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Belite Bio Reports Third Quarter 2024 Financial Results and Provides a Corporate Update

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Belite Bio Reports Third Quarter 2024 Financial Results and Provides a Corporate Update
  • Dosed first patient in Phase 2/3 DRAGON II trial of Tinlarebant for the treatment of Stargardt disease (STGD1)

  • Pivotal global Phase 3 PHOENIX trial of Tinlarebant in geographic atrophy (GA) subjects is ongoing with more than 280 subjects enrolled

  • Appointed Hendrik P.N. Scholl, MD, MA, a globally recognized leader in the field of ophthalmology and the coordinating principal investigator of the largest natural history study of Stargardt disease, as Chief Medical Officer

  • Interim analysis from the pivotal global Phase 3 DRAGON trial of Tinlarebant in adolescent STGD1 subjects anticipated by end of 2024 or early 2025

  • Company to host webcast on Tuesday, November 12, 2024, at 4:30 p.m. EST

SAN DIEGO, Nov. 12, 2024 (GLOBE NEWSWIRE) — Belite Bio, Inc (NASDAQ: BLTE) (“Belite” or the “Company”), a clinical-stage biopharmaceutical drug development company focused on advancing novel therapeutics targeting degenerative retinal diseases that have significant unmet medical needs, today announced its financial results for the third quarter ended September 30, 2024, and provided a general business update.

“I am pleased with the continued progress we made across our clinical programs. The pace of enrollment for the PHOENIX trial remains strong, and in the quarter, we completed the Phase 1b DRAGON II trial of Tinlarebant in Stargardt disease in Japan and dosed the first patient in the Phase 2/3 portion of the trial. We are well-positioned to achieve critical milestones and look forward to providing an update on the interim analysis from our pivotal Phase 3 DRAGON trial toward the end of 2024 or early 2025,” said Dr. Tom Lin, Chairman and CEO of Belite. “In the quarter, we were also excited to welcome Dr. Scholl, a leading global expert in Stargardt disease and age-related macular degeneration, as our Chief Medical Officer. Dr. Scholl’s decision to join Belite following his experience as Chair of the Data and Safety Monitoring Board for both our Phase 2 and Phase 3 Stargardt disease trials further validates our belief in Tinlarebant’s immense potential.”

Third Quarter 2024 Business Highlights and Upcoming Milestones:

Clinical Highlights

Tinlarebant (LBS-008) is an oral, potent, once daily retinol binding protein 4 (RBP4) antagonist that decreases RBP4 levels in the blood and reduces vitamin A (retinol) delivery to the eye without disrupting systemic retinol delivery to other tissues. Vitamin A is critical to normal vision but can accumulate as toxic byproducts in individuals affected with STGD1 and GA (the advanced form of dry age-related macular degeneration (dry AMD) leading to retinal cell death and loss of vision.

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Personal Finance: New housing affordability law has promising provisions | Chattanooga Times Free Press

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Personal Finance: New housing affordability law has promising provisions | Chattanooga Times Free Press

On June 23, members of Congress did something commendable and all too rare: They came together to pass legislation in a broadly bipartisan move to address the housing affordability crisis in the U.S. The new law, designated the 21st Century Road to Housing Act, includes an expansive compilation of 56 separate provisions aimed at increasing the supply of housing, improving access to financing and limiting ownership by large financial institutions.

The act is more evolutionary than revolutionary, since many of the barriers are down to state and local zoning and building codes that are beyond the reach of the federal government. Still, the measure creates a framework for streamlining local permitting, removes several obstacles to expansion of manufactured homes and includes many incremental incentives that should materially improve the supply of residential housing units over time.

Housing affordability has emerged as a public policy priority in recent years, as costs have accelerated faster than incomes since the COVID pandemic. The median price of a single-family home today is $440,000, up 50% over the past six years according to the National Association of Realtors. Zillow reports that the cost to rent a single-family home has risen by 45% over the same period, while apartment rents are up 28%. Meanwhile, median nominal household income has risen by just 25% since 2020.

