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Exercise improves fitness for kids, adults with FA, study finds

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Exercise improves fitness for kids, adults with FA, study finds

A combination of exercise and an energy-boosting supplement may improve physical fitness in children and adults with Friedreich’s ataxia (FA), although the added benefit of the supplement over exercise alone remains unclear, according to results from a clinical trial.

Those who participated in a 12-week program combining aerobic and strength training with nicotinamide riboside supplementation saw a significant increase in cardiopulmonary fitness, the body’s ability to supply oxygen to muscles during physical activity, compared with trial participants who did not exercise and received a placebo.

However, researchers found no significant difference between the combination group and participants who followed the same exercise program without supplementation, indicating the study did not show a clear added benefit of the supplement beyond exercise alone.

“The combination of nicotinamide riboside plus exercise for 12 weeks was safe and increased cardiopulmonary fitness in children and adults with Friedreich’s ataxia,” the researchers wrote. “Longer studies are needed to establish whether adding nicotinamide riboside to exercise could be considered as part of a long-term, comprehensive treatment approach.”

The study, “Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich’s ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial,” was published in The Lancet Neurology.

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Fatigue, safety worries limit participation

FA is caused by mutations that reduce the production of frataxin, a protein needed for cells to generate energy. When frataxin levels are too low, cells in energy-demanding tissues, such as the nervous system, heart, and muscles, gradually deteriorate, leading to FA symptoms including impaired coordination, fatigue, muscle weakness, and difficulty walking. People with FA also have markedly reduced cardiopulmonary fitness.

Although current guidelines recommend exercise to help manage symptoms, clinical evidence in people with FA is limited, and participation is often low due to barriers such as fatigue and safety concerns, the researchers noted.

Studies in other conditions have shown that supplementation with NAD+ precursors — compounds that raise levels of NAD+, a molecule involved in cellular energy production — can improve muscle function. These findings have raised the possibility that increasing NAD+ might complement or enhance the benefits of exercise alone. However, there’s limited research on whether these therapies might improve FA patients’ ability to exercise.

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The team of researchers in the U.S. conducted a 12-week clinical trial (NCT04192136) involving 66 people with FA enrolled at a single center in Philadelphia from September 2020 to April 2025.

Half of the participants were children, ages 10 to 17, and half were adults, ages 18 and older. Most (56%) were male. The overall mean age was 20.3. At the start of the study, participants generally had lower-than-average muscle mass and slightly higher body fat compared with reference values for the general population.

Participants were randomly assigned to one of four groups: 17 received a placebo and served as controls, 17 received only the NAD+ precursor nicotinamide riboside, 16 followed a structured exercise program and were given a placebo, and 16 followed the exercise program in addition to supplementation with nicotinamide riboside. All participants completed the study.

The exercise program consisted of three aerobic and two resistance training sessions per week, performed at home under remote supervision. Participants took nicotinamide riboside or placebo orally each day using weight-based dosing: one capsule (300 mg) for patients weighing 24-48 kg (about 53-110 lbs) and three capsules (900 mg) for patients weighing more than 72 kg (about 159 lbs). The study’s main goal was to assess changes in peak oxygen uptake (VO₂), a key measure of cardiopulmonary fitness.

At the end of the 12-week program, participants who received both exercise and nicotinamide riboside showed the greatest improvements in cardiopulmonary fitness. Peak VO₂ increased by 13.2% in the combination group, compared with a 3.9% decline in the control group.

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VO₂ rose by 9.5% with exercise alone and 5% with nicotinamide riboside alone, but those changes were not statistically significant compared with controls.

The combination was not significantly more effective than exercise alone, indicating no clear added benefit from the supplement.

Some secondary measures improved. Compared with controls, the combination group reached higher maximum workloads during exercise, and oxygen pulse — a measure of how efficiently the body uses oxygen — improved in both the combination and exercise-only groups. Participants in the combination group also reported spending more time in physical activity and leisure exercise.

The interventions were generally safe and well-tolerated. No serious adverse events were reported, and all side effects were mild or moderate. The most common ones were skin problems (53%), gastrointestinal symptoms (45%), upper respiratory infections (35%), and falls (20%).

Falls, a known barrier to exercise in FA, occurred at similar rates across all groups, and no increase in heart-related or other adverse events was seen in participants assigned to exercise.

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In an accompanying commentary, “Targeting exercise, energy, or both in Friedreich’s ataxia,” published in The Lancet Neurology, two researchers in Germany highlighted the study’s implications.

The trial’s findings extend existing clinical evidence on the benefits of exercise in FA by using an objective measure of fitness, such as peak VO₂, and by demonstrating that a home-based intervention is feasible, they wrote. Further studies “are needed to determine durability and clinical significance of fitness gains and to clarify any incremental contribution of nicotinamide riboside beyond structured exercise,” they said.

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Fitness

I’m A Longevity Doctor—These Are The 6 Types Of Exercise Every Woman Should Be Doing For Healthy Ageing

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I’m A Longevity Doctor—These Are The 6 Types Of Exercise Every Woman Should Be Doing For Healthy Ageing

Scratch the surface, and you might think women have the upper hand when it comes to longevity. According to data from the Office for National Statistics, here in the UK, we live an average of 3.9 years longer than men.

