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Ozempic may help diabetes patients quit smoking, study finds

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Ozempic may help diabetes patients quit smoking, study finds
  • A new study found that smokers with type 2 diabetes taking Ozempic had fewer tobacco-related medical encounters compared to those using other diabetes medications.
  • The study, based on electronic health records of nearly 229,000 patients, suggests a potential link between Ozempic and reduced tobacco use.
  • Reports indicated that semaglutide, the active ingredient in Ozempic, might reduce smoking desire by affecting nicotine’s reward effects.

Smokers with type 2 diabetes taking Novo Nordisk’s Ozempic had fewer tobacco-related medical encounters and fewer interventions to help them quit smoking than those who received other diabetes drugs, according to a study of electronic health records published on Monday.

In the year after starting treatment, Ozempic users with a previous diagnosis of tobacco use disorder were up to 32% less likely to discuss tobacco use with a healthcare provider than those taking other diabetes medications. This was true even compared with those taking medicines in the same class, known as GLP-1 receptor agonists, researchers reported in Annals of Internal Medicine.

They were also up to 68% less likely to receive prescriptions for smoking cessation medication and up to 21% less likely to receive smoking cessation counseling.

DIABETES PATIENTS USING OZEMPIC, OTHER TREATMENTS INSTEAD OF INSULIN HAVE LOWER CANCER RISK, STUDY FINDS

The findings were drawn from electronic health record data on nearly 229,000 patients, including 6,000 recipients of Ozempic.

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A box of Ozempic made by Novo Nordisk is seen at a pharmacy on March 8, 2024. Smokers with type 2 diabetes taking Novo Nordisk’s Ozempic had fewer tobacco-related medical encounters and fewer interventions to help them quit smoking than those who received other diabetes drugs, according to a study of electronic health records published on Monday. (REUTERS/Hollie Adams/File Photo)

The researchers called for clinical trials to evaluate the potential of the drug’s active ingredient, semaglutide, for use in smoking cessation to backup the findings from this study sponsored by the U.S. National Institutes of Health.

They noted earlier reports have suggested a reduced desire to smoke in patients treated with semaglutide, possibly related to a dampening of addictive nicotine’s reward effects in the brain. Novo’s wildly popular weight-loss drug Wegovy has the same active ingredient.

The current study did not include data showing whether patients actually stopped or decreased tobacco use after starting on the various drugs.

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While the observed reduction in tobacco disorder-related encounters might suggest reductions in tobacco use or relapses, it “could also reflect other scenarios, such as a reduced willingness to seek help to quit smoking,” the researchers acknowledged.

The classes of diabetes drugs looked at in the study included insulins, metformin, DPP-4 inhibitors, SGLT-2 inhibitors, sulfonylureas, thiazolidinediones and other GLP-1’s than Ozempic.

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With some Olympic events postponed, Seine River water quality poses concerns

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With some Olympic events postponed, Seine River water quality poses concerns

As Paris opened the 2024 Summer Olympic Games along the Seine River, it was easy for many to fall in love with the romantic waterway and forget what lies beneath.

But the steady rain this past Friday was a reminder of how the weather impacts the river’s water quality.

Organizers canceled the practice run for the upcoming triathlon on both Sunday and Monday due to concerns that the heavy rains negatively impacted the water quality, according to multiple reports.

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Officials were still optimistic that warmer temperatures would reduce the bacteria levels so the men’s triathlon could proceed as planned on Tuesday — but the race was ultimately postponed.

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“Despite the improvement in the water quality levels in the last hours, the readings at some points of the swim course are above acceptable levels,” the World Triathlon said in a statement on X.

Triathlon athletes dive in the Seine River during a test event for the women’s triathlon for the upcoming 2024 Olympic Games in Paris, on Aug. 17, 2023. Organizers canceled the practice run for the upcoming triathlon on both Sunday and Monday due to concerns that the heavy rains negatively impacted the water quality. (Getty Images)

Experts from University of Florida (UF) Health, a member of the U.S. Olympic & Paralympic Medical Network, discussed with Fox News Digital how the Seine River could impact athletes’ health.

