kill the tumor cells,” he added.
Intravenous vitamin C could also help combat other kinds of cancer, according to Cullen, who mentioned that his colleagues are looking into treating lung and brain cancer.
The patients in the study tolerated chemo better with high-dose IV vitamin C, the researcher said. (iStock)
Dr. Georgios Georgakis, a surgical oncologist at Stony Brook Medicine in New York, noted that these findings could “potentially be a breakthrough” for cancer patients.
“It seems to be working synergistically with chemotherapy,” Georgakis, who was not involved in the study, said in a separate conversation with Fox News Digital.
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Dr. Joshua Strauss, an attending hematologist and medical oncologist at Advanced Care Oncology and Hematology Associates of the Atlantic Medical Group in Morristown, New Jersey, also expressed his support for this method.
“Small clinical trials such as this one have recently provided exciting and consistent signals that vitamin C, which is inexpensive and well-tolerated, may improve the efficacy of chemotherapy with a good quality of life,” the oncologist, who also was not involved in this new research, said in a statement sent to Fox News Digital.
The benefits of vitamin C
Vitamin C, or ascorbic acid, is an “essential dietary nutrient” found in various foods like citrus fruits, tomatoes, potatoes, broccoli, strawberries, cabbage and spinach, according to Strauss.
Georgakis noted that vitamin C can help with tissue growth and repair, collagen production, wound healing, bone and skin health, and immune support.
In lower doses, vitamin C acts as an antioxidant. The Food and Drug Administration (FDA) recommends getting 75mg to 90mg daily.
Vitamin C can help the body with tissue growth and repair, collagen production, wound healing, bone and skin health, immune support and more. (iStock)
Once the body has taken in enough vitamin C, any excess is excreted through the kidneys and won’t be absorbed, Cullen pointed out.
But once the dosage is bumped to much higher levels, such as 75 grams, it acts as a pro-oxidant.
“So, it actually makes these reactive oxygen species that kill cancer cells well,” he said.
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It would take backing from a pharmaceutical company to support what would be a “multi-million-dollar” phase 3 trial to continue research, according to Cullen.
For now, he suggests that cancer patients interested in exploring IV vitamin C should talk to their oncologist and seek out professionals who can administer it.
Strauss applauded the researchers and the National Cancer Institute for their efforts, noting that he read the results with “cautious optimism.”
“It seems to be working synergistically with chemotherapy,” an oncologist commented on the method. (iStock)
“Pancreatic cancer can be extremely difficult to treat, and I am hopeful whenever I read positive results from a phase 2 study,” he went on. “However, the study has several limitations, and the results should be carefully interpreted.”
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Strauss and the study authors acknowledged some of those limitations, including the small sample size of 34 patients and lack of diversity.
“Larger randomized phase 3 trials are needed to confirm the results before this is adopted into widespread clinical use,” Strauss told Fox News Digital.
Georgakis agreed that although the trial did have a “very good outcome,” this is “not the golden bullet for treating cancer.”
“However, this is exactly what we need – incremental, good outcomes in our fight against cancer,” he said.
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Parents are being warned of a new trend among kids, involving alcohol and an open flame.
The “fire-breathing” challenge has led to reports of severe burns, according to local news outlets.
Kids and teens are reportedly holding alcohol in their mouths and blowing it onto a match or another open flame to mimic “breathing fire.”
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According to Philadelphia’s 6ABC News (WPVI), a teen in Pitcairn, Pennsylvania, was intubated and treated for burns to the face, neck and chest after attempting the trend.
A “fire-breathing” challenge is leaving kids with severe burns, according to local reports. (iStock)
“Luckily, in this particular case, it did not burn the building down,” Al Hussey, Wilmerding Borough fire marshal, told WPVI.
“But somebody really got hurt, and, you know, is going to have life-altering injuries.”
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Pitcairn Fire Chief Tommy Dick told CBS News Pittsburgh (KDKA) the 14-year-old girl was playing with isopropyl alcohol at an apartment complex.
“It’s not a very smart thing for anybody to do, let alone children,” Dick said. “It’s supposed to be for cleaning off wounds and cuts and stuff, not ingesting and trying to blow fire.
A local fire chief told CBS News Pittsburgh that the incident could have been fatal for the teen. (iStock)
“This could have easily gone inside their digestive tract, and she could have died.”
Anyone who has ingested isopropyl alcohol requires immediate medical attention, according to Healthline, because it can cause stomach pain, dizziness, confusion and slowed breathing. In severe cases, it can lead to a coma.
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Fire experts are urging parents to closely monitor which household products are within their children’s reach.
Ingesting isopropyl alcohol requires immediate medical attention, according to experts. (iStock)
“If they’re doing their hair with chemicals, if they’re taking isopropyl alcohol in the room or any type of fingernail polish remover,” Hussey said. “Obviously, monitor your lighters and your matches and educate your children.”
