The Milwaukee Brewers are headed to Cincinnati to take on the Reds in what is the first of five out of six series to be played against NL Central foes heading into the All-Star break. While any series could technically “make or break” a season, this stretch of 21 games (18 of them against the division) over the next 21 days just feels more important.

Milwaukee is fresh off a disappointing series loss in Atlanta, as the Brewers lost the first two games by one run each before the offense exploded for nine runs in a win on Sunday. On the other side, the Reds are coming off a 4-2 week in which they took two of three from both New York teams — they outscored the Mets 26-12 at home to begin the week before outscoring the Yankees 14-8 in the Bronx over the weekend. Cincinnati sits in last place in the division, 9.5 games behind the first place Crew.

The Brewers are currently without pitchers Brandon Woodruff (expected to return for the series opener — more on him below), Logan Henderson (early July return), Jared Koenig (late June/early July), Coleman Crow (July), DL Hall (late July), Rob Zastryzny (late June/early July), Brian Fitzpatrick (TBD), Carlos Rodriguez (TBD), Angel Zerpa (out for season), and Quinn Priester (out for season). Outfielder Brandon Lockridge is the lone position player on the IL, and he’s reportedly close to a rehab assignment after a setback in the last few weeks.

The Reds are without position players Elly De La Cruz (expected to return either Monday or Tuesday) and Ke’Bryan Hayes (TBD), as well as pitchers Pierce Johnson (expected to return on Monday), Brandon Williamson (second half), Emilio Pagán (late June/July), Hunter Greene (July), and Graham Ashcraft (second half).

Jake Bauers leads the Brewer offense with 13 homers this year, with Brice Turang (11 homers) and Jackson Chourio (10 homers) right behind him. Chourio, Andrew Vaughn, and William Contreras lead the regulars in batting average, as Chourio is hitting .301, Vaughn is hitting .352, and Contreras is hitting .299 after a 4-for-5 day on Sunday. Gary Sánchez, Garrett Mitchell, Christian Yelich, Sal Frelick, Cooper Pratt, and David Hamilton also play key roles offensively, with Joey Ortiz and Blake Perkins rounding things out. As a team, the Brewers are hitting .256/.340/.394 (.734 OPS ranks ninth), with 68 homers (tied for 27th), 397 runs (third), and 75 steals (fourth).

Rookie Sal Stewart leads the Cincy offense with 14 homers this season, with JJ Bleday (13 homers), De La Cruz (12 homers), and Spencer Steer (12 homers) not far behind him. Speaking of De La Cruz, his return will be big for a Reds’ offense that has scuffled over the last month or so, as he’s hitting .280/.346/.509 and is always a threat to steal bags. Nathaniel Lowe, Matt McLain, Eugenio Suárez, Tyler Stephenson, and Dane Myers are the other regulars for the Reds, with Noelvi Marte, Blake Dunn, Will Benson, Edwin Arroyo, and Jose Trevino serving as depth. As a team, the Reds are hitting .229/.311/.395 (.706 OPS ranks 21st), with 96 homers (11th), 325 runs (22nd), and 59 steals (11th).

The Brewer bullpen is led by Aaron Ashby, who just took his first loss after 10 wins on Saturday evening. Grant Anderson, Abner Uribe, and Trevor Megill have also been effective, with Chad Patrick serving in a long-relief role. Joel Kuhnel, Drew Rom, and Craig Yoho serve as Milwaukee’s “B” bullpen as it stands. As a staff, the Brewers have a 3.45 team ERA (third), including a 3.37 starter ERA (fourth) and a 3.55 bullpen ERA (seventh). They’ve struck out 736 batters (first) over 670 2/3 innings.

Brock Burke and Sam Moll lead the Reds bullpen, as Burke has a 3.00 ERA and 31 strikeouts over 36 innings and Moll has a 3.19 ERA and 34 strikeouts over 31 innings. Tony Santillan has struggled to a 5.10 ERA, but Tejay Antone (2.75 ERA) and Caleb Ferguson (1.50 ERA) have both been effective. Zach Maxwell (9.90 ERA), Chris Paddack (6.04 ERA), and Chase Petty (4.41 ERA) have also struggled, and with Johnson expected to return, one of them seems like the most likely odd man out. As a staff, the Reds have a 4.58 team ERA (24th), including a 4.43 starter ERA (24th) and a 4.81 bullpen ERA (16th). They’ve struck out 597 batters (26th) over 678 innings.