Look a little closer, however, and there’s a catch. Thanks to a longstanding lack of investment in women’s health research, our underrepresentation in clinical trials and fewer treatment options designed for our bodies, we spend 25% more of our lives in ill health than men.

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Regular Exercise, Key To Wellness, Long Life – Fitness Expert

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Regular Exercise, Key To Wellness, Long Life – Fitness Expert

A fitness expert and chairman of Gategold Limited, Sir Goodluck Obi, has proffered solutions to rampant cases of sudden deaths of some high profile Nigerians in public places. Obi blamed the incidents on lack of awareness on regular health checks, lack of exercise and lifestyle issues.

Obi told journalists that, ”I became a fitness buff when I took ill some years ago and I went to the USA for treatment.

”The doctor carried out thorough checks and concluded that I should go and do exercise for some time and comeback.

”I complied. After I returned to the doctor, ççhe said I should intensity the exercise for four days and come back to see him. I repeated this routine.

”Finally, he gave me a clean bill of health without administering any treatment. That was what opened my eyes and gave birth to the vision of promoting fitness as a key regimen for long life and wellness. This happened around 2007. That was the beginning of Gategold. It was set up to promote longevity, and healthy life style”.

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According to Obi, his business is not just about making money. “Gategold is the vehicle I use to promote my calling for healthy living because I benefited from it myself.”

He revealed that prior to the launch of the Gategold company,he was a successful automobile spare parts dealer.

‘I left a thriving business to promote this vision; a calling indeed that benefits humanity’, he added.

 

Obi gave insights into human health challenges.’I am not a medical doctor, but by experience, I know that you can be slim and not be healthy. You may look and feel good and not be healthy.

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He noted that children exercise themselves by playing, running around, jumping and all that, which helps them grow into healthy adults.

 

‘For one to stay healthy, you must listen to the voice of your body and react accordingly, before it’s too late’, he added.

 

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Yes, Exercise Can Reverse Brain Aging. How Much Is Less Than You Might Think.

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Yes, Exercise Can Reverse Brain Aging. How Much Is Less Than You Might Think.

SCIENTISTS HAVE JUST given you one more reason not to skip your workout. Regular exercise could be turning back the age of your brain—by almost a year.

It didn’t take a lot of exercise, either. When people exercised for 150 minutes a week, their brains stayed younger. (If the number sounds familiar, it’s what multiple health organizations, including the CDC recommends for physical activity.) All they did was break their workouts into two 60-minute cardio sessions in the researchers’ lab, followed by a half-hour home workout.

When scientists reviewed the MRI brain scans before and after the year-long trial, they saw that the brains of the regular exercisers were 0.6 years younger than when they first started out. Researchers also looked at the brains of people who didn’t work out at all. Their brains were 0.35 years older. Put together, the difference in brain aging between both groups was nearly a year.

“These absolute changes were modest, but even a one-year shift in brain age could matter over the course of decades,” says Lu Wan, research neuroscience data scientist at the AdventHealth Research Institute and lead study author. Wan and her team unveiled the full results in the Journal of Sport and Health Science.

Considering the 130 people in the study were between 26 and 58, the findings suggest there’s still time to help your brain even if you’ve been sedentary for most of your life.

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“Each additional ‘year’ of brain age is associated with meaningful differences in later-life health,” adds Kirk Erickson, PhD, director of translational neuroscience at AdventHealth Research Institute and senior author. “From a lifespan perspective, nudging the brain in a younger direction in midlife could be very important. If we can slow brain aging before major problems appear, we may be able to delay or reduce the risk of later-life cognitive decline and dementia.”

How Does Exercise Help Maintain a Younger Brain?

THE RESEARCHERS LOOKED at several potential pathways exercise might work through—changes in fitness, body composition, blood pressure, or potential changes in a protein called BDNF that helps promote the creation of new brain connections. While exercise improved people’s overall fitness, the team did not find that any of these measures could statistically explain the reversal in brain aging in this trial.

“That was a surprise,” Wan says. “We expected improvements in fitness or blood pressure to account for the effect, but they didn’t. Exercise may be acting through additional mechanisms we haven’t captured yet, such as subtle changes in brain structure, inflammation, vascular health or other molecular factors.”

Still, there’s no need to wait for scientists to figure out the mechanism. Taking action now—whether you’re in your 30s, 40s, and 50s can make a difference later in maintaining a youthful brain.

“People often ask, ‘Is there anything I can do now to protect my brain later?’” DR. Erickson says. “Our findings support the idea that following current exercise guidelines—150 minutes per week of moderate-to-vigorous aerobic activity—may help keep the brain biologically younger, even in midlife.”

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Jocelyn Solis-Moreira, MS is the associate health & fitness for Men’s Health and has previously written for CNN, Scientific American, Popular Science, and National Geographic before joining the brand. When she’s not working, she’s doing circus arts or working towards the perfect pull-up.

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