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The Genius New Way to Lower Cholesterol Has Nothing to Do With Diet or Exercise

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The Genius New Way to Lower Cholesterol Has Nothing to Do With Diet or Exercise

  • Scientists are using CRISPR-Cas9 technology to permanently turn off two iver genes, PCSK9 and angiopoietin-like protein 3. Both are common drug targets for lowering LDL cholesterol levels.
  • Small clinical trials show promising results with creating a ‘one and done’ treatment. Turning off the PCSK9 gene lowered cholesterol levels by 62 percent. Turning off angiopoietin-like protein 3 lowered cholesterol by nearly 50 percent.
  • Heart doctors find “incredible potential” in gene therapy and a future where people may not need daily cholesterol-lowering pills.

GETTING A DIAGNOSIS of high cholesterol is not fun. It requires a revamp of lifestyle basics like how you eat and making sure you’re taking medications on time. Not to mention the never-ending worry of what would happen if cholesterol levels don’t improve. Because no one wants a future filled with potential stroke and heart attacks.

Cue this radical, ingenious method that sounds like something out of The Twilight Zone. Scientists have found a way to permanently stop cholesterol from ever building up in your body. All it requires is a little snip of your genes.

Here’s what you need to know.

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Turning off Two Cholesterol Genes

BEFORE YOU WRITE this off as mad science, know there is some legitimacy to a gene-editing approach. Scientists have been using a gene editing technology called CRISPR-Cas 9 for years. The tool acts as a molecular scissor where it “cuts” a certain sequence of DNA bases. It then takes advantages of the DNA repair system to replace the existing segment with a customized DNA sequence that could fix the mutation or even turn the gene off. In other words, CRISPR lets you rewrite the genetic code. CRISPR is already in use for treatments of genetic disorders such as sickle cell anemia.

Two separate studies found gene-editing a promising approach to tackling high cholesterol.

In May 2026, The New England Journal of Medicine published the results of a small phase 1b study of a drug called VERVE-102. VERVE-102 works by editing the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene. People with overactive versions of the enzyme liver gene, PCSK9, tend to have a harder time clearing out LDL (“bad”) cholesterol in the blood. Meanwhile, people with defective versions of PCSK9 tend to have lower LDL levels, making PCSK9 a favorable target for high cholesterol.

The new drug works by making a small rewrite in the PCSK9 genetic code. The new instructions stops the gene from ever producing the PCSK9 enzyme.

Thirty-five people at risk for early heart disease or genetically have high cholesterol were given different doses of the drug to test if it was safe. There were no major side effects (the most common was a temporary increase in a separate liver enzyme, suggesting minor liver injury). Though the study was small, it did show that a single infusion of the highest dose lowered cholesterol levels by 62 percent.

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In November 2025, a separate group of scientists edited a separate gene called angiopoietin-like protein 3. This gene increases cholesterol levels by inhibiting enzymes used to break down fat. Their phase 1 clinical also published in the The New England Journal of Medicine used an experimental CRISPR-Cas9 tool called CTX310 to create a mutation to make the angiopoietin-like protein 3 lose function, thereby reducing LDL cholesterol, along with triglycerides (a type of fat in the body).

Within 2 weeks, people’s LDL cholesterol and triglyceride levels dropped and stayed low for at least 60 days. While the researchers originally planned to consider a 30 to 40 percent drop a success, CTX310 reduced LDL cholesterol and triglycerides by nearly 50 percent or more on average at the highest dose.

“This is a permanent change,” says Steven Nissen, MD, study co-author and chairman of the department of cardiovascular medicine at the Cleveland Clinic. “It’s a one and done treatment. That’s why it’s so exciting. It allows us to permanently fix a gene.”

Heart Doctors Find “Incredible Potential” With Gene-Editing

THE GENE-EDITING approach is already getting a lot of buzz in the medical community. “There is incredible potential with this,” says Yu-Ming Ni, MD, cardiologist and lipidologist at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center in Fountain Valley, CA. “It’s really quite amazing that you can permanently remove this as a risk factor for heart disease in one treatment.”

