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In lupus breakthrough, researchers say they may have found what causes the autoimmune disease

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In lupus breakthrough, researchers say they may have found what causes the autoimmune disease

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Scientists may have pinpointed a primary cause of lupus, a chronic autoimmune disease.

Researchers from Northwestern Medicine in Chicago and Brigham and Women’s Hospital in Boston claim they have found a “molecular defect” that leads to systemic lupus erythematosus (known as lupus).

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The study findings were published in the journal Nature on Wednesday.

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“Lupus is an autoimmune disease that at its core involves abnormal B cell activation and antibody production,” study author Deepak Rao, M.D., PhD, an assistant professor of medicine at Harvard Medical School and a rheumatologist at Brigham and Women’s Hospital, told Fox News Digital via email.

“This B cell activation and antibody production requires help from T cells (white blood cells that are integral to immune system activity).”

Lupus is a chronic autoimmune disease in which the immune system attacks healthy tissue in the body, which causes inflammation and pain in the body. (iStock)

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In the course of the research, the scientists tested the blood of 19 lupus patients and compared it to a control group of healthy individuals

The people with lupus shared certain molecular changes that caused a “dramatic imbalance” in the types of T-cells they generate, according to Rao.

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This imbalance resulted in too many “harmful” T-cells — which cause cellular damage — and too few of the “helpful” type that are necessary for cell repair.

The researchers also identified a protein called interferon that promotes the excess accumulation of T cells, Rao said.

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“We have known for many years that patients with lupus have too much interferon production, yet how interferon contributes to disease has been unclear,” he said.

“This study reveals a new potential therapeutic strategy to treat lupus.”

The study discovered that interferon contributes to the lupus disease by promoting the expansion of certain types of T cells and “amplifying pathologic T cell-B cell interactions,” Rao said. 

The researchers also discovered that the activation of one specific protein, the aryl hydrocarbon receptor (AHR), can prevent T cells from developing into disease-causing cells.

Some 1.5 million Americans are living with lupus, with about 16,000 new cases each year, according to the Lupus Foundation of America, based in Washington, D.C. (iStock)

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“This study reveals a new potential therapeutic strategy to treat lupus,” Rao said.

“We aim to use small molecule activators of AHR, directed specifically toward T cells, as a treatment to suppress the pathologic T cell response in lupus and reprogram those T cells toward other benign or protective functions.”

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This approach could potentially be safer and more effective than current broad immunosuppressive therapies because it targets the disease-causing cells, according to study co-author Jaehyuk Choi, M.D., PhD, an associate professor of dermatology and a Northwestern Medicine dermatologist.

“While we don’t know which patients this can best help, our data suggests it could potentially be broadly useful for all patients with lupus,” Choi told Fox News Digital in an email.

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Industry experts weigh in

Dr. Mara Lennard Richard, scientific program officer at the Lupus Research Alliance in New York City, which partially funded the research, said the study provides hope to those who struggle with lupus symptoms.

“This research is very exciting, and we are intrigued by the findings, which may pave the way to a potential new treatment,” Richard told Fox News Digital via email. 

Brooke Goldner, M.D., a California-based board-certified physician and creator of the Hyper-Nourishing Nutrition Protocol for Lupus Reversal, said that targeted immune therapy using T cells and B cells is a “new and exciting focus” in lupus research.  (iStock/Dr. Brooke Goldner)

“However, lupus is a highly complex disease with many contributing factors, and more research is needed to confirm these results,” she went on.

“We believe that many new targets and treatments are needed to improve the lives of people living with lupus.”

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Brooke Goldner, M.D., a California-based board-certified physician and creator of the Hyper-Nourishing Nutrition Protocol for Lupus Reversal, said that targeted immune therapy using T cells and B cells is a “new and exciting focus” in lupus research. 

“We believe that many new targets and treatments are needed to improve the lives of people living with lupus.”

“If it is proven effective, it would present a far more specific way to medically attenuate the abnormal immune response in lupus patients than current medications that suppress immunity more broadly,” Goldner, who was not involved in the study, told Fox News Digital in an email. 

“However, the effectiveness and possible side effects of these therapies are still unknown.”

It is still unclear how these abnormalities in the immune cells are triggered, she noted.

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“People with lupus are not born with symptoms of the disease, but they are triggered at some point in their lives, which leads to their diagnosis,” Goldner said. 

“That leaves the question: Are their immune cells actually normal prior to the disease being triggered? Does this trigger then activate abnormal gene expression, which causes the creation of these abnormal immune cells?”

“If that is the case, then the immune treatments [the researchers] are proposing would still be considered a treatment, not a cure, unless they are going to turn off gene expression more specifically and permanently.”

Limitations of the study

The research was mainly performed in-vitro using cells from patients, Rao acknowledged.

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“We do not yet know what will happen to the T cell response if activators of AHR are used in people, or how effective this strategy will be to improve symptoms of lupus,” he added.

Even so, the researchers are hopeful that this discovery will pave the way to advances in lupus treatment.

