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Biden’s New Covid Plan: Preparing for New Variants and Avoiding Shutdowns

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Biden’s New Covid Plan: Preparing for New Variants and Avoiding Shutdowns

Though Paxlovid tablets have been comparatively scarce since they have been approved late final 12 months, Mr. Biden stated in his speech on Tuesday that “Pfizer is working time beyond regulation to get us a million tablets this month and greater than double that subsequent month.”

There’s a median of about 60,000 new U.S. circumstances a day, in line with a New York Instances database. That’s far lower than the each day common of 800,000 in January, on the peak of the winter surge fueled by Omicron. However it’s nonetheless a lot larger than the each day caseload final June, earlier than Delta drove a summer season surge.

Even because the White Home asserts that issues are getting higher and new federal pointers counsel 70 % of Individuals can cease sporting masks for now, giant teams of individuals stay in danger. Kids underneath 5 are usually not but eligible for vaccines. On Monday, New York State well being officers launched knowledge displaying that Pfizer-BioNTech’s vaccine is way much less efficient in stopping an infection in 5- to 11-year-olds than in adolescents or adults.

And an estimated seven million Individuals have weak immune techniques, sicknesses or different disabilities that make them extra susceptible to extreme Covid. The White Home introduced final week that it was taking a number of steps to make masks and exams extra accessible to these teams.

However Gregg Gonsalves, an epidemiologist at Yale College, stated that with masks mandates dropping across the nation, the administration — and specifically the Facilities for Illness Management and Prevention, which relaxed its masks steering final week — had put an excessive amount of of a burden on susceptible Individuals to guard themselves.

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One masks mandate that won’t be dropped — at the least not for the subsequent few weeks — is the one Mr. Biden imposed on airplanes, trains and different types of journey. Jeffrey D. Zients, the White Home coronavirus response coordinator, stated that it could stay in impact till at the least March 18, however that the C.D.C. is reviewing it.

In his State of the Union handle, Mr. Biden referred to as on Congress to supply new funding for the administration to stockpile extra exams, masks and tablets. And he stated that Individuals who ordered free at-home exams from a authorities web site, covidtests.gov, would have the ability to order extra subsequent week.

“I can’t promise a brand new variant gained’t come,” Mr. Biden stated. “However I can promise you we’ll do every part inside our energy to be prepared if it does.”

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Texas Grandma's 253-Lb Weight Loss Journey: How She Revived Her Thyroid—No Surgery, No Ozempic

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Texas Grandma's 253-Lb Weight Loss Journey: How She Revived Her Thyroid—No Surgery, No Ozempic


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Aging slowdown could be surprise benefit of existing medication, research shows

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Aging slowdown could be surprise benefit of existing medication, research shows

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A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging.

The immune-suppressing medication rapamycin, also known as sirolimus, is being used off-label as a means of extending longevity.

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“By targeting a key pathway (mTOR) in cells, this drug has been shown to extend lifespan in animals and could be beneficial to prevent age-related diseases in humans,” Dr. Andrea B. Maier — a professor in healthy aging and dementia research at the Director of the Centre for Healthy Longevity at the National University of Singapore — told Fox News Digital.

AGING SPEEDS UP ‘MASSIVELY’ AT TWO POINTS IN ONE’S LIFETIME, STANFORD STUDY FINDS: ‘ABRUPT CHANGES’

Maier was co-author of a recent review study that explored how rapamycin affected healthy humans.

A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging. (iStock)

The review, which was published in the journal Lancet Healthy Longevity, found that the medication improved the effects of aging on the skin.

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“Rapamycin and its derivatives improve the immune and cardiovascular function of healthy individuals or individuals with aging-related diseases,” Maier said in an email.

11 TIPS FOR ADULTS AGE 65 AND OVER TO ‘LIVE WELL’ OVER TIME, ACCORDING TO GERONTOLOGISTS

Daniel Tawfik, a molecular biologist and co-founder of Healthspan, a digital medical clinic that focuses on anti-aging and longevity-promoting therapies, said his team uses rapamycin to help slow down the rate of aging. 

“We view this through the lens of reducing the accumulation of damaged senescent cells,” Tawfik, who is based in Santa Monica, California, told Fox News Digital.

Rapamycin

The immune-suppressing medication rapamycin is being used off-label as a means of extending longevity. (iStock)

Senescent cells are cells that no longer function properly, but linger in the body and can contribute to tissue deterioration and inflammation, the expert said.

