Connect with us

Health

FDA greenlights first drug for severe frostbite: ‘Very important approval’

Published

on

FDA greenlights first drug for severe frostbite: ‘Very important approval’

Frostbite may have met its match.

The U.S. Food and Drug Administration (FDA) has approved the first medication to treat severe frostbite, the agency announced this week.

The drug, iloprost (brand name Aurlumyn) is intended to reduce the risk of finger and toe amputations due to dangerously cold extremities.

NEED A ‘WINTER RESET’? EXPERTS SHARE BENEFITS OF SLOWING DOWN DURING COLDER MONTHS

Iloprost was originally approved for treatment of pulmonary arterial hypertension, a condition in which high blood pressure affects arteries in the lungs and heart.

Advertisement

“This approval provides patients with the first-ever treatment option for severe frostbite,” said Norman Stockbridge, M.D., Ph.D., director of the Division of Cardiology and Nephrology in the FDA’s Center for Drug Evaluation and Research, in a press release. 

Frostbite occurs when cold temperatures cause parts of the body to freeze, primarily the fingers, toes, nose, cheeks and chin. (iStock)

“Having this new option provides physicians with a tool that will help prevent the life-changing amputation of one’s frostbitten fingers or toes.” 

Frostbite occurs when cold temperatures cause parts of the body to freeze, primarily the fingers, toes, nose, cheeks and chin, according to the U.S. Centers for Disease Control and Prevention (CDC).

ASK A DOC: ‘HOW SHOULD I CARE FOR MY SKIN DURING THE WINTER?’

Advertisement

Initial symptoms include numbness, tingling or color changes, Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, told Fox News Digital.

“Severe frostbite can cause white or blue skin and, later, fluid-filled blisters,” said Siegel, who was not involved in the drug development.

Initial symptoms of frostbite include numbness, tingling or color changes. (iStock)

Prolonged frostbite can lead to permanent damage or amputation, the CDC stated.

Aurlumyn is intended for severe frostbite cases, in which both the skin and the underlying tissue are frozen, and blood flow is stopped.

Advertisement

WHY YOU FEEL MORE ACHES AND PAINS IN THE COLD WEATHER — AND WHAT YOU CAN DO ABOUT IT

“Iloprost, the active ingredient in Aurlumyn, is a vasodilator, a drug that opens blood vessels and prevents blood from clotting,” the FDA release stated.

The FDA’s approval follows a randomized clinical trial that included 47 adults with severe frostbite, who were divided into three groups.

Prolonged frostbite can lead to permanent damage or amputation, the CDC stated. (IStock)

One group received iloprost intravenously for six hours daily for up to eight days. 

Advertisement

Another group received other medications that are not approved for frostbite, combined with iloprost.

A third group received other medications without iloprost.

SNOW SHOVELING SAFETY TIPS TO PREVENT INJURY AND HEART ATTACKS: ‘VERY STRENUOUS ACTIVITY’

Seven days after the initial frostbite, each participant received a bone scan to determine whether fingers or toes would need amputation. 

The patients who received iloprost did not require any amputation, compared to 19% of patients who received iloprost with other medications and 60% of patients who only received other medications.

Advertisement

Signage is seen outside the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, on Aug. 29, 2020.  (REUTERS/Andrew Kelly/File Photo)

“This is a very important approval,” Siegel told Fox News Digital.

“Severe frostbite causes blood clotting and can lead to amputation. This new drug’s active ingredient, ilopost, is a vasodilator that preserves blood flow to the area of severe frostbite and prevented the need for amputation in all cases in a small study.”

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Aurlumyn, which was developed by Eicos Sciences Inc. in Maryland, was found to cause some side effects, the FDA noted. 

Advertisement

Those included heart palpitations, accelerated heart rate, nausea, headache, flushing, vomiting, dizziness and low blood pressure.

For that reason, Siegel noted, the drug can only be administered by a physician.

Fox News Digital reached out to Eicos Sciences Inc. and the FDA requesting additional comment.

For more Health articles, visit www.foxnews.com/health.

Advertisement

Health

Doctors thought man had brain cancer — they found live tapeworms instead

Published

on

Doctors thought man had brain cancer — they found live tapeworms instead

NEWYou can now listen to Fox News articles!

Doctors thought a 60-year-old man had metastatic brain cancer after scans revealed multiple tumors – but further testing revealed a shocking diagnosis.

Advertisement

The Spanish man, who was not named, was found to have a parasitic tapeworm larvae lodged in his brain — a case of neurocysticercosis, a parasitic infection of the central nervous system caused by the pork tapeworm (Taenia solium).

