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Blood test could predict when Alzheimer’s symptoms will start years in advance

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Blood test could predict when Alzheimer’s symptoms will start years in advance

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A simple blood test could predict not only a person’s risk of developing Alzheimer’s disease, but also the year symptoms will begin.

Researchers at the Washington University School of Medicine in St. Louis set out to determine if levels of a specific protein in the blood could be used as a “biological clock” to predict when signs of the disease will emerge.

The specific protein, known as p-tau217, forms “tangles” in the brain that disrupt communication between nerve cells. In a healthy brain, tau helps to stabilize the structure of nerve cells.

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In some cases, brain scans can be used to detect these tangles when diagnosing Alzheimer’s. Preliminary studies have suggested that the same method could be used to determine a progression timeline.

As these imaging tests are often complex and expensive, the research team wanted to explore whether a blood test could monitor the same proteins and produce similar results.

By comparing blood samples with participants’ cognitive performance over several years, the team found that p-tau217 levels rise in a “remarkably consistent” pattern long before memory loss begins. (iStock)

The study, published in the journal Nature Medicine, analyzed data from more than 600 older adults enrolled in two long-term Alzheimer’s research projects.

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By comparing blood samples with participants’ cognitive performance over several years, the team found that p-tau217 levels rise in a “remarkably consistent” pattern long before memory loss begins, according to a press release.

The team then created a model that uses a patient’s age and protein levels to estimate when symptoms will appear, with a margin of error of three to four years.

The team created a model that uses a patient’s age and protein levels to estimate when symptoms will appear, with a margin of error of three to four years. (iStock)

“We show that a single blood test measuring p-tau217 can provide a rough estimate of when an individual is likely to develop symptoms of Alzheimer’s disease,” lead author Kellen K. Petersen, PhD, instructor of neurology at Washington University in St. Louis, told Fox News Digital.

The researchers found that older adults developed symptoms much more rapidly after p-tau217 became abnormal, he noted.

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“For example, people who first had abnormal p-tau217 levels around age 60 didn’t develop Alzheimer’s symptoms for about 20 years, whereas those who first had abnormal p-tau217 levels around age 80 developed symptoms after only about 10 years,” Petersen said. 

This suggests that age and disease-related changes in the brain can influence how quickly Alzheimer’s symptoms become apparent, the researcher concluded.

“At this point, we do not recommend that any cognitively unimpaired individuals have any Alzheimer’s disease biomarker test.”

“This could transform how researchers design clinical trials and, eventually, how clinicians identify people at highest risk for cognitive decline associated with Alzheimer’s years before decline begins,” Chicago-based Rebecca M. Edelmayer, PhD, vice president of scientific engagement at the Alzheimer’s Association, told Fox News Digital.

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“A blood test is generally much less expensive and easier to administer than a brain scan or spinal‑fluid test. In the future, it could help doctors and researchers identify people who may benefit from early treatments,” added Edelmayer, who was not involved in the study.

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The study did have some limitations and caveats.

“We were only able to make predictions for individuals whose p-tau217 levels fell within a certain range, although it was a fairly wide range,” Petersen shared. “The models were developed in relatively healthy and well-educated research cohorts that were not diverse, so the results may not apply well to the broader population.”

The research suggests that age and disease-related changes in the brain can influence how quickly Alzheimer’s symptoms become apparent. (iStock)

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While the researchers referenced in-home blood tests in this study, they cautioned against people seeking out and taking these tests themselves.

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“At this point, we do not recommend that any cognitively unimpaired individuals have any Alzheimer’s disease biomarker test,” Dr. Suzanne Schindler, a neurologist at Washington University who was a co-author of the study, said in the press release.

Peterson acknowledged that these results are still experimental and ripe for improvement.

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“The current estimate is not yet accurate enough for clinical use or personal medical decision-making, but we expect that it will be possible to create more accurate models,” he told Fox News Digital.

Looking ahead, the team hopes to refine the test by researching other Alzheimer’s-linked proteins to narrow the margin of error, Schindler said. More diverse participants are also needed to confirm the results.

Two large clinical trials are in progress to determine whether people with high levels of the protein can benefit from treatment. (iStock)

Two large clinical trials are now in progress, aiming to determine whether people with high levels of this protein can benefit from treatment with one of two Alzheimer’s drugs before symptoms appear.

Lecanemab and donanemab are the only approved drugs designed to reduce levels of plaques in the brain associated with Alzheimer’s disease. Researchers hope that treating people earlier may boost the drugs’ effectiveness.

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“There are many other blood and imaging biomarkers, as well as cognitive tests, that we can combine with plasma p-tau217 to improve the accuracy of predicting symptom onset,” Petersen said. “We hope this work will lead to even better models that will be useful to individuals.”

