Health
Dementia report reveals 'shocking' signs at age 60 that you'll develop the disease by age 80
The onset of dementia can come as a shock, but various signs could predict the condition as long as 20 years before symptoms.
A new study published by the RAND Corporation in California identified several major predictors occurring around age 60 that are likely to lead to cognitive impairment and dementia in individuals by age 80.
Researchers evaluated 181 potential risk factors, including demographics, socioeconomic status, lifestyle and health behaviors, health history, psycho-social factors and more.
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Below are some of the strongest predictors at age 60 that indicate a higher chance of developing cognitive impairment and dementia, according to the report.
See the list of 14 predictors.
RAND researchers uncovered several surprising predictors of dementia risk, like never drinking and never working. (iStock)
1. Poor physical health
2. History of stroke
3. Genetics
4. Being born in the Southern United States
5. Not having private health insurance at age 60
6. Never working or only working for a few years
7. History of diabetes
8. Having a body mass index of 35 or more
9. Never drinking alcohol or drinking excessively
10. Never exercising
11. Scoring low on physical tests
12. Being less conscientious
13. Low engagement in hobbies
14. Low cognitive function and engagement
Parental health, family size, marital history and demographics were the weakest predictors, according to the research.
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In an interview with Fox News Digital, study co-author Peter Hudomiet, a RAND economist in California, shared details of the study, which worked with a large dataset and followed individuals “for decades.”
Parental health, family size, marital history and demographics were the weakest predictors, according to the research. (iStock)
“Overall, we found that risk factors had a similar effect in the short and long term, which reassured us that the findings from prior literature may hold in the long term,” he said.
“Nevertheless, we also had quite a few surprising findings.”
Digging into dementia drivers
The researcher said he was surprised to find that those who never exercised had a “substantially higher chance” of developing dementia than those who lightly exercised at least a few times per month.
“Exercising even more often (weekly or daily) had some additional benefits, but not that much,” he noted.
“In other words, the main risk factor for dementia was never exercising.”
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“These behavioral factors were more important predictors of dementia than having the right genes,” Hudomiet added.
While having a body mass index (BMI) over 30 at age 60 was a weak predictor of dementia, a BMI over 35 was a “powerful predictor.”
The risk of dementia is “about half as much among those who regularly exercise compared to those who never do,” said the researcher (not pictured). (iStock)
Never participating in cognitive activities offered a much higher risk of developing dementia compared to sometimes participating, as well as only having zero to 11 years of education compared to having high school or advanced degrees, said Hudomiet.
Another unexpected finding was the substantially higher dementia risk faced by Americans born in the Southeastern U.S. compared to the rest of the country.
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“This differential remained strong even when our statistical models accounted for differences in income, health, and other differences between regions,” the researcher noted.
“It is possible that the quality of education (which we could not measure in our data) was lower in the Southeastern part of the U.S., especially in the older cohorts we analyzed.”
“Less than 1% of health care dollars go toward educating the public on positive health care strategies,” according to a gerontologist. (iStock)
People not covered by a private health insurance plan at age 60 had an 11% higher chance of developing dementia than those who had coverage, Hudomiet added.
That’s “partly because private health insurance helps individuals remain healthy longer,” he suggested.
“The choices you make now will determine how you will live later.”
The study results suggested that “maintaining good physical and mental health is beneficial not just to staying in shape, but also to staying sharp and delaying cognitive decline,” Hudomiet told Fox News Digital.
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Gerontologist Dr. Macie P. Smith in South Carolina, who was not involved in the study, also reacted to the findings in a separate interview with Fox News Digital, saying the researchers are “spot on.”
“Having this researched information presented … brings about a heightened sense of responsibility to everyone who claims to be in the fight to end Alzheimer’s disease and related dementias (ADRD),” she wrote in an email response.
A person’s genetics are less of a risk factor than certain habits and behaviors such as exercise, a researcher noted. (iStock)
Smith said it is “pretty shocking” that never drinking alcohol increases dementia risk.
“This stands out to me because drinking alcohol excessively increases one’s risk significantly of brain deterioration and can lead to alcohol-induced dementia,” she said.
The expert suggested that self-reported data could have led to this finding — or red wine could have been factored in, as it’s been found to “contain brain-enhancing nutrients, such as resveratrol.”
Ways to reduce the risk
While cognitive decline is sometimes impossible to prevent, Hudomiet mentioned that some risk factors can be reduced through lifestyle changes.
These include exercising regularly, maintaining a healthy body weight, getting proper nutrition and engaging in challenging cognitive activities.
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“Health care providers and the government should consider promoting healthy behaviors in the adult population and strengthening individuals’ access to quality health care, which may decrease the prevalence of dementia and the burden of the disease in the future,” Hudomiet recommended.
“Understanding that what’s good for the heart is good for the brain and adopting healthy lifestyle practices puts people in control of their brain fate,” one expert said. (iStock)
Smith added that reducing dementia risk “doesn’t begin or end with medication.”
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For those who are middle-aged, paying attention to these early predictors is a “matter of life and death,” she stated.
“It is incumbent on everyone with a brain to take heed of the warning signs that your body gives you,” she said. “Your body always reminds you about what your brain sometimes ignores.”
“You have the power to take control over what your life looks like down the road,” she went on.
“The choices you make now will determine how you will live later.”
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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