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“By lowering the rate at which healthy cells transform into senescent cells, rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health as we age,” he added.

Off-label use

In the U.S., rapamycin is approved by the Food and Drug Administration (FDA) for its immune-suppressing properties in patients with kidney transplants and certain cancers. 

It is not approved for use as an age-defying drug.  

“Sirolimus (rapamycin) has not been evaluated by the FDA for safety and effectiveness as an anti-aging treatment,” a press officer for the FDA confirmed to Fox News Digital.

“Rapamycin can slow the aging process at the tissue level, helping to preserve organ function and overall health.”

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Despite this, rapamycin is being used “off-label” for anti-aging purposes, according to Elaena Quattrocchi, a registered pharmacist and an associate professor at Long Island University College of Pharmacy in Brooklyn, New York.

“Off-label means the FDA has not approved the drug for this use,” she told Fox News Digital.

Sirolimus

Rapamycin, which is also known as Sirolimus,  is being used “off-label” for anti-aging purposes, experts say. (iStock)

When prescribing a drug for off-label use, the provider must explain to the patient that the medication has not been approved for the indication for which they are prescribing it, Quattrocchi noted.

“People taking this medication must discuss with their primary care provider and pharmacist about the potential side effects and drug interactions,” she said.

Benefits of rapamycin

Tawfik’s company currently treats more than 3,500 patients with rapamycin, he told Fox News Digital. 

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His team has seen numerous benefits of its off-label anti-aging use, he said, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity.

“Under proper medical supervision, many of our patients experience a marked reduction in inflammation and improvement in conditions related to autoimmunity,” Tawfik said.  

Man at doctor

When prescribing a drug for off-label use, the provider should explain to the patient that the medication has not been approved for the indication for which they are prescribing it, according to experts. (iStock)

“For example, patients with osteoarthritis often report significant relief from joint pain after starting rapamycin.”

The expert also noted that certain biomarkers linked to healthspan and longevity — such as reduced inflammation markers and enhanced metabolic health — were seen in the bloodwork of the patients using rapamycin.

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Screening and safety

Patients need a prescription for rapamycin, experts told Fox News Digital. 

Individuals are screened to determine whether they are candidates for the treatment. If it is prescribed, patients are monitored carefully when taking the drug.

“It is essential that rapamycin use is overseen by a physician.”

“It is essential that rapamycin use is overseen by a physician to ensure that dosing is effective yet safe, as high doses can lead to unwanted immunosuppression,” Tawfik warned. 

Maier echoed that rapamycin and its derivatives are not for self-medication use. 

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“An important step is to first measure the patient’s biological age and investigate why the pace of aging might be faster,” she told Fox News Digital. 

“Then a tailored approach to match the measures with interventions at need is required.”

Quattrocchi and Tawfik both emphasized the importance of working with an accredited pharmacy that sources the drug directly from a reputable manufacturer.

Filling prescription

Rapamycin and its derivatives are not for self-medication use, experts cautioned. (iStock)

Rapamycin is not recommended for immunocompromised individuals or those taking immunosuppressant medication, Tawfik cautioned.  

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It is not typically used in younger adults, he added, since starting this regimen at such an early age is unnecessary.

Calls for more research

There are limited studies on the effects of rapamycin on humans and organ systems, Maier noted.

In researching studies of the drug, Maier’s research team found that adverse reactions in healthy individuals were classified “as mild or moderate and were reversible after the discontinuation of treatment.”

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However, the study authors stated, “there were increased numbers of infections and increases in total cholesterol, LDL cholesterol and triglycerides in individuals with aging-related diseases.”

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“Future studies should assess the remaining unexamined systems and test the effects of long-term exposure to rapamycin and its derivatives.”

Woman face lotion

Experts have reported numerous anti-aging benefits of rapamycin, including improved cellular health, reduced risk of age-related diseases and the potential for enhanced longevity. (iStock)

The majority of studies exploring rapamycin’s effects on aging have been conducted on mice and other animals as well as experimental models, researchers told Fox News Digital.

“The reason scientists are so interested in rapamycin is that in every species that’s been studied to date – yeast, worms, flies, mice – when they are given rapamycin, healthspan and lifespan are extended,” Tawfik noted.

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“No other intervention has that degree of validation.”

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Quattrocchi agreed that further research is needed into the drug’s proper dosing, adverse effects, and potential anti-aging benefits in healthy individuals and those with medical conditions.

