Health
Ferret study shows bird flu found in US cows carries low risk of airborne transmission
CDC issues alert over bird flu case
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- Researchers at the University of Wisconsin-Madison found that the strain of avian influenza found in U.S. cows is not easily transmitted through the air among ferrets, but it does have some capability of spreading this way.
- The experiment involved ferrets infected with bird flu being placed near healthy animals, but not close enough for physical contact. No virus was recovered from the healthy ferrets during the study, but one of them produced antibodies suggesting it had been infected.
- The pandemic threat of H5N1 is assessed by public health agencies worldwide as low, as there is no evidence yet of any human-to-human transmission.
The bird flu strain found in cows in the United States is not easily transmitted through the air among ferrets, a new study shows, although the scientist who led the work said it had shown some ability to spread this way.
Ferrets are considered to be the best small mammal for studying influenza virus infection and transmission, and are often used to inform assessments of the public health risk of emerging viruses.
In the experiment led by researchers at the University of Wisconsin-Madison, ferrets infected with a sample of the H5N1 bird flu strain were placed near healthy animals, but not close enough for physical contact.
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None of the four healthy ferrets exposed in this way became ill, and no virus was recovered from them during the study.
However, one of the ferrets had produced antibodies to the virus, the researchers later found, suggesting it had been infected.
“It is good news that the virus does not have extensive transmissibility between ferrets through the air, but it is concerning that it has the ability to transmit (at all in this way),” said study author and flu virologist Yoshihiro Kawaoka.
Cows stand in their pen at a cattle farm in Rockford, Illinois, U.S., April 9, 2024. Fact (Reuters/Jim Vondruska/File Photo)
A virus that can spread easily through the air between humans would pose a greater pandemic threat than H5N1 currently does.
That risk is currently assessed by public health agencies worldwide as low, as there is no evidence yet of any human-to-human transmission.
Four human cases have been reported in the U.S. since avian flu was confirmed in dairy cows in March. All have recovered.
The study, published on Monday in Nature, also showed the bird flu virus in cows can bind to human-type receptors under lab conditions. These receptors are how flu viruses typically enter and infect human cells in the real world.
Bird flu prefers to bind to avian-type receptors only, which are scarce in humans. The lab results need further study to assess their real-world implications, scientists said, as in the past flu viruses that developed the ability to bind to both types have caused human pandemics.
The study also confirmed that the virus, isolated from the milk of an infected cow in New Mexico, made both mice and ferrets sick after exposure to the unpasteurized milk.
It also spread through the body to muscles and mammary glands in infected mice, as it appears to do in cows.
Angela Rasmussen, a virologist at the University of Saskatchewan in Canada, said it was a relief to see the virus had not yet acquired the capability to cause a human pandemic, but this did not mean it would never do so, particularly if the spread among cows goes unchecked.
“It’s always better to stop a pandemic before it starts than to respond to it once it has started. We should heed this warning and take action now,” she said via email.
Health
New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
Health
One extra serving of processed meat a day linked to higher cancer risk
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
Health
The Surprising Hormone That Could Make Menopause Weight Loss Easier
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