Health
Aging slowdown could be surprise benefit of existing medication, research shows
A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging.
The immune-suppressing medication rapamycin, also known as sirolimus, is being used off-label as a means of extending longevity.
“By targeting a key pathway (mTOR) in cells, this drug has been shown to extend lifespan in animals and could be beneficial to prevent age-related diseases in humans,” Dr. Andrea B. Maier — a professor in healthy aging and dementia research at the Director of the Centre for Healthy Longevity at the National University of Singapore — told Fox News Digital.
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Maier was co-author of a recent review study that explored how rapamycin affected healthy humans.
A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging. (iStock)
The review, which was published in the journal Lancet Healthy Longevity, found that the medication improved the effects of aging on the skin.
“Rapamycin and its derivatives improve the immune and cardiovascular function of healthy individuals or individuals with aging-related diseases,” Maier said in an email.
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Daniel Tawfik, a molecular biologist and co-founder of Healthspan, a digital medical clinic that focuses on anti-aging and longevity-promoting therapies, said his team uses rapamycin to help slow down the rate of aging.
“We view this through the lens of reducing the accumulation of damaged senescent cells,” Tawfik, who is based in Santa Monica, California, told Fox News Digital.
The immune-suppressing medication rapamycin is being used off-label as a means of extending longevity. (iStock)
Senescent cells are cells that no longer function properly, but linger in the body and can contribute to tissue deterioration and inflammation, the expert said.
“By lowering the rate at which healthy cells transform into senescent cells, rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health as we age,” he added.
Off-label use
In the U.S., rapamycin is approved by the Food and Drug Administration (FDA) for its immune-suppressing properties in patients with kidney transplants and certain cancers.
It is not approved for use as an age-defying drug.
“Sirolimus (rapamycin) has not been evaluated by the FDA for safety and effectiveness as an anti-aging treatment,” a press officer for the FDA confirmed to Fox News Digital.
“Rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health.”
Despite this, rapamycin is being used “off-label” for anti-aging purposes, according to Elaena Quattrocchi, a registered pharmacist and an associate professor at Long Island University College of Pharmacy in Brooklyn, New York.
“Off-label means the FDA has not approved the drug for this use,” she told Fox News Digital.
Rapamycin, which is also known as Sirolimus, is being used “off-label” for anti-aging purposes, experts say. (iStock)
When prescribing a drug for off-label use, the provider must explain to the patient that the medication has not been approved for the indication for which they are prescribing it, Quattrocchi noted.
“People taking this medication must discuss with their primary care provider and pharmacist about the potential side effects and drug interactions,” she said.
Benefits of rapamycin
Tawfik’s company currently treats more than 3,500 patients with rapamycin, he told Fox News Digital.
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His team has seen numerous benefits of its off-label anti-aging use, he said, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity.
“Under proper medical supervision, many of our patients experience a marked reduction in inflammation and improvement in conditions related to autoimmunity,” Tawfik said.
When prescribing a drug for off-label use, the provider should explain to the patient that the medication has not been approved for the indication for which they are prescribing it, according to experts. (iStock)
“For example, patients with osteoarthritis often report significant relief from joint pain after starting rapamycin.”
The expert also noted that certain biomarkers linked to healthspan and longevity — such as reduced inflammation markers and enhanced metabolic health — were seen in the bloodwork of the patients using rapamycin.
Screening and safety
Patients need a prescription for rapamycin, experts told Fox News Digital.
Individuals are screened to determine whether they are candidates for the treatment. If it is prescribed, patients are monitored carefully when taking the drug.
“It is essential that rapamycin use is overseen by a physician.”
“It is essential that rapamycin use is overseen by a physician to ensure that dosing is effective yet safe, as high doses can lead to unwanted immunosuppression,” Tawfik warned.
Maier echoed that rapamycin and its derivatives are not for self-medication use.
“An important step is to first measure the patient’s biological age and investigate why the pace of aging might be faster,” she told Fox News Digital.
“Then a tailored approach to match the measures with interventions at need is required.”
Quattrocchi and Tawfik both emphasized the importance of working with an accredited pharmacy that sources the drug directly from a reputable manufacturer.
Rapamycin and its derivatives are not for self-medication use, experts cautioned. (iStock)
Rapamycin is not recommended for immunocompromised individuals or those taking immunosuppressant medication, Tawfik cautioned.
It is not typically used in younger adults, he added, since starting this regimen at such an early age is unnecessary.
Calls for more research
There are limited studies on the effects of rapamycin on humans and organ systems, Maier noted.
In researching studies of the drug, Maier’s research team found that adverse reactions in healthy individuals were classified “as mild or moderate and were reversible after the discontinuation of treatment.”
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However, the study authors stated, “there were increased numbers of infections and increases in total cholesterol, LDL cholesterol and triglycerides in individuals with aging-related diseases.”
“Future studies should assess the remaining unexamined systems and test the effects of long-term exposure to rapamycin and its derivatives.”
