Health
Hidden belly fat could signal Alzheimer’s disease risk 15 years before symptoms show up, study finds

Even if you can’t see it, fat buried deep within the belly can increase the risk of Alzheimer’s disease.
That’s according to research released by the Radiological Society of North America (RSNA) on Monday.
Visceral fat, which surrounds the internal organs in the belly, has been linked to brain changes that could point to future dementia in people as young as 50, up to 15 years before symptoms appear, as noted in a press release from RSNA.
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The findings, published in the journal Aging and Disease, will be presented at the RSNA’s annual meeting next week.
Researchers analyzed the brain MRIs and PET scans of 54 “cognitively healthy” participants between the ages of 40 and 60, focusing on any inflammation and “plaques and tangles” that are typically seen in Alzheimer’s patients.
Fat buried deep within the belly can increase the risk of developing Alzheimer’s disease, according to research released by the Radiological Society of North America (RSNA). (iStock)
They also assessed the middle-aged adults’ body mass index (BMI), obesity levels, blood glucose and abdominal fatty tissue.
“Even though there have been other studies linking BMI with brain atrophy or even a higher dementia risk, no prior study has linked a specific type of fat to the actual Alzheimer’s disease protein in cognitively normal people,” said study author Mahsa Dolatshahi, M.D., post-doctoral research fellow with the Mallinckrodt Institute of Radiology (MIR) at Washington University School of Medicine in St. Louis, in the release.
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“Similar studies have not investigated the differential role of visceral and subcutaneous fat, especially in terms of Alzheimer’s amyloid pathology, as early as midlife.”
The researchers found that those with more visceral fat also had higher levels of amyloid in the precuneus cortex, which is the region of the brain that usually shows the earliest signs of Alzheimer’s disease.
They also had greater inflammation in the brain.

Before this research, no prior study has linked a specific type of fat to the actual Alzheimer’s disease protein in cognitively normal people. (iStock)
Men were more likely to show this correlation than women.
“We found the hidden fat-Alzheimer biomarker connection in persons at midlife — 40s and 50s — on average 15 years before the earliest symptoms of Alzheimer’s typically appear,” Raji added.
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Visceral fat may also lead to inflammation in the brain, one of the main mechanisms that contribute to Alzheimer’s disease, according to the researchers.
Looking ahead, the hope is that these findings can be a springboard to new targeted treatments.

More than six million Americans are living with Alzheimer’s disease, according to the Alzheimer’s Association. (iStock)
“We found the hidden fat-Alzheimer biomarker connection in persons at midlife — 40s and 50s — on average 15 years before the earliest symptoms of Alzheimer’s typically appear,” Raji added.
Visceral fat may also lead to inflammation in the brain, one of the main mechanisms contributing to Alzheimer’s disease, according to the researchers.
Looking ahead, the hope is that these findings can be a springboard to new targeted treatments.

Researchers analyzed brain MRIs and PET scans of 54 “cognitively healthy” participants between the ages of 40 and 60, focusing on any inflammation and “plaques and tangles” that are typically seen in Alzheimer’s patients. (iStock)
“By moving beyond body mass index in better characterizing the anatomical distribution of body fat on MRI, we now have a uniquely better understanding of why this factor may increase risk for Alzheimer’s disease,” said Raji.
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the study but said the findings aligned with his expectations.
“This is because belly fat is filled with inflammation,” he told Fox News Digital.
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“Cytokines and interleukin 6 (inflammatory proteins) not only lead to heart disease, but there is increasing evidence that this inflammation also leads to neurodegenerative disease and poor brain cell function, and can accelerate Alzheimer’s,” Siegel added.
“This study reinforces that association.”
The main limitation of the research is the small sample size and the fact that it’s a cross-sectional study, Raji noted.

One in every five women and one out of 10 men will develop Alzheimer’s disease in their lifetime. (AP Photo/Charles Dharapak, File)
“We are recruiting more participants for this study and want to do a longitudinal version of this work in the future,” he said.
The hope is that the research will help to raise awareness that body and brain health are linked, Raji added.
More than six million Americans are living with Alzheimer’s disease, according to the Alzheimer’s Association.
This number is expected to approach 13 million by 2050.
One in every five women and one out of 10 men will develop the common form of dementia in their lifetime.
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Health
Cases of COVID variant BA.2.86 have tripled in 2 weeks, says CDC report