Cardiologist and Men’s Health advisory board member Christopher Kelly, MD, says this treatment is “approaching magic” for people with high cholesterol. “It’s definitely where the future of medicine is headed.” He adds that gene therapy is helpful in shifting away from taking daily pills.

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Both gene editing therapies will move on to a phase 2 clinical trial. That will be larger and involve more participants to better study the effectiveness of the treatment. Kelly is hopeful of promising results once the technique is reviewed and approved for use. “Once the technique is perfected, the side effects will probably be minimal, since specific genes are targeted in very precise ways.”

Still, even if everything continues to go well, don’t expect your doctor to recommend custom gene therapy yet. Because CRISPR-Cas9 changes your DNA, the US Food and Drug Administration recommends long-term safety monitoring. That’s usually 15 years for CRISPR-based treatments. In other words, there’s still a long way before you can simply roll up to your doctor’s office with high cholesterol and leave with altered genes and a lower cholesterol status.

“This won’t be a treatment for everybody but, for people who are difficult to treat, the concept of a one and done treatment is attractive,” Nissen says. Ni agrees. “This could be a major game-changer,” he says.

Headshot of Korin Miller

Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Men’s Health, Women’s Health, Self, Glamour, and more. She has a master’s degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.

Headshot of Jocelyn Solis-Moreira

Jocelyn Solis-Moreira, MS is the associate health & fitness for Men’s Health and has previously written for CNN, Scientific American, Popular Science, and National Geographic before joining the brand. When she’s not working, she’s doing circus arts or working towards the perfect pull-up.

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This unspectacular full-body exercise could be the secret to long-term fitness

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This unspectacular full-body exercise could be the secret to long-term fitness

Fitness, like anything else, is partial to trends, and at the moment, exercise is portrayed in extremes. “You’ve got to do HIIT training. You’ve got to run marathons. You’ve got to lift heavy.” The actual truth is much less snappy and attention-grabbing: fitness should be balanced and well-rounded. Slow and intentional is better than intense and sloppy.

There’s one functional exercise which is particularly good at challenging us in the ways we often forget, and most of us have never heard of it: the Turkish get-up.

But what is the Turkish get-up, and why is it so good for you?

What is functional movement?

Functional movement is any exercise which mimics and builds on the way we move in everyday life. Rather than aiming for aesthetic results or personal bests, the goal of functional exercise is to feel a little better all the time, in every movement you do, whether that be taking the stairs, lifting heavy boxes, or, if you’re a mum like me, bending down to pick a child up off the floor.

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Functional movement incorporates multiple muscle groups, or the entire body, to build strength in a way you’ll actually use, multiple times a day, without even really thinking about it – the best type of exercise. But functional movements aren’t all about building muscle – they also crucially improve coordination, joint stability, shoulder strength, balance, hip mobility, and, perhaps most importantly, core stability and strength.

Over on Strong Like Mum, functional exercise is the name of the game. If you or someone you know is postnatal and ready to start rebuilding core strength, we’ve just released week three of the Strong Like Mum core challenge – all you need is 15 minutes, for a stronger core in just 6 weeks.

Start from week one to start building the vital foundations needed to rehabilitate a strong core. Join the Strong Like Mum core challenge:

What is the Turkish get-up?

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See the step-by-step guide below for how to do a Turkish get-up.

The Turkish get-up is an incredibly beneficial, multi-step, multi-joint, full-body exercise targeting every major muscle, which has a simple goal: get from lying down on the floor to standing up, while holding a weight in one hand.

The whole movement is about being balanced, steady, and controlled. It takes an incredible amount of strength to move with intention, rather than trying to go as fast or hard as your body can take. High-impact exercise can be great, but slow and controlled movements can challenge your body in loads of ways, too.

Record breaker

In April of this year, strongman Mike Aidala broke the Guinness World Record for the heaviest Turkish get-up with a whopping 118.6kg

It’s ideal for hitting all the areas we often forget while we’re pushing for a heavier weight or racing to break a personal best. It’s about slow control, brain function, focus, and coordination.

