Fitness
Higher Fitness Levels Amplify Brain Benefits After Exercise, Study Finds
Increasing our level of physical fitness leads to a bigger release of brain-boosting proteins following one session of exercise, a new study led by a UCL researcher has found.
The study, published in Brain Research, took a group of inactive unfit participants through a 12-week training programme of cycling three times per week and made them fitter. Researchers found as their fitness increased, so did the amount of brain-derived neurotrophic factor (BDNF) released following exercise, resulting in improved brain function.
Just 15 minutes of moderate to vigorous aerobic exercise releases BDNF, a brain protein which is known to support the formation of new neurons and new synapses (connections between brain cells), and maintains the health of existing neurons. This is the first study to show that for unfit people, just 12 weeks of consistent training can boost the brain’s response to a single 15-minute workout.
The study, led by Dr Flaminia Ronca (UCL Surgery & Interventional Science, and the Institute of Sport, Exercise and Health), involved 30 participants – 23 male and seven female – taking part in the 12-week programme. To assess fitness levels throughout the programme, participants completed VO2max tests every six weeks, which measures the maximum rate of oxygen your body can consume and use during intense exercise.
BDNF levels were measured pre- and post-VO2max testing, alongside a series of cognitive and memory tests, while also measuring changes in brain activity in the prefrontal cortex – where executive functions such as decision-making, emotion regulation, attention and impulsivity are controlled.
By the final week of the trial, results showed that baseline levels of BDNF did not change, but participants did show a larger spike of BDNF following intense exercise, compared to how their brains responded to intense exercise before the 12-week programme. This was linked to improvements in VO2max (aerobic fitness).
Higher overall BDNF levels and stronger exercise-induced increases were also associated with changes in activity across key areas of the prefrontal cortex during attention and inhibition tasks, though not during memory tasks.
Overall, the results showed that increasing physical fitness can enhance the brain’s ability to produce BDNF in response to acute bouts of exercise, which can have a strong positive influence on neural activity.
Lead author Dr Flaminia Ronca said: “We’ve known for a while that exercise is good for our brain, but the mechanisms through which this occurs are still being disentangled. The most exciting finding from our study is that if we become fitter, our brains benefit even more from a single session of exercise, and this can change in only six weeks.”
Notes to editors:
For more information or to speak to the researchers involved, please contact: Tom Cramp, UCL Media Relations , T: +447586 711698, E: [email protected]
The research paper: ‘BDNF relates to prefrontal cortex activity in the context of physical exercise’, Flaminia Ronca, Cian Xu, Ellen Kong, Dennis Chan, Antonia Hamilton, Giampietro Schiavo, Ilias Tachtsidis, Paola Pinti, Benjamin Tari, Tom Gurney, Paul W. Burgess, is published in Brain Research, March 2026,
About UCL (University College London)
UCL is a diverse global community of world-class academics, students, industry links, external partners, and alumni. Our powerful collective of individuals and institutions work together to explore new possibilities.
Since 1826, we have championed independent thought by attracting and nurturing the world’s best minds. Our community of more than 50,000 students from 150 countries and over 16,000 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.
We are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.
We have a progressive and integrated approach to our teaching and research – championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.
For 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.
We were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.
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Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Method of Research
Experimental study
Subject of Research
People
Article Title
BDNF relates to prefrontal cortex activity in the context of physical exercise
Article Publication Date
4-Mar-2026
Media Contact
Tom Cramp
University College London
[email protected]
Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Method of Research
Experimental study
Subject of Research
People
Article Title
BDNF relates to prefrontal cortex activity in the context of physical exercise
Article Publication Date
4-Mar-2026
Tags
/Health and medicine/Human health/Physical exercise
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
Subject of Research:
Article Title:
News Publication Date:
Web References:
References:
Image Credits:
Keywords
Tags: 12-week cycling training program benefitsbrain plasticity and physical fitnessbrain-derived neurotrophic factor after exerciseeffects of aerobic exercise on BDNFexercise and neuron healthexercise-induced neurogenesisfitness level impact on brain proteinsfitness training for cognitive improvementimproving brain function through fitnessmoderate to vigorous aerobic exercise effectsphysical fitness and brain healthVO2max and brain function correlation
Fitness
Steffie Bryant, Alistair Brownlee to Share AI, Performance Insights at European Congress – Health & Fitness Association
From artificial intelligence to elite sport, the HFA European Congress keynote speakers will explore the forces reshaping health and fitness around the world.
