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Children with autism may see speech improvements with off-label prescription drug

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Children with autism may see speech improvements with off-label prescription drug

An off-label prescription drug has been shown to help some non-verbal children with autism discover the ability to speak.

The drug, leucovorin, is a prescription vitamin that functions similarly to folic acid, helping to restore folate levels in patients who may have difficulty absorbing or using it, according to Katy Dubinsky, a New York pharmacist and the CEO and co-founder of Vitalize, a private supplement company.

“Leucovorin is FDA-approved to reduce the toxic effects of high-dose methotrexate in cancer treatment and to prevent or treat certain types of anemia caused by folate deficiency,” Dubinsky told Fox News Digital.

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While leucovorin isn’t prescribed for the treatment of autism, some families have found that its off-label use has led to significant improvements in autistic children’s communication skills, experts say.

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Richard E. Frye, M.D., PhD, a behavioral child neurologist in Arizona, has studied the drug in his research of experimental treatments for children with autism spectrum disorder.

An off-label prescription drug has been shown to help some non-verbal children with autism discover the ability to speak. (iStock)

“Leucovorin is a special form of vitamin B9 that is water-soluble and does not build up in your body,” he told Fox News Digital. 

“Folates have been found to be safe long-term for many years and that is why we supplement our food with folate.”

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The main benefit of leucovorin for children with autism is improvement in language, Frye said, but other advantages may include enhanced social function, reduced repetitive behaviors and stronger attention skills.

“Our goal is to get leucovorin approved by the FDA for autism so it can be widely prescribed to children as one of the first treatments once they are diagnosed.”

“We do find that leucovorin helps a substantial number of children with autism,” he said. “Language is one of the most obvious things, so that is what we measured in our clinical trial.”

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News’ senior medical analyst, also spoke to Fox News Digital about why the drug may have this positive impact.

While leucovorin isn’t prescribed for autism treatment, some families have found that its off-label use has led to significant improvements in the communication skills of children with autism.  (iStock)

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“Central folate deficiency is a lack of folate in the brain, which can interfere with neurological function,” he said. “A high percentage of children with autism spectrum disorder have been found to have antibodies against folic receptor alpha in the brain.”

Leucovorin is converted to folate in the brain by a different pathway, Siegel said.

“Small studies are showing that it improves neurological function and communication skills in kids with ASD, but larger studies need to be done.”

Experts urge caution

The fact that leucovorin has already been used long-term helps to reduce the associated risk, according to doctors.

“One of the advantages of using leucovorin is that it has been used for decades to protect the body from the effects of chemotherapy, so we know what dose to use and any side effects it may produce,” Frye told Fox News Digital.

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However, some children do become “extremely hyperactive,” do not respond to leucovorin and end up needing alternative treatments, the doctor noted.

It’s important for families to work with a medical professional when exploring the use of leucovorin for autism, he advised.

The drug leucovorin is a prescription vitamin that functions similarly to folic acid, helping to restore folate levels in patients who may have difficulty absorbing or using it, according to a pharmacist. (iStock)

“Leucovorin is given at much higher doses than regular vitamins, so it’s very important to work with a doctor knowledgeable in how to prescribe it,” Frye said. 

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“It is important to test the patient for abnormalities in the folate pathway, such as the folate receptor autoantibody, so we know that they are a candidate for this medication.”

      

While leucovorin is available in the pharmacy, Frye noted that some children need a compounded form because they are sensitive to some of the additives in commercial products.

“Our goal is to get leucovorin approved by the FDA for autism so it can be widely prescribed to children as one of the first treatments once they are diagnosed,” he said.

Frye pointed out that there is “no magic bullet” for autism, with many children benefiting from a combination of multiple treatments.  (iStock)

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Dubinsky agreed that physicians may prescribe the “widely used and well-tolerated drug” for autism treatment based on their “clinical judgment and emerging evidence,” but she also stressed the importance of clinical trials.

“While doctors can prescribe leucovorin now, FDA approval would provide stronger medical backing, making it a recognized treatment rather than just an off-label option,” she told Fox News Digital. 