Experts have reported numerous anti-aging benefits of rapamycin, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity. (iStock)
The majority of studies exploring rapamycin’s effects on aging have been conducted on mice and other animals as well as experimental models, researchers told Fox News Digital.
“The reason scientists are so interested in rapamycin is that in every species that’s been studied to date – yeast, worms, flies, mice – when they are given rapamycin, healthspan and lifespan are extended,” Tawfik noted.
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“No other intervention has that degree of validation.”
Quattrocchi agreed that further research is needed into the drug’s proper dosing, adverse effects, and potential anti-aging benefits in healthy individuals and those with medical conditions.
Health
Dr Oz links obesity to chronic disease surge, says GLP-1s can ‘jumpstart’ better health
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Washington, DC – GLP-1 weight-loss drugs have become a prevalent part of American healthcare, and the current administration is getting behind the movement.
In an exclusive interview with Fox News Digital at the Great American State Fair in the nation’s capital on July 6, CMS Administrator Dr. Mehmet Oz voiced his support for the use of GLP-1 (glucagon-like peptide-1) medications, such as Ozempic, for appropriate uses.
“I’m a fan of GLP-1 drugs when used correctly,” he said. “They do help people who are overweight lose weight quite effectively. They’re not a replacement for diet and exercise, but they might jumpstart the system so it’s easier for you to use healthier tactics.”
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This is especially helpful for those who may have trouble moving due to joint pain or are experiencing internal dysfunction, Oz said.
Certain GLP-1 drugs are covered by Medicare for overweight candidates with certain conditions, such as high blood pressure and diabetes, and Oz projected the benefits will continue to benefit taxpayers.
Dr. Mehmet Oz is pictured in Washington, D.C., at the Great American State Fair, where he spoke about federal health policy. (Angelica Stabile/Fox News Digital)
“We believe these are so effective in reducing conditions like high blood pressure and diabetes that they’ll actually save money for the federal taxpayer, because [they’re] going to make you healthy enough that you don’t have to consume health services,” Oz said.
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“We think about 70% of all the money we spend on healthcare is caused by chronic conditions, and obesity is the No. 1 driver of all that, so it’s a smart decision.”
Oz recently announced the launch of the Medicare GLP-1 Bridge program, which will allow more seniors to access GLP-1 drugs for only $50 a month if they meet qualifying health criteria and receive prior authorization from a doctor.
The doctor expressed support for broadening affordable access to GLP-1 medications for Americans. (iStock)
“There are a lot of overweight people who don’t have high blood pressure, diabetes or other conditions, so they don’t get access to the drug normally,” he said. “We want them to have the ability to use it as well.”
Although these access shifts could boost Americans’ overall health — and in some cases could be lifesaving — Oz noted that there is “no silver bullet” when it comes to these medications.
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“I love the fact that the innovation that’s coming out of pharmaceutical companies is allowing us to save lives and make lives better,” he said. “But the real secret to longevity is eating right, exercising, sleeping, dealing with the stress of your life, finding some purpose in your existence [and] realizing you have agency over the future.”
“These are things that your mom would have told you [and that] you don’t need a doctor to be emphasizing.”
Medicating appropriately, combined with eating right, exercising and staying connected with others, can help make health goals attainable, the doctor said. (iStock)
While GLP-1s may not be a fix-all, combining these medications with foundational health practices “makes a lot of sense,” Oz said.
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“I don’t want people being fat-shamed … I don’t want you feeling guilty that you’re gaining weight even though everyone else around you seems to have figured it out,” he said. “It’s not that simple — our set points for hunger are different. We have different things going on in our lives.”
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“But if you realize how precious you are — the temple of the soul is so valuable. It’s the greatest gift your parents ever gave you, and you take advantage of every tool out there to make it work … which includes using medications when appropriate. That, to me, is MAHA.”
Health
Deadly Legionnaires’ disease outbreak sparks concern in major US city: Know the symptoms
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Amid warnings of a Legionnaires’ disease outbreak on Manhattan’s Upper East Side, health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups.
New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms.
As of July 6, the New York City Health Department had confirmed 23 cases and 17 hospitalizations associated with the respiratory infection. No deaths have been reported.
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Officials are investigating contaminated cooling towers as the likely source. They have emphasized that the illness is not spread person-to-person and is not linked to the city’s drinking water.
Health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups. (iStock)
“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early,” said NYC Health Commissioner Dr. Alister Martin in a press release. “New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin.”
What is Legionnaires’?
Legionnaires’ disease is a type of pneumonia caused by Legionella bacteria.
The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC.
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That can include shower heads, sink faucets, hot tubs, water features/fountains, plumbing systems and other water systems.
When people swallow or breathe in droplets of water that contain Legionella, they can potentially become ill.
Although human transmission is possible in rare cases, the disease is not typically transmitted among people, per the Centers for Disease Control and Prevention.
Symptoms of infection
Infections can lead to severe pneumonia in older people and those with compromised immune systems, according to Dr. Andrew Handel, a pediatric infectious diseases expert at Stony Brook Children’s Hospital on Long Island, New York.
Symptoms of Legionnaires’ disease usually show up between two and 14 days after exposure.