The patient, a lifelong resident of Castellón, Spain, had not traveled to any regions where the disease is endemic, according to the case report published in the CDC journal Emerging Infectious Diseases.

DEADLY ‘FOX TAPEWORM’ LINKED TO LETHAL DISEASE DETECTED IN WEST COAST WILDLIFE

The man had initially come to the hospital after suffering two weeks of progressive headaches and mild behavioral changes.

Radiologic findings from a study of autochthonous neurocysticercosis brain lesions mimicking metastatic disease. (Emerging Infectious Diseases)

Advertisement

CT scans showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer.

However, whole-body scans, a colonoscopy and specialized imaging failed to identify cancer anywhere in the patient’s body, the case report stated.

NEUROLOGISTS REVEAL THE TOP 3 FOODS TO AVOID TO PROTECT YOUR BRAIN AND NERVOUS SYSTEM

When doctors performed a more detailed MRI, they discovered several fluid-filled cysts in the brain, some of which contained the head of a tapeworm. A blood test confirmed the diagnosis of neurocysticercosis.

The man was treated with a combination of albendazole and praziquantel (two antiparasitic medications), as well as corticosteroids to reduce inflammation. He successfully recovered with no complications, according to the case report.

Advertisement

CT scans (not pictured) showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer. (iStock)

The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier.

The exposure may have occurred while working a construction job with migrant coworkers from regions where neurocysticercosis is endemic.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

People can catch the pork tapeworm in two different ways. Eating undercooked infected pork usually leads to an intestinal tapeworm, but accidentally swallowing the parasite’s eggs — typically through food or water contaminated with feces — can send the larvae into the bloodstream, where they may form cysts in the brain and other organs. This can cause the disease the patient in the case report acquired.

Advertisement

A photomicrograph shows histopathologic features in a brain tissue specimen from a case of neurocysticercosis caused by the pork tapeworm Taenia solium. The image documents pathological changes associated with this parasitic infection. (Smith Collection/Gado/Getty Images)

As this was just a single case, the source of transmission could not be proven, the researchers acknowledged, and the findings cannot be generalized to a wider population. The report shows that there is a possibility of local transmission in non-endemic settings, but cannot establish how often this occurs.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

In the United States, less than 2% of neurocysticercosis cases are considered domestically acquired, according to the case report.

A prior systematic review identified only 18 confirmed locally acquired cases in Western Europe between 1990 and 2011.

Advertisement

The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier. (Associated Press)

In some cases, NCC can cause serious symptoms, including seizures, stroke, neurological deficits and cognitive decline.

CLICK HERE FOR MORE HEALTH STORIES

“Our case emphasizes that the absence of travel history should not preclude NCC from the differential diagnosis of multiple ring-enhancing brain lesions, even in regions where metastatic cancer is statistically much more likely,” the researchers concluded in the case study.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Advertisement

Detecting the worms earlier could have prevented “unnecessary invasive oncologic procedures and led to prompt, targeted antiparasitic therapy,” they added.

Fox News Digital reached out to the researchers for comment.

Advertisement
Continue Reading

Health

Rare tick-borne virus turns deadly fast as US cases reach record high, experts warn

Published

on

Rare tick-borne virus turns deadly fast as US cases reach record high, experts warn

NEWYou can now listen to Fox News articles!

A rare and potentially fatal tick-borne illness currently spreading across the United States can be traced back to a 1958 case involving a young boy on a farm.

The disease, known as Powassan virus, was named for the Ontario town near where it was first discovered.

At the time of his death, Lincoln Byers, a 4-year-old living in Canada, had a condition that medical professionals could not explain, the Boston Globe reported.

DEADLY ‘FOX TAPEWORM’ LINKED TO LETHAL DISEASE DETECTED IN WEST COAST WILDLIFE

Advertisement

Years later, researchers discovered a tick harboring the same virus on a dead squirrel, finally providing an answer to the tragedy, but foreshadowing a growing public health challenge.

While once considered an obscure medical anomaly, Powassan virus cases have reached historic highs in the U.S., data show.

Powassan is most prevalent from late spring through mid-fall, when tick populations peak and outdoor activity increases. (iStock)

According to the Centers for Disease Control and Prevention, 76 Americans were diagnosed with the virus in 2025, the highest annual total on record. Previously, the U.S. averaged just seven to eight diagnoses each year.

The virus is primarily transmitted to humans through the bite of an infected woodchuck tick or deer tick. Like other tick-borne illnesses, Powassan is most prevalent from late spring through mid-fall, when tick populations peak and outdoor activity increases.

Advertisement

Public health experts warn that the virus’s transmission speed makes it uniquely dangerous.