Cases of the COVID-19 variant Omicron BA.2.86, also known as Pirola, have tripled in two weeks, comprising between 5% and 15% of all infections, according to the Centers for Disease Control and Prevention (CDC).
The COVID-19 variant Omicron BA.2.86 — as well as its offshoots, including JN.1 — has been reclassified as a “variant of interest” by the World Health Organization (WHO).
Despite its prevalence, BA.2.86 “does not appear to be driving increases in infections or hospitalizations in the United States,” the CDC stated in its report.
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Both the CDC and WHO agree that “the public health risk posed by this variant is low compared with other circulating variants.”
The updated COVID-19 vaccines that were approved by the FDA in September are believed to “increase protection against BA.2.86, as they do for other variants,” the CDC noted.
Cases of the COVID-19 variant Omicron BA.2.86, also known as Pirola, have tripled in two weeks, comprising between 5% and 15% of all infections, according to the CDC. (iStock)
“To date, existing vaccines have been very effective in protecting people, particularly those who have been boosted multiple times through a vaccine or natural infection, not only from symptomatic infection, but importantly from severe disease, hospitalization and death,” said Richard Reithinger, PhD, a distinguished research fellow in the Global Health Division at International Development Group in Washington, D.C., in a statement to Fox News Digital.
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The CDC said it is not clear whether BA.2.86 causes different symptoms — but noted that most variants produce similar effects.
“The types of symptoms and how severe they are usually depend more on a person’s immunity than which variant causes the infection,” the statement said.

Despite its prevalence, BA.2.86 (also known as Pirola) “does not appear to be driving increases in infections or hospitalizations in the United States,” the CDC stated in its report. (iStock)
The variant is also expected to respond to the current tests and treatments.
Reithinger noted that while the pandemic is officially over, COVID-19 is not a thing of the past.
“A concern of the new BA.2.86 variant was that because it has 35 mutations in the spike protein, it would be able to evade the immune response more readily than other variants that emerged in the last couple of months,” he told Fox News Digital.
“Early clinical data does not seem to indicate this being the case.”
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The increase in BA.2.86 cases is due to the U.S. entering the “COVID-19 season” and also a sufficient number of people having developed non-BA.2.86 immunity, according to the doctor.
Outside of vaccines, Reithinger recommends that high-risk groups adopt risk-mitigating behaviors, including wearing masks, frequently washing hands and avoiding crowded environments.

The updated COVID-19 vaccines that were approved by the FDA in September are believed to “increase protection against BA.2.86, as they do for other variants,” the CDC noted. (iStock)
“People — particularly those with greater risk of infection and severe disease — should continue to be sensitized and vigilant about COVID-19 and the disease it may cause,” he told Fox News Digital.
“People who are at greater risk of infection and severe disease should consult with their physicians about whether they should be administered one of the currently available boosters,” he added.
Those at highest risk include people older than 60 years, the immunocompromised, those with comorbidities such as asthma and diabetes, and people working in high-risk-of-exposure employment, such as the service industry, Reithinger noted.
For more Health articles, visit www.foxnews/health.
Health
Friends run for a cure for lupus, completing NYC Marathon in honor of longtime pal and lupus sufferer

All marathoners have their own particular motivations for running a 26.2-mile race — and for Molly Anderson, Sarah Edwards and Laura Haley, it was to honor Rosie De Queljoe Herzog, their longtime friend who is living with lupus.
As a 30th birthday surprise, the three runners flew De Queljoe Herzog from her home in Los Angeles to the Big Apple, where she was able to cheer them on as they ran the New York City Marathon on Nov. 5.
Anderson, Edwards and Haley were part of Team Life Without Lupus, the official competitive team of the Lupus Research Alliance, the largest private funder of lupus research in the world.
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The four friends shared with Fox News Digital what the experience meant to them — and how its impact is lasting well beyond that one day.
‘Something larger’
It was in 2021 when De Queljoe Herzog, a public relations professional, first started noticing symptoms, including rapid hair loss, joint pain, fatigue, swelling of her face and hands — and a malar rash (butterfly rash) on her face.
Pictured left to right: Molly Supple Anderson, Sarah Edwards, Rosie Herzog and Laura Haley at the NYC Marathon on Nov. 5, 2023. (Lupus Research Alliance)
“In the early days, I attributed the hair loss to a stressful 2020 and stressful work schedule, but it turned out to be something larger,” she told Fox News Digital.
In early 2022, De Queljoe Herzog was officially diagnosed with systemic lupus erythematosus, an inflammatory disease that occurs when the immune system attacks its own tissues.
She was hospitalized due to a lupus flare-up shortly after that.
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“I was put on a number of drugs to help quell the flare,” she said.
“I’ve been able to taper off some of the drugs since then, but am still on a few to help keep future flares at bay. I am no longer in a flare and am back to feeling healthy and ‘normal.’”
Over a decade of friendship
The four friends, all 30 years old, attended college together at the University of Arizona, where they competed on the triathlon team and developed an “inseparable bond,” said De Queljoe Herzog.
Their friendships continued to thrive after graduation. They were in each other’s weddings and took trips together.