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Want to age better? Researchers say 4-minute routine may help prevent dangerous falls

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Want to age better? Researchers say 4-minute routine may help prevent dangerous falls

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Just four minutes of daily strength exercises can dramatically improve mobility, balance and leg strength in older adults, per new research from the Penn State College of Medicine.

Standard public health guidelines recommend at least 150 minutes of moderate exercise per week. However, the study suggests that fewer than one in five older adults meet the recommended muscle-strengthening guidelines.

The research team designed a home-based program called Functional Activity Strength Training, or FAST-2. They evaluated 97 sedentary participants 65 and older, with an average age of 74.

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Before entering the study, these individuals were averaging just 18 minutes of total physical activity each week.

The older adults were randomly split into two groups, with one group performing the daily exercise routine and the other serving as a control group that received no intervention, according to the study’s press release.

Just four minutes of daily home strength training can significantly improve mobility, balance and leg strength in older adults, according to a Penn State College of Medicine study. (iStock)

Participants performed four basic movements for 30 seconds each, separated by 30-second rest intervals. The entire routine lasted exactly four minutes. The circuit consisted of push-ups, chair stands, two-arm resistance-band rows and stair stepping.

To keep the routine accessible, researchers provided written explanations and simple modifications. For example, participants could perform push-ups against a kitchen counter or wall, or use their hands on their knees for support during chair stands.

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Participants were also given four elastic resistance bands and an adjustable step platform.

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“Exercise is actually really complicated, because you have to decide how many repetitions, how far, how many sets, how much rest and how many times per week,” co-author Smita Dandekar, associate professor of pediatrics at Penn State College of Medicine, said in the press release.

“It’s hard work … so if we can make it short, we’re part [of the] way there.”

The program consisted of four basic movements: push-ups, chair stands, resistance-band rows and stair stepping. (iStock)

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As the participants grew stronger, they were encouraged to progress to higher levels of difficulty, such as transitioning away from modifications or increasing the height of the stepper.

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After 12 weeks, the results suggested that a tiny dose of regular exercise could yield noticeable physical benefits. In a 30-second chair-stand test, the exercise group performed an average of 4.2 more repetitions than the control group.

“These indicators … give you a sense of whether or not you’re going to be able to be active in the future.”

The adults doing the exercises also shaved 2.3 seconds off their time during a test measuring how they could stand up and sit down five times consecutively. Furthermore, they extended their one-legged balance time by an average of 3.6 seconds.

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The researchers emphasized that these specific measurements are critical medical indicators of an older adult’s future health.

By keeping the routine ultra-short, researchers eliminated common barriers like time constraints and exhaustion, resulting in an exceptionally high 81% workout completion rate. (iStock)

“These indicators predict your future ability to go into a nursing home, your future likelihood of falling and of developing difficulty walking,” noted lead author Christopher Sciamanna, professor of medicine and of public health at Penn State College of Medicine, in the press release.

“They give you a sense of whether or not you’re going to be able to be active in the future.”

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While traditional home exercise programs generally see low engagement, the participants in this study successfully completed their workouts on 81% of the tracked days, according to the researchers.

After 12 weeks, exercising seniors gained the ability to complete an average of four more chair-stand repetitions than those who did not exercise. (iStock)

The study had several noted limitations. As it tracked a relatively small sample size of fewer than 100 individuals over a brief 12-week time frame, it is unknown whether these mobility gains can be sustained long-term.

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Additionally, the researchers did not specify the exact dropout rates or detail how the routine might affect seniors who already relied on assistive devices like walkers or canes.

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Because the final trial results reflected a specific group of participants who met the entry criteria, further investigation is required to determine whether the short routine can safely benefit older adults facing more severe physical limitations or cognitive decline.

The study was published in the journal PLOS One.

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Popular mommy blogger dies at 48 two years after devastating cancer diagnosis

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Popular mommy blogger dies at 48 two years after devastating cancer diagnosis

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Jill Smokler, founder of Scary Mommy, has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer.

The popular “mommy blogger” had been fighting the disease for the past two years, according to an announcement posted on ScaryMommy.com on Monday.

The stay-at-home mother of three launched the blog in 2008 as a place to share the “joys and pitfalls” of parenting, according to the article.

As Scary Mommy expanded from a personal blog into a major parenting brand, Smokler built a following with her honest, often self-deprecating take on motherhood. She went on to speak at blogging conferences, author bestselling books, appear on national television programs and earn three Webby Awards, her biography states.

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“Jill spent her life telling the truth about motherhood — that it could be wonderful and impossible in the very same breath — and in doing so, she gave millions of women permission to stop pretending and feel a little less alone,” her family shared in a statement following her passing.

Jill Smokler, founder of Scary Mommy (pictured in 2018), has died at age 48 after a battle with glioblastoma, an aggressive form of brain cancer. (Lloyd Fox/Baltimore Sun/ZUMA Press Wire / Shutterstock)

“She was funny, fearless, generous and entirely herself. More than anything she built, Jill was proudest of her three children, Lily, Ben and Evan. We are heartbroken to lose her, and endlessly proud of the mark she left on the world.”

