Health
Hantavirus Vaccines and Treatments Are in the Pipeline
The deadly hantavirus outbreak aboard the cruise ship MV Hondius has put the spotlight on a rare pathogen that typically attracts relatively little attention, even from scientists.
There are no targeted treatments for hantaviruses, which are typically carried by rodents, and no widely available vaccines. So when passengers began falling ill in the middle of the Atlantic Ocean, doctors and public health experts were limited in what they could offer.
“It’s kind of a wake-up call,” said Dr. Vaithi Arumugaswami, an infectious disease researcher at the University of California, Los Angeles. “Our tool kit is almost empty.”
That’s not for lack of trying. A handful of scientific teams around the world have been working — for decades, in some cases — to develop hantavirus treatments and vaccines. But it has not been easy to find funding or nurture commercial interest in medical interventions for a type of pathogen that does not infect humans often and does not spread easily between people.
“It’s not an airborne, highly contagious viral threat, so it hasn’t been as high a priority for groups trying to prevent pandemics,” said Jay Hooper, a virologist at the United States Army Medical Research Institute of Infectious Diseases.
But there are promising vaccines and treatments in development. And some of them, experts said, could be moved through the pipeline rapidly if hantavirus interventions became a priority.
“I do think there are things that are sitting there on the bench that could be quickly developed,” said Dr. Ronald Nahass, the president of the Infectious Diseases Society of America. “But nothing is ready.”
Vaccine development
There are two main types of hantaviruses: Old World viruses, which circulate primarily in Asia and Europe, and New World viruses, which are found in the Americas. The cruise ship outbreak has been linked to a New World virus known as the Andes virus, which is endemic to South America and is the only hantavirus known to spread between people.
There are vaccines that target some of the Old World viruses in Asia, but their efficacy is modest, experts said. And there are no licensed vaccines for the New World viruses, which include the Sin Nombre virus endemic to rodents in the western United States.
But there are some in development. Dr. Hooper and his colleagues have developed a DNA vaccine for the Andes virus, which proved promising in a small phase 1 trial. Under certain dosing regimens, the researchers found, more than 80 percent of participants produced neutralizing antibodies. “It’s pretty amazing,” said Dr. Hooper, who is an inventor on multiple hantavirus vaccine patents owned by the U.S. government. “Getting these kinds of neutralizing antibodies in humans is impressive.”
There were drawbacks, including that the vaccine seemed to require at least three doses. But the vaccine is ready for further development “if there’s a need,” Dr. Hooper said. “We’ve done the science. It’s just other forces that are required to move vaccines forward — markets, government demand.”
Other teams have potential vaccines in earlier stages of development. For instance, Bryce Warner, a hantavirus researcher at the University of Saskatchewan, and his colleagues are exploring a variety of approaches, including a nasal vaccine that they hope might spark a more robust immune response in the airway.
But the research, which is being conducted in hamsters, is still in early stages, and hantavirus vaccine candidates can be challenging to move forward. Scientists lack good large-animal models for hantaviruses, Dr. Warner said, and human cases are rare enough to make trials tricky. “It’s very difficult to conduct a clinical trial when you only have a limited number of cases annually,” he said. “You don’t have the numbers of people to really show a robust effect.”
Drug hunting
Currently, the primary treatment for hantavirus infection is supportive care, which may include supplemental oxygen or heart-lung bypass machines. Doctors also sometimes prescribe an existing antiviral drug, called ribavirin, but there is not strong evidence that it is effective for New World viruses, scientists said.
The hunt for new drugs is underway, though. At U.C.L.A., Dr. Arumugaswami and his colleagues found that favipiravir, an antiviral approved to treat influenza in Japan, inhibited the Andes virus in human cells. They also identified several compounds that had broad antiviral activity, blocking hantaviruses as well as other types of viruses, in human organoids, miniature clusters of tissue that mimic the function of organs.
Other teams have been working to develop therapeutic antibody treatments, often working from blood samples collected from hantavirus survivors. “We were able to isolate the natural antibodies that people are making and basically winnow them down and find one that was really good,” said Kartik Chandran, a virologist at the Albert Einstein College of Medicine in New York. “We actually found several.”
When Dr. Chandran and his colleagues tested these antibodies in hamsters, one produced especially encouraging results: It seemed to work against both Old and New World hantaviruses and was effective even when given relatively late in the course of infection, Dr. Chandran said.
(Dr. Chandran is listed as an inventor on patents for hantavirus antibodies.)
