A University of Missouri School of Medicine professor and researcher has received a $2.8 million grant to study infant kidney injury.
Adebowale Adebiyi received the grant from the National Institutes of Health to study a previously unrecognized contributor to acute kidney injury: voltage-gated sodium channels.
These proteins help move sodium molecules through cells, but Adebiyi’s research identified another function.
“We found that during infant kidney injury, when blood flow is restricted, these sodium channels are overactivated in blood vessels,” Adebiyi said. “This triggers a cascade of events that causes the kidney’s small blood vessels to constrict, depriving the kidney of oxygenated blood when it’s most needed, and can lead to organ dysfunction or failure.”
This project will focus specifically on restoring healthy blood flow to infant kidneys, studying how nitric oxide works with specific sodium channels in blood vessels.