Multiple cases of children’s injuries have occurred in recent weeks after being allegedly “inspired” by online stunts, WPVI reported. One trend involved microwaving a toy that burst and left severe burns on a 9-year-old’s face.
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Valerian, an herbal supplement long used for sleep and relaxation, has been referred to as “nature’s Valium” — but experts are divided on whether it truly compares to the prescription sedative.
The herb, which is sold as a dietary supplement in the U.S., is a common ingredient in products marketed as “mild sedatives” and sleep aids, according to the National Institutes of Health.
Valium, the brand name for diazepam, is used to treat anxiety, seizures and muscle spasms by calming the nervous system, Cleveland Clinic notes.
Valerian supplements are derived from the roots of Valeriana officinalis, a flowering plant native to Europe and Asia that has also naturalized in northeastern America, according to the American Botanical Council (ABC).
The plant has a “long history of medicinal use,” per the ABC, with the primary goal of reducing anxiety and stress as well as improving sleep quality. It has historically also been used for migraines, fatigue and stomach cramps.
Valerian has historically been used for migraines, fatigue and stomach cramps. (iStock)
Dried valerian roots can be prepared as teas or tinctures, while other plant materials and extracts have been distributed as capsules or tablets, per the NIH.
The agency noted, however, that there is a “relatively small amount of research” investigating the herb’s impact on various conditions.
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However, Stefan Gafner, Ph.D., chief science officer of the American Botanical Council in Texas, confirmed that some clinical trials have explored valerian root’s effects.
A 2020 medical review published in the Journal of Evidence-Based Integrative Medicine found that both powdered root and root extracts show a “clear” benefit in treating anxiety, Gafner told Fox News Digital.
Valerian root and other parts of the plant can be prepared as teas, extracts, capsules and tablets. (iStock)
The researchers concluded that valerian could be a “safe and effective herb to promote sleep and prevent associated disorders.”
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While valerian may have some benefits, Gafner said he doesn’t think it “makes sense” to compare it to diazepam (Valium).
“I can understand that both are used to relieve anxiety, but valerian is a much milder ingredient, and is really used for mild cases of anxiety and sleep issues,” he told Fox News Digital.
Some valerian users have reported improved sleep and reduced anxiety, according to recent research. (iStock)
Unlike valerian, diazepam carries a risk of dependence and is generally prescribed short-term, the expert said, and the spectrum of potential adverse effects is “very different.”
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Gafner said he “absolutely” recommends the use of valerian root to relieve anxiety and stress and to improve sleep.
“I have used it myself and I believe it’s an ingredient with well-documented benefits, especially for people with problems falling asleep,” he said. “It is well-tolerated and very safe… although some sources caution [against] driving a car or using heavy machinery when using valerian.”
Valeriana officinalis, a herbal plant used as a mild sedative, in bloom. (iStock)
Dr. Joseph Mercola, a board-certified family medicine osteopathic physician and author of the new book “Weight Loss Cure,” said valerian’s comparisons to Valium may “exaggerate what the science actually shows.”
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“Valerian root contains compounds that appear to enhance calming brain chemicals, particularly the neurotransmitter GABA, which helps quiet nerve activity and supports relaxation,” the Florida-based expert told Fox News Digital.
“Some studies do report modest improvements in sleep quality or shorter time to fall asleep, while others find no meaningful difference compared with placebo.”
Valerian supplementation may not be right for everyone seeking better sleep, one doctor said. (iStock)
Side effects may include headaches, dizziness, digestive upset or next-day grogginess, Mercola noted, adding that he would not recommend it as a primary strategy for anxiety, stress or sleep.
“Because long-term safety studies remain limited, and supplement quality varies widely, you should approach valerian with caution rather than view it as a universal sleep solution,” he advised.
“You should approach valerian with caution rather than view it as a universal sleep solution.”
“I encourage people to focus first on strategies that correct the underlying drivers of poor sleep,” Mercola advised. “When you fix those foundations, you often find that you no longer need an herbal sedative at all.”
“I encourage people to focus first on strategies that correct the underlying drivers of poor sleep,” one doctor advised. (iStock)
“Bright sunlight during the day helps regulate your circadian rhythm and signals your brain to produce melatonin later at night,” he said. “At the same time, complete darkness [at night] supports the hormonal signals that allow deep, restorative sleep.”
Certain nutrients can also promote relaxation and sleep quality, including magnesium, which helps to regulate the nervous system, according to the doctor.
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GABA may help to calm nerve activity, reduce stress markers and improve perceived sleep quality, Mercola said, while glycine — taken at about 3 grams an hour before bed — may support relaxation, promote the body’s nighttime temperature drop, and improve sleep onset and overall quality.