By Lia Palazzo, Manager of Public Affairs
Steffie Bryant and Alistair Brownlee are set to offer the two keynote addresses at the 2026 HFA European Congress.
Artificial intelligence and high-performance leadership will take center stage at the 2026 HFA European Congress, where Keepme.ai President Steffie Bryant and two-time Olympic triathlon champion Alistair Brownlee will headline the annual gathering of fitness industry leaders.
The Congress, scheduled for September 24-26 at London Stadium in Queen Elizabeth Olympic Park, will bring together executives, operators, suppliers, investors, and innovators from more than 35 countries to explore the trends shaping the future of health and fitness.
Bryant will open the event on September 24 with a keynote examining how artificial intelligence is transforming fitness businesses. As president of Keepme.ai, she has helped clubs adopt AI-driven tools to strengthen member engagement, improve operations, and drive sustainable growth. Her session will focus on how operators can leverage emerging technology while maintaining a people-first approach. Her keynote is sponsored by Keepme.ai.
Brownlee will headline the second day of the Congress, sharing lessons from Olympic competition, entrepreneurship, and health innovation. The only athlete to win two Olympic gold medals in the individual triathlon, Brownlee is also founder of sports nutrition company truefuels, an investor in health and wellness companies, and co-founder of the Brownlee Foundation, which promotes youth participation in sport.
The speaker lineup reflects this year’s Congress theme, One Vision. One Voice., which focuses on the role innovation, collaboration, and leadership will play in the next chapter of the global fitness industry.
In addition to the keynote presentations, attendees will hear from more than 40 speakers from the fitness sector and related industries addressing trends, GLP-1 usage and exercise, emerging markets to watch, investment opportunities, retention, payment ecosystems, corporate wellness, community initiatives, and more. The full schedule can be viewed here and includes time to connect with suppliers in the Sponsor Marketplace. On September 26, attendees can participate in club and studio tours across London. The club tours can be added at the time of registration.
Presented in partnership with ukactive and hosted by industry leader David Minton of EVOLVE, the HFA European Congress is the industry’s premier European event, offering business leaders insight into emerging trends, new technologies, and opportunities shaping the future of the industry.
Fitness
Health Watch: Fitness Friday – exercise and dementia
...RED FLAG WARNING REMAINS IN EFFECT UNTIL 11 PM PDT SATURDAY FOR GUSTY WINDS AND LOW HUMIDITY FOR THE SIERRA FRONT... * Affected Area...Fire Weather Zone 420 Northern Sierra Front including Carson City, Douglas, Storey, Southern Washoe, Western Lyon, and Far Southern Lassen Counties. * Winds...West 20 to 30 mph with gusts up to 45 mph. * Humidity...Afternoon minimums of 12 to 20 percent. * Duration...2 to 5 hours Friday with 3 to 8 hours Saturday. * Impacts...The combination of gusty winds and dry fuels can cause fire to rapidly grow in size and intensity before first responders can contain them. PRECAUTIONARY/PREPAREDNESS ACTIONS... Avoid outdoor activities that can cause a spark near dry vegetation, such as yard work, target shooting, or campfires. Follow local fire restrictions. Check weather.gov/reno for updates and livingwithfire.info for preparedness tips. &&
...LAKE WIND ADVISORY REMAINS IN EFFECT UNTIL 11 PM PDT SATURDAY FOR WASHOE LAKE... * WHAT...Southwest winds 20 to 30 mph with gusts up to 45 mph for Washoe Lake. * WHERE...Greater Reno-Carson City-Minden Area. * WHEN...Until 11 PM PDT Saturday. * IMPACTS...Small boats, kayaks and paddle boards will be prone to capsizing and should remain off lake waters until conditions improve. * ADDITIONAL DETAILS...Winds may briefly subside tonight before increasing again early Saturday morning. PRECAUTIONARY/PREPAREDNESS ACTIONS... Check lake conditions before heading out and be prepared for a sudden increase in winds and wave heights. Consider postponing boating activities on the lake until a day with less wind. &&
Fitness
Can VR Fitness Replace Traditional Exercise? – TechRound
In 2025, the global Virtual Reality fitness market was estimated to be worth between $30 – $50 billion dollars and by the mid 2030’s, it is likely to be estimated to be worth up to 400 billion dollars. Big name companies like Meta, Apple, Sony, Samsung and Nike, are investing a lot of money into the field.