Team Life Without Lupus, the official competitive team of the Lupus Research Alliance, are pictured with family and friends. “The energy and spectators, especially all our friends and family who came out to watch, were absolutely electric,” said Edwards. (Lupus Research Alliance)
“We’re all so uniquely different, but have such an incredible time when we’re all together,” De Queljoe Herzog told Fox News Digital.
She was “floored” when her friends said they would be running the NYC Marathon on her behalf to support the Lupus Research Alliance.
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“It was such a selfless act of friendship and love,” she told Fox News Digital. “They know how much lupus has impacted my overall health, and to see them rally around me and around lupus research was astonishing.”
De Queljoe Herzog and her husband traveled to New York City to watch the race.
“It was such a fun weekend and race day — we were able to catch them at three different points during the race to cheer them on,” she said. “It was an emotional day that I’ll remember for the rest of my life.”
“They know how much lupus has impacted my overall health, and to see them rally around me and around lupus research was astonishing.”
For those who are just starting their lupus journeys, De Queljoe Herzog stressed the importance of finding a support system to lean on.
“It can be a lonely road, but friends and family make it so much more manageable — especially friends who provide an endless supply of belly laughs.”
A race to remember
For the three runners, the race represented a way to support their friend while also marking a significant accomplishment.
“As much as I would do anything to take Rosie’s symptoms and flares away, I can’t,” said Anderson, who lives in Spain and works as a sports psychologist.

The team is pictured with Rosie De Queljoe Herzog along the race course. “Being able to run with two of my best friends for such a great purpose was incredibly gratifying and emotional,” said Anderson. (Lupus Research Alliance)
“It’s difficult living so far away, but after her diagnosis, I began to brainstorm ways to support her in my own way,” she went on. “That was when I had the idea to fund-raise for lupus research and encourage her to come to support the race.”
The other two runners, Edwards and Haley, were on board right away.
“We have always been motivated by physical and athletic challenges, so this seemed like the perfect combination of a challenge for us and raising money for an amazing cause,” said Edwards, who lives in Bend, Oregon, and works as an outreach coordinator for environmental organizations.
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“I’ve always dreamed of experiencing the magic of New York City and the energy I had always heard about in the marathon setting,” she went on.
Race day exceeded the team’s expectations, the women agreed.
“Being able to run with two of my best friends for such a great purpose was incredibly gratifying and emotional,” said Anderson.

The friends embrace along the NYC Marathon race course. Edwards described the race as “pure magic from start to finish.” (Lupus Research Alliance)
Edwards described the race as “pure magic from start to finish.”
“It was like running on cloud nine — it felt like a dream,” she said. “The energy and spectators, especially all our friends and family who came out to watch, were absolutely electric.”
She added, “My most sore muscles after the race were my cheeks from smiling the whole time.”
“Seeing Rosie at mile 18 made me remember why I was doing this, made me cry and helped me get to the finish line.”
Haley, who lives in Tucson, Arizona, and works as a physical therapist, said the best part of the race was taking the ferry to Staten Island and watching the sunrise over Manhattan with her best friends, as well as running through Brooklyn and the Bronx.
“The people were so fun and full of life, energy and support,” she said.
Haley said she struggled at around mile 16, and found herself wishing she had trained more.

The team is pictured celebrating along the marathon race course. “Every time I got tired or frustrated during training for this race, I would think of how much frustration Rosie has been through with lupus,” Edwards said. (Lupus Research Alliance)
“Oftentimes, while training or running the marathon, I would want to stop or ask myself, ‘Why am I doing this? This is miserable,’” she recalled.
“And those moments are when I would remember Rosie’s challenges. It would make me grateful for my healthy body and carry me through those rough times.”
Haley added, “Seeing Rosie at mile 18 made me remember why I was doing this, made me cry and helped me get to the finish line.”
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Running the marathon was “a huge joy” for all of them, said Edwards.
“And what has been even better is raising so much awareness among our family and friends through the fundraising process,” she said. “The more people know about lupus, the more support we can raise to find a cure one day.”
“Every time I got tired or frustrated during training for this race, I would think of how much frustration Rosie has been through with lupus.”
While De Queljoe Herzog is grateful for her friends’ support, they all agree that she is a huge source of motivation for them.
“Before her diagnosis, Rosie was always the most positive person I knew,” said Anderson. “She is an incredible listener and has an incredible ability to process information in a way that is productive. After her diagnosis, she was able to channel these parts of herself to listen to her body and manage her symptoms.”

