Health
Alzheimer’s on mother’s side of the family could increase disease risk, study