Health
Drug Company to Share Revenues With Indigenous People Who Donated Their Genes
When Stephane Castel first met with a group of Māori people and other Pacific Islanders in New Zealand to talk about his drug company’s plans for genetic research, locals worried he might be seeking to profit from the genes of community members without much thought to them.
Instead, Dr. Castel and his colleagues explained, they were aiming to strike an unconventional bargain: In exchange for entrusting them with their genetic heritage, participating communities would receive a share of the company’s revenues. Dr. Castel also vowed not to patent any genes — as many other companies had done — but rather the drugs his company developed from the partnership.
“A lot of people told us this was a crazy idea, and it wouldn’t work,” Dr. Castel said. But five years after that first conversation during an Indigenous health research conference in March 2019, Dr. Castel’s gambit is beginning to pay off for both parties.
On Tuesday, his company, Variant Bio, based in Seattle, announced a $50 million collaboration with the drugmaker Novo Nordisk to develop drugs for metabolic disorders, including diabetes and obesity, using data collected from Indigenous populations. Variant Bio will distribute a portion of those funds to the communities it worked with in nine countries or territories, including the Māori, and will seek to make any medicines that result from its work available to those communities at an affordable price.
Experts on Indigenous genetics said the deal was a positive step for a field that has been plagued by accusations of exploitation and a gulf of mistrust.
“In the past, researchers would enter Indigenous communities with empty promises,” said Krystal Tsosie, a geneticist and bioethicist at Arizona State University who runs a nonprofit genetic repository for Indigenous people. “Variant Bio is the only company, to the best of my knowledge, that has explicitly talked about benefit-sharing as part of their mission.”
The concept for Variant Bio was hatched in a Manhattan bar in August 2018 over drinks between Dr. Castel and Kaja Wasik, who had become friends during their graduate studies in genetics at Cold Spring Harbor Laboratory on Long Island.
Though their laboratory research kept them under the glare of fluorescent lights, they shared a zest for international travel, which they indulged during backpacking trips together in Peru and Chile. They dreamed of building a company that could get them to remote places.
At the time, drugmakers were establishing partnerships with biological repositories such as UK Biobank, which contains biological samples and health records from a half-million people living in Britain, in order to hunt for associations between genes and disease.
But these databases are primarily made up of genes from people of European descent.
“What’s the value of sequencing the 500,001st British person?” Dr. Castel said. “There are only so many insights to find by studying the same group of people.”
He and Dr. Wasik were more enthusiastic about recent findings from underrepresented groups, such as the discovery of novel gene variants affecting metabolism that were first identified in Inuit populations in Greenland.
Such variants may be more common, and consequently easier to identify, in historically isolated populations because they confer some functional benefit to people with a certain diet or lifestyle, or simply because of chance events in their history. Yet they can also serve as promising drug targets that will help a wider swath of the global population.
With $16 million in seed funding from Lux Capital, a venture capital firm in New York City, Dr. Castel and Dr. Wasik quit their jobs and began working full-time for their startup. Dr. Wasik hopped across eight countries in Africa, Asia, Europe and the Pacific in the company’s first year, while Dr. Castel, for the most part, dutifully built their software platform from his base in the United States.
They enlisted ethical advisers to develop a benefit-sharing model and went on a listening tour. They knew from the get-go they would have to tread carefully.
In 2007, a member of the Karitiana tribe in Brazil told The New York Times that his community had been “duped, lied to and exploited” by scientists who had collected their blood and DNA, which was later sold for $85 per sample. The tribe members, who said they had been wooed with promises of medicines, received nothing.
Ten years later, there was still no consensus about the optimal way to conduct such work. To protect against so-called biopiracy, many countries ratified the Nagoya Protocol under the United Nations Convention on Biological Diversity, which requires the “equitable sharing of benefits” emerging from genetic resources. But the protocol excluded human genomic information.
During Dr. Castel’s and Dr. Wasik’s trip to New Zealand in 2019, the researchers and community members were troubled by a previous attempt by U.S. researchers to patent a test for obesity risk based on genetic studies carried out in Samoa. The researchers’ universities did not include their Samoan collaborators on their patent application as co-inventors, nor did they have formal benefit-sharing agreements in place with local institutions. (That patent application has since been abandoned, and the researchers said they always intended to share benefits with their partners.)
One of Variant’s first advisers was Keolu Fox, an outspoken geneticist at the University of California, San Diego, who had been harshly critical of the Samoan research.
“This is an extension of all these other forms of colonialism,” said Dr. Fox, who is Native Hawaiian and joined Dr. Wasik and Dr. Castel on their New Zealand outreach trip. He believed that Variant could lead by example.
In the company’s benefit-sharing program, up to 10 percent of a project’s budget goes toward community programs, typically by funding local organizations.