Several other teams have also produced antibodies that were broadly effective in small animals, but that is where a number of potential products have stalled, experts said.
“We have a lead drug, and now what we need is someone to pay the money, which would be something like $40 million, to go the next step,” said Dr. James Crowe, director of the Vanderbilt Center for Antibody Therapeutics. “We have neither government nor foundation nor company support to do that. So we’re just waiting to find a partner.”
(Vanderbilt University has applied for patents related to these antibodies; Dr. Crowe is listed as the inventor.)
Experts said that they hoped the current outbreak might help bring attention to a family of often-overlooked viruses.
“Certainly judging by just my inbox and text messages, there’s a renewed interest in these agents, and renewed interest in maybe at least revisiting where they are in the priority list,” Dr. Chandran said.
Whether that interest can be sustained after the virus fades from the headlines remains to be seen, experts acknowledged.
“Raising awareness never hurts,” Dr. Warner said. “We’ll see whether or not it leads to anything tangible, at least in terms of funding and resources for advancing some of these things that are lacking for hantavirus.”
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Potentially deadly sepsis may be more likely in certain patients due to problems in the gut.
Researchers from the Korea Research Institute of Bioscience and Biotechnology’s Infectious Disease Research Center used female mouse models to investigate why sepsis outcomes can vary so dramatically.
The study, published in the journal Nature, looked at genetically similar mice with different gut microbiomes. The mice were infected with Acinetobacter baumannii — a highly resilient bacterium that can lead to sepsis.
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The researchers compared groups of mice with higher and lower survival rates, examining differences in their gut microbiomes, the amount of bacteria in their blood and organs, and other cellular markers, according to the study press release.
Gut health could signal severe sepsis prior to infection, the study suggests. (iStock)
Measures of risk
Although some mice were genetically similar, the more vulnerable mice had a higher concentration of Muribaculaceae bacteria in the gut. In one comparison, these bacteria made up about 28% of the microbiome in poor surviving mice, but only 0.15% in better surviving mice.
Mice with worse survival showed an early and strong inflammatory response, which later led to more bacteria in the blood, lungs and spleen. This suggests that the microbiome causes the immune system to be more reactive, according to the researchers.
GUT MICROBES COULD BE KEY TO FIGHTING TOXIC, LONG-LASTING ‘FOREVER CHEMICALS,’ RESEARCH SAYS
In the microbiome of mice with worse survival, the researchers also noticed that one strain of bacteria — Sangeribacter muris KT1-3 — was most prominent. The mice that typically survived at high rates fared much worse when housed with KTI-3 mice, with their survival falling to 10%.
More vulnerable mice had a higher concentration of Muribaculaceae bacteria in the gut. (iStock)
This bacterial strain also appeared to worsen inflammation during certain infections, making sepsis more severe.
These findings suggest that the gut microbiome can signal how the immune system will react before an infection begins.
The microbiome’s surprising influence
Andrew Fleming, MD, section chief of Infectious Diseases & Immunology at NYU Langone Hospital, Brooklyn, said it has been “known for years” that gut bacteria and bacterial toxins can be released into the bloodstream during sepsis.
This worsens the inflammatory response to the initial infection, according to Fleming, who was not involved in the study.
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“This process is particularly important in septic shock, where the intestinal wall becomes more permeable to translocation (or leaking) of bacterial products,” Fleming said.
Interactions between the gut microbiome and the immune system are “complex and variable from person to person,” the doctor described.
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“But there is mounting evidence that a diverse and healthy gut microbiome – the community of bacteria that lives in a person’s gut – is protective in some ways against severe sepsis,” he went on. “And a dysregulated microbiome – for example, one severely altered by antibiotics – can impair or worsen the immune system’s response during sepsis.”
Interactions between the gut microbiome and the immune system are “complex and variable from person to person,” a doctor described. (iStock)
Scientists are starting to think of the gut microbiome “almost as a living organ,” according to Fleming, much like the heart, kidneys or liver, all serving “multiple functions” to keep the body healthy.
CLICK HERE FOR MORE HEALTH STORIES
An unhealthy microbiome can have “detrimental effects across a range of health issues,” he added – including how the body responds to infections.
“Compared to our other organs, we currently have fewer readily available tests in the doctor’s office to measure the health of our microbiome,” Fleming said. “However, this should not prevent us from thinking about our gut microbiome and how to keep it healthy.”
