Health
Cheap Ozempic knock-offs have risen in popularity — but are they safe?
As prices for Ozempic have risen in recent months, many people may be seeking cheaper alternatives for managing diabetes or weight loss.
Some doctors, along with the U.S. Food and Drug Administration (FDA), are warning of the potential risks of using “knock-off brands” of semaglutides, which belong to the GLP-1 class of medications.
Dr. Brett Osborn, a Florida neurosurgeon and longevity doctor who has prescribed pharmaceutical-grade versions of these medications since 2019, said he is “concerned” by this trend.
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“Due to the cost of brand-name Ozempic, more and more people are turning to cheaper knock-off versions, often found online or through non-regulated channels,” he told Fox News Digital.
As prices for Ozempic have risen in recent months, many people may be seeking cheaper alternatives for managing diabetes or weight loss. (REUTERS/Hollie Adams/File Photo)
“These knock-offs are synthesized in non-medical environments without the necessary quality assurance or quality control, making them inherently risky.”
There is the potential for these medications to be harmful when there’s no oversight of their source or production quality, Osborn warned.
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“When they’re made in unregulated environments, there’s no telling what you’re putting into your body.”
Dr. Sue Decotiis, MD, a weight-loss doctor in New York City, confirmed that some people are seeking low-cost alternatives, but noted that their potential dangers are becoming more widely known.
“This happened to one of my patients before he came to me,” she shared with Fox News Digital.
There is the potential for these medications to be harmful when there’s no oversight of their source or production quality, a doctor warned. (iStock)
“He got a medication from a pharmacy in Florida and then the drug just stopped working. Weeks later, the pharmacy shut down.”
Many of the illegitimate pharmacies that are not credited by their state’s local pharmacy board will “just disappear,” Decotiis said.
“You should only be using pharmaceutical-grade versions prescribed by a licensed doctor.”
The biggest risk is that the patient has no idea what’s in the medications, she warned, as disreputable providers could add fillers to the products.
Consider the source
Medications like Ozempic require “precision in manufacturing,” according to Osborn.
“You should only be using pharmaceutical-grade versions prescribed by a licensed doctor,” he said.
“The risk with these variants is too high, and there’s no regulation to ensure they are made properly.”
While some online platforms may be legal because a health care provider is writing the prescription, there could be other associated risks, a doctor warned. (iStock)
People should use caution when ordering any medication online, doctors agree.
“Unless you’re getting the medication from a licensed pharmacy with a valid prescription from a doctor, purchasing Ozempic or its knockoffs online is dangerous,” Osborn warned. “You can’t verify the product’s source, ingredients or safety.”
“I know of several nurse practitioners who stockpile Ozempic knock-offs and sell them on their Facebook pages,” he noted. “In essence, there is a massive black market for it.”
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While some online platforms may be legal because a health care provider is writing the prescription, there could be other associated risks, Decotiis noted.
“It may be that there isn’t any personalized care or any body composition being followed.”
Shortages of these unregulated medications are also common.
“This is problematic after paying upfront, as many patients never get the medication they thought they would get,” Decotiis said. “The buyer must be aware.”
One of the biggest red flags is if an online platform offers to directly send a medication, Decotiis noted.
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“If you can buy it directly, it is an unlawful site,” she noted. “These sites get shut down daily — who knows what they are actually dispensing.”
Legitimate compound companies only work with physicians, Decotiis said, and do not communicate directly with patients.
Cost-saving options
If cost is a concern, there are safer alternatives than purchasing knock-off brands, experts say.
“Many pharmaceutical companies offer patient assistance programs — your doctor can guide you to those options,” Osborn said.
“There are other prescription medications that may be more affordable, but still safe and effective for lowering insulin levels and driving weight loss,” he added, a doctor said. (iStock)
“There are other prescription medications that may be more affordable, but still safe and effective for lowering insulin levels and driving weight loss,” he added.
One example is metformin, another time-tested diabetes medication.
Added Osborn, “Under no circumstances should you turn to unregulated alternatives just to save money.”
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Decotiis acknowledged that it can be “very difficult” for many people to obtain Ozempic and similar medications.
“These drugs are expensive, and it’s hard for many people to get the care they need,” she said.
“Under no circumstances should you turn to unregulated alternatives just to save money.”
“For compounded products, you’re paying by ounce, while with big pharma, you’re paying for a monthly supply,” she went on.
“With the big pharma drugs, you’re paying more up front, but as it goes up in dose, it’s actually cheaper.”
Medications like Ozempic should only be prescribed by a physician licensed to write prescription, doctors advise. (iStock)
With compounded medications, a licensed pharmacist or physician combines, mixes or alters the ingredients to create a customized drug to meet a patient’s individual needs, but it is not FDA-approved, according to the agency.