The housing bill cleared the House of Representatives on a vote of 358 to 32 and passed in the U.S. Senate by a margin of 85 to 5, a commendable accomplishment. However, on June 24, the president abruptly cancelled a scheduled signing ceremony in reaction to the Senate’s unwillingness to pass new voter restrictions, calling the housing act a “big yawn.” Legislators from both parties were blindsided, having anticipated a high-profile bipartisan victory to tout in advance of the approaching midterm elections.

The president’s action did provide Americans with an interesting constitutional lesson. When Congress passes a bill, the president may either sign it into law or veto the bill, challenging Congress to muster a 2/3 majority to override the veto. However, the president can also simply refuse to sign, in which case the bill becomes law after 10 calendar days, excluding Sundays, if Congress is in session. The 21st Century Road to Housing Act therefore went into effect automatically at midnight on July 11.

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Among the numerous provisions in the law, a few stand out as particularly promising.

Manufactured housing. In what may be the most impactful action, the act eliminates one of the biggest impediments to expanding manufactured housing: the permanent chassis requirement. Since 1976, thanks to lobbying from traditional homebuilding interests, the federal government has forbidden the removal of the heavy steel trailer on which the unit was built even though 90% are never moved, and many are set on permanent foundations. This rule is risibly applied even in cases where an additional unit was stacked to form a second story. As I wrote in this space in October, factory-built homes can be produced more efficiently and therefore more affordably through mass production techniques. Eliminating the useless chassis after delivery could save a typical buyer an additional 5% and 10% of the purchase price as well as qualifying for more traditional mortgage financing.

Financial incentives to cities. Although the act does not include any additional federal funding, it directs a significant reallocation of existing incentives. The 1970s-era Community Development Block Grant program is reimagined, providing extra grant funding to high-cost metro areas that move aggressively to build affordable housing. The program is cost neutral, transferring funds from other cities that continue to discourage new unit construction through restrictive local policies.

Improving access to financing. Nearly half of the surge in housing costs is due to sharply higher mortgage interest rates since 2020. The housing act cannot impact rates, but it does provide additional access to financing. Small dollar loans of $100,000 or less will now be eligible for Federal Housing Administration guarantees, providing more access to lower-income buyers. The act also more than doubles the Federal Housing Administration loan limit for multifamily housing units.

Promoting rental homebuilding. The role of large institutions in purchasing single-family homes since the 2008 financial crisis has garnered significant public attention. The housing bill strikes a constructive balance.

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“Large institutional investors”, defined in the bill as investors holding 350 or more single-family residences, are now prohibited from acquiring additional homes subject to specific exemptions. For instance, homes purchased for the specific purpose of renovation for rental are excluded. These institutional investors are also not required to divest their existing holdings.

Importantly, the restrictions do not apply to so-called build-to-rent acquisitions wherein large investors purchase newly constructed homes specifically for rental. Economic research generally finds that large investor ownership tends to push up home purchase prices to buyers but reduces pressure on rent costs by adding to supply, just what the doctor ordered.

Local zoning and permitting reforms. As mentioned above, states and municipalities retain jurisdiction for their own local building and zoning codes, many of which have served to hinder the construction of more affordable residential units. The new housing act directs the Department of Housing and Urban Development to create a template incorporating best practices for modernizing zoning and land use policies to support more housing construction and renovation.

A curiously unrelated addition to the bill forbids the Federal Reserve from issuing a digital cryptocurrency version of the U.S. dollar, called a stablecoin, until 2030. The crypto industry has vigorously opposed an official U.S. stablecoin and accounted for nearly half of all corporate political contributions to federal election candidates in 2024. The president himself has amassed $1.4 billion in profits from his various crypto ventures since taking office in 2025.

Additional elements include a variety of incremental pilot projects, regulatory reforms and tweaks to existing federal housing programs that, taken together, could also have a meaningful impact and set the stage for further progress based upon the results. And perhaps most important: bipartisan cooperation, compromise and agreement.

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Christopher A. Hopkins, CFA, is a co-founder of Apogee Wealth Partners in Chattanooga.