New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms. (iStock)
“Legionella infections cause symptoms that are similar to other forms of pneumonia — fever, coughing, difficulty breathing, shortness of breath and chest pain,” Handel previously told Fox News Digital.
“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early.”
The signs are similar to other types of pneumonia, and include the following:
- Cough
- Fever
- Shortness of breath
- Muscle aches and headaches
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Some patients may also experience nausea, diarrhea and confusion, the CDC noted.
Diagnosis, treatment and prevention
A medical professional can diagnose the infection with laboratory tests and chest X-rays.
The condition is typically treated with antibiotics. In cases of severe infection, hospitalization may be required for breathing support and IV hydration.
Around 10% of people who contract Legionnaires’ disease will die from those complications — and the mortality risk rises to 25% for those who get Legionnaires’ while staying in a healthcare facility, according to the CDC.
The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC. (iStock)
“Treatment needs to be early and aggressive,” Dr. Nathan Goodyear, an Arizona-based integrative medicine expert, previously told Fox News Digital. “Legionella infection is an intracellular infection that requires antibiotic treatment.”
Antibiotics that are appropriate for Legionella infection include Levofloxacin and Azithromycin.
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“Therapy can be prescribed orally in healthy individuals… but intravenous antibiotics often prove to be the initial option for treatment secondary to the pathogenicity of the disease,” Goodyear said.
Currently, there are no vaccines for Legionnaires’ disease.
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The best strategy to prevent infection is to reduce the growth and spread of the Legionella bacteria. The CDC recommends that building owners and managers use a water management program to reduce the risk.
“New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin,” city officials stated. (iStock)
To prevent serious illness from Legionnaires’, Goodyear recommends that all smokers kick the habit, and also emphasizes the need to “aggressively support” chronic pulmonary disease.
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“Increasing immune support (vitamin D3, vitamin C, Zinc) is required to counter the immune dysfunction associated with advancing age.”
Obesity is another foundational risk factor for all chronic inflammatory diseases, the doctor added.
Health
Katie Couric couldn’t remember the year or the president during frightening brain episode
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Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27.
In a post on Substack titled “The Day I’ll Never Remember,” she detailed a sudden episode that left her unable to recall the current month, year and president.
“I thought it was 2024. And I believed Joe Biden was president,” she wrote.
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The event occurred while Couric was attending the Aspen Ideas Festival in Colorado, during which she participated in two public panels — one on AI and one on journalism — both of which she cannot remember at all.
“I have no idea what we talked about, or of what occurred when the panels ended,” she said.
Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27. (Getty Images)
John Molner — Couric’s husband, who was in attendance at the festival and the two panels — also shared his account.
After the event, someone told Molner that Katie wasn’t feeling well. When he reached her, an EMT and a doctor were tending to her. “I could tell something was off,” he wrote. “It could have been altitude sickness, but Katie was definitely not all there.”
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At the hospital, when Couric struggled to recall the year, the president and her grandchildren’s names, doctors began checking for a stroke.
An MRI revealed no signs of stroke, which was a relief, but “Katie’s ‘fog’ became a lot more apparent,” Molner wrote.
John Molner, Couric’s husband, who was in attendance at the festival and the two panels, also shared his account. (Getty Images)
“She repeatedly asked me the same questions: ‘What was I doing before we got to the hospital?’ ‘Why am I at the hospital?’”
Couric was ultimately diagnosed with transient global amnesia, a sudden, temporary episode of memory loss that prevents a person from forming new memories and may also erase some recent memories, according to Mayo Clinic.
“The cause seems to be as mysterious as the brain itself.”
It is not caused by a stroke, seizure or head injury, and it usually resolves completely within 24 hours.
“[It’s] just a very weird neural episode that’s pretty uncommon and, at least in most cases, is a ‘one and done’ experience,” Molner said.
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Couric said she finally began feeling “like herself” again around 9 p.m. and went to sleep at 2 a.m.
As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.”
As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.” (Getty Images)
Data shows that approximately three to eight people per 100,000 will have an episode of transient global amnesia, with people 50 years of age and older at higher risk.
The specific cause of TGA is not known, but some experts believe it stems from a “temporary dysfunction in the brain’s hippocampus — the area responsible for creating new memories,” Couric shared.
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“Doctors believe this is driven by brief interruptions in blood or oxygen flow, or microscopic spasm in the blood vessels.”
Episodes could potentially be triggered by intense physical exertion, emotional distress, extreme temperature changes or migraines, experts say.
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Approximately 15% of patients will have a recurrence 10 years later.
“Why did this happen to me? Was the altitude an issue? Was I dehydrated? Tired? Stressed? The literature doesn’t seem to indicate that these are contributing factors, but the cause seems to be as mysterious as the brain itself,” Couric wrote.
Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise. (iStock)
“All I know is that those hours will be forever lost. Someone described it as my brain failing to hit the ‘record button.’”
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“While this was a freaky occurrence, it could have been much more serious. So ultimately, I’m relieved — even though several hours of a Saturday in June will always be missing for me.”
Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise.
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