Health
Lingering lung disorders 5 years post-COVID: Here's what to know
The COVID-19 pandemic engulfed the U.S. five years ago this month, leaving not only lingering mental health effects but also long-term physical symptoms.
One of those included a condition known as post-COVID pulmonary fibrosis, which involves scarring of the lungs that can worsen over time and may require a lung transplant, according to pulmonologists.
Early infection caused extensive inflammation in many different body systems, noted Dr. Scott Scheinin, MD, director of lung transplantation for Mount Sinai Health System in New York City.
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“Once they cleared that infection, a lot of people were left with some amount of lung tissue being destroyed,” Scheinin told Fox News Digital during an interview.
Post-COVID pulmonary fibrosis involves scarring of the lungs that can worsen over time and may require a lung transplant. (iStock)
Scheinin provided medical care on the frontlines in New York City in the first wave of the pandemic.
“The early COVID experience in New York was the worst thing I’ve ever experienced in my life. It was just horrible,” he recalled.
One patient’s story
One of Scheinin’s patients was a pastor in his mid-50s who was infected with COVID-19 in March 2020.
Pastor Benjamin Thomas of East Meadow, Long Island, spent nearly 100 days in the hospital — 54 of which were on a ventilator — and six weeks in a medically induced coma.
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He was discharged in July 2020 with an oxygen tank. Despite overcoming the initial infection, Thomas’ condition deteriorated.
In 2022, the pastor noticed that his daily activity tolerance diminished dramatically and he required more oxygen for simple tasks.
The inflammatory response sparked by early mutations of the novel coronavirus led to scarring of lungs in many individuals. (iStock)
“I couldn’t take a shower for more than 30 seconds without being on oxygen,” he told Fox News Digital in an interview.
Scheinin said the pastor had no underlying conditions before contracting COVID. A lung biopsy showed that Thomas’ symptoms were consistent with post-inflammatory pulmonary fibrosis due to the COVID-19 infection.
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Thomas’ story was remarkable in that he survived the first bout with COVID, but two years later, his lungs had deteriorated so badly from the scarring that he needed a double lung transplant, Scheinin shared.
After spending seven months on the wait list, Thomas opted to settle for one lung since that would be faster than waiting for two. His surgery was performed on Feb. 28, 2023.
“The flu and any other illness would be exacerbated because of the underlying scarring of the lung.”
Now, two years after his lung transplant, Thomas says he no longer needs oxygen supplementation and is back to performing his daily pastoral activities at his church in Queens Village, New York, albeit at a slower pace than before.
The pastor has returned to long-distance driving and can now walk for about 30 minutes. He attributes his successful recovery to the efforts of his Mount Sinai medical team, his faith and prayers from his congregation.
What is post-COVID fibrosis?
A healthy lung allows for the normal exchange of gases, such as oxygen and carbon dioxide, when one breathes air, Scheinin told Fox News Digital.
The inflammatory response sparked by early mutations of the novel coronavirus led to scarring of lungs in many individuals.
Testing for this condition is relatively non-invasive, typically including a cat scan or X-ray to check for structural lung damage, as well as blood tests and a pulmonary function test. (iStock)
In certain cases, the doctor said, the lungs no longer function as well as they did before the infection.
“The normal gas exchange is impeded because now you have areas of the lung tissue that are scarred, and therefore they’re not functioning normally,” he said.
“If it’s a small area, it may be insignificant and unnoticeable, but as more of the lung tissue becomes scarred, more of the normal lung function is destroyed, [and] the patient becomes short of breath.”
This could lead to future issues, especially if the patient is exposed to other respiratory ailments.
“The flu and any other illness would be exacerbated because of the underlying scarring of the lung,” Scheinin said. “I think it just makes the lungs more susceptible to injury.”
Symptoms, diagnosis and treatment
Symptoms of post-COVID pulmonary fibrosis can mimic other types of interstitial lung diseases, which are disorders that cause progressive scarring and inflammation of lung tissue.
If a person who previously had a COVID infection continues to experience shortness of breath, chronic cough and change in their exercise tolerance — or if they smoke or have an underlying condition such as emphysema — they should see their physician or a pulmonologist, according to Scheinin.
