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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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Seattle Mariners FanFest: Quick hits from Dipoto, Cal, more

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Seattle Mariners FanFest: Quick hits from Dipoto, Cal, more


It was good to see the ballpark buzzing once again as the full-fledged Seattle Mariners FanFest returned to T-Mobile Park.

Steelheads uniforms will be Mariners’ new home Sunday look

Fans had the opportunity to get behind the scenes and tour the Mariners’ and visitor’s clubhouses, run the bases, take a picture at home plate with the trident and throw from the bullpen mound. There were autograph opportunities and “Dugout Dialogues” as well, with numerous players on hand taking part, including Cal Raleigh, Julio Rodríguez, Josh Naylor, George Kirby, Gabe Speier and a number of the Mariners’ highly touted prospects.

On the airwaves and in person, Gary Hill, Aaron Goldsmith and I held a live Hot Stove Show from Edgar’s Cantina, with former Mariners center fielder Franklin Gutierrez, president of baseball operations Jerry Dipoto, Raleigh, Speier, Kirby and Emerson Hancock stopping by.

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Here are some quick hits from those conversations.

Guti talks J-Rod and Laz

Gutierrez, who has been working with Mariners outfielders since 2021 as a special assignment coach, raised an eyebrow when he talked about Rodríguez – who this week was named baseball’s best center fielder by MLB Network.

“He is still developing as one of the best in the business,” Gutierrez said. “He likes to listen, he likes to improve on every area of his game. That’s why he’s going to be so successful.”

So, he thinks the ceiling for Rodriguez in center field is even higher?

“I do,” Gutierrez said. “He’s still grinding in there. He’s still asking questions about how he can get better, especially how he can prepare himself on every pitch, how he can move better. All of those questions are very important for him just to be who he wants to be.”

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Gutierrez raised another ceiling when talking about highly touted outfield prospect Lazaro Montes, who he has also worked closely with.

“His attitude is pretty much like Julio’s,” Gutierrez said. “He’s different. He will be (a corner outfielder), but he wants to get better. He wants to know what he can do better in the outfield, how he can move. I think he is still young, still developing. In my mind, I think he’s going to be a really, really, really good player. He’s not going to be average. I think he is going to be a little bit above average in the outfield.”

Dipoto: M’s not done adding

Dipoto indicated not once, but twice, that the Mariners are not finished when it comes to player acquisitions.

When asked to sum up the offseason, he said they were still working to make an addition. And then again, he echoed that sentiment when asked what they were bringing into spring training in two weeks compared to what they finished the season with on the field in Game 7 of the ALCS in Toronto.

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“I do think there is one more player that is coming along for the ride that is not in a Mariners uniform just yet,” Dipoto said.

WBC creates spring training opportunity for M’s prospects

Another topic addressed was the World Baseball Classic, which will take a large number of players out of Mariners camp.

“We have in the organization 19 players on preliminary rosters – 13 are associated with the big league team – and we think we will lose 11 when it starts,” Dipoto said. “Only the Dodgers have more.”

This leaves huge opportunity for the Mariners’ prospects in spring training. Dipoto relayed a conversation he had with Colt Emerson earlier in the day, with his message being to take advantage of the runway we are giving you. He’s excited to see what the 20-year-old top prospect is able to do.

“He’s not going to knock on the door. He’s just going to knock it down. You know when you are watching it,” Dipoto said. “We trust that if these guys come into spring training and do their thing and are ready to go, we are going to give them their chance.”

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Speier, Cal discuss WBC invites

Among those leaving camp will be Speier, who was thrilled to be selected to Team USA. He shared the story of how he got the news after a workout when he saw a missed call notice on his phone from: “Maybe Mark DeRosa.”

“Just the feelings going through me when I saw this, it was an easy yes,” Speier said.

It has been quite an ascension for Speier, who was pitching at Triple-A just two years ago.

“It’s wild to just take a step back and reflect how I got to this point,” Speier said. “A lot of thanks to the M’s for believing in me and claiming me off waivers from Kansas City and putting the ball in my hands in big spots. I’m proud to play for Team USA and rep the country. It’s wild to think about.”

Raleigh was also an “easy yes” to DeRosa and Team USA. Perhaps a little too easy.

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“We were in New York playing the Mets and D-Ro called me,” Raleigh said. “I was super excited. I was like, yes, I’m in. I was so excited. Dream came true. Such a cool thing to do. I committed.”

Did he perhaps forget something that day?