“This means the agency does not review compounded drugs for safety, effectiveness or quality before they are marketed,” the FDA states on its website.
‘Safety first’
Osborn reiterated that medications like Ozempic should only be prescribed by a physician licensed to write prescriptions — “not a nurse practitioner via a telemedicine visit or a chiropractor.”
“When used correctly, these medications are powerful tools, but can be dangerous in the wrong hands,” he said.
“Always consult a health care provider with the proper training and experience in using these medications. Safety first.”
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The FDA and the World Health Organization (WHO) have both investigated cases of counterfeit Ozempic products in recent months and years.
The FDA recommends that retail pharmacies only purchase authentic Ozempic through authorized distributors of Novo Nordisk, the company that makes Ozempic and Wegovy, and that patients only obtain Ozempic with a valid prescription through state-licensed pharmacies. (iStock)
“FDA is aware that some patients and health care professionals may look to unapproved versions of GLP-1 (glucagon-like peptide-1 receptor agonists) drugs, including semaglutide and tirzepatide, as an option for weight loss,” the agency wrote in a recent announcement on its website.
“This can be risky for patients, as unapproved versions do not undergo FDA’s review for safety, effectiveness and quality before they are marketed.”
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The FDA recommends that retail pharmacies only purchase authentic Ozempic through authorized distributors of Novo Nordisk, the company that makes Ozempic and Wegovy, and that patients only obtain Ozempic with a valid prescription through state-licensed pharmacies.
Fox News Digital reached out to Novo Nordisk and the FDA for comment.
Health
How Well Will You Age? Take Our Quiz to Find Out.
Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.
Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.
Health
Red hair may be increasing as study points to surprising evolution trend
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A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.
By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.
“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.
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The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”
Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.
Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)
Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.
“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.
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The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.
Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)
As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”
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While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.
However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.
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While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.
While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)
Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.
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The researchers urged caution in how these findings are interpreted.
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“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.
Health
Aging in Place: How Technology Might Help You Grow Old at Home
Dr. Megan Jack, a neurosurgeon in Cleveland, often works 60 or 70 hours a week. And she’s completely unavailable when she’s in the operating room. That makes it tough to be a caregiver for her 76-year-old mother, who lives in a separate unit on Dr. Jack’s property, 30 minutes away from the hospital.
To help care for her mother, who has Alzheimer’s disease, Dr. Jack uses an array of high-tech tools, some of which didn’t exist just a few years ago. She manages her mother’s medications with a smart pill box. She changes her television channels with an app, sends appointment reminders through a digital message board — and, with her mother’s blessing, uses cameras for communication and monitoring.
“It’s been invaluable that I can both make sure she’s safe and make sure everything is going well,” Dr. Jack said, “but also give her the independence and the freedom that she still deserves.”
America is aging rapidly. Roughly 11,000 people are turning 65 each day in the United States. And many of them — 75 percent of people over 50, according to AARP’s most recent survey, from 2024 — hope to spend their remaining years in the comfort of their homes, rather than in assisted-living or other care facilities.
One thing that could help fulfill those wishes is the budding field of “age tech,” which encompasses tools that support older adults. Industry experts say that age tech is making homes safer for older adults and is easing the minds of their caregivers, especially those who live far away or work outside the home.
Dr. Jack said that age tech had “really allowed me to integrate caregiving into my life, as opposed to caregiving taking over my life.”
The age tech boom
If older adults don’t have loved ones who are both close by and able to help, they might believe they don’t have a ton of options. They can live independently, or, if they can afford it and qualify medically, they can move to an assisted-living facility or a nursing home, without a lot of choices in between. In-home help can be expensive without Medicaid and can also be difficult to find, given the serious shortage of home care workers.
Age tech can help bridge some important gaps, said Emily Nabors, the associate director of innovation at the National Council on Aging, a nonprofit advocacy group. Already, AARP reports that 25 percent of caregivers are remotely monitoring their loved ones with apps, videos or wearables, nearly double the percentage from five years ago.
“We used to say homes are the health care settings of the future, but they really are health care settings now,” Ms. Nabors said. “Aging in place is very realistic.”
More than 700 companies are in AARP’s AgeTech Collaborative, a group that connects businesses, nonprofits and funders to help get new technologies off the ground. Altogether, the collaborative’s start-ups have raised nearly $1 billion in the past four years.
The products include smart walkers, glasses with lenses that provide real-time captions of conversations for those with hearing issues, and a concierge service that connects older people to drivers and deliveries, even if they don’t have a smartphone.
