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Mpox declared public health emergency in Africa as authorities battle multiple variants

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Mpox declared public health emergency in Africa as authorities battle multiple variants
  • The Africa Centers for Disease Control and Prevention declared the increasing spread of mpox a health emergency, warning the virus might spread across international borders. 
  • A new form of mpox that can kill up to 10% of people and may spread more easily was detected in Congo. The new form is harder to spot.
  • The World Health Organization director-general said officials were dealing with several mpox outbreaks in various countries with “different modes of transmission and different levels of risk.”

The Africa Centers for Disease Control and Prevention declared this week that the increasing spread of mpox across the continent is a health emergency, warning the virus might ultimately spill across international borders.

On Wednesday, the World Health Organization is convening its own expert meeting to consider making a similar emergency declaration over mpox. The U.N. health agency said there have been more than 14,000 cases and 524 deaths this year, which already exceed last year’s figures.

So far, more than 96% of all cases and deaths are in a single country — Congo. Scientists are concerned by the spread of a new version of the disease there that might be more easily transmitted among people.

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Here’s a look at what we know about mpox, and what might be done to contain it:

What is mpox?

Mpox, also known as monkeypox, was first identified by scientists in 1958 when there were outbreaks of a “pox-like” disease in monkeys. Until recently, most human cases were seen in people in central and west Africa who had close contact with infected animals.

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In 2022, the virus was confirmed to spread via sex for the first time and triggered outbreaks in more than 70 countries that had not previously reported mpox.

A nurse practitioner prepares a syringe with the mpox vaccine before inoculating a patient on Aug. 30, 2022, in the Brooklyn borough of New York City. (AP Photo/Jeenah Moon, File)

Mpox belongs to the same family of viruses as smallpox but causes milder symptoms like fever, chills and body aches. People with more serious cases can develop lesions on the face, hands, chest and genitals.

What’s happening in Africa that’s causing all this concern?

The number of cases has jumped dramatically. Last week, the Africa CDC reported that mpox has now been detected in at least 13 African countries. Compared with the same period last year, the agency said cases are up 160% and deaths have increased by 19%.

Earlier this year, scientists reported the emergence of a new form of mpox in a Congolese mining town that can kill up to 10% of people and may spread more easily.

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Unlike in previous mpox outbreaks, where lesions were mostly seen on the chest, hands and feet, the new form of mpox causes milder symptoms and lesions on the genitals. That makes it harder to spot, meaning people might also sicken others without knowing they’re infected.

WHO said mpox was recently identified for the first time in four East African countries: Burundi, Kenya, Rwanda and Uganda. All of those outbreaks were linked to the epidemic in Congo.

In the Ivory Coast and South Africa, health authorities have reported outbreaks of a different and less dangerous version of mpox that spread worldwide in 2022.

What does an mpox emergency declaration mean?

Africa CDC Director General Dr. Jean Kaseya said the agency’s declaration of a public health emergency was meant “to mobilize our institutions, our collective will and our resources to act swiftly and decisively.” He appealed to Africa’s international partners for help, saying that the escalating caseload in Africa had largely been ignored.

“It’s clear that current control strategies aren’t working and there is a clear need for more resources,” said Michael Marks, a professor of medicine at the London School of Hygiene and Tropical Medicine. “If a (global emergency declaration) is the mechanism to unlock these things, then it is warranted,” he said.

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What’s different about the current outbreak in Africa compared to the 2022 epidemic?

During the global outbreak of mpox in 2022, gay and bisexual men made up the vast majority of cases and the virus was mostly spread through close contact, including sex.

Although some similar patterns have been seen in Africa, children under 15 now account for more than 70% of the mpox cases and 85% of deaths in Congo.

Ahead of its emergency meeting on mpox, WHO Director-General Tedros Adhanom Ghebreyesus said officials were dealing with several mpox outbreaks in various countries with “different modes of transmission and different levels of risk.”

“Stopping these outbreaks will require a tailored and comprehensive response,” he said.

Greg Ramm, Save the Children’s Congo director, said the organization was particularly worried about the spread of mpox in the crowded camps for refugees in the east, noting there were 345,000 children “crammed into tents in unsanitary conditions.” He said the country’s health system was already “collapsing” under the strain of malnutrition, measles and cholera.

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Dr. Boghuma Titanji, an infectious diseases expert at Emory University, said it was unclear why children were so disproportionately hit by mpox in Congo. She said it might be because kids are more susceptible to the virus or that social factors, like overcrowding and exposure to parents who caught the disease, might explain it.

How might mpox be stopped?

The 2022 outbreak of mpox in dozens of countries was largely shut down with the use of vaccines and treatments in rich countries, in addition to convincing people to avoid risky behavior. But barely any vaccines or treatments have been available in Africa.

Marks, of the London School of Hygiene and Tropical Medicine, said that immunization would likely help — including inoculating people against smallpox, a related virus.

“We need a large supply of vaccine so that we can vaccinate populations most at risk,” he said, adding that would mean sex workers, children and adults living in outbreak regions.

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Congo has said it’s in talks with donors about possible vaccine donations and has gotten some financial aid from Britain and the U.S.

WHO said it had released $1.45 million from its emergency fund to support the response to mpox in Africa.

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New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds

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New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds

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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.

While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.

By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.

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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.

“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.

While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)

While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.

Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.

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“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”

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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.

The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.

Clinical treatments remain identical for both primary strains of the flu virus. (iStock)

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During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.

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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.

Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.

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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.

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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”

This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)

“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”

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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.

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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.

Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.

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One extra serving of processed meat a day linked to higher cancer risk

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One extra serving of processed meat a day linked to higher cancer risk

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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.

While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.

To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years. 

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The study group included 131,426 men and 318,686 women, according to the study’s press release.

During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.

For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)

Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.

The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.

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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.

A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.

An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)

An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.

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The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.

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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.

The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.

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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.

Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)

Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.

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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.

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The findings were published in the International Journal of Cancer.

Fox News Digital reached out to the researchers requesting comment.

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The Surprising Hormone That Could Make Menopause Weight Loss Easier

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The Surprising Hormone That Could Make Menopause Weight Loss Easier


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The Hormone That Could Make Menopause Weight Loss Easier




















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