Lupus is one of the most complex autoimmune diseases, according to the Lupus Research Alliance, which is based in New York City. “It affects each person differently with symptoms that are sometimes hard to detect and differ from patient to patient,” the organization notes on its website. (iStock)
Edwards said thoughts of her friend’s challenges helped get her through the race preparations.
“Every time I got tired or frustrated during training for this race, I would think of how much frustration Rosie has been through with lupus,” she told Fox News Digital.
“She is incredibly thoughtful and the kindest person I know. She motivates me to be a better person every day.”
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Albert Roy, president and CEO of Lupus Research Alliance, noted the significant impact that all of the teams make toward advancing research.
“We so appreciate how these young women and all the members of our Team Life Without Lupus ran the world’s largest marathon to raise both awareness and funds for lupus research,” he commented to Fox News Digital.
Women make up about 9 out of 10 adults with the disease.
“By pushing themselves to reach the finish line, they challenge us to keep striving to reach our goal — more treatments and ultimately a cure.”
Lupus is one of the most complex autoimmune diseases an individual can have, the organization notes. “It affects each person differently, with symptoms that are sometimes hard to detect and differ from patient to patient,” the group says on its website (lupusresearch.org).
While anyone can get lupus, the disease most often affects women, who make up about 9 out of 10 adults with the disease, the group also notes.
The chronic autoimmune disease affects millions of people worldwide. Doctors don’t know exactly what causes lupus, but they believe that something, or a combination of things, triggers the immune system to attack the body, WebMD indicates.
For more Health articles, visit www.foxnews/health.
Health
Could flu vaccination reduce the risk of heart attacks and cardiovascular deaths?

People who get the flu vaccine may have improved heart health, according to a recent study published in Scientific Reports.
Researchers from the Shahid Beheshti University of Medical Sciences in Tehran, Iran, concluded that patients who received flu vaccinations had a 26% reduced risk of having a heart attack and were 33% less likely to die from cardiovascular disease.
This finding is based on a review of five randomized controlled trials that focused on myocardial disease and influenza vaccines.
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The patients who participated in the studies had all been diagnosed with cardiovascular disease previously and were 61 years old, on average.
Out of the total of 9,059 patients, 4,529 of them received the flu vaccine, while 4,530 received a placebo shot.
People who get the flu vaccine may have improved heart health, according to a recent study published in Scientific Reports. (iStock)
After a nine-month period, 621 of the people who received the placebo shot experienced “major cardiovascular events,” compared to 517 of the patients who received the flu vaccine.
Those outcomes included myocardial infarction, cardiovascular death and stroke.
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“Revealing a compelling insight into the potential benefits of influenza vaccination, our comprehensive meta-analysis, based on the latest randomized controlled trial data, demonstrates a significant interaction between influenza vaccination and the reduction of major cardiovascular events,” wrote the researchers of the study.
“Notably, patients who received the influenza vaccine experienced a remarkable risk reduction of over 20% in cardiovascular death.”

Patients who received flu vaccinations had a 26% reduced risk of having a heart attack and were 33% less likely to die from cardiovascular disease. (Joe Raedle/Getty Images)
As for why influenza vaccines seem to reduce the risk, the researchers noted that the shot could prevent inflammation and secondary infections, while also stabilizing plaque amounts in the heart.
The vaccine could also help stimulate the immune system, which the study authors noted is essential for cardiovascular health.
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Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, called the study “important” and said it “builds on what we already knew.”
He was not involved in the research.

Heart disease is the primary cause of death among U.S. adults, killing one person every 33 seconds, according to the CDC. (iStock)
“It is not surprising that flu shots would decrease the risk of heart attacks,” Siegel told Fox News Digital.
“The flu is one of the great enablers,” he went on. “It adds stress and inflammation to the body and decreases the overall immune response, all of which can lead to acute cardiac events.”
The flu “adds stress and inflammation to the body and decreases the overall immune response.”
The researchers called for further research to “elucidate the precise mechanisms driving this association and to explore the long-term impact of influenza vaccination on cardiovascular outcomes.”
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In the meantime, they recommended that “health care providers and policymakers should take heed of these findings and consider prioritizing influenza vaccination for patients with recent cardiovascular disease as a feasible and potentially life-saving preventive measure.”
Fox News Digital reached out to the study authors for additional comment.
Heart disease is the primary cause of death among U.S. adults, killing one person every 33 seconds, according to the Centers for Disease Control and Prevention (CDC).
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