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Lack of sleep during pregnancy could impact baby's development, study reveals

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Lack of sleep during pregnancy could impact baby's development, study reveals

Sleep is crucial, especially for pregnant women.

Inadequate sleep during pregnancy can have many negative effects, including neurodevelopmental delays for the child, according to a new study.

The research, which was published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism, examined the effects of short sleep duration (SSD) — defined as sleeping fewer than seven hours per night — on pregnant women.

AMERICANS ARE HAVING FEWER BABIES AS BIRTH RATE HITS HISTORIC LOW, CDC REVEALS

The China-based researchers analyzed sleep data from 7,059 mother-child pairs from three Chinese hospitals. The children were screened for developmental delays from 6 months to 3 years old.

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Insufficient sleep during pregnancy was associated with an increased risk of delays in nervous system development, the researchers found.

Boys, compared to girls, have a higher risk of neurodevelopmental issues when their mothers experience SSD, the study found. (iStock)

“Our findings highlight the importance of addressing sleep quality during pregnancy to potentially mitigate the risk of long-term cognitive and behavioral issues in children,” lead study author Peng Zhu, M.D., of Anhui Medical University and the MOE Key Laboratory of Population Health Across Life Cycle in Hefei, China, told Fox News Digital. 

“Additionally, we discovered that cord blood C-peptide levels partially mediate this association, indicating that maternal sleep might impact fetal glucose metabolism and, consequently, the child’s neurodevelopment.”

LACK OF SLEEP POSES CONCERNING RISK FOR KIDS, STUDY FINDS

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The neurodevelopmental delays can lead to slower development of social, emotional, behavioral, motor, cognitive or speech skills, the new study revealed.

Boys, compared to girls, have a higher risk of these issues when their mothers experience SSD, the researchers found.

Pregnant woman sleeping

Poor sleep during pregnancy has also been associated with other complications, including preeclampsia and gestational diabetes. (iStock)

“This suggests that male fetuses might be more sensitive to the metabolic environment influenced by maternal sleep patterns,” Zhu said.

“This insight could lead to tailored interventions and a deeper understanding of how prenatal factors affect neurodevelopmental outcomes in a sex-specific manner.”

TO IMPROVE YOUR SLEEP, DO THIS ACTIVITY BEFORE BED, EXPERTS SUGGEST

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Pregnant women may have trouble sleeping due to hormonal changes, discomfort, frequent urination and other factors, the Endocrine Society noted in a press release.

Young mother holding baby while he asleep

Prenatal health is important for the health of both the expectant mother and the unborn child. (iStock)

Dr. Jillian LoPiano, a Miami-based OB-GYN and chief health officer at the reproductive telehealth platform Wisp, acknowledged that the study measured a “possible biological marker” in neurological development.

“Much more research is needed to assess this relationship, but adequate sleep is known to be associated with proper growth and socioemotional development,” she told Fox News Digital.

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Poor sleep during pregnancy is also associated with other complications, including preeclampsia and gestational diabetes, LoPiano detailed.

“Adequate sleep is known to be associated with proper growth and socioemotional development.”

The expert recommended that pregnant women who are experiencing trouble sleeping consult with a doctor.

She also shared a few simple methods that can help improve sleep, including sleeping in a cool, dark room, minimizing screen time and distractions before bed, having adequate wind-down time, meditating and using support pillows.

pregnant mother trying to rest at home, lying on her couch holding her head.

Pregnant women may have trouble sleeping due to hormonal changes, discomfort, frequent urination and other factors, experts say. (iStock)

The study researchers reiterated the importance of sleep hygiene.

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“Pregnant women should be advised on strategies to improve sleep hygiene, such as maintaining a consistent sleep schedule, creating a relaxing bedtime environment, and avoiding caffeine and electronic devices before bed,” Zhu told Fox News Digital.

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The researchers also recommend that health care providers screen pregnant women for sleep quality and provide guidance on achieving sufficient sleep. 

“Furthermore, monitoring and managing gestational diabetes, which is linked to sleep patterns, should be emphasized,” Zhu added.

Pregnant woman napping

Experts emphasized the importance of proper sleep hygiene during pregnancy. (iStock)

The study did have some potential limitations, the researchers acknowledged.

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“As an observational study, we can only establish associations rather than causality,” Zhu told Fox News Digital.

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“Additionally, sleep duration was self-reported, which may introduce some level of bias.” 

Future studies with objective sleep measurements and larger sample sizes could help to validate the findings, the researcher added.

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