Connect with us

Health

Alzheimer's disease could be prevented by antiviral drug already on market

Published

on

Alzheimer's disease could be prevented by antiviral drug already on market

An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers.

NRTIs (nucleoside reverse transcriptase inhibitors) are antivirals that are approved to treat HIV infection, but scientists from UVA Health at the University of Virginia found that patients taking them were less likely to develop the common form of dementia.

There was a roughly 10% annual reduction in the risk of developing Alzheimer’s disease in people taking NRTIs for every year of use of these drugs, according to lead study author Dr. Jayakrishna Ambati, M.D., professor of ophthalmology at UVA, who spoke to Fox News Digital about the finding.

ALZHEIMER’S BRAIN TREATMENT SHOWS PROMISING RESULTS IN NEW STUDY

After coming across another mechanism that could potentially prevent Alzheimer’s, the researchers analyzed 24 years of health insurance data, including 270,000 patients.

Advertisement

The Alzheimer’s risk reduction among patients taking NRTIs was “significant and substantial,” the researchers wrote in the findings, which were published in the journal Alzheimer’s & Dementia.

An existing drug for HIV could double as a preventative therapy for Alzheimer’s disease, according to researchers. (iStock)

Now, the UVA team is calling for clinical trials of NRTIs to gauge their use for treating Alzheimer’s.

Approximately 10 million people worldwide are diagnosed with the common dementia each year.

ALZHEIMER’S RATES HAVE REACHED STAGGERING NUMBER AS EXPERTS CALL FOR CHANGE

Advertisement

“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” Ambati told Fox News Digital. 

In addition to keeping the HIV virus from replicating, NRTIs also prevent the activation of inflammasomes, proteins that are involved in the development of Alzheimer’s.

“This level of protection could translate into 60,000 fewer cases of Alzheimer’s disease every year in our country, and up to one million fewer cases every year around the world,” the lead study author told Fox News Digital. (iStock)

“We had previously shown that NRTIs blocked the inflammasome, so it wasn’t altogether surprising that people taking NRTIs might be protecting against this disease,” Ambati noted. 

“However, the degree of protection against Alzheimer’s was quite surprising.”

Advertisement

“It is very possible that this drug may be useful in Alzheimer’s prevention.”

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, was not involved in the study but commented on the findings.

“Inflammasomes are intracellular protein complexes that trigger the release of inflammatory cytokines,” he told Fox News Digital. “HIV uses these inflammasomes to fight the immune system.”

Repurposing existing drugs can offer a “promising pathway,” according to an expert from the Alzheimer’s Association. (iStock)

“These chemicals are likely responsible for making Alzheimer’s worse, or for accelerating the process of cognitive decline based on neuro-inflammation.”

Advertisement

Rebecca Edelmeyer, Ph.D., vice president of Scientific Engagement at the Alzheimer’s Association in Chicago, also reviewed the study’s findings, which she called “interesting.”

‘I’M A NEUROLOGIST — HERE’S WHY DEMENTIA IS RISING AND HOW TO REDUCE YOUR RISK’

“Further research and specifically designed clinical trials are needed to fully understand the potential future use of NRTIs to reduce the risk of Alzheimer’s, but the study highlights the potential role drug repurposing can play in advancing new Alzheimer’s treatments,” she told Fox News Digital. 

Repurposing existing drugs can offer a “promising pathway,” according to Edelmayer. As existing drugs’ safety and side effects are often already known, the studies can be quicker and less expensive than with new treatments, she added.  

Potential limitations and next steps

The research team acknowledged some limitations of the study.

Advertisement

“Like all retrospective health insurance database studies, the findings of our study are an association between this class of drugs and the development of Alzheimer’s disease,” Ambati told Fox News Digital.

“They don’t necessarily provide a cause and effect — however, the fact that we found this link in multiple databases increases confidence in this result.”

Siegel agreed that the new study is observational, but noted that it takes place over many years.

“It also shows that only this particular HIV drug — inflammasome — dramatically decreases the risk of Alzheimer’s, not the other HIV drugs, including protease inhibitors,” the doctor said.

Advertisement

Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association.  (iStock)

“I think this is convincing preliminary evidence that warrants further study,” Siegel added. “It is very possible that this drug may be useful in Alzheimer’s prevention, given the increasing evidence implicating immune dysregulation and inflammation as causes of AD.”

Looking ahead, the researchers have developed a new drug called K9. Like NRTIs, the novel medication blocks inflammasomes, but is “safer and more effective,” according to Ambati.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

“The fact that the new drug reversed memory loss and improved spatial learning in mice further increases confidence in our findings,” he told Fox News Digital.