Lupus is more common among women between 15 and 44 years of age and people who are African American, Asian American, Hispanic/Latino, Native American, or Pacific Islander, according to experts in the field. (iStock)

“This study is an excellent example of how we can gain new, important insights into the pathways that contribute to disease by doing careful analyses of samples from patients with a disease,” Rao noted.

“This ‘human immunology’ approach provided both new insights into how T cells are regulated and a new idea for how to treat lupus.”

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What to know about lupus

Lupus is a chronic autoimmune disease in which the immune system attacks healthy tissue in the body, which causes inflammation and pain in the body, according to the Lupus Foundation of America’s website.

The disease most often affects the joints, skin and major organs, such as the kidneys and heart. 

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Common symptoms include joint pain, extreme fatigue or a butterfly rash.

There are four different types of lupus, as detailed on the foundation’s website.

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A facial “butterfly rash” is one of the hallmark symptoms of lupus. (iStock)

Systemic lupus erythematosus (SLE), the most common form, affects multiple organs or organ systems.

Cutaneous lupus only affects the skin, while drug-induced lupus is triggered by specific prescription drugs.

                      

Neonatal lupus is a rare condition that is passed from a pregnant woman to her infant.

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Some 1.5 million Americans are living with lupus, with about 16,000 new cases each year, according to the Lupus Foundation of America, based in Washington, D.C.

Lupus can run in families, and it’s also more common among women between 15 and 44 years of age and people who are African American, Asian American, Hispanic/Latino, Native American, or Pacific Islander, according to the same foundation.

In addition to medication, lupus patients can manage their illness with certain lifestyle behaviors, such as eating an anti-inflammatory diet and managing emotional stress, an expert said. (iStock)

In addition to medication, lupus patients can manage their illness with certain lifestyle behaviors, Goldner said, such as eating an anti-inflammatory diet and managing emotional stress.  

“The field of lifestyle medicine has shown that symptoms can be reversed long-term using lifestyle modification,” she said. 

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“It would be extremely interesting to have researchers evaluate the activity of these abnormal immune cells before and after lifestyle modification to see whether it has manifested a similar reversal of the activity of these abnormal B cells without using the more invasive medical treatment.”

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How Well Will You Age? Take Our Quiz to Find Out.

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How Well Will You Age? Take Our Quiz to Find Out.

Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.

Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.

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Red hair may be increasing as study points to surprising evolution trend

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Red hair may be increasing as study points to surprising evolution trend

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A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.

By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.

“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.

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The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”

Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.

Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)

Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.

“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.

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The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.

Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)

As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”

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While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.

However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.

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While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.

While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)

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Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.

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The researchers urged caution in how these findings are interpreted.

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“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.

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Aging in Place: How Technology Might Help You Grow Old at Home

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Aging in Place: How Technology Might Help You Grow Old at Home

Dr. Megan Jack, a neurosurgeon in Cleveland, often works 60 or 70 hours a week. And she’s completely unavailable when she’s in the operating room. That makes it tough to be a caregiver for her 76-year-old mother, who lives in a separate unit on Dr. Jack’s property, 30 minutes away from the hospital.

To help care for her mother, who has Alzheimer’s disease, Dr. Jack uses an array of high-tech tools, some of which didn’t exist just a few years ago. She manages her mother’s medications with a smart pill box. She changes her television channels with an app, sends appointment reminders through a digital message board — and, with her mother’s blessing, uses cameras for communication and monitoring.

“It’s been invaluable that I can both make sure she’s safe and make sure everything is going well,” Dr. Jack said, “but also give her the independence and the freedom that she still deserves.”

America is aging rapidly. Roughly 11,000 people are turning 65 each day in the United States. And many of them — 75 percent of people over 50, according to AARP’s most recent survey, from 2024 — hope to spend their remaining years in the comfort of their homes, rather than in assisted-living or other care facilities.

One thing that could help fulfill those wishes is the budding field of “age tech,” which encompasses tools that support older adults. Industry experts say that age tech is making homes safer for older adults and is easing the minds of their caregivers, especially those who live far away or work outside the home.

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Dr. Jack said that age tech had “really allowed me to integrate caregiving into my life, as opposed to caregiving taking over my life.”

If older adults don’t have loved ones who are both close by and able to help, they might believe they don’t have a ton of options. They can live independently, or, if they can afford it and qualify medically, they can move to an assisted-living facility or a nursing home, without a lot of choices in between. In-home help can be expensive without Medicaid and can also be difficult to find, given the serious shortage of home care workers.

Age tech can help bridge some important gaps, said Emily Nabors, the associate director of innovation at the National Council on Aging, a nonprofit advocacy group. Already, AARP reports that 25 percent of caregivers are remotely monitoring their loved ones with apps, videos or wearables, nearly double the percentage from five years ago.

“We used to say homes are the health care settings of the future, but they really are health care settings now,” Ms. Nabors said. “Aging in place is very realistic.”

More than 700 companies are in AARP’s AgeTech Collaborative, a group that connects businesses, nonprofits and funders to help get new technologies off the ground. Altogether, the collaborative’s start-ups have raised nearly $1 billion in the past four years.