The role of antibiotics
The use of antibiotics has “major and long-lasting effects” on the microbiome, Fleming noted. Up to 80% of adults in the U.S. are prescribed an antibiotic every year, while 30% are estimated to be unnecessary, according to the CDC.
“Antibiotics deplete the diversity of the microbiome and create a void in the gut microbial community that can be filled by harmful bacteria from the environment,” the doctor told Fox News Digital.
Antibiotics “deplete the diversity of the microbiome and create a void in the gut microbial community that can be filled by harmful bacteria from the environment,” the doctor said. (iStock)
“We must begin to think much more critically about our antibiotic use and overuse, both to maintain our gut health and to reduce the spread of antibiotic resistance.”
The study findings are an “intriguing starting point to further research,” Fleming said, although there were some key limitations.
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“Sangeribacter muris is not typically found in humans, so the exact mechanism of this bacterial strain worsening sepsis that is demonstrated in this study cannot be directly extrapolated to people,” he said. “Well-designed clinical trials should be conducted to explore how similar gut microbiome effects may play out in sepsis in humans.”
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Despite these limitations, the doctor said he supports the hypothesis that maintaining a healthy gut microbiome can help keep the immune system well-regulated while reducing the risk of developing severe sepsis.
NEWYou can now listen to Fox News articles!
Potentially deadly sepsis may be more likely in certain patients due to problems in the gut.
Researchers from the Korea Research Institute of Bioscience and Biotechnology’s Infectious Disease Research Center used female mouse models to investigate why sepsis outcomes can vary so dramatically.
The study, published in the journal Nature, looked at genetically similar mice with different gut microbiomes. The mice were infected with Acinetobacter baumannii — a highly resilient bacterium that can lead to sepsis.
ER DOCTOR REVEALS HOW PNEUMONIA CAN SUDDENLY TURN DEADLY AFTER KYLE BUSCH’S DEATH
The researchers compared groups of mice with higher and lower survival rates, examining differences in their gut microbiomes, the amount of bacteria in their blood and organs, and other cellular markers, according to the study press release.
Gut health could signal severe sepsis prior to infection, the study suggests. (iStock)
Measures of risk
Although some mice were genetically similar, the more vulnerable mice had a higher concentration of Muribaculaceae bacteria in the gut. In one comparison, these bacteria made up about 28% of the microbiome in poor surviving mice, but only 0.15% in better surviving mice.
Mice with worse survival showed an early and strong inflammatory response, which later led to more bacteria in the blood, lungs and spleen. This suggests that the microbiome causes the immune system to be more reactive, according to the researchers.
GUT MICROBES COULD BE KEY TO FIGHTING TOXIC, LONG-LASTING ‘FOREVER CHEMICALS,’ RESEARCH SAYS
In the microbiome of mice with worse survival, the researchers also noticed that one strain of bacteria — Sangeribacter muris KT1-3 — was most prominent. The mice that typically survived at high rates fared much worse when housed with KTI-3 mice, with their survival falling to 10%.
More vulnerable mice had a higher concentration of Muribaculaceae bacteria in the gut. (iStock)
This bacterial strain also appeared to worsen inflammation during certain infections, making sepsis more severe.
These findings suggest that the gut microbiome can signal how the immune system will react before an infection begins.
The microbiome’s surprising influence
Andrew Fleming, MD, section chief of Infectious Diseases & Immunology at NYU Langone Hospital, Brooklyn, said it has been “known for years” that gut bacteria and bacterial toxins can be released into the bloodstream during sepsis.
This worsens the inflammatory response to the initial infection, according to Fleming, who was not involved in the study.
5 GUT-BOOSTING FRUITS TO EAT MORE OF IN 2026 FOR BETTER DIGESTION, EXPERTS SAY
“This process is particularly important in septic shock, where the intestinal wall becomes more permeable to translocation (or leaking) of bacterial products,” Fleming said.
Interactions between the gut microbiome and the immune system are “complex and variable from person to person,” the doctor described.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“But there is mounting evidence that a diverse and healthy gut microbiome – the community of bacteria that lives in a person’s gut – is protective in some ways against severe sepsis,” he went on. “And a dysregulated microbiome – for example, one severely altered by antibiotics – can impair or worsen the immune system’s response during sepsis.”
Interactions between the gut microbiome and the immune system are “complex and variable from person to person,” a doctor described. (iStock)
Scientists are starting to think of the gut microbiome “almost as a living organ,” according to Fleming, much like the heart, kidneys or liver, all serving “multiple functions” to keep the body healthy.