“It kind of hit me a couple of days after – Oh, I didn’t tell Jerry or Justin (Hollander) or Dan (Wilson). I might get in trouble for this,” Raleigh said sheepishly. “So I had to backtrack a little bit, reach out and ask. I think they knew. I think D-Ro called them too, but I was like, hey, I kind of went the wrong way. I said yes because I was so excited, but having to backtrack, I thought it was kind of funny.”

Catching up with Kirby and Hancock

It was good to catch up with Kirby, who has not added a new pitch but, as always, was happy to talk about his knuckleball.

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It was interesting to hear that he had been throwing bullpens to new catcher Andrew Knizer in Florida. Last week on the Hot Stove Show, Logan Gilbert noted Knizer had called him a few times and was going about the business of learning the pitchers.

Hancock is an interesting one heading into spring training. With the loss of Logan Evans to UCL surgery, pitching as a reliever exclusively appears to be off the table for Hancock, and he is preparing as such.

“I think this offseason has just been the normal build-up, then just adjust if we have to,” Hancock said.

Hancock’s attitude and outlook about his role over the last year has been fantastic, despite often not knowing where he will be day to day.

“Just go out there and enjoy it with the guys. Be grateful for the job you have been given and do the best you can when your name is called,” Hancock said. “It was a good year.

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“The baseball season is so long, there is so much up and down and so much you learn, and then the next thing you know, you’re out of the bullpen,” he said with a laugh. “But awesome. What a year, what an experience, the run that we had. And to share it with the fans, it was incredible.”

More on the Seattle Mariners

• Seattle Mariners lose RHP Logan Evans to UCL surgery
• Seattle Mariners’ non-roster spring invites include top picks of 2025
• Logan Gilbert has the scoop on what Mariners’ rotation has been up to
• Mariners reveal the ways to watch games on TV this season
• Coach’s Insight: Why this could be Julio’s big year






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WEST SEATTLE SATURDAY: 23 things to know about!

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WEST SEATTLE SATURDAY: 23 things to know about!


(American Robin photographed by Jerry Simmons)

Happy Saturday! Highlights for today and tonight include music, running, walking, volunteering, and more, mostly from the West Seattle Event Calendar:

SATURDAY GROUP RUN: At West Seattle Runner (2743 California SW; WSB sponsor), you can join the Saturday 8 am free group run.

FREE MEDITATION: Start the weekend with Heavily Meditated, 9 am free meditation at Inner Alchemy Studio/Sanctuary (3620 SW Alaska).

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INTRODUCTORY WALK and WALKING FOR WELL-BEING: 9:30 am, walk a mile as a prelude to the 10 am well-being walk (or just show up for that one). Both start from 47th SW and Fontanelle.

ADOPT A DAY-LABOR CORNER INFO SESSION: Earlier this week, we reported on local volunteers who are part of this movement. Today, you can find out how to join them in standing with local day laborers. 10 am-noon at High Point Library (3411 SW Raymond).

ANNIVERSARY DEAL: Happy Lemon Alki Beach (2718 Alki SW) celebrates its first anniversary today, and is offering “buy one, get one free” deals on certain beverages. Open 10 am-8 pm.

FAMILY-MUSIC CONCERT: Recess Monkey, live at Westside School (10404 34th SW; WSB sponsor), 10:30 am, $10 per family in advance or at the door, benefits the West Seattle Food Bank

MORNING MUSIC AT THE COFFEEHOUSE: 10:30 am-noon at C & P Coffee (5612 California SW; WSB sponsor), Marco de Carvalho and Friends perform. Info about Marco’s music is here.

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FREE WRITING GROUP: 10:30 am free, weekly, in-person, critique-free group – details in our calendar listing.

ALEX PRETTI MEMORIAL RIDE: Meet at 11 am at Alki Bike and Board (2606 California SW) for a family-friendly five-mile ride in memory of the community advocate, nurse, and bicyclist killed by federal agents in Minnesota.

FAMILY READING TIME: At Paper Boat Booksellers, 11 am family reading time. (4522 California SW; WSB sponsor)

LOG HOUSE MUSEUM: The home of West Seattle’s history is open, noon-4 pm (61st SW and SW Stevens).

VIETNAMESE CULTURAL CENTER: The center is open to visitors noon-3 pm Saturdays, as explained here. (2236 SW Orchard)

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VISCON CELLARS TASTING ROOM/WINE BAR: Tasting room open, with wine by the glass or bottle – 1-6 pm at Viscon Cellars (5910 California SW; WSB sponsor).