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“This could lead to insurance coverage, standardized dosing guidelines and broader acceptance in the medical community.”

Siegel added that leucovorin is a “safe drug” and should be considered for large-scale use based on the findings of recent research.

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‘No magic bullet’

Frye pointed out that there is “no magic bullet” for autism, with many children benefiting from a combination of multiple treatments. 

“It is unlikely that leucovorin will be used alone — it must be used with behavioral and speech therapy,” he said. “We believe that leucovorin can improve outcomes for these therapies.”

“There is little evidence to suggest that the benefits observed in this individual case can be generalized to the broader autistic community.”

Andy Shih, PhD, chief science officer of Autism Speaks in New York, noted that every child’s experience with autism is unique.

“There is little evidence to suggest that the benefits observed in this individual case can be generalized to the broader autistic community,” he told Fox News Digital. 

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“While some small studies have explored leucovorin as a potential treatment for people with autism, larger controlled clinical trials are needed to determine its efficacy and safety. We urge families to consult with their doctors before considering off-label treatments.”

Dubinsky added that if larger studies confirm leucovorin’s effectiveness, it could become a more accessible treatment for children with autism who may benefit from it.

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Healthy diets spark lung cancer risk in non-smokers as pesticides loom

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Healthy diets spark lung cancer risk in non-smokers as pesticides loom

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Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests.

The observational study, led by Jorge Nieva, M.D., of the USC Norris Comprehensive Cancer Center at Keck Medicine, was presented this month at the American Association for Cancer Research (AACR) annual meeting in San Diego. It has not yet been peer-reviewed. 

Researchers looked at dietary, smoking and demographic data for 187 patients who were diagnosed with lung cancer at age 50 or younger. 

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They found that among non-smokers, there was a link between healthier-than-average diets – rich in fruits, vegetables and whole grains – and the chance of lung cancer development.

Young lung cancer patients ate more servings of dark green vegetables, legumes and whole grains compared to the average U.S. adult, the researchers found.

Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests. (iStock)

The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association.

“Commercially produced (non-organic) fruits, vegetables and whole grains are more likely to be associated with a higher residue of pesticides than dairy, meat and many processed foods,” according to Nieva. He also noted that agricultural workers exposed to pesticides tend to have higher rates of lung cancer.

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“There is a large subset of lung cancer patients whose disease is not caused by smoking,” Nieva told Fox News Digital.

The disease is becoming more common in non-smokers 50 and younger, especially women – despite the fact that smoking rates have been falling for decades, the researcher noted.

The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association. (iStock)

“These patients tend to have eaten much healthier diets before their diagnosis than the average American,” he went on. “We need to support research into understanding why Americans – and women in particular – who no longer smoke very much are still having lung cancer,” he said.

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The study did have some limitations, Nieva acknowledged, primarily that it relied on survey data and was limited by the participants’ memories of their food intake.  

“Also, the survey participants were self-selected, and this could have biased the findings,” he told Fox News Digital.

“There is a large subset of lung cancer patients whose disease is not caused by smoking.”

The researchers did not test specific foods for pesticides, relying instead on average pesticide levels for certain types of food. Looking ahead, they plan to test patients’ blood and urine samples to directly measure pesticide levels, Nieva said.

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Although the study shows only an association and does not prove that pesticides caused lung cancer, Nieva recommends that people wash their produce before eating and choose organic foods whenever possible.

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“This work represents a critical step toward identifying modifiable environmental factors that may contribute to lung cancer in young adults,” said Nieva. “Our hope is that these insights can guide both public health recommendations and future investigation into lung cancer prevention.”  

“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but is by no means certain,” a doctor said. (AP Photo/Charlie Neibergall)

Dr. Marc Siegel, Fox News senior medical analyst, said the study is “interesting,” but that it “raises far more questions than it answers.”

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“It is a small study (around 150) and observational, so no proof,” the doctor, who was not involved in the research, told Fox News Digital.

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“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but it is by no means certain,” Siegel went on. “How much exposure is needed? How much of it gets into food and in which areas? This requires much further study.”