CLICK HERE FOR MORE HEALTH STORIES
An unhealthy microbiome can have “detrimental effects across a range of health issues,” he added – including how the body responds to infections.
“Compared to our other organs, we currently have fewer readily available tests in the doctor’s office to measure the health of our microbiome,” Fleming said. “However, this should not prevent us from thinking about our gut microbiome and how to keep it healthy.”
The role of antibiotics
The use of antibiotics has “major and long-lasting effects” on the microbiome, Fleming noted. Up to 80% of adults in the U.S. are prescribed an antibiotic every year, while 30% are estimated to be unnecessary, according to the CDC.
“Antibiotics deplete the diversity of the microbiome and create a void in the gut microbial community that can be filled by harmful bacteria from the environment,” the doctor told Fox News Digital.
Antibiotics “deplete the diversity of the microbiome and create a void in the gut microbial community that can be filled by harmful bacteria from the environment,” the doctor said. (iStock)
“We must begin to think much more critically about our antibiotic use and overuse, both to maintain our gut health and to reduce the spread of antibiotic resistance.”
The study findings are an “intriguing starting point to further research,” Fleming said, although there were some key limitations.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Sangeribacter muris is not typically found in humans, so the exact mechanism of this bacterial strain worsening sepsis that is demonstrated in this study cannot be directly extrapolated to people,” he said. “Well-designed clinical trials should be conducted to explore how similar gut microbiome effects may play out in sepsis in humans.”
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
Despite these limitations, the doctor said he supports the hypothesis that maintaining a healthy gut microbiome can help keep the immune system well-regulated while reducing the risk of developing severe sepsis.
NEWYou can now listen to Fox News articles!
The old saying that laughter is the best medicine may be true, according to new research that suggests it is also a vital catalyst for children’s development.
Laughter and play are fundamental to healthy brain growth, emotional well-being and social bonding, according to Jacqueline Harding, Ph.D., an early childhood expert at Middlesex University in London.
In her book, “The Brain That Loves to Laugh,” Harding argues that joy is a complex biological phenomenon that helps children navigate stress and build more resilient, receptive minds, news agency SWNS reported.
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“When we see children laugh, we witness the brilliance of the brain in action: learning, connecting and growing,” Harding told SWNS.
“Hope and humor, it seems, are not just the seasoning of life, but foundational to a recipe for healthy development.”
Laughter alters internal chemistry by decreasing stress hormones and boosting feel-good chemicals like serotonin, experts say. (iStock)
Laughter activates broad brain networks, including motor regions and the prefrontal cortex, long before children learn to speak. By helping the brain resolve conflicting ideas, it boosts creativity and engages working memory, acting as a “mental workout,” experts say.
At a molecular level, laughter alters the internal chemistry by decreasing stress hormones like cortisol and epinephrine. It also increases “happiness chemicals” like dopamine, serotonin and endorphins.
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Additionally, laughter is known to boost oxytocin, which deepens emotional bonds between parents and children.
Prolonged stress does the exact opposite: It impairs learning, suppresses immune function and alters the developing limbic system, which governs emotion and long-term memory, according to SWNS.
Prolonged stress can negatively impact not only children’s mental well-being, but their physical state as well. (iStock)
“Stated simply, the emotional state of young children directly influences how they navigate their way through the world,” Harding said.
Parents can foster these benefits through moments of spontaneous play and joyful connection, the expert advised.
“Spontaneous, joyful play is an antidote to stress.”
These interactions do more than spark laughter — they help children develop emotional regulation, strengthen feelings of safety and connection, and support social and cognitive development, according to the American Academy of Pediatrics.
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“Spontaneous, joyful play is an antidote to stress, as it increases levels of endorphins released by the brain,” Harding said. “Creative, happy play does its most brilliant work at a molecular level, especially at a time when the human brain is at its most receptive.”
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This shared joy also establishes “co-regulation,” where a child learns to manage their own stress by drawing on a biological store of positive early experiences.
Spontaneous, joyful play is an antidote to stress, as it increases levels of endorphins released by the brain, the expert said. (iStock)
Harding advocates for integrating humor directly into classrooms to reduce cognitive load and improve how children retain key concepts.
By uplifting the nervous system, joy creates an optimal environment for information absorption, as the SWNS piece noted.
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“Safe relationships and non-stressful play environments promote learning,” she added.
“The curriculum must never be prioritized over those two fundamental factors.”
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