Risk factors for post-COVID pulmonary fibrosis typically include an underlying chronic condition, older age, and the use of mechanical ventilation during the acute phase of COVID. (iStock)
Testing for this condition is relatively non-invasive, typically including a cat scan or X-ray to check for structural lung damage, as well as blood tests and a pulmonary function test, the doctor told Fox News Digital.
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Not everyone infected with COVID will develop pulmonary fibrosis, and the condition can vary in severity and recovery, the lung specialist noted.
In some cases, a person may have been susceptible to developing lung fibrosis due to an underlying condition and the COVID-19 infection may accelerate the fibrotic progression.
It is important to get checked out by a medical professional if you have symptoms, a lung specialist said, especially shortness of breath. (iStock)
It is important to get checked out by a medical professional if you have symptoms, Scheinin said, especially shortness of breath.
Risk factors for post-COVID pulmonary fibrosis typically include an underlying chronic condition, older age, and the use of mechanical ventilation during the acute phase of COVID, according to previous studies.
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Researchers are investigating the use of antifibrotic medications to treat the condition, along with steroids and other anti-inflammatories that are currently used to treat other lung diseases.
Besides medications, treatment may also include pulmonary rehabilitation, exercise training and behavioral modifications, according to lung specialists.
Health
Flu by state: Where this season’s highly contagious variant is spreading the most
New flu strain emerging as a severe health threat
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A new form of the flu, which is highly contagious and aggressive, is sweeping the nation this season.
A mutation of influenza A H3N2, called subclade K, has been detected as the culprit in rising global cases, including in the U.S.
The World Health Organization stated on its website that the K variant marks “a notable evolution in influenza A (H3N2) viruses,” which some say calls into question the effectiveness of this season’s influenza vaccine against the strain.
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The K variant causes more intense flu symptoms, including fever, chills, headache, fatigue, cough, sore throat and runny nose, according to experts.
Multiple states in the northeast are reporting high rates of respiratory illness this month. (iStock)
Among 216 influenza A(H3N2) viruses collected since Sept. 28, 89.8% belonged to subclade K, a CDC report states.
The agency continues to release a weekly influenza surveillance report, tracking which states are seeing the most activity for outpatient respiratory illness.
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Below are the states and regions within the highest range of reported medical visits, not necessarily confirmed influenza cases, as of the week ending Dec. 13.
The CDC’s weekly influenza surveillance report, an outpatient respiratory illness activity map, based on data reported to ILINet for the week ending Dec. 13, 2025. (CDC FluView)
Very High (Level 1)
Very High (Level 2)
Very High (Level 3)
- New Jersey
- Rhode Island
- Louisiana
- Colorado
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High (Level 1)
- Massachusetts
- Connecticut
- Michigan
- Idaho
- South Carolina
High (Level 2)
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High (Level 3)
- Washington, D.C.
- Maryland
- North Carolina
- Georgia
The CDC has estimated that there have been at least 4.6 million illnesses, 49,000 hospitalizations and 1,900 flu deaths this season so far. The flu vaccine is recommended as the best line of defense against the virus.
The flu vaccine is recommended as the best line of defense against the virus. (iStock)
In an interview with Fox News Digital, Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, shared details on the early severity of this emerging flu strain.
“It’s becoming evident that this is a pretty severe variant of the flu,” he said. “Certainly, in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”
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Subclade K is the “perfect storm” for an aggressive flu season, Maniar suggested, as vaccination rates overall are down, and it’s uncertain whether this year’s flu vaccine directly addresses this specific mutation.
“The vaccine is very important to get, but because it’s not perfectly aligned with this variant, I think that’s also contributing to some degree to the severity of cases we’re seeing,” he said. “We’re going in [to this flu season] with lower vaccination rates and a variant that in itself seems to be more aggressive.”
Subclade K has “caused some severe illness, and we’re seeing an aggressive flu season already,” a doctor said. (iStock)
Maniar stressed that it’s not too late to get the flu vaccine, as peak flu season has not yet arrived.
“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” he said. “There are likely to be lots of indoor gatherings and other events that create risk of exposure, so protection is important.”
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Even healthy individuals can become seriously ill from the flu, Maniar noted, “so a vaccine is beneficial for almost everyone.”
“Individuals typically start to develop some degree of protection within a few days and gain the full benefit within about two weeks, so now is the time for anyone who hasn’t gotten the vaccine yet.”