Advertisement

The UVA team now plans to test K9 in clinical trials for Azheimer’s.

The study author cautioned that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial.  (iStock)

Ambati noted that people should not take NRTIs for Alzheimer’s prevention unless they are in the context of a clinical trial. 

“If interested, they should be on the lookout for such trials for themselves or loved ones who may be affected,” he advised.

For more Health articles, visit www.foxnews.com/health

Advertisement

Nearly seven million people in the U.S. are currently living with Alzheimer’s, and the number is expected to reach 13 million by 2050, according to the Alzheimer’s Association. 

The UVA study was funded in part by the UVA Strategic Investment Fund and the National Institutes of Health.

Advertisement

Health

Seniors over 80 who eat specific diet may be less likely to reach 100 years old

Published

on

Seniors over 80 who eat specific diet may be less likely to reach 100 years old

NEWYou can now listen to Fox News articles!

Older adults who avoid meat in their golden years may be less likely to reach age 100 than their meat-eating counterparts, new research suggests.

Researchers tracked more than 5,000 adults aged 80 or older who were enrolled in the Chinese Longitudinal Healthy Longevity Survey.

Between 1998 and 2018, data showed that those who did not eat meat were less likely to reach their 100th birthday than those who consumed animal products regularly.

The findings seem to contradict previous studies that have linked vegetarianism and plant-based diets to lower risks of heart disease, stroke, diabetes and obesity.

Advertisement

Most evidence supporting the benefits of plant-based diets comes from studies tracking younger populations, the researchers noted. 

The findings contrast with previous research praising plant-based diets for their positive influence on heart health. (iStock)

The study, published in The American Journal of Clinical Nutrition, points to losses in muscle mass and bone density with age, shifts that can increase the risk of malnutrition and frailty in the “oldest old.”

As people enter their 80s and 90s, the nutritional priority often shifts from preventing long-term chronic diseases to maintaining day-to-day physical function, experts say.

HOW MUCH RED MEAT IS TOO MUCH? EXPERTS WEIGH IN ON FOOD PYRAMID UPDATES

Advertisement

“The headline ‘vegetarians over 80 less likely to reach 100’ sounds surprising, because it contrasts with decades of data linking plant‑forward diets to lower chronic disease risk earlier in life,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital. 

“However, once you see that this research is limited to adults over the age of 80 who are also underweight — and that this link disappears with the consumption of eggs, dairy and fish — the results are less surprising.”

While diets earlier in life tend to emphasize avoiding long-term disease, older age necessitates nutrients and weight maintenance, experts say. (iStock)

In those over 80, restricting animal proteins may be less likely to promote longevity, according to Palinski-Wade, who was not involved in the study.

Eliminating all animal protein — particularly in a population that may already experience diminished hunger cues — can make it more difficult to meet adequate protein needs, potentially increasing the risk of nutrient deficiencies, the nutritionist said.

Advertisement

ALZHEIMER’S SYMPTOMS COULD BE PREDICTED YEARS IN ADVANCE THROUGH ONE SIMPLE TEST

In addition to a higher tendency to be underweight, older populations also face a greater risk of bone fractures due to lower calcium and protein intake.

Potential limitations

The lower rate of vegetarians reaching 100 was only observed in participants identified as underweight, the researchers noted. No such association was found in people who maintained a healthy weight.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Because being underweight is already linked to greater frailty and mortality risk, the researchers noted that body weight may partly explain the findings, making it difficult to determine whether diet itself played a direct role.

Advertisement

Those incorporating animal-sourced products other than meat were just as likely to live to 100. (iStock)

Additionally, the shortened lifespans were not found in people who continued to eat non-meat animal products, such as fish, dairy and eggs. 

Older adults with these more flexible diets were just as likely to live to 100 as those eating meat, as these foods may provide the nutrients necessary for maintaining muscle and bone health, the researchers noted.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

“This is an observational study, so it can only show associations, and does not prove that avoiding meat directly reduces the odds of reaching 100,” Palinski-Wade added.

Advertisement

CLICK HERE FOR MORE HEALTH STORIES

The researchers suggested that including small amounts of animal-sourced foods could help older seniors maintain essential nutrients and avoid the muscle loss often seen in those who stick strictly to plants.

Eliminating all animal protein — particularly in a population that may already experience diminished hunger cues — can make it more difficult to meet adequate protein needs, potentially increasing the risk of nutrient deficiencies. (iStock)

Palinski-Wade offered some guidance for those looking to optimize nutrition later in life.