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Former Bank chief financial officer sentenced to three years for $4.3 million loan fraud

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Former Bank chief financial officer sentenced to three years for .3 million loan fraud

LINCOLN, Neb. (KOLN) – A former bank chief financial officer was sentenced to three years in prison for a bank fraud scheme involving a car wash and undisclosed debts in a $4.3 million loan scheme.

The Department of Justice said Aaron T. Luneke, 44, of Columbus, was sentenced after being convicted of committing bank fraud and attempted bank fraud in connection with loans he sought to build and operate a Legacy Express Wash, a car wash in Columbus.

According to the DOJ, Luneke was sentenced to 36 months’ imprisonment. There is no parole in the federal system.

After his release from prison, Luneke will begin a five-year term of supervised release. Luneke was also ordered to pay a $10,000 fine.

The jury found that Luneke attempted to defraud Stearns Bank, located in St. Cloud, Minnesota, by using fraudulent and inflated contractor invoices to artificially inflate the valuation of the car wash property in pursuit of a $3.5 million refinancing loan. Further evidence at trial established that Luneke failed to reveal significant personal debts owed to family members in connection with the Stearns Bank loan application.

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The jury also found that Luneke defrauded Bank of the Valley by submitting fraudulent and inflated invoices from contractors as the basis for additional construction loan proceeds, obtaining two loans totaling approximately $4,320,000.

At the sentencing, the judge found that Luneke’s abuse of his position as chief financial officer at Bank of the Valley significantly allowed for the fraud against the victim bank to occur, and helped to conceal the crime.

The DOJ said the court further determined that Luneke employed sophisticated means to carry out the scheme, and that he served an aggravating role by organizing, leading, managing, or supervising others in executing aspects of the fraud.

Luneke also obstructed justice by providing false testimony during trial and caused a victim to suffer substantial financial hardship.

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Butterfield Readies CIBC Caribbean Purchase

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Butterfield Readies CIBC Caribbean Purchase

The Bermuda bank agrees to buy a 91.7% stake in CIBC Caribbean Bank for $1.8 billion, creating a regional giant.

This article appears in the July/August issue of Global Finance Magazine.

Butterfield Group has agreed to acquire a 91.7% stake in CIBC Caribbean Bank Limited for $1.8 billion — $1.09 billion in cash and the remainder in shares — in a deal that would create one of the region’s largest banking groups.

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This is at least the third time in the past seven years that the Canadian Imperial Bank of Commerce (CIBC) has attempted to sell some of its Caribbean interests.

“This deal combines two storied, complementary banks with significant local scale advantages and time-honored customer relationships in their respective core jurisdictions,” said Michael Collins, Butterfield’s chairman and chief executive, in a statement. 

The new banking group will hold an estimated $29 billion in assets. The Bermuda-based Butterfield Group—formerly The Bank of N.T. Butterfield & Son Limited—also operates in The Bahamas, the Cayman Islands, the Channel Islands, Singapore, Switzerland, and the U.K. CIBC has a presence in 10 countries and is based in Barbados.

CIBC will hold about 22% of the enlarged Butterfield Group and will have the right to appoint two directors to the board. 

The bank’s top brass says the deal underscores a shift in the Caribbean financial sector. 

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“This is really a change in Butterfield’s positioning because it now picks up both a retail and a business portfolio that spans the entire gamut of the region, and it probably could make it the biggest bank in the region,” former Butterfield CEO Mariano Browne told the Trinidad and Tobago Guardian.

Butterfield has promised to maintain CIBC’s Barbados office. Customers should expect no immediate changes. Existing branches will remain open, and clients can expect improved cross-border payments and expanded consumer, digital, and merchant banking.

The deal, pending regulatory approval, should close in the first half of 2027.

In 2018, CIBC attempted to list FirstCaribbean on U.S. stock markets to raise up to $240 million but withdrew the application less than a month later after failing to drum up sufficient investor interest. A 2019 deal to sell 66.7% of CIBC to GNB Financial Group for $797 million fell through after the deal failed to secure regulatory approval.

Nic Wirtz is a contributing writer based in Guatemala.

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