Health
6 things to know about pancreatic cancer after former senator’s diagnosis
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Former U.S. Sen. Ben Sasse of Nebraska announced this week that he has been diagnosed with metastatic stage 4 pancreatic cancer, calling the disease “a death sentence” in a message posted on X.
Sasse, 53, said the cancer has spread and acknowledged that he has “less time than I’d prefer,” although he also mentioned recent scientific advances and his intention to pursue treatment.
“I’m not going down without a fight,” Sasse said when revealing his diagnosis. “One sub-part of God’s grace is found in the jaw-dropping advances science has made the past few years in immunotherapy and more.”
HIDDEN FACTOR IN CANCER TREATMENT TIMING MAY AFFECT SURVIVAL, RESEARCHERS SAY
Pancreatic cancer is known to be one of the deadliest forms of cancer, with ongoing research efforts aiming to improve outcomes.
Below are six key things to know about the disease.
No. 1: Pancreatic cancer is often diagnosed late and is highly deadly
Pancreatic cancer is notoriously aggressive and difficult to treat, according to the American Cancer Society. Most patients are not diagnosed until the disease has already spread to other organs, largely because there aren’t reliable screening tests and early symptoms can be vague or absent.
Ben Sasse, a former U.S. senator from Nebraska, announced that he has been diagnosed with metastatic stage 4 pancreatic cancer. (Getty Images; iStock)
The ACS estimates that 67,440 Americans will be diagnosed with pancreatic cancer in 2025, and about 51,980 are expected to die from it. The tumor’s biology creates physical and chemical barriers that reduce the effectiveness of many traditional treatments.
No. 2: New immunotherapies are showing early promise
Researchers at UCLA recently reported progress on an experimental, off-the-shelf, cell-based immunotherapy designed to attack pancreatic cancer.
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In mouse studies, the therapy slowed tumor growth, extended survival and remained effective even after the cancer had spread to other organs, such as the liver and lungs.
The treatment uses special immune cells called natural killer T (NKT) cells, which are genetically modified so they can specifically recognize and attack pancreatic cancer cells.
Early research is exploring new approaches to pancreatic cancer, including experimental immunotherapies and studies of risk factors, but many findings are still in preclinical or observational stages. (iStock)
Unlike personalized therapies, the NKT cells are naturally compatible with different immune systems and can be mass-produced from donor stem cells.
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Researchers estimate that one donor could supply cells for thousands of treatments, with a potential cost of around $5,000 per dose. All testing so far has been done in mice, and human trials have not yet begun.
No. 3: Diet and gut health may affect treatment recovery
Separate research from the Massachusetts Institute of Technology has suggested that the amino acid cysteine could help the gut heal after cancer treatments, such as chemotherapy and radiation.
In mouse studies, cysteine — found in foods like meat, eggs, dairy products, legumes and nuts — helped to regenerate intestinal stem cells that are often damaged during cancer therapy.
Researchers are studying how diet, including nutrients such as cysteine found in high-protein foods, may help support recovery from pancreatic cancer treatments. (iStock)
Additional unpublished research showed benefits after treatment with 5-fluorouracil, a chemotherapy drug used for colon and pancreatic cancers.
Researchers emphasized that human studies are still needed and that cysteine is not a cure for cancer itself.
No. 4: Alcohol and lifestyle factors may raise cancer risk
Recent research published in PLOS Medicine by the International Agency for Research on Cancer found that alcohol consumption is associated with an increased risk of pancreatic cancer.
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The study followed 2.5 million people for about 16 years, finding that each additional 10 grams of ethanol consumed per day was linked to a 3% increase in risk. Higher intake levels were associated with greater risk, particularly with beer and spirits.
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Researchers noted that the study was observational and that more work is needed to understand lifetime drinking patterns.
No. 5: Symptoms are often subtle and easily missed
When symptoms do occur, they can include abdominal pain that spreads to the sides or back, loss of appetite and unexplained weight loss, according to Mayo Clinic.
Some patients develop jaundice — yellowing of the skin and whites of the eyes — along with light-colored or floating stools, dark urine and itching.
Common warning signs of pancreatic cancer can include abdominal pain, unexplained weight loss and loss of appetite. (iStock)
Other possible signs include a new diagnosis of diabetes (or diabetes that becomes harder to control), pain and swelling in an arm or leg that may be linked to a blood clot, and persistent tiredness or weakness.
