Seattle, WA
New discoveries from Seattle scientists could help manage brain's aging process
SEATTLE – A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.
This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).
Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.
The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.
They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”
In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.
“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”
The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.
“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”
The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.
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Seattle, WA
Seattle fans pack waterfront hours early as USA defeats Australia, advances in World Cup
SEATTLE — Soccer fans descended on Seattle’s waterfront well before kickoff Friday, staking out their spots early to watch a highly anticipated World Cup matchup at Seattle Stadium between the United States and Australia. That patience paid off as Team USA won the match and now advances to the knockout round.
The atmosphere at Pier 62 was electric from the start, with fans lining up for prime viewing positions, whether down on the water’s edge or taking in the sweeping scene from the waterfront overlook above.
“I mean, look at all these people that are here hours beforehand to celebrate this incredible game,” said Paul Hanson, who was rooting for Team USA. “The hairs are going up on the arm.”
The energy was a draw in itself.
“The energy is amazing, everyone’s in a great mood, it’s just a lot of fun to be down here,” Maggie McNeil said.
Not everyone in the crowd was wearing red, white, and blue.
Lizzie Manning hails from Melbourne, Australia, and is now living in the Pacific Northwest.
Manning told KOMO News she hasn’t been back home in nearly a decade, but taking in the U.S.A-Australia match with the waterfront crowd gave her a taste of it.
“Whenever I see another Australian I’m like, ‘Aussie Aussie Aussie, oy oy oy,’” she said. “I feel so close to home. I need a meat pie, life’s good.”
“I’ve met so many people who are visiting from other countries,” Seattle resident Maddie Chaplain said. “I sat next to a couple yesterday who was eating dumplings for the first time from Argentina, that was so awesome.”
With Team USA advancing, fans like Aaron Olson say they’ll be back for more.
“USA’s gonna win it,” Olson said. “I will come down here every game. This is spectacular.”
The World Cup watch parties continue on Pier 62 throughout the tournament. They are free and open to the public with online registration, but capacity is limited.
Seattle News Weekly S1E44: FIFA Frenzy hits the PNW
The 2026 FIFA World Cup is off and running as Seattle prepares to host the United States vs. Australia match on Friday. With more matches to be played in the Emerald City after that, FOX 13’s David Rose, Dan Griffin and Austin Lane are taking a closer look at the biggest stories surrounding the international tournament. Dan is hearing from fans on Seattle Mayor Katie Wilson’s decision to turn on CCTV cameras during the World Cup, Austin is taking a deeper dive into why ties are a good thing in the group stage, and David revisits the lessons learned from the first match hosted in Seattle between Egypt and Belgium.
SEATTLE – The FIFA World Cup has taken Seattle by storm, bringing global excitement to our city and visitors from across the world.
On this week’s episode of the ‘Seattle News Weekly’ podcast, David Rose, Dan Griffin and Austin Lane discuss the top headlines of the week that have emerged alongside the buzz about the FIFA World Cup 2026.
A Massive Tournament Expansion
The hosts open the podcast with a discussion on how historically large this year’s FIFA World Cup is compared to years past. Expanded to 48 teams (up from 32), the tournament features a record 104 matches over 39 days across 16 host cities. Seattle is hosting six of those matches.
Austin explains the value of “ties” in the group stage—especially with the new format where 32 teams advance to the knockout stage instead of 16—meaning a single point from a tie carries significant weight.
At the time of recording, the US had already defeated Paraguay and is preparing to face Australia at “Seattle Stadium,” where a win would guarantee advancement.
Transit Tactics
Dan Griffin reports on the city’s transit system, noting that while the light rail is moving a massive influx of people smoothly, transit authorities are actively “throttling” passengers.
This practice involves controlling crowd flow onto platforms to ensure safety, which has caused wait times of over an hour for some fans on TikTok. Transit officials recommend that fans walk to stations slightly further away from the stadium district to get moving faster.
The CCTV Security Debate
The hosts talk about how security is a major focal point. The FBI has already had to confiscate drones being flown illegally downtown. More prominently, Seattle Mayor Katie Wilson activated controversial closed-circuit television (CCTV) cameras in the Stadium District following “general but credible threats” identified by law enforcement.
While an activist group called Community, Not Cameras expressed fears that the surveillance puts vulnerable populations at risk due to federal agency presence, visitors and fans interviewed largely welcomed the extra layer of security. The cameras are expected to be turned off after the World Cup concludes.
Cultural Celebrations and Fan Experiences
The hosts play a clip from reporter Lauren Donovan who provides a colorful look at the fan festivities happening in the city. She highlights the “March to the Match,” describing Monday morning where Belgian fans swarmed Victory Hall alongside middle school band directors from the Stanwood-Camano district who were recruited to drum for them.
She also joins celebrating Egyptian fans, whose match against Belgium ended in an enthusiastic tie. The hosts note that international fans (like those from Australia) are already flooding local attractions, including Seattle Mariners baseball games, turning the sporting event into a broader West Coast vacation.
Seattle News Weekly is a podcast that goes in depth and gives context to the stories that matter to the western Washington community. Check back every Thursday for a new episode on your favorite podcast platform, including Spotify, Apple Podcasts, Pandora, Stitcher, Amazon Music, TuneIn and Audible or YouTube.
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To get the best local news, weather and sports in Seattle for free, sign up for the daily FOX Seattle Newsletter.
Download the free FOX LOCAL app for mobile in the Apple App Store or Google Play Store for live Seattle news, top stories, weather updates and more local and national news.
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