For example, as part of its New Zealand-based study into the genetic causes of kidney disease and other metabolic disorders in the Māori and other people of Pacific ancestry, the company spent $100,000 to fund several local health organizations along with scholarships and scientific conferences for Indigenous people.
“Before Variant came along, we didn’t do that because we couldn’t afford to do so,” said Tony Merriman, a gout expert at the University of Alabama at Birmingham who has collaborated with the company on two projects in the Pacific region.
Dr. Merriman said that he also appreciated that the company ensured that its findings were shared with the community. In French Polynesia, the company’s research has encouraged increased access to a gout medication after concluding that the local population did not have an elevated risk of a fatal drug reaction that had been observed in certain Asian populations.
The new Novo Nordisk deal kicks off a second, longer-term phase of the benefit-sharing program. Communities will share in a 4 percent slice of Variant’s revenue and, if the company is ever sold or goes public, 4 percent of its equity. That percentage is comparable to the royalties that universities receive for licenses to their patents.
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Gym membership in the U.S. hit a record high in 2025, according to the Health & Fitness Association, giving consumers more workout options — and more choices to sort through when picking the right fitness space.
Amid today’s wellness renaissance, many gyms and fitness clubs can cost hundreds of dollars per month, depending on the level of access and amenities offered.
In an interview with Fox News Digital, Kenny Santucci — New York City fitness trainer, gym owner and host of the “Strong New York” podcast — revealed the attributes of a great gym.
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“A lot of people traditionally look at gyms [as if] they have to have all the bells and whistles,” he said. “Spa, bathrooms, all these things. For me, a gym is a gym. I go there for the equipment, I go for the culture, I go for the look and feel of the place.”
He added, “You can have an incredible gym [that’s] a garage gym, and you can have an incredible gym [that] somebody could have built for $10 million.”
Amid today’s wellness renaissance, many gyms and fitness clubs can cost hundreds of dollars per month, depending on the level of access and amenities offered. A New York City fitness trainer (not pictured) has a different view of what makes the best gyms.
Santucci, who visits new gyms across the country and posts his experiences on social media, said he looks for a balance between aesthetics and equipment quality, as well as “great people.”
“I think you could go and get in a sweat or a workout anywhere — but if the people are great, that’s what creates that great culture,” he said.
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“If you ask the average person who goes to most big-box gyms, the things they tell you they love about the gym are, ‘Oh, I love the showers. They have really nice towels.’ It’s nothing that actually pertains to the gym, and I believe that people should go to the gym to progress and get better,” he added.
With these goals in mind, Santucci revealed some of his top-rated gyms in the U.S.
Life Time Fitness
Life Time is a chain of luxury health clubs in the U.S., offering amenities like indoor courts, swimming pools, saunas and group fitness classes.
Santucci applauded the gym’s founder and CEO, Bahram Akradi, for being a “very hands-on owner and operator,” overseeing hundreds of gyms across the country.
The facade of an upscale Lifetime gym is shown in Walnut Creek, California, on April 8, 2025. (Smith Collection/Gado/Getty Images)
“[Bahran’s] mentality and belief system around the fitness space, I absolutely love,” he said.
“I give a lot of credit to the guys who are owners and operators,” Santucci added. “They’re in the space, they’re making sure things are going really well. I think if you’re going to be in the gym business, you should be one of those people.”
Anatomy Gyms (Florida)
Santucci also shouted out Marc Megna, co-founder and co-CEO of Florida-based Anatomy Fitness for building a must-visit space.
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“It’s an incredible culture there, and I think that’s what they really push at that gym,” he said.
“The way the gym’s set up, the cleanliness of it, the aesthetics – you walk in that place, and you want to train … and those are things you can’t just buy … You have to live it, love it and be involved in the day-to-day operations.”
Powerhouse (New York/New Jersey)
In a newer recommendation, Santucci said he’s enjoyed stopping into Powerhouse Gym in New York City.
The New York- and New Jersey-based gym focuses on weight training and bodybuilding, including a powerlifting room and boxing rig at its locations.
“I just started going there, once or twice a week,” he said. “I really love the people and the culture.”
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The Training Lab (NYC)
For more of a group fitness and Hyrox training experience, Santucci recommends The Training Lab in New York City. (Hyrox is a global fitness racing brand and training system with affiliated gyms and training clubs.)
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“The guys over at Training Lab are incredible,” he told Fox News Digital. “Another owner-operator who’s involved in the business, who partakes in everything. I think they’re another great gym.”
“If you’re looking for group training, Training Lab’s a great space.”
Participants compete in the burpee broad jumps event during the Hyrox fitness race at the Bangkok International Trade and Exhibition Centre in Bangkok on March 21, 2026. (Amaury Paul/AFP)
The price of wellness
While some premier gym memberships can cost upward of $300 a month, Santucci said it isn’t necessary to spend a lot to get results, although it may result in more of an “experience.”