Ms. Nabors does foresee some affordability and access barriers to age tech, including the lack of high-speed internet in rural areas, but she said one vital resource would be local aging agencies, which can offer advice and, sometimes, free support.
Janet Marasa leaned on the agency near her home in Rockland County, N.Y., to get a free robotic pet for her mother, Carol DeMaio, 80, who has dementia. The pets, manufactured by a company called Joy for All, aim to offer emotional support without the upkeep.
Ms. DeMaio named the robotic dog Sabrina, after a golden retriever who died. The new Sabrina stays at the foot of her bed at night. As soon as Ms. DeMaio stirs awake, the dog reacts. “She said it gives her a reason to get up in the morning,” Ms. Marasa said.
The dog has been a boon to her, too. “It provides comfort and interaction that I can’t provide every second,” said Ms. Marasa, who lives with her mother but works full time for the county government. “It gives her something that she can feel like is totally her own.”
In Broward County, Fla., where the population of residents over 85 is expected to nearly triple over the next few decades, the local agency on aging has used state and federal money and private grants to provide technologies to nearly 4,000 of the county’s seniors at no cost.
Its offerings include a company that uses radar to sense falls and a program that allows seniors to make video calls through their televisions.
“The possibilities are endless,” Charlotte Mather-Taylor, the agency’s chief executive, said. “It’s pretty great to see all the new technology coming out so quickly, and I think that can only benefit our older population and also our caregivers.”
Here comes A.I.
Even technologies not specifically marketed as age tech can help older adults maintain their independence, said Laurie Orlov, founder of the blog Aging and Health Technology Watch. She pointed to video-calling and telehealth platforms; remotely controlled thermostats and lights; and smart speakers, doorbells and watches.
“All technology can be customized to help older adults stay longer in their homes and help their family members feel good about it, or at least tolerate it,” Ms. Orlov said.
That will only become more true with the continued proliferation of artificial intelligence, Ms. Orlov added. Some older adults are already using conversational A.I. to get answers about things like the weather or their medications. (Relying too heavily on A.I. can, however, have negative consequences because chatbots often give flawed medical advice and can lead patients astray.) A.I. can also assist in pattern detection: alerting caregivers to signals that might indicate declines in someone’s cognition or mental health, such as changing their speech pattern or leaving the house less frequently.
One A.I.-powered age tech tool is ElliQ, a tabletop companion robot that looks like a sleek silver desk lamp with a screen. About a year and a half ago, Camille Wolsonovich got one for free, thanks to a local nonprofit, for her 90-year-old father, Bill Castellano. He lives alone in a senior community.
Ms. Wolsonovich, who runs a consulting business, relies on ElliQ to lead her father in exercises and remind him to take his pills and drink water. The robot also asks her father about his sleep and mood via automated check-ins.
“Everything’s just another layer that gives us more confidence, from a caregiving standpoint, that he’s good,” Ms. Wolsonovich said. “I don’t have to necessarily track everything all the time and be overbearing.”
As for Mr. Castellano? He plays trivia digitally and converses daily with ElliQ. The robot, which has a friendly female voice, asks questions, cracks jokes and remembers his likes, dislikes and friends. “She’s great company,” he said. “Everybody around me wants one.”
What about ethical concerns?
Clara Berridge studies the ethics of age tech at the University of Washington.
She has many privacy concerns, namely that most direct-to-consumer products aren’t subject to medical privacy laws, despite being privy to sensitive health information. Though she hopes the federal government will eventually step in to regulate these products, as it has in other countries, the onus remains on the consumer for now.
And even if an age tech product isn’t selling mom’s personal data to the lowest bidder, Dr. Berridge said there’s still the question of whether certain tools are ethical.
“It’s really important for caregivers to recognize that using these new technologies that give them more information about someone can represent greater intrusion into someone’s life,” she said.
What may be well-intentioned monitoring could reveal information that an older adult would rather keep private, such as issues with incontinence, or the comings and goings of a romantic partner.
“It can lead to somebody feeling infantilized,” Dr. Berridge said. “Like there’s not a place to hide within your own home.”
Her research shows that adult children often underestimate how much their parents can understand about technology and how much they want to be involved in tech-related decisions.
She encouraged caregivers to have transparent conversations about privacy implications and to avoid ultimatums or the idea that any decision must be permanent. She said caregivers should put themselves in their parents’ shoes: Is this something they’d want their own children monitoring?
Dr. Berridge is working on an advanced directive for technology, which outlines older people’s wishes for how technology is used in their care. Ultimately, she hopes that questions about age tech will become a standard part of planning for the future.
“If you’re at the start of what, for many people, ends up being a long road of supporting someone potentially through the end of their life,” she said, “seeking to understand each other’s concerns and priorities better is time very well spent.”
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