NORTHWEST WINE ACADEMY TASTING ROOM, WINE BAR, STORE: Open 1-6 pm on north end of South Seattle College (6000 16th SW; WSB sponsor) campus.

FEEDING THE CAULDRON: “An informal witchy skillshare meetup for queers, punks, and outcasts,” 2-5 pm at Mr. B’s Mead Center. (9444 Delridge Way SW)

FREE MASSAGE: 3-5 pm walk-in clinic offering short, specific massages at Nepenthe. (9447 35th SW)

ASTRA LUMINA: Held over into February, the celestially inspired light show on the grounds of the Seattle Chinese Garden at the north end of the South Seattle College (WSB sponsor) campus, first admission 5:45 pm. Tickets and info here; extended through February.

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CARTOON MESS LIVE! AT KENYON HALL: Reopening weekend continues with the latest performance of this live/animation mashup, doors 7 pm, show 7:30 pm, a few tickets remain here. (7904 35th SW)

DRAG AT THE SKYLARK: “Hey Baby,” showcase for new drag performers, at The Skylark, doors 7 pm, show 8 pm, presented by Kimme Ka$h, all ages, $10 advance/$15 door. (3803 Delridge Way SW)

LIVE MUSIC AT MR. B’S MEAD CENTER: Elephant Crows, 7:30-9:30 pm, no cover. (9444 Delridge Way SW)

REVELRY ROOM: 9 pm, DJ KP spins. (4547 California SW)

SK8 PARTY: 9 pm-midnight at Southgate Roller Rink (9676 17th SW), with rotating DJs spinning old-school funk & hip-hop, $18 plus $5 skate rental.

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KARAOKE AT TALARICO’S: 10 pm karaoke at Talarico’s Pizzeria. (4718 California SW)

Have a West Seattle event coming up? If community members are welcome, your event is welcome to a listing on our calendar, free of charge, always! Please email info to westseattleblog@gmail.com – thank you!





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Convicted sex offender arrested again in Seattle, formerly in custody on McNeil Island

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Convicted sex offender arrested again in Seattle, formerly in custody on McNeil Island


A registered sex offender repeatedly convicted of sexually assaulting children is back in jail, after being arrested by Seattle police in the Chinatown-International District on Thursday.

Officers arrested Richard Eugene Jackson, a 57-year-old sex offender who’s spent time in state prison and the Special Commitment Center on McNeil Island. Jackson’s criminal history spans decades, and he’s now accused of possessing and distributing child sex abuse material months after being released from prior custody.

The Seattle Police Department’s (SPD) Internet Crimes Against Children Unit has been investigating Jackson since last summer, according to SPD. Detectives said they received 18 cyber-tips over a short period of time, accusing Jackson of having and sharing images of children engaging in sexual conduct.

SPD has collected evidence from Jackson’s car and apartment on King Street. Detectives have not uncovered new evidence of Jackson physically abusing children, SPD said.

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Jackson waived his first appearance in King County jail Court on Friday afternoon, where a judge found probable cause to hold him. Judge Matthew York set Jackson’s bail at $750,000 and ordered the defendant to have no contact with minors or access to internet devices. King County prosecutors argued Jackson’s extensive, violent background makes him an ongoing threat to society.

“His record demonstrates he is not capable or unwilling to conform to the law, and the state does believe that if released, he will not follow the conditions of release,” the state argued in court.

Jackson has eight prior sex offense convictions, according to the state. These offenses include the sexual assaults of a 12-year-old boy and a 7-year-old boy, similar child sex abuse material charges, and attempts to connect with elementary-aged boys for sexual contact, according to the sex offender registry.

In a previous case, Jackson admitted to sexually abusing around 70 children, young boys and girls. Court records state Jackson was sent to the Special Commitment Center on McNeil Island in 2003, a facility run by the Department of Social and Human Services to house sexually violent predators likely to reoffend if they’re not securely detained.

In 2019, Jackson was conditionally released from McNeil Island to the Secure Community Transition Facility in King County. Over the next few years, Jackson was released into less restrictive custody and then recommitted after alleged violations, according to court documents.

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Then, in March of 2025, the state’s sexually violent predator (SVP) petition against Jackson was dismissed, following an SVP evaluation report of Jackson by the State’s expert, Harry Goldberg, Ph.D. Court records show Jackson was then granted unconditional release from community custody in March, which would be just months before Seattle police began investigating Jackson for these new allegations.

Jackson will remain in the King County Jail. He’s expected back in court on Feb 2.



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