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“We need to restructure the way we think about health and wellness,” he said. “People aren’t going out as much anymore. They’re not spending as much on alcohol.
“It’s all what you prioritize. I prioritize fitness,” he went on. “I belong to multiple gyms. I have a membership to TMPL Gym here in [New York City]. I have a membership to Renzo Gracie’s. That’s what I like to do with my money.”
While some premier gym memberships can cost upward of $300 a month, Santucci emphasized that it isn’t necessary to spend a lot to get results. (iStock)
Santucci said what he’s paying for goes beyond the equipment — pointing to the staff, community and overall atmosphere as part of the value.
“If you want that elevated experience, you’re going to pay for that just like you would at a hotel or a restaurant or anything else,” he said.
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The expert suggested that wellness has recently become a “third form of hygiene.”
“It’s like you take a shower, you brush your teeth and you go to the gym,” he said. “I think those are three non-negotiables for almost everybody on a daily basis when it comes to your hygiene.”
Ants can be a nuisance. Just ask officials at a hospital in Canada who are dealing with an “appearance of ants within the operating room” that has forced them to indefinitely suspend some surgeries there.
The ants appeared recently at Carman Memorial Hospital in Carman Manitoba, according to a statement from Southern Health-Santé Sud, the provincial authority that oversees the hospital.
It was not clear when the hospital would resume operations, but Southern Health said on Friday that a “limited number of elective surgeries” had been postponed and that the hospital was working with patients to reschedule them. Portage Online, a local news website, reported that 16 operations had been postponed, citing information from Southern Health.
It’s not the first time ants have disrupted operations at the hospital. The insects appeared there in August 2024, but “the issue resolved within a few weeks,” Southern Health said. They returned last summer. But with their reappearance this week, the hospital said it was taking more drastic measures. The hospital serves the area around Carman, a town with a population of around 3,000 residents about 47 miles southwest of Winnipeg.
“Any factor that could impact the safety or integrity of the operating room environment requires the suspension of surgical activity until the issue can be resolved,” Southern Health said. “The safety of patients, staff and physicians is paramount.”
The hospital is working with exterminators “to identify the source of the ants and implement additional measures and support a long-term resolution.” Southern Health told Portage Online that exterminators had “surveyed and cleaned drains, opened walls and sealed cracks.”
“Several methods have been used to bait the ants in an effort to find where they are originating from,” the authority said.
In a separate statement to the CBC, Southern Health said that it believed that an ant colony had made its home near the hospital and that they appeared to be “simply seeking food sources inside buildings as ants are known to do.”
The hospital also told the CBC that the ant problem at the hospital did not amount to an “infestation.”
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The U.S. government is moving to evacuate American passengers from a cruise ship linked to a deadly hantavirus outbreak, with plans to transport them to a military base in Nebraska for quarantine and monitoring, federal health officials said Friday.
The Centers for Disease Control and Prevention said the risk to the American public remains extremely low as officials move forward with a medical repatriation flight for passengers aboard the M/V Hondius.
President Donald Trump said earlier Friday that the situation appears to be under control, pointing to the virus being difficult to transmit.
“We have very good people looking at it. It seems to be okay. They know the virus very well. They’ve worked with it for a long time. They know it very well. Not easy to pass on. So we hope that’s true,” he said.
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Health workers in protective gear evacuate patients from the MV Hondius cruise ship at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
“We seem to have things under very good control. They know that virus very well. It’s been around a long time. Not easily transferable, unlike COVID. But we’ll see. We have very good people studying it very closely.”
The outbreak has escalated over several weeks, beginning with a passenger who became sick in early April and later resulting in at least three deaths, according to the World Health Organization.
Cases are now reported across multiple countries after passengers disembarked in Africa and Europe, prompting health officials to trace contacts globally.
Authorities in Cape Verde at one point blocked passengers from leaving the ship, underscoring concerns about containment.
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An ambulance evacuates patients from the MV Hondius cruise ship to the airport in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
Hantavirus is a rare but potentially deadly disease typically spread through contact with infected rodents or their droppings, according to the CDC. While most strains do not spread between people, health officials say the Andes virus — identified in some cases linked to the cruise ship — is the only known strain capable of limited person-to-person transmission.
The vessel is expected to dock in Spain’s Canary Islands, where international teams are coordinating next steps for passengers and crew.
A CDC team has been deployed to the Canary Islands to assess potential exposure among American passengers and determine monitoring needs.
Returning passengers are expected to be flown on a U.S. government medical repatriation flight to Offutt Air Force Base in Omaha, Nebraska.
Health workers in protective gear evacuate patients from the MV Hondius cruise ship into an ambulance at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
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They will then be transported to the National Quarantine Center at the University of Nebraska Medical Center for further monitoring.
Additional CDC personnel will be stationed at Offutt Air Force Base to support health assessments.
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