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The Turkish get-up is also really easy to replicate if you have children, as it seems more like a fun mobility challenge than an exercise routine. Maybe you could call it a teddy bear get-up: rather than holding a weight, they’ve got to balance their teddy bear in their hand.

How to do a Turkish get-up

Here’s a rundown on how to do a Turkish get-up.

Video Player Placeholder

Why is the Turkish get-up so good?

There’s a growing interest in longevity and healthy ageing at the moment. People are starting to think about the long game and what’s going to help create strong foundations for future exercise, in the immediate short-term and into older age.

This is where Strong Like Mum comes in. If you’re postnatal and want to be able to do high-intensity exercise, lift heavy weights, and run marathons, that’s great! But in order to get there, we need to start in the right way. We need to build those strong foundations in order to have longevity with our health. If you want to be able to get the maximum benefit out of this exercise, you’re going to have to do it with the right technique, and that’s where the six-week core program will really help.

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For another great full-body workout, check out this video from Strong Like Mum:

If you do this exercise wrong, it can actually cause you all sorts of issues, like back pain or shoulder strain. You have to do it right, and doing it right comes with laying all the foundations that we learn over on Strong Like Mum.

For more evidence-based postnatal recovery advice, pelvic floor education and realistic fitness guidance for women navigating motherhood and midlife, subscribe to Strong Like Mum on YouTube.

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Business News: Stock and Share Market News, Economy and Finance News, Sensex, Nifty, Global Market, NSE, BSE Live IPO News – Moneycontrol.com

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Business News: Stock and Share Market News, Economy and Finance News, Sensex, Nifty, Global Market, NSE, BSE Live IPO News – Moneycontrol.com


Moneycontrol Pro Panorama | Glitter fades

In this edition of Moneycontrol Pro Panorama: India’s payment ecosystem must prioritise trust alongside scale, family-run companies face complex succession beyond conventional myths, Pakistan’s budget underscores military dominance over national economy, and more

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Les Mills, NZ Olympian and founder of global fitness brand, dies aged 91

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Les Mills, NZ Olympian and founder of global fitness brand, dies aged 91

Les Mills, the New Zealand Olympian who opened an Auckland gym in 1968 that grew into an international group fitness brand, has died aged 91, his family confirmed.

Mills, a four-time Olympic athlete and former Auckland mayor, and his wife, Colleen, founded the first Les Mills gym on Victoria Street in central Auckland after a sporting career in which he represented New Zealand in shot put and discus.

More than five decades later, Les Mills workouts are used by clubs around the world.

The business, now run by later generations of the Mills family, became internationally known for choreographed group-exercise classes set to music.

Mills’s son, Phillip, joined the business full-time in 1980, and his partner, Jackie, helped develop the music-driven group-fitness model that became central to its global expansion.

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Les Mills became an international fitness brand.  (Supplied: Les Mills)

Phillip Mills said in a statement that his father had achieved a great deal in his life, but the common thread was that he always wanted to help others.

“Dad was immensely strong, driven, and always cared deeply for the less advantaged,” he said.

He left a lasting impression on everyone he met, and his spirit lives on in gym workouts around the world, continuing to help people fall in love with fitness.

Les Mills was born Leslie Roy Mills in Auckland in 1934.

He competed at four Olympic Games from 1960 to 1972 and won five Commonwealth Games medals, including discus gold at the 1966 British Empire and Commonwealth Games in Kingston, Jamaica.

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Move into politics

He later moved into local politics and served as mayor of Auckland from 1990 to 1998.

Juliet Yates served on Auckland Council during his first term.

She told RNZ he brought others together.

“He was a very, very pleasant person to work with,” she said.

“He was really good at bringing people together and achieving things for the benefit of the city,”

she said.

“At the time, I think the achievements of the council he was mayor of were benefiting the whole of the city.”

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He also remained active in sport as a coach, helping guide New Zealand discus thrower Beatrice Faumuina to the world title in 1997 and Commonwealth Games gold in 1998.

Les Mills was appointed a Member of the Order of the British Empire in 1973 for services to sport and a Companion of the New Zealand Order of Merit in 2002 for services to local government and sport.

Reuters

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