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Kayla Nichols, communications director for Pesticide Action & Agroecology Network, a distributed global network, said the organization agrees with the study’s conclusion that more research should be done on the rise in lung cancer, particularly in individuals eating diets higher in produce and fiber.

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“There is a large subset of lung cancer patients whose disease is not caused by smoking,” the researcher told Fox News Digital. (iStock)

“There is a bounty of existing research that already links pesticide exposure to increased risk of multiple types of cancers,” Nichols, who was also not involved in the study, told Fox News Digital. She called for more research on chronic, low-level exposures to pesticides, as well as more effective policies to protect the public from pesticide residues on food.

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The study was supported by the National Institutes of Health and the National Cancer Institute, as well as industry partners including AstraZeneca and Genentech, among others.

Fox News Digital reached out to several pesticide companies and trade groups for comment.

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Deaths from one type of cancer are surging among younger adults without college degrees

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Deaths from one type of cancer are surging among younger adults without college degrees

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Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. New research shows one group getting hit the hardest – those without a college degree.

A recent study from the American Cancer Society analyzed data from over 101,000 adults aged 25 to 49 who died from colorectal cancer between 1994 and 2023.

While death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed.

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For young adults with a high school education or less, the mortality rate rose from 4.0 to 5.2 per 100,000 people, while the rate for those with at least a bachelor’s degree stayed flat, at approximately 2.7 per 100,000.

This does not mean that a degree offers some kind of biological protection, researchers cautioned.

Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. (iStock)

The difference is likely driven by the conditions in which people live and work, which often correlate with education levels, the researchers noted.

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The study suggests that the higher death rates are likely driven by differences in the prevalence of risk factors, including obesity, physical inactivity, smoking and diet, which are “known to be elevated among children and young adults with lower [socioeconomic status].”

Because the study relied on death certificates, researchers couldn’t say exactly why college graduates had better outcomes.

Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes. (iStock)

Certificates typically list the cause of death, age, race and education level, but they do not include a person’s full medical history.

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Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes.

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Colorectal cancer is now the leading cause of cancer death for men under 50 and the second leading cause for women in the same age group, according to recent statistics.

While colorectal cancer death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed. (iStock)

Because the disease is highly treatable when caught early, the U.S. Preventive Services Task Force (USPSTF) lowered the recommended screening age from 50 to 45 in 2021.

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Common signs and symptoms of colorectal cancer can include a change in bowel habits, such as diarrhea, constipation or narrowing of the stool, that lasts for more than a few days, according to the American Cancer Society.

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Other signs that warrant seeing a doctor include blood in the stool or a persistent feeling of needing to go to the bathroom but being unable to go.

The research was published in JAMA Oncology.

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Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

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Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

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A young woman who started vaping at the age of 15 has been given just 18 months to live — after being diagnosed with lung cancer in her early 20s. 

Kayley Boda, 22, of Manchester, in the United Kingdom, was engaging in heavy vaping on a regular basis when she started coughing up a brown substance with “grainy bits” in it in January 2025, news agency SWNS reported. 

The retail assistant said doctors turned her away eight times, telling her she had a chest infection — until she began coughing up blood.    

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After seven biopsies, Boda was diagnosed with lung cancer. She underwent surgery to remove the lower lobe of her right lung, as well as chemotherapy — and in February 2026, got the all-clear, the same source reported.

Two months later, though, doctors said the cancer had come back in the pleural lining. Now she’s been given 18 months to live.

Kayley Boda, 22, is shown in the hospital. She started coughing up a brown substance with “grainy bits” in January 2025, she said. She had been vaping since the age of 15.  (SWNS)

The young woman has now issued a warning to others to be aware of the dangers of vaping.

Boda said she smoked a bit as a young teenager. She took up vaping after that. 

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Then, “a few months after I switched from reusable vapes to disposable ones, I started coughing up brown, grainy mucus,” as SWNS reported.

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“Doctors turned me away eight times with a chest infection. … Then I started coughing up blood, so they did an X-ray and found a shadow on my lung,” she added.