One 2025 study by the University of Victoria found that more people utilising VR fitness programs were exercising for longer periods of time. VR based fitness users actively worked out sessions that were an average of 34% longer and VR fitness users were also 2.2 times more likely to complete weekly physical workout requirements than users of traditional home workout equipment.
The real question is, how viable is the market and how much of an opportunity is there for VC-funded startups that are working on the future of fitness technology?
Why Virtual Fitness is Worth Watching
VR fitness is built to solve the problem of the dropout of users of home fitness programs. According to studies, traditional home workouts suffer from dropout rates of 50% within three months. Repetitive workouts become boring and are a drain on motivation.
However, exercising in VR allows fitness to be gamified and VR fitness studies have uncovered an important phenomenon: users perceive their heart rate and effort to be lower than it is and are likely to work out even harder than in traditional settings.
Can You Actually Become Fitter With VR Fitness?
There is no shortage of virtual fitness games out there and yes, you can actually become fitter through a faster heart rate and all while ‘playing a game’ that might not seem so exhaustive when compared to the gym. Active VR games can create an effective aerobic workout and burn calories on par with biking or light jogging.
These games produce real results and the research backs it up. Active VR workouts consistently produce heart rates in the aerobic zone. Game examples include Beat Saber, Supernatural, Les Mills Body Combat VR and Thrill of the Fight.
Opportunities to Expand into Mental Well-Being Through VR
VR fitness isn’t just about physical output. Immersive environments have documented effects on stress and mood, exercising in a virtual forest or on a clifftop coastline produces different psychological responses to a gym mirror.
This mental wellness dimension is opening a new product category: VR fitness platforms that blur into mindfulness apps, targeting the significant overlap between corporate wellness programmes and mental health investment.
What Are The Limitations of Virtual Fitness?
Currently the biggest weakness in VR fitness is the lack of options for strength training. The types of movements that build and maintain muscle mass, like squats and deadlifts, can’t be effectively done in VR without some added equipment. One of the few companies that have started to tackle this problem is Black Box VR, which offers gyms combining VR and cable resistance.
Startups Worth Keeping an Eye On in The VR Fitness Sector
There are a handful of innovative startups in the VR fitness industry that are worth watching in 2026 and beyond- from subscription-based fitness tools to interactive challenges that help increase stamina and even strength:
Supernatural
In 2023, Meta completed its acquisition of Supernatural and integrated the VR fitness platform into the expanding Meta Quest ecosystem. The service offers users daily workouts set in immersive real-world locations, enhanced by licensed music and guided instruction.
As a subscription-based platform, Supernatural has consistently demonstrated some of the strongest retention rates in the consumer VR market, highlighting the viability of the VR fitness subscription model. In 2026, Meta announced that Supernatural would be spun off into a new independent company, Supernatural Health, led by the platform’s original founders. Supernatural Health is expected to relaunch in autumn 2026 with higher subscription pricing, reflecting a renewed focus on growing the platform as a standalone fitness business.
Black Box VR

Purpose-built VR gyms seem to be the focus of Black Box VR. Combining resistance machines and immersive environments is an interesting approach, especially with the existing VR home ecosystems providing frictionless workouts. Black Box VR’s franchise model suggests that they believe the hybrid VR/gym model will bring an edge over the competition when compared to only a software solution.
HOLOFIT

HOLOFIT is a virtual reality fitness platform developed by Holodia that transforms cardio workouts into immersive experiences. Using a VR headset, users can row, cycle, run, or perform bodyweight exercises while exploring virtual worlds and completing interactive challenges.
The platform connects with rowing machines, exercise bikes and ellipticals, making workouts more engaging and motivating through gamification, virtual coaching and online competitions.
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