Monday, June 22 @ 6:10 p.m.: RHP Brandon Woodruff (2-1, 3.60 ERA, 3.97 FIP) vs. RHP Brady Singer (3-6, 5.32 ERA, 6.15 FIP)

Woodruff is slated to make his return in the series opener, as he’s missed nearly two months after a shoulder injury that became blatantly clear in his last start due to diminished velocity. For the season, he’s made six starts, totaling 30 innings with a 3.60 ERA, 3.97 FIP, and 25 strikeouts. In a pair of rehab appearances with the ACL Brewers and High-A Wisconsin Timber Rattlers, Big Woo totaled nine innings, allowing six runs on 10 hits and three walks while striking out 11. In 15 career appearances (13 starts) against the Reds, Woodruff is 7-4 with a 3.48 ERA and 106 strikeouts over 75 innings.

Singer, 29, has had a rough second season in Cincinnati after being acquired in the Jonathan India trade last offseason. After putting up a 14-12 record with a 4.03 ERA in 2025, he’s 3-6 with a 5.32 ERA and 6.15 FIP over 66 innings this season. He’s looked a bit better in his last two outings, though, allowing three runs on nine hits and four walks with 10 strikeouts over 11 innings in a win over the Mets and a no-decision against the Padres. Singer has made four career starts against Milwaukee — including three last season — with a 2-2 record, a 4.82 ERA, and 20 strikeouts across 18 2/3 innings.

Tuesday, June 23 @ 6:10 p.m.: RHP Brandon Sproat (1-4, 5.94 ERA, 5.52 FIP) vs. LHP Nick Lodolo (2-2, 6.12 ERA, 5.80 FIP)

Sproat has a 5.94 ERA and 5.52 FIP with 63 strikeouts across 63 2/3 innings this season, and he’s been about as inconsistent as those numbers indicate — he’s shown flashes of top-of-the-rotation stuff, but he’s also struggled with homers and walks. His last start was a microcosm of his season, as he went three perfect innings before allowing a pair of walks and a pair of hits — including a grand slam — in the fourth inning against the Guardians. He struck out six but exited after just 63 pitches in that fourth, as he dealt with cramps (something that seems to be a larger issue among Milwaukee’s young pitching staff). Sproat’s only appearance against the Reds came last year in his MLB debut while with the Mets. He took the loss in that one, allowing three runs on three hits and four walks with seven strikeouts over six frames.

Lodolo, who had the numbers of a top-of-the-rotation guy last season with a 3.33 ERA, 3.81 FIP, and 156 strikeouts, has struggled mightily in eight starts thus far this year, with a 6.12 ERA, 5.80 FIP, and 32 strikeouts over 42 2/3 innings. The 28-year-old lefty got roughed up big time against the Mets in his last appearance, allowing seven runs on 11 hits and two walks while striking out just two over 4 2/3 innings. Lodolo has made six career appearances (five starts) against Milwaukee, with a 1-1 record, 2.84 ERA, and 29 strikeouts over 31 2/3 innings.

Wednesday, June 24 @ 6:10 p.m.: LHP Shane Drohan (3-2, 3.40 ERA, 3.17 FIP) vs. RHP Rhett Lowder (3-4, 4.82 ERA, 4.46 FIP)

Drohan has turned into a reliable five-inning guy for the Brewers over the last month, as he has a 3.40 ERA, 3.17 FIP, and 47 strikeouts over 47 2/3 innings this season. He took a no-decision in his last outing against the Guardians, going five frames with one run allowed on three hits and three walks, striking out three on 91 pitches. This marks Drohan’s first career start against Cincinnati.

Lowder, 24, is a former No. 7 overall pick who debuted at just 22 in 2024, pitching to a 1.17 ERA with 22 strikeouts over 30 2/3 innings that year. After missing all of 2025 due to injuries, he hasn’t looked quite the same in 2026 through 11 starts. He has a 4.82 ERA, 4.46 FIP, and 42 strikeouts over 52 1/3 innings. He took the loss in his last appearance against the Yankees, allowing four runs on six hits and three walks with five strikeouts over 5 1/3 innings. Lowder made his lone career start against Milwaukee back in August 2024. He took the loss, allowing one run on two hits and four walks with six strikeouts across four innings.

Monday, June 22: Brewers TV; listen via radio on the Brewers Radio Network (620 WTMJ in Milwaukee)

Tuesday, June 23: Brewers TV; listen via radio on the Brewers Radio Network (620 WTMJ in Milwaukee)

Wednesday, June 24: Brewers TV; listen via radio on the Brewers Radio Network (620 WTMJ in Milwaukee)

The Brewers hit a tough rut in Atlanta over the weekend, but this Reds team has been struggling after jumping out to a hot start. I’ll take the Crew to win two of three to wrap up the road trip.