“They told me they were 99% sure, [since I was] so young, that it wasn’t cancer, so not to worry about it. When I got the results back, and they told me it was lung cancer, it felt so surreal.”

Boda said she was “very naive” before her diagnosis and thought that “something like this would never happen to me.”

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She said that she had surgery to remove half of her right lung.

“After the surgery, I started chemo and I had a terrible reaction to it. I couldn’t lift my head up. I was throwing up blood. I was urinating blood. I couldn’t eat. I couldn’t sleep.”

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She said that when she got the “all clear [in Feb. 2026], it felt amazing, but just two months later I was told the cancer had come back, and I have 18 months to live.”

She added, “I’m 22. This isn’t meant to happen to somebody my age.”

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“Stay off the vapes because they will catch up with you.”  

She blames her cancer on vaping, she said.  

“My symptoms started a few months after I started disposable vapes, and there’s no lung cancer in my family,” she said. “I haven’t vaped for three months, I’ve made my partner stop, I’ve made my mom stop, I’m urging all my friends to stop. Stay off the vapes,” she continued, “because they will catch up with you.”  

When doctors did an X-ray, they found a shadow on Boda’s right lung. She was later diagnosed with lung cancer and has undergone surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

She said she’d been using reusable vapes since the age of 15 and began using disposable vapes a few months before her cancer symptoms started.

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In November 2024, when she developed a rash all over her body, doctors said it could have been due to shingles, chicken pox or scabies, she told SWNS.    

‘Nothing worked’

“I got treated for all three, and nothing worked,” Boda said. “It got to the point where I was cutting myself from scratching so hard.” 

A few months after that, she began coughing up a dark brown mucus, with “grainy bits, the consistency of sugar, in it,” she said. When the coughing continued, she visited the doctor’s office, but was told it could be scarring from pneumonia or a chest infection, she also said.    

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It wasn’t until March 2025 that she began coughing up bright red blood. At that point, doctors gave her a chest X-ray and told her they’d found a shadow on her lower right lung.    

Over the next four months, she had seven biopsies as doctors took samples from the “shadow.” In August, when she went to get the results, she was told she had stage one lung cancer.

Boda is shown in the hospital. She was diagnosed with lung cancer and had surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

In September 2025, she had surgery to remove the lower lobe of her right lung, and the surrounding lymph nodes. During the surgery, doctors upstaged her cancer from stage one to stage three after finding cancer in six surrounding lymph nodes, she said.  

Following the surgery, Boda was unable to breathe properly and had to learn to walk all over again.  

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“The oncologist said this is so rare.”

After finishing chemotherapy in February 2026, Kayley was given the all clear, leaving her feeling elated. 

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However, just a month after that, she began experiencing extreme chest pains and was told by doctors she had a pleural effusion — a build-up of fluid in the lungs. She had the fluid removed, but when doctors tested it, they discovered her cancer had returned to the pleural lining of her lungs, giving her 18 months to live.  

“The oncologist said this is so rare, and usually something they see in patients that are 80 years old,” she said, as SWNS reported.  

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Increasingly, vacation hot spots are enforcing strict bans on the use of e-cigarettes in public venues.  (iStock)

Boda claimed that doctors were unable to pin her cancer to a specific cause — but told her that smoking and vaping definitely didn’t help.

Since her diagnosis, she has stopped and is urging others to stop, too.    

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She’s hoping to raise the thousands of dollars needed for treatment to try to prolong her life, she said.  

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Last year, Fox News Digital reported on the case of a Pennsylvania woman, 26, who said she vaped for just one year before her lungs collapsed. She was 22 when she took up the habit, she said in an interview. 

“Everybody warned me about it, but I didn’t listen — I wish that I did,” she said.

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Dr. David Campbell, clinical director and program director at Recover Together Bend in Oregon, told Fox News Digital at that time that signs of collapsed lungs include sharp chest or shoulder pain, shortness of breath and difficulty breathing.

Lung issues are just one of the many health issues linked to vaping, he warned. The habit can also increase the risk of heart disease and stroke, as well as exposure to harmful heavy metals.

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Melissa Rudy of Fox News Digital contributed reporting. 

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