IN COLORADO, PLAGUE CASE CONFIRMED IN HUMAN, HEALTH OFFICIALS SAY: ‘MUST BE TREATED PROMPTLY’

The quality of water may vary depending on the time of day and the number of infectious particles consumed, Kartikeya Cherabuddi, M.D., professor of infectious diseases and global medicine at the University of Florida, told Fox News Digital.

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“Taking precautions and being aware of potential symptoms so they can be managed early is important,” he said.

River gets a makeover

For the past 100 years, swimming has been illegal in the Seine River due to poor water quality — with the exception of rare competitions, according to multiple reports.

“The city of Paris has put a great deal of effort into cleaning up the Seine,” Nicole Iovine, M.D., Ph.D., chief epidemiologist and chief quality officer at UF Health, told Fox News Digital.

Seine River Olympics 2024

A general view of the pontoon used by triathlon athletes moored on the River Seine, Paris, on the second day of the 2024 Paris Olympic Games in France. Poor water quality in the Seine caused swimming training for the triathlon to be canceled on Sunday. (Getty Images)

“[As in] many old cities, both sewage and storm runoff travel in the same pipe that is destined for water treatment plants,” she said.

“If there are heavy rains, the pipe capacity can be overwhelmed, and the excess can end up in the Seine.”

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ON THIS DAY IN HISTORY, JULY 20, 1968, FIRST SPECIAL OLYMPICS SUMMER GAMES ARE HELD IN CHICAGO

To prepare for the Olympics, the city spent $1.5 billion to build an underground storage basin, called “Austerlitz Basin,” along with a renovated sewer system and upgraded treatment plants.

The goal was for the improved system to collect excess rain to prevent wastewater from flowing into the Seine, according to a recent report.

Heavy rains, however, could thwart those efforts.

Daily water testing

About one week before the Olympic Games, Paris Mayor Anne Hidalgo took a highly publicized dip on July 17 to show that the waters were safe for the triathlon and marathon events.

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Later testing, however, revealed that in some areas, levels of E. coli bacteria were above Europe’s maximum safety limit, which is 900 colony-forming units per 100 milliliters.

One person swimming in the river doesn’t prove that the water is safe, experts pointed out.

Paris Mayor Anne Hidalgo treads water in the Seine River.

Paris Mayor Anne Hidalgo is shown swimming in the Seine River on July 17, 2024, in Paris. One person swimming in the river doesn’t prove that the water is safe, experts pointed out. (AP Photo/Michel Euler)

“The risk of aspirating river water is much greater when engaged in a highly exertional activity like a competitive race compared to a more leisurely dip in the Seine,” Iovine said.

Eau de Paris, the largest public water company in France, found that the Seine’s water quality for the week of July 17 “reached the compliance thresholds of the European directive at all four points monitored over four days,” according to the city’s website.

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The water is tested early each morning during the Olympics to ensure that the events can proceed as planned, officials say. 

The tests typically screen for certain types of bacteria called total coliforms, and generally do not look for other germs, like viruses and parasites, Iovine noted.

E.coli

E. coli (Escherichia coli) is a group of bacteria in the intestinal tract that helps to digest food and protect the body from harmful germs, but some types can cause illness. (iStock)

Most coliforms, which are found naturally in the environment as well as in human and animal waste, are not harmful — and the ones that can cause illness are usually present in low amounts that don’t pose a threat, he said.

High levels of coliforms, however, can be a marker of excessive fecal matter, which can make people sick, according to experts.

“If the amount of coliforms increases, that could be because significant numbers of pathogenic bacteria, like E. coli, have entered the water, making it potentially unsafe,” Iovine warned.

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Potentially harmful contaminants

E. coli (Escherichia coli) is a group of bacteria in the intestinal tract that helps to digest food and protect the body from harmful germs, according to the Centers for Disease Control and Prevention (CDC).

Some types, however, can cause illness.