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“When you combine sunlight exposure, magnesium, GABA and glycine, you support the biological systems that control sleep instead of relying on a sedating herb with mixed evidence,” the doctor concluded.
Fox News Digital reached out to valerian root manufacturers requesting comment.
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GLP-1 medications such as Ozempic and Wegovy have transformed treatment for Type 2 diabetes and obesity, but new research suggests doctors may need to pay closer attention to bone health, especially in older patients taking the drugs.
Older adults with Type 2 diabetes who started GLP-1s had an 11% higher risk of fragility fractures compared to those taking other diabetes medications, a study published in February in the Journal of Clinical Endocrinology & Metabolism found.
Dr. Michal Kasher Meron, an endocrinologist at Meir Medical Center in Israel and lead author of the study, said the relative increase may sound small, but it carries weight for an at-risk population.
“Both older age and Type 2 diabetes are independent risk factors for fragility fractures,” Kasher Meron told Fox News Digital. “This is a population that deserves special attention.”
A new study suggests older adults with Type 2 diabetes taking GLP-1 medications may face increased fracture risk. (iStock)
Fragility fractures are breaks from minor falls or routine activity, often linked to osteoporosis, and can lead to hospitalization, loss of independence and even increased mortality in older adults, Kasher Meron noted.
The study followed more than 46,000 adults 65 and older for nearly three years. After adjustments, GLP-1 users had a modest but statistically significant increase in fracture risk.
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Previous research in younger patients using older GLP-1s did not show increased fracture risk, but newer, more potent versions are now widely prescribed to older adults, Kasher Meron noted.
“In older adults treated with contemporary medications, the fracture risk picture looks different and warrants close attention,” she said.
Separate research found slightly higher rates of osteoporosis and gout among adults using GLP-1s. (iStock)
The study, however, was observational, meaning it shows an association but not causation. Researchers were unable to determine whether the risk was driven by weight loss, changes in diet, muscle loss or a direct effect on bone.
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Nonetheless, Kasher Meron says, “Bone health should be assessed before starting these medications in older patients — not as an afterthought.”
The findings come as separate research presented at the American Academy of Orthopaedic Surgeons’ annual meeting this month raised additional bone health concerns.
In an analysis of more than 146,000 adults with obesity and Type 2 diabetes, GLP-1 users were found to have a 29% higher relative risk of osteoporosis over five years compared to nonusers, according to reports.
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Rates of gout were also slightly higher, affecting 7.4% of GLP-1 users compared to 6.6% of nonusers — about a 12% relative increase.
Experts recommend bone density screening for older adults taking GLP-1 medications. (iStock)
Osteomalacia, a softening of the bones, was rare but occurred about twice as often in GLP-1 users, according to the study, which has not yet been peer reviewed. It was also observational, showing only an association. Fox News Digital has reached out to the researcher for comment.
Several mechanisms could be at play, experts say. GLP-1 medications suppress appetite and can lead to rapid weight loss. Significant weight loss is known to reduce bone density, partly because less mechanical load is placed on the skeleton.
“It’s the same idea as when we always hear about astronauts going up into space, and they’re in a gravity-zero environment for too long,” lead author Dr. John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania, told NBC News.
“There’s nothing forcing their bones to kind of hold their weight anymore. And a lot of those astronauts come back with low bone density.”
Additionally, eating fewer calories may also mean lower intake of calcium, vitamin D and protein, nutrients critical for bone strength.
GLP-1 medications like Ozempic and Wegovy are widely used to treat Type 2 diabetes and obesity. (iStock)
Rapid weight loss can also temporarily increase uric acid levels, a byproduct of tissue breakdown, which may explain the uptick in gout cases.
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Despite the findings, experts say the results should not discourage appropriate use of GLP-1 medications, which have proven benefits for blood sugar control, weight loss and cardiovascular risk reduction.
In addition to bone density screening, experts say patients should ensure adequate nutrition and resistance training to help preserve muscle and bone during weight loss.
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A spokesperson for Novo Nordisk, which manufactures GLP-1 medications, said the company prioritizes patient safety, works closely with the U.S. Food and Drug Administration (FDA) and welcomes independent research into its products.
Experts also recommend proper nutrition and resistance training to help preserve muscle and bone health during weight loss. (iStock)
The known risks and benefits of the drugs are reflected in the current FDA-approved labeling, Liz Skrbkova, head of U.S. media relations for Novo Nordisk, told Fox News Digital. She emphasized that semaglutide has demonstrated cardiovascular, kidney and liver benefits when used under medical supervision.
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“Osteoporosis is a complex condition that develops over many years as a result of interdependent risk factors,” Skrbkova added.
Fox News Digital’s Melissa Rudy contributed reporting.
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