Those who are experiencing symptoms should consult with a healthcare professional.
No. 6: Age, genetics and health conditions can raise risk
Pancreatic cancer risk is influenced by a combination of genetic, medical and lifestyle factors.
The disease becomes more likely with age, and men are slightly more susceptible, according to the ACS. Those with a family history or inherited genetic mutation also have a higher risk, as do people with type 2 diabetes, obesity and lack of physical activity.
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Diets high in processed or red meats and low in fruits and vegetables, as well as high alcohol consumption, may also contribute to pancreatic cancer risk, along with some occupational chemical exposures, per multiple cancer agencies.
Experts note, however, that many people are diagnosed with the disease despite having no clear risk factors.
Deirdre Bardolf, Ashley J. DiMella, Alex Nitzberg and Angelica Stabile, all of Fox News Digital, contributed reporting.
Health
New Wegovy pill offers needle-free weight loss — but may not work for everyone
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The first oral GLP-1 medication for weight loss has been approved for use in the U.S.
The Wegovy pill, from drugmaker Novo Nordisk, was cleared by the Food and Drug Administration to reduce excess body weight, maintain long-term weight reduction and lower the risk of major cardiovascular events.
Approval of the once-daily 25mg semaglutide pill was based on the results of two clinical trials — the OASIS trial program and the SELECT trial.
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The Wegovy pill demonstrated a mean weight loss of 16.6% in the OASIS 4 trial among adults who were obese or overweight and had one or more comorbidities (other medical conditions), according to a press release. In the same trial, one in three participants experienced 20% or greater weight loss.
The first oral GLP-1 medication for weight loss has been approved for use in the U.S. (iStock)
Novo Nordisk reported that the weight loss achieved with the pill is similar to that of injectable Wegovy and has a similar safety profile.
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“With today’s approval of the Wegovy pill, patients will have a convenient, once-daily pill that can help them lose as much weight as the original Wegovy injection,” said Mike Doustdar, president and CEO of Novo Nordisk, in the press release.
Novo Nordisk reported that the weight loss achieved with the pill is similar to that of injectable Wegovy and has a similar safety profile. (James Manning/PA Images via Getty Images)
“As the first oral GLP-1 treatment for people living with overweight or obesity, the Wegovy pill provides patients with a new, convenient treatment option that can help patients start or continue their weight-loss journey.”
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The oral GLP-1 is expected to launch in the U.S. in early January 2026. Novo Nordisk has also submitted oral semaglutide for obesity to the European Medicines Agency (EMA) and other regulatory authorities.
“Most side effects will be GI-related and should be similar to the injectable, such as nausea, vomiting and constipation,” an expert said. (iStock)
Dr. Sue Decotiis, a medical weight-loss doctor in New York City, confirmed in an interview with Fox News Digital that studies show oral Wegovy is comparable to the weekly injectable, just without the needles.
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Although the pill may result in better compliance and ease of use, Decotiis warned that some patients may not absorb the medication through the gastrointestinal tract as well as with the injectable version due to individual idiosyncrasies in the body.
“Most side effects will be GI-related and should be similar to the injectable, such as nausea, vomiting and constipation,” she said.
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“In my practice, I have found tirzepatide (Mounjaro and Zepbound) to yield more weight loss and fat loss than semaglutide by about 20%,” the doctor added. “This has been shown in studies, often [with] fewer side effects.”
More oral GLP-1s may be coming in 2026, according to Decotiis, including an Orforglipron application by Lilly and a new combination Novo Nordisk drug, which is pending approval later next year.
One expert warned that some patients may not absorb the medication through the gastrointestinal tract as well as with the injectable version. (iStock)
“There will be more new drugs available in the future that will be more effective for patients who are more insulin-resistant and have not responded as well to semaglutide and/or tirzepatide,” the doctor said. “This is great news, as novel drugs affecting more receptors mean better long-term results in more patients.”
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As these medications become cheaper and easier to access, Decotiis emphasized that keeping up with healthy lifestyle habits — including proper nutrition with sufficient protein and fiber, as well as increased hydration — is essential to ensuring lasting results.
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“If not, patients will regain weight and could lose muscle and not enough body fat,” she said.
Fox News Digital reached out to Novo Nordisk for comment.
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