“I am concerned that if the level of harmful bacteria is too high, the athletes [could be] at risk for contracting gastrointestinal illness.”

People can get infected by swallowing water that is contaminated with the waste of an infected person.

Common bacterial symptoms include watery or bloody diarrhea, severe stomach cramps, and vomiting that may be associated with a fever, according to the CDC.

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Other bacteria associated with sewage, such as Enterococcus, Salmonella and Campylobacter, can cause a similar array of infections, Iovine warned.

“I am concerned that if the level of harmful bacteria is too high, the athletes [could be] at risk for contracting gastrointestinal illness,” she said.

      

Skin and eye infections are also possible if people have small nicks or abrasions on their skin before entering the water.

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Parasites, like Giardia, amoebas and Cryptosporidium — and viruses, such as norovirus, hepatitis A and hepatitis E — may also be present in human and animal sewage, Iovine added.

Seine River Olympics 2024

A tourist boat navigates on the Seine River under the Alexandre III Bridge, after the first triathlon training session was canceled during the Paris 2024 Olympic Games on July 28, 2024, due to poor water quality. (Getty Images)

Symptoms of viruses and parasites are predominantly stomach-related, such as nausea, vomiting, diarrhea and abdominal pain, but can also include fevers, headaches, and respiratory or urinary issues, Cherabuddi noted.

“Symptoms may start within one to two days, but could present a week or two later,” he added.

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Harmful pathogens carried by rodents can also enter the river with overflow from rainwater, Iovine said.

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The urine of rodents, for example, can contain bacteria called Leptospires, which can cause a bacterial disease called leptospirosis. 

Seine River Olympics 2024

Triathlon athletes compete and swim in the Seine River during a test event for the women’s triathlon for the upcoming 2024 Olympic Games in Paris, on Aug. 17, 2023. (Getty Images)

That condition can cause nausea, vomiting, body aches, red eyes, fever and headache, according to Iovine.

“Since these athletes are young and healthy, I would expect them to recover from these infections if they occurred, but it could impact their ability to compete in their events if they are sick,” she said.

For more Health articles, visit www.foxnews/health

Athletes who are immunocompromised may experience more severe illness than those with healthy immune systems.

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Fox News Digital reached out to the International Olympics Committee and Eau de Paris requesting comment.

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Alzheimer’s and Parkinson’s risk is higher for people with body fat in two specific areas

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Alzheimer’s and Parkinson’s risk is higher for people with body fat in two specific areas

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Excess fat in certain areas of the human body could make people more prone to neurological diseases like Alzheimer’s and Parkinson’s, a new study suggests.

The study, published in the journal Neurology — the medical journal of the American Academy of Neurology — linked higher levels of body fat in the arms and belly with a greater chance of developing these conditions.

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In another key finding, people who have more muscle strength were at lower risk of developing these diseases.

HIDDEN BELLY FAT COULD SIGNAL ALZHEIMER’S DISEASE RISK 15 YEARS BEFORE SYMPTOMS SHOW UP, STUDY FINDS

“Overall, the key takeaway message from our study finding is that body composition and cardiovascular diseases may be potential targets for preventing neurodegenerative diseases,” said lead study author Shishi Xu, a clinician in the Department of Endocrinology and Metabolism at West China Hospital of Sichuan University, in a statement to Fox News Digital.

The study group that had higher levels of belly fat had a 13% greater chance of developing neurological diseases like Alzheimer’s and Parkinson’s compared to those with lower levels, the researchers found.

Excess fat in certain areas of the body could make people more prone to neurological diseases such as Alzheimer’s and Parkinson’s, a new study suggests. (iStock)

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Participants with higher levels of arm fat had an 18% higher risk.

Those with high muscle strength were 26% less likely to develop these types of diseases than those with low levels of strength, according to Xu. 

BOOST BRAIN HEALTH AND SLOW MENTAL AGING WITH 10 INTRIGUING TIPS FROM LONGEVITY EXPERTS

Cardiovascular disease risk plays a role, too, she said.

“If you are exposed to adverse body composition patterns, such as belly fat, you will have a higher risk of developing cardiovascular diseases, which significantly increases your risk of future neurodegenerative diseases,” Xu said. 

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Arm fat

Higher levels of body fat in the arms and belly were linked to a greater chance of developing neurological conditions. (iStock)

“On contrast, actively preventing CVDs at an early stage after exposure to adverse body composition patterns may decrease your future risk of neurodegenerative diseases by 10.7% to 35.3%.”

Dr. James Galvin, director of the Comprehensive Center for Brain Health at the University of Miami Health System, was not involved in the study, but said the findings did not surprise him.

“Body composition and cardiovascular diseases may be potential targets for preventing neurodegenerative diseases.”

“This is consistent with a body of literature suggesting a bidirectional relationship between brain and body,” he told Fox News Digital.

“Loss of muscle mass and strength (sarcopenia) and increase in body fat, particularly visceral fat, are risk factors for cognitive impairment.”

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Potential limitations

In observational studies like this one, it can be tough to distinguish between correlation or causation, Xu said.

“Although we have made significant efforts in this study to approach a causal relationship, we acknowledge that residual reverse causation may still bias our findings,” she told Fox News Digital.

Nutritionist

Taking steps to achieve healthier body composition may be more effective for preventing neurological diseases than general weight control, researchers said. (iStock)

Although the study suggests that body composition and cardiovascular diseases may be potential targets for preventing neurodegenerative diseases, Xu noted that more evidence is needed to confirm that these are causal risk factors.

FASTING COULD REDUCE SIGNS OF ALZHEIMER’S DISEASE, STUDIES SUGGEST: ‘PROFOUND EFFECTS’

Galvin noted that another major limitation of the study was the lack of diversity in the sample. 

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“This is unfortunate, as obesity is an important risk factor in many minoritized populations, and our own research has demonstrated that physical frailty is an important mediator of cognitive decline in African American older adults,” he said.

Recommended lifestyle changes

Based on the findings, the researchers said, taking steps to achieve healthier body composition — such as reducing belly and arm fat while promoting healthy muscle development — may be more effective for preventing neurological diseases than general weight control. 

“Lifestyle modifications like engaging in resistance training, reducing sedentary behavior and adhering to a balanced diet can be effective in reducing abdominal fat as well as enhancing muscle strength, which may potentially offer greater neuroprotective benefits than weight-focused anti-obesity medications,” Xu said.

      

The researchers also stated that early management of cardiovascular diseases may reduce the risk of neurodegenerative diseases.

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Girl stepping on scale

The quality or distribution of muscle and fat, rather than the absolute weight, may be more important for your health, according to researchers. (iStock)

The quality or distribution of muscle and fat, rather than the absolute weight, may be more important for your health, according to Xu.

“In recent years, due to the widespread use and even abuse of weight-loss drugs, people have become overly concerned with overall weight and often overlook the key role of different body components,” she said.

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Muscle strength is often overlooked, the researcher noted.

“Our current study findings highlight that enhancing muscle strength is important and may potentially offer neuroprotective benefits,” she said. 

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Woman lifting weights

“Our current study findings highlight that enhancing muscle strength is important and may potentially offer neuroprotective benefits,” the researcher said.  (iStock)

“Therefore, maintaining a healthy lifestyle and enhancing your muscle strength are crucial.”

Galvin agreed, recommending that people should focus on reducing body fat while maintaining skeletal muscle by adding resistance and flexibility training and changing nutrition patterns. 

For more Health articles, visit www.foxnews/health

Added the doctor, “As we learn more about the impact of lifestyle on brain health and risk of disease, it is increasingly evident that there are many ways to build a better brain as we age.”

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Melt Pounds While Sitting Down? Yes! Chair Exercises for Weight Loss Make It Easy

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Melt Pounds While Sitting Down? Yes! Chair Exercises for Weight Loss Make It Easy


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Chair Exercises for Weight Loss Rev Metabolism and Tone Muscles | Woman’s World
























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