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Smokler’s first sign of the disease was in April 2024, when she experienced a sudden seizure. She then underwent surgery to remove a brain tumor, after which she didn’t recognize her own children, she previously shared with Today.

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“I am definitely grateful that I don’t remember the looks on their faces when I didn’t recognize them,” she said. “That must have been gutting.”

Smokler was diagnosed with glioblastoma, the most common malignant primary brain tumor in adults and one of the deadliest forms of brain cancer. There is currently no cure.

About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. (iStock)

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Following surgery, the blogger underwent radiation and chemotherapy, during which she was open about her treatment side effects, including fatigue and hair loss. Additional surgeries and clinical trials followed, according to previous interviews.

“Thank you, Jill, for everything. May you rest in peace,” the Scary Mommy post concluded.

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About 13.9% of all brain tumors are glioblastomas, according to the American Brain Tumor Association. More than 12,000 new cases are diagnosed in the U.S. each year.

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Median survival is approximately 12 to 18 months after diagnosis, even with treatment. Only about 5% to 7% of patients survive five years after diagnosis, data shows.

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8 common food preservatives linked to higher risk of high blood pressure and heart disease

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8 common food preservatives linked to higher risk of high blood pressure and heart disease

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Common food preservatives may contribute to higher risks of high blood pressure and cardiovascular disease, according to a large French study.

Researchers analyzed data from 112,395 adults averaging 42 years of age, assessing their detailed dietary intake with an average follow-up of nearly eight years.

Among the participants, 5,544 developed hypertension during the follow-up period, and 2,450 experienced cardiovascular disease events.

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Higher consumption of total non-antioxidant preservatives was associated with a 29% greater risk of hypertension and a 16% higher risk of cardiovascular disease.

Higher consumption of total antioxidant preservatives was linked to a 22% spike in hypertension risk.

Common food preservatives may contribute to higher risks of high blood pressure and cardiovascular disease, according to a large French study. (iStock)

Out of the 17 preservative additives consumed by at least 10% of participants, eight in particular were associated with higher rates of hypertension, including the following.

  • Potassium sorbate
  • Sorbic acid
  • Sodium nitrite
  • Potassium nitrite
  • Sodium metabisulphite
  • Potassium metabisulphite
  • Citric acid
  • Tripotassium citrate

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Only one of the preservatives – ascorbic acid, which is the food additive form of vitamin C – was significantly associated with higher cardiovascular disease risk.

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The finding does not mean that dietary vitamin C itself causes cardiovascular disease, the researchers noted. The study examined ascorbic acid in the form used as a food additive in processed foods, not vitamin C from fruits, vegetables or supplements.

Out of the 17 preservative additives consumed by at least 10% of participants, eight in particular were associated with higher rates of hypertension. (iStock)

The findings were published in the European Heart Journal.

“This is a very important study that puts together what we already know – that preservatives of all kinds raise blood pressure and contribute directly to heart disease and stroke over eight years,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.

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“Whereas potassium itself can lower blood pressure, the additive potassium sorbate has previously been found to be associated with hypertension in a large study in the European Heart Journal,” the doctor, who was not involved in the study, told Fox News Digital. “Potassium metabisulphite was also found to raise pressure in the same study.”

The same was found for sodium nitrite in the new study, Siegel noted, with 73% of participants consuming it regularly – “mostly in processed foods like hot dogs, ham, bacon and deli meats.”

“Preservatives of all kinds raise blood pressure and contribute directly to heart disease and stroke over eight years,” a doctor told Fox News Digital. (iStock)

“This has been found in previous research for many years,” he added.

Siegel also discussed the 22% increased risk linked to ascorbic acid. “I am dubious about this association, as it has not generally been found before, but perhaps the risk is when it is used as a chemical preservative.”

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“For all the sodium additives, this is expected, but surprising with extracts of rosemary and citric acid – the key to both of these ingredients is when they are used as preservatives (chemicals),” he added.

Potential limitations

As this was an observational study, it could not prove that the additives caused the health conditions.

Also, the participants who volunteered for the study were generally healthier, more educated and more often female than the general French population, the researchers noted.

As this was an observational study, it could not prove that the additives caused the health conditions. (FG Trade / Getty Images)

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There was also the chance that hypertension was underdiagnosed in some participants.

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While the researchers estimated people’s dietary intake as accurately as possible, there was a chance that some consumption was inaccurately reported.

The authors emphasized that these findings need to be confirmed in further research of other populations.

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If the results are replicated in future research, some food preservatives may face additional safety reviews focused on their effects on the cardiovascular system, the researchers suggested.

“The take-home is to use natural ingredients as much as possible, and especially beware of sodium chemical preservatives when it comes to risk of heart disease and stroke from associated hypertension,” Siegel concluded.

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