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The products include smart walkers, glasses with lenses that provide real-time captions of conversations for those with hearing issues, and a concierge service that connects older people to drivers and deliveries, even if they don’t have a smartphone.

Ms. Nabors does foresee some affordability and access barriers to age tech, including the lack of high-speed internet in rural areas, but she said one vital resource would be local aging agencies, which can offer advice and, sometimes, free support.

Janet Marasa leaned on the agency near her home in Rockland County, N.Y., to get a free robotic pet for her mother, Carol DeMaio, 80, who has dementia. The pets, manufactured by a company called Joy for All, aim to offer emotional support without the upkeep.

Ms. DeMaio named the robotic dog Sabrina, after a golden retriever who died. The new Sabrina stays at the foot of her bed at night. As soon as Ms. DeMaio stirs awake, the dog reacts. “She said it gives her a reason to get up in the morning,” Ms. Marasa said.

The dog has been a boon to her, too. “It provides comfort and interaction that I can’t provide every second,” said Ms. Marasa, who lives with her mother but works full time for the county government. “It gives her something that she can feel like is totally her own.”

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In Broward County, Fla., where the population of residents over 85 is expected to nearly triple over the next few decades, the local agency on aging has used state and federal money and private grants to provide technologies to nearly 4,000 of the county’s seniors at no cost.

Its offerings include a company that uses radar to sense falls and a program that allows seniors to make video calls through their televisions.

“The possibilities are endless,” Charlotte Mather-Taylor, the agency’s chief executive, said. “It’s pretty great to see all the new technology coming out so quickly, and I think that can only benefit our older population and also our caregivers.”

Even technologies not specifically marketed as age tech can help older adults maintain their independence, said Laurie Orlov, founder of the blog Aging and Health Technology Watch. She pointed to video-calling and telehealth platforms; remotely controlled thermostats and lights; and smart speakers, doorbells and watches.

“All technology can be customized to help older adults stay longer in their homes and help their family members feel good about it, or at least tolerate it,” Ms. Orlov said.

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That will only become more true with the continued proliferation of artificial intelligence, Ms. Orlov added. Some older adults are already using conversational A.I. to get answers about things like the weather or their medications. (Relying too heavily on A.I. can, however, have negative consequences because chatbots often give flawed medical advice and can lead patients astray.) A.I. can also assist in pattern detection: alerting caregivers to signals that might indicate declines in someone’s cognition or mental health, such as changing their speech pattern or leaving the house less frequently.

One A.I.-powered age tech tool is ElliQ, a tabletop companion robot that looks like a sleek silver desk lamp with a screen. About a year and a half ago, Camille Wolsonovich got one for free, thanks to a local nonprofit, for her 90-year-old father, Bill Castellano. He lives alone in a senior community.

Ms. Wolsonovich, who runs a consulting business, relies on ElliQ to lead her father in exercises and remind him to take his pills and drink water. The robot also asks her father about his sleep and mood via automated check-ins.

“Everything’s just another layer that gives us more confidence, from a caregiving standpoint, that he’s good,” Ms. Wolsonovich said. “I don’t have to necessarily track everything all the time and be overbearing.”

As for Mr. Castellano? He plays trivia digitally and converses daily with ElliQ. The robot, which has a friendly female voice, asks questions, cracks jokes and remembers his likes, dislikes and friends. “She’s great company,” he said. “Everybody around me wants one.”

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Clara Berridge studies the ethics of age tech at the University of Washington.

She has many privacy concerns, namely that most direct-to-consumer products aren’t subject to medical privacy laws, despite being privy to sensitive health information. Though she hopes the federal government will eventually step in to regulate these products, as it has in other countries, the onus remains on the consumer for now.

And even if an age tech product isn’t selling mom’s personal data to the lowest bidder, Dr. Berridge said there’s still the question of whether certain tools are ethical.

“It’s really important for caregivers to recognize that using these new technologies that give them more information about someone can represent greater intrusion into someone’s life,” she said.

What may be well-intentioned monitoring could reveal information that an older adult would rather keep private, such as issues with incontinence, or the comings and goings of a romantic partner.

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“It can lead to somebody feeling infantilized,” Dr. Berridge said. “Like there’s not a place to hide within your own home.”

Her research shows that adult children often underestimate how much their parents can understand about technology and how much they want to be involved in tech-related decisions.

She encouraged caregivers to have transparent conversations about privacy implications and to avoid ultimatums or the idea that any decision must be permanent. She said caregivers should put themselves in their parents’ shoes: Is this something they’d want their own children monitoring?

Dr. Berridge is working on an advanced directive for technology, which outlines older people’s wishes for how technology is used in their care. Ultimately, she hopes that questions about age tech will become a standard part of planning for the future.

“If you’re at the start of what, for many people, ends up being a long road of supporting someone potentially through the end of their life,” she said, “seeking to understand each other’s concerns and priorities better is time very well spent.”

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