“For adults in their 80s and beyond, especially anyone losing weight or muscle, the priority should be maintaining a healthy weight and meeting protein and micronutrient needs — even if that means adding or increasing fish, eggs, dairy or well‑planned, fortified plant proteins and supplements.”

Advertisement

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

Strict vegan or very low‑protein patterns at that age should be carefully monitored by a dietitian or clinician, with attention to B12, vitamin D, calcium and total protein, according to Palinski-Wade.

“Younger and healthier adults can still confidently use plant‑forward or vegetarian patterns to lower long‑term chronic disease risk,” she added.

Related Article

Scientists reveal the one practice that could prevent dementia as you age
Continue Reading

Health

The Latest on Natural Ozempic Alternatives: How To Lose Weight Without GLP-1s

Published

on

The Latest on Natural Ozempic Alternatives: How To Lose Weight Without GLP-1s


Advertisement




Natural Ozempic Alternatives That Boost GLP-1 for Weight Loss | Woman’s World




















Advertisement





Advertisement


Use left and right arrow keys to navigate between menu items.


Use escape to exit the menu.

Advertisement

Continue Reading

Health

Punch the monkey, viral star, experiences dramatic breakthrough among zoo mates

Published

on

Punch the monkey, viral star, experiences dramatic breakthrough among zoo mates

NEWYou can now listen to Fox News articles!

In a dramatic turn of events that’s captured the attention of animal lovers worldwide, Punch — the young macaque at a zoo in Japan famous for his inseparable bond with a stuffed orangutan toy — has reached a major milestone in his journey toward social integration.

On Thursday, visitors and staff at the Ichikawa Zoological and Botanical Garden witnessed a breakthrough: Punch was seen cuddling with and hitching a ride on the back of a fellow macaque.

Punch’s story began with hardship. He was abandoned by his mother shortly after his birth in July 2025 — and to ensure his survival, zookeepers stepped in to hand-rear the primate.

On Jan. 19, 2026, the zoo officially began the process of reintegrating Punch into the “monkey mountain” enclosure.

Advertisement

The transition was initially fraught with tension. 

Punch’s story began with hardship when he was abandoned by his mother shortly after he was born. To help him, zookeepers gave him a stuffed toy that he began dragging around everywhere he went.  (David Mareuil/Anadolu via Getty Images)

As a hand-reared infant, Punch was bullied and ignored by the established group of monkeys.

He was often seen huddled alone with his orange plush companion while the rest of the troop interacted.

BABY MONKEY CARRIES FAITHFUL STUFFED COMPANION EVERYWHERE HE GOES, DRAWING CROWDS AT ZOO

Advertisement

In an official statement released Feb. 27, the Ichikawa Zoological and Botanical Garden detailed the meticulous care behind this process.

Previous viral videos showed Punch bullied by the rest of the troop, running to his plushy toy for comfort. (David Mareuil/Anadolu via Getty Images)

“From an animal welfare perspective, our primary goal is to reintegrate Punch with the troop,” the zoo said. 

CLICK HERE FOR MORE LIFESTYLE STORIES

The strategy involved nursing Punch within the enclosure, so the troop could recognize him as one of their own, and pairing him with a gentle young female macaque prior to his full release to build his confidence.

Advertisement

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

The latest footage, captured by X user @tate_gf, suggested the zoo’s patience is paying off. 

The video shows Punch seeking physical contact not from his toy, but from another monkey — eventually climbing onto its back for a vital social behavior for young macaques: the “piggyback ride.”

The zoo’s strategy appears to be paying off: Punch, shown at far left, was recently seen riding on the back of a fellow macaque. (David Mareuil/Anadolu via Getty Images)

While Punch still carries his stuffed toy for comfort during moments of perceived danger, the zoo remains optimistic about his progress. 

Advertisement

The organization cited the successful 2009 case of Otome, another hand-reared macaque who eventually outgrew her stuffed toy, successfully integrated — and went on to raise four offspring of her own.

The zoo has had crowds coming to see Punch, with hundreds of people lining up to get inside to see the young star, according to reports. 

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

“I’m hoping Punch has a good life like everybody else does, and think he’s a cute little guy,” one person commented online. 

Advertisement

“Such a precious baby,” another person wrote. 

Related Article

Orphaned baby monkey finds comfort in stuffed animal after being abandoned by mother at birth
Continue Reading
Advertisement

Trending