TICK BITE ER VISITS HIT HIGHEST SEASONAL LEVEL IN YEARS AS DOCTORS WARN OF DISEASE SURGE

“One of the most dangerous aspects is its rapid transmission,” Dr. Jorge P. Parada, a medical advisor at the National Pest Management Association in Chicago, told Fox News Digital.

“Powassan can be transmitted in as little as 15 minutes after the infected tick bites, while Lyme disease usually requires a 36- to 48-hour attachment time for transmission.”

Powassan carries an incubation period of one to four weeks before symptoms manifest. (iStock)

Advertisement

Parada noted that while Powassan remains rare compared to Lyme disease, it poses clinical concern.

CLICK HERE FOR MORE HEALTH STORIES

Dr. Marc Siegel, senior medical analyst for Fox News, confirmed that the virus transmits significantly faster than Lyme disease. He noted that Powassan carries an incubation period of one to four weeks before symptoms manifest.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

Initial symptoms include fever, headache, vomiting and weakness, though some infected individuals remain asymptomatic, according to the CDC.

Advertisement

There are currently no specific medications or vaccines to treat or prevent Powassan virus. (iStock)

The virus can progress to severe neurological complications, including encephalitis (inflammation of the brain) and meningitis (inflammation of the spinal cord membranes).

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

In severe cases, patients may experience confusion, loss of coordination, difficulty speaking and seizures, per the CDC.

“One of the most dangerous aspects of it is its rapid transmission.”

Advertisement

Approximately 10% of Powassan cases involving severe neurological disease are fatal, and many survivors experience long-term neurological issues.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

There are currently no specific medications or vaccines to treat or prevent Powassan virus; clinical care is limited to supportive therapy, such as intravenous fluids and respiratory support.

While anyone can develop severe illness, those at the highest risk include children, older adults and immunocompromised individuals, experts caution.

Advertisement
Continue Reading

Health

America’s lifespan has doubled since 1776 — experts reveal what changed

Published

on

America’s lifespan has doubled since 1776 — experts reveal what changed

NEWYou can now listen to Fox News articles!

Americans today live roughly twice as long, on average, as they did when the Declaration of Independence was signed.

When the nation was founded in 1776, life expectancy was around 35 to 40 years old, historians estimate. However, someone who survived childhood in colonial America often lived into their 60s or even 70s.

Today, the average lifespan is about 79 years old, according to data from the Centers for Disease Control and Prevention.

FILTERED WATER AT SPECIFIC AGES COULD ADD MONTHS TO YOUR LIFESPAN DECADES LATER, NEW STUDY FINDS

Advertisement

The improvement in lifespan over the centuries has been largely attributed to reduced deaths in infancy and from infectious diseases, multiple researchers have stated. Advances in sanitation, clean water, nutrition, vaccination and medical care have also contributed to lower mortality rates.

“Much of this vast discrepancy is related to the extremely high rates of infant, childhood and maternal mortality,” Dr. Omer Awan, physician and professor at the University of Maryland School of Medicine, told Fox News Digital.

Americans today live roughly twice as long, on average, as they did when the Declaration of Independence was signed. (Milan Markovic/iStock)

“Childbirth was dangerous, and without antibiotics and vaccines, many infectious diseases, such as measles, smallpox and pneumonia, were deadly,” he went on. “Now we have cleaner water and sanitation, vaccines and antibiotics that have significantly prolonged life.”

Advances in treatments of chronic diseases such as high blood pressure, cancer and diabetes have also significantly prolonged life, the Harvard-trained doctor noted.

Advertisement

WANT TO AGE BETTER? RESEARCHERS SAY 4-MINUTE ROUTINE MAY HELP PREVENT DANGEROUS FALLS

According to the CDC, improved prevention and treatment of high blood pressure has helped reduce deaths from heart disease and stroke, two of the nation’s leading causes of death.

Mia Kazanjian, MD, a Stanford-trained body and breast radiologist with an interest in longevity who is based in Greenwich, Connecticut, attributes the shorter life expectancy in the 1700s to suboptimal sanitation, poor hygiene and limited medical treatments.

Today, the average lifespan is about 79 years old, according to data from the Centers for Disease Control and Prevention. (iStock)

“Many babies and children died from infections like dysentery, diphtheria, scarlet fever and pneumonia,” she told Fox News Digital. Children who survived into adulthood often succumbed to infections like tuberculosis, cholera and typhoid fever.

Advertisement

Maternal mortality has also fallen dramatically over the past century due to advances in antibiotics, blood transfusions and safer obstetric care, according to the CDC.

Milestones in public health

Kazanjian pointed to several key advancements over the centuries that contributed to longevity improvements, including the development of early municipal water systems that provided cleaner drinking sources.

“Sewer system networks were built, the first in Brooklyn in 1857,” she said. “These allowed people to drink clean water and dispose of waste. Indoor plumbing with toilets and bathrooms became more widespread.”

“Without antibiotics and vaccines, many infectious diseases, such as measles, smallpox and pneumonia, were deadly.”

At this time, people’s understanding of disease started to improve, and public health measures were developed to minimize risk.

Advertisement

During the late 1800s, germ theory became widely accepted in medicine and public health, helping shape the Sanitary Era, the expert said.

COULD ‘HUMANMAXXING’ ACTUALLY HELP YOU LIVE LONGER? HERE’S WHAT EXPERTS SAY

“The Federal Quarantine Act of 1878 allowed the government to prevent spread of infection from out of the country, from epidemics like yellow fever,” she said. “Food safety regulations went into effect in 1906, when the Pure Food and Drug Act and Federal Meat Inspection Act were passed.”

By 1900, the average life expectancy was about 49 years old, according to the National Vitals Statistics Report.

Another major landmark in increasing lifespan came with the development of vaccines and antibiotics to prevent and treat disease, Kazanjian noted.

Advertisement

One major landmark in increasing lifespan came with the development of vaccines and antibiotics to prevent and treat disease, experts say. (iStock)

“Jenner developed the smallpox vaccine in 1796, Pasteur created vaccines for rabies and anthrax in the 1880s, and several scientists created vaccines for polio, measles, influenza, mumps and rubella in the mid 1900s,” she said.

“Antibiotics proliferated in the 1940s, specifically penicillin and tetracycline. By 1950, the US life expectancy was about 68 years old.”

FINDING THE SLEEP ‘SWEET SPOT’ COULD HELP YOU LIVE LONGER, STUDY SUGGESTS

From the mid-20th century to 2014, life expectancy continued to rise, Kazanjian said, largely due to “major gains” in medical knowledge of ways to prevent heart disease and stroke.

Advertisement

Public health campaigns promoting smoking cessation also played a role, as declining smoking rates helped reduce deaths from lung cancer, heart disease and stroke, according to the CDC.

“Motor vehicles became safer and carseats became staples,” Kazanjian noted.

Modern longevity is more focused on preventing chronic disease and less about surviving childhood infections. (iStock)

According to the National Institutes of Health, advances in emergency medical services and trauma care have substantially reduced deaths after serious injuries.

Development of pharmaceuticals for cardiovascular disease and cancer also contributed to longer lives, according to Kazanjian.

Advertisement

Today’s longevity challenges

Modern longevity is more focused on preventing chronic disease and less about surviving childhood infections, noted Nneoma Oparaji, MD, a triple board-certified media physician specializing in obesity, lifestyle and internal medicine.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

“The next frontier will be less about living longer, but more about living healthier longer,” Houston-based Oparaji told Fox News Digital.

Kazanjian pointed out that between 2014 and 2026, there has been a fall and a rise in lifespan.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

Advertisement

“The fall was due to young adult deaths from drug overdoses, particularly the opioid epidemic, suicides and alcohol-related deaths,” she told Fox News Digital.

The COVID-19 pandemic reduced U.S. life expectancy by more than two years between 2019 and 2021 before it began recovering, CDC data shows.

Advances in sanitation, clean water, nutrition, vaccination and medical care have contributed to lower mortality rates. (iStock)

Although U.S. life expectancy has rebounded since the pandemic, it remains below that of other high-income countries, largely because of higher death rates from chronic diseases, substance use and other preventable causes, according to KFF.

CLICK HERE FOR MORE HEALTH STORIES

Advertisement

Obesity rates also continue to climb, contributing to higher numbers of cardiovascular disease, diabetes and cancer, Kazanjian said.

“Most concerning is the rise in obesity in children,” she added.

“The next frontier will be less about living longer, but more about living healthier longer.”

Changing cancer trends are also affecting lifespan among younger adults, data shows.

“My generation, the millennials, has seen an unprecedented rise in young adult cancers, particularly colon and breast,” Kazanjian said, citing factors that include sedentary lifestyles, poor diet, alcohol, obesity and smoking, among others.

Advertisement

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

The doctor said she aims to raise public health awareness of ways to improve lifespan.

“We need to get off our screens, move around more, eat a whole food, plant-based diet, sleep seven hours a night, do our screening exams, and avoid toxins like alcohol and cigarettes.”

Continue Reading
Advertisement

Trending