Health
Friends, family may protect against heart attack, stroke and type 2 diabetes, study suggests
New research is emphasizing that socializing with friends and family may help protect people against heart attack, stroke, type 2 diabetes and other conditions and illnesses.
The study suggests that social interactions may keep people healthy because these interactions boost the immune system and reduce the risk of disease.
Cambridge University researchers, along with colleagues in China, came to these conclusions after studying protein in blood samples taken from over 42,000 adults recruited to the U.K. Biobank, news agency SWNS reported.
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The study team said social relationships play a key role in well-being.
Professor Barbara Sahakian of the Department of Psychiatry at the University of Cambridge said, “These findings drive home the importance of social contact in keeping us well. More and more people of all ages are reporting feeling lonely,” as SWNS noted.
Socializing with friends and family may help protect people against heart attack, stroke, type 2 diabetes and other conditions and illnesses, a new study suggests. (iStock courtesy of user skynesher)
“That’s why the World Health Organization has described social isolation and loneliness as a global public health concern … We need to find ways to tackle this growing problem and keep people connected to help them stay healthy.”
Evidence increasingly shows that both social isolation and loneliness are linked to poorer health and an early death, the same source reported. But the underlying mechanisms through which social relationships impact health apparently have remained elusive until now, the news agency also said.
“We need to find ways to keep people connected to help them stay healthy.”
U.S. Surgeon General Dr. Vivek Murthy previously warned against the health risks of loneliness, as Fox News Digital reported earlier.
“Loneliness is a common feeling that many people experience,” he said when issuing an advisory nearly two years ago on the topic, per The Associated Press. “It’s like hunger or thirst. It’s a feeling the body sends us when something we need for survival is missing.”
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“Millions of people in America are struggling in the shadows, and that’s not right,” he also said at the time. “That’s why I issued this advisory to pull back the curtain on a struggle that too many people are experiencing.”
The researchers connected to the new study said that one way to explore biological mechanisms is to look at proteins circulating in the blood, SWNS noted. Proteins, which are molecules produced by genes, are essential for helping the human body function properly.
They can also serve as useful drug targets, allowing scientists to develop new treatments to tackle diseases.
“Social relationships play an important part in keeping us healthy,” said one of the scientists connected to a new study. (iStock)
The Cambridge team and scientists at Fudan University, China, examined the “proteomes,” or the suite of proteins, in blood samples donated by more than 42,000 British adults aged 40 to 69.
That allowed them to see which proteins were present at higher levels among people who were socially isolated or lonely — and how these proteins were connected to poorer health, SWNS said.
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The team calculated social isolation and loneliness scores for individuals in the study, which was published in Nature Human Behaviour, a monthly peer-reviewed journal.
Social isolation is an objective measure based on, for example, whether people live alone, how frequently they have contact with others and whether they take part in social activities, the team said.
“We know that social isolation and loneliness are linked to poorer health, but we’ve never understood why.”
Loneliness, by contrast, is a subjective measure based on whether an individual feels lonely.
When the researchers analyzed the proteomes and adjusted for factors including age, sex and socio-economic background, they found 175 proteins associated with social isolation and 26 proteins associated with loneliness.
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Many of the proteins are produced in response to inflammation, viral infection and as part of immune responses, the team said — and they also showed links to cardiovascular disease, type 2 diabetes, stroke and early death.
The findings, said a researcher, “drive home the importance of social contact in keeping us well.” (iStock)
The researchers then used a statistical technique to explore the causal relationship between social isolation and loneliness, on the one hand, and proteins on the other.
With that approach, they identified five proteins that were found in abundance during periods of loneliness.
“We know that social isolation and loneliness are linked to poorer health, but we’ve never understood why,” said Dr. Chun Shen of the department of clinical neurosciences at the University of Cambridge and the Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University.
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“Our work has highlighted a number of proteins that appear to play a key role in this relationship, with levels of some proteins in particular increasing as a direct consequence of loneliness,” he said, as SWNS reported.
Professor Jianfeng Feng of the University of Warwick said, “There are more than 100,000 proteins and many of their variants in the human body … AI and high-throughput proteomics can help us pinpoint some key proteins in prevention, diagnosis, treatment and prognosis for many human diseases and revolutionize the traditional view of human health.”
“AI and high-throughput proteomics can help us pinpoint some key proteins in prevention, diagnosis, treatment and prognosis in many human diseases.” (iStock)
He also said, “The proteins we’ve identified give us clues to the biology underpinning poor health among people who are socially isolated or lonely, highlighting why social relationships play such an important part in keeping us healthy.”
One of the proteins produced at higher levels as a result of loneliness was ADM.
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Previous studies have shown that ADM plays a role in responding to stress and in regulating stress hormones and social hormones, such as oxytocin — known as the “love hormone” — which can reduce stress and improve mood.
The team found a “strong” association between ADM and the volume of the insula, a brain hub for interoception, the ability to sense what’s happening inside the body.
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The greater the ADM levels, the smaller the volume of the region.
Higher ADM levels were also linked to lower volume of the left caudate — a region involved in emotional, reward and social processes. Higher levels of ADM were also linked to an increased risk of dying young.
The researchers said another of the proteins, ASGR1, is associated with higher cholesterol and an increased risk of cardiovascular disease — while other identified proteins play roles in the development of insulin resistance, “furring” of the arteries and cancer progression.
Melissa Rudy of Fox News Digital contributed reporting.
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In a dramatic turn of events that’s captured the attention of animal lovers worldwide, Punch — the young macaque at a zoo in Japan famous for his inseparable bond with a stuffed orangutan toy — has reached a major milestone in his journey toward social integration.
On Thursday, visitors and staff at the Ichikawa Zoological and Botanical Garden witnessed a breakthrough: Punch was seen cuddling with and hitching a ride on the back of a fellow macaque.
Punch’s story began with hardship. He was abandoned by his mother shortly after his birth in July 2025 — and to ensure his survival, zookeepers stepped in to hand-rear the primate.
On Jan. 19, 2026, the zoo officially began the process of reintegrating Punch into the “monkey mountain” enclosure.
The transition was initially fraught with tension.
Punch’s story began with hardship when he was abandoned by his mother shortly after he was born. To help him, zookeepers gave him a stuffed toy that he began dragging around everywhere he went. (David Mareuil/Anadolu via Getty Images)
As a hand-reared infant, Punch was bullied and ignored by the established group of monkeys.
He was often seen huddled alone with his orange plush companion while the rest of the troop interacted.
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In an official statement released Feb. 27, the Ichikawa Zoological and Botanical Garden detailed the meticulous care behind this process.
Previous viral videos showed Punch bullied by the rest of the troop, running to his plushy toy for comfort. (David Mareuil/Anadolu via Getty Images)
“From an animal welfare perspective, our primary goal is to reintegrate Punch with the troop,” the zoo said.
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The strategy involved nursing Punch within the enclosure, so the troop could recognize him as one of their own, and pairing him with a gentle young female macaque prior to his full release to build his confidence.
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The latest footage, captured by X user @tate_gf, suggested the zoo’s patience is paying off.
The video shows Punch seeking physical contact not from his toy, but from another monkey — eventually climbing onto its back for a vital social behavior for young macaques: the “piggyback ride.”
The zoo’s strategy appears to be paying off: Punch, shown at far left, was recently seen riding on the back of a fellow macaque. (David Mareuil/Anadolu via Getty Images)
While Punch still carries his stuffed toy for comfort during moments of perceived danger, the zoo remains optimistic about his progress.
The organization cited the successful 2009 case of Otome, another hand-reared macaque who eventually outgrew her stuffed toy, successfully integrated — and went on to raise four offspring of her own.
The zoo has had crowds coming to see Punch, with hundreds of people lining up to get inside to see the young star, according to reports.
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“I’m hoping Punch has a good life like everybody else does, and think he’s a cute little guy,” one person commented online.
“Such a precious baby,” another person wrote.
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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).
Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice.
In January, OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool.
The company introduced the tool as “a dedicated experience that securely brings your health information and ChatGPT’s intelligence together, to help you feel more informed, prepared and confident navigating your health.”
But researchers at the Icahn School of Medicine at Mount Sinai have found that the tool failed to recommend emergency care for a “significant number” of serious medical cases.
The study, published in the journal Nature Medicine on Feb. 23, aimed to explore how ChatGPT Health — which is reported to have about 40 million users daily — handles situations where people are asking whether to seek emergency care.
Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice. (iStock)
“Right now, no independent body evaluates these products before they reach the public,” lead author Ashwin Ramaswamy, M.D., instructor of urology at the Icahn School of Medicine at Mount Sinai in New York City, told Fox News Digital.
“We wouldn’t accept that for a medication or a medical device, and we shouldn’t accept it for a product that tens of millions of people are using to make health decisions.”
Emergency scenarios
The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies.
Three independent physicians then assigned an appropriate level of urgency for each case, based on published clinical practice guidelines in 56 medical societies.
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The researchers conducted 960 interactions with ChatGPT Health to see how the tool responded, taking into account gender, race, barriers to care and “social dynamics.”
While “clear-cut emergencies” — such as stroke or severe allergy — were generally handled well, the researchers found that the tool “under-triaged” many urgent medical issues.
The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies. (iStock)
For example, in one asthma scenario, the system acknowledged that the patient was showing early signs of respiratory failure — but still recommended waiting instead of seeking emergency care.
“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum — the cases where getting it right matters most,” Ramaswamy told Fox News Digital. “It under-triaged over half of genuine emergencies and over-triaged roughly two-thirds of mild cases that clinical guidelines say should be managed at home.”
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Under-triage can be life-threatening, the doctor noted, while over-triage can overwhelm emergency departments and delay care for those in real need.
Researchers also identified inconsistencies in suicide risk alerts. In some cases, it directed users to the 988 Suicide and Crisis Lifeline in lower-risk scenarios, and in others, it failed to offer that recommendation even when a person discussed suicidal ideations.
“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum.”
“The suicide guardrail failure was the most alarming,” study co-author Girish N. Nadkarni, M.D., chief AI officer of the Mount Sinai Health System, told Fox News Digital.
ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm, the researcher noted.
OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool, in January 2026. (Gabby Jones/Bloomberg via Getty Images)
“We tested it with a 27-year-old patient who said he’d been thinking about taking a lot of pills,” Nadkarni said. “When he described his symptoms alone, the banner appeared 100% of the time. Then we added normal lab results — same patient, same words, same severity — and the banner vanished.”
“A safety feature that works perfectly in one context and completely fails in a nearly identical context … is a fundamental safety problem.”
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The researchers were also surprised by the social influence aspect.
“When a family member in the scenario said ‘it’s nothing serious’ — which happens all the time in real life — the system became nearly 12 times more likely to downplay the patient’s symptoms,” Nadkarni said. “Everyone has a spouse or parent who tells them they’re overreacting. The AI shouldn’t be agreeing with them during a potential emergency.”
Fox News Digital reached out to Open AI, creator of ChatGPT, requesting comment.
Physicians react
Dr. Marc Siegel, Fox News senior medical analyst, called the new study “important.”
“It underlines the principle that while large language models can triage clear-cut emergencies, they have much more trouble with nuanced situations,” Siegel, who was not involved in the study, told Fox News Digital.
ChatGPT and other LLMs can be helpful tools, a doctor said, but they “should not be used to give medical direction.” (iStock)
“This is where doctors and clinical judgment come in — knowing the nuances of a patient’s history and how they report symptoms and their approach to health.”
ChatGPT and other LLMs can be helpful tools, Siegel said, but they “should not be used to give medical direction.”
“Machine learning and continued input of data can help, but will never compensate for the essential problem – human judgment is needed to decide whether something is a true emergency or not.”
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Dr. Harvey Castro, an emergency physician and AI expert in Texas, echoed the importance of the study, calling it “exactly the kind of independent safety evaluation we need.”
“Innovation moves fast. Oversight has to move just as fast,” Castro, who also did not work on the study, told Fox News Digital. “In healthcare, the most dangerous mistakes happen at the extremes, when something looks mild but is actually catastrophic. That’s where clinical judgment matters most, and where AI must be stress-tested.”
Study limitations
The researchers acknowledged some potential limitations in the study design.
“We used physician-written clinical scenarios rather than real patient conversations, and we tested at a single point in time — these systems update frequently, so performance may change,” Ramaswamy told Fox News Digital.
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Additionally, most of the missed emergencies happened in situations where the danger depended on how the condition was changing over time. It’s not clear whether the same problem would happen with acute medical emergencies.
Because the system had to choose just one fixed urgency category, the test may not reflect the more nuanced advice it might give in a back-and-forth conversation, the researchers noted.
ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm. (iStock)
Also, the study wasn’t large enough to confidently detect small differences in how recommendations might vary by race or gender.
“We need continuous auditing, not one-time studies,” Castro noted. “These systems update frequently, so evaluation must be ongoing.”
‘Don’t wait’
The researchers emphasized the importance of seeking immediate care for serious issues.
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“If something feels seriously wrong — chest pain, difficulty breathing, a severe allergic reaction, thoughts of self-harm — go to the emergency department or call 988,” Ramaswamy advised. “Don’t wait for an AI to tell you it’s OK.”
The researchers noted that they support the use of AI to improve healthcare access, and that they didn’t conduct the study to “tear down the technology.”
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“These tools can be genuinely useful for the right things — understanding a diagnosis you’ve already received, looking up what your medications do and their side effects, or getting answers to questions that didn’t get fully addressed in a short doctor’s visit,” Ramaswamy said.
“That’s a very different use case from deciding whether you need emergency care. Treat them as a complement to your doctor, not a replacement.”
“This study doesn’t mean we abandon AI in healthcare.”
Castro agreed that the benefits of AI health tools should be weighed against the risks.
“AI health tools can increase access, reduce unnecessary visits and empower patients with information,” he said. “They are not inherently unsafe, but they are not yet substitutes for clinical judgment.”
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“This study doesn’t mean we abandon AI in healthcare,” he went on. “It means we mature it. Independent testing and stronger guardrails will determine whether AI becomes a safety net or a liability.”
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