Health
New York resident dies from mosquito-borne disease as experts warn of widening risk
New York has reported the state’s first death from Eastern equine encephalitis (EEE), a disease that spreads through bites from mosquitoes.
The patient was the first person to contract EEE in New York since 2015, according to a press release issued by the state on Monday.
“Keeping New Yorkers safe is my top priority,” Governor Hochul said in a statement.
WHAT IS EEE, THE MOSQUITO-BORNE DISEASE THAT KILLED A NEW HAMPSHIRE MAN?
“Following the first confirmed human case of EEE, my administration took statewide action to help protect communities – and with today’s declaration, we’re making more state resources available to local departments to support their public health response.”
New York has reported the state’s first death from Eastern equine encephalitis (EEE), a disease that spreads through bites from mosquitoes. (iStock)
“We’ve been informed this patient has passed away from EEE; we extend our sympathies and our hearts go out to their family.”
State Health Commissioner Dr. James McDonald has declared EEE an imminent threat to public health, which will make more resources available for prevention measures, such as spraying to reduce mosquitoes.
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The state has announced plans to expand access to insect repellent in parks and campgrounds, and is encouraging New York residents to take steps to protect against mosquito-borne illness.
What is EEE?
Eastern equine encephalitis is caused by a virus that is spread through the bite of an infected mosquito, according to the Centers for Disease Control and Prevention (CDC), which describes EEE as a “rare but serious disease.”
Only a few cases are reported in the U.S. each year, most in the Eastern or Gulf Coast states, the agency states on its website.
Some Northeastern towns have enacted voluntary lockdowns due to the rise in EEE cases. (iStock)
Humans and other animals that contract the virus are considered “dead-end hosts,” the CDC states, which means they can’t spread it to mosquitoes that bite them.
“EEE is only spread to humans via a mosquito bite, and cannot be transmitted directly by other humans or horses,” Dr. Kurt Vandock, PhD, a public health expert and VP of strategic growth for Mosquito Squad, told Fox News Digital.
The patient was the first person to contract EEE in New York since 2015.
Common symptoms of EEE include fever, vomiting, diarrhea, headache, stiff neck, seizures, behavioral changes and drowsiness.
These usually appear five to 10 days after being bitten.
“Most people have no symptoms; others get only a mild, flu-like illness with fever, headache and sore throat,” Vandock said.
Using insect repellents that contain DEET can help to protect against mosquito bites, experts say. (iStock)
“For people with an infection of the central nervous system, a sudden fever (103º to 106º), severe headache and stiff neck can be followed quickly by seizures and coma.”
The disease can be deadly, resulting in fatalities for 30% of infected people. It can also lead to chronic neurological deficiencies, per the CDC.
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“The best way to confirm any illness is with an approved and accurate test administered by a medical professional,” said Vandock.
“Eastern equine encephalitis is a serious disease with symptoms occurring fast,” he warned.
“If you live in an area with noted EEE activity and have flu-like symptoms after being bitten by a mosquito, you should seek medical care immediately.”
Concerns of wider infection
In addition to New York, other states that have reported human EEE cases include Massachusetts, Vermont, New Jersey, Rhode Island, Wisconsin and New Hampshire.
“Anytime life is put at risk by vector-borne disease, we are concerned,” Vandock said.
“As viral loads increase and transmission rates follow this trend, it is a sign that interventions are necessary to help reduce the risk of transmission,” he went on.
Common symptoms of EEE include fever, vomiting, diarrhea, headache, stiff neck, seizures, behavioral changes and drowsiness. (iStock)
“One case of any vector-borne disease is one too many.”
As far as why cases have been more prevalent in northeastern states, Vandock said there’s no simple answer.
“Conducive weather patterns, high population density, the heavy presence of the primary vector and seasonality — coinciding with increased outdoor activity — can create the perfect storm for rapid transmission,” he said.
“One case of any vector-borne disease is one too many.”
The black-tailed mosquito (Culiseta melanura), the primary vector of EEE, can be found in large numbers in the Northeastern United States, according to Vandock.
“It is known to feed mainly on birds, but does not typically feed on humans,” he said. “As a result, the transmission of EEE to humans and horses is generally thought to occur via ‘bridge vectors,’ which contract the virus from infected birds and can then pass the virus on to other hosts.”
The mosquitoes that act as “bridge vectors” can be found in the Northeast areas where transmission is occurring, the expert noted.
The risk of contracting the EEE virus is highest during the summer months — especially toward the end of summer, when people go back outdoors as temperatures cool, Vandock said.
The mosquitoes that act as “bridge vectors” can be found in the Northeast areas where transmission is occurring, an expert noted. (iStock)
“Anyone who lives or works close to wetlands and swamps is also at an increased risk,” he said.
The Midwest saw a similar outbreak of EEE in 2019 in Michigan, Vandock noted, as many schools canceled after-school activities after numerous fatalities from the disease.
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“Current trends suggest that with increasing globalization, population densities, ranges of competent hosts and a favorable climate, the occurrence of EEE and other vector-borne diseases will increase,” he added.
Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, said he is not concerned by the increase in cases.
“It is still a very slight uptick, and it is confined to mosquito transmission,” he told Fox News Digital, adding that he only anticipates “sparse cases” in other parts of the country.
Treatment and prevention
There is currently no vaccine for Eastern equine encephalitis, and supportive care is the only means of treating symptoms.
A mosquito control inspector sprays pesticide to kill mosquitos amid a Zika virus outbreak in Miami, Florida, in 2016. (Getty Images)
Educating the public about the risk, encouraging mosquito repellent use, and spraying to control the mosquito population are the best ways to prevent infection, according to experts.
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The state of New York issued the following recommendations for prevention.
- Wear long sleeves, pants and socks when outdoors during periods of high mosquito activity, such as dusk or dawn.
- Use insect repellents that contain DEET.
- Ensure that there are screens in all windows and doors.
- Eliminate standing water in outdoor areas where mosquitoes tend to breed.
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
BACTERIA IN YOUR MOUTH MAY TRAVEL TO THE GUT AND TRIGGER STOMACH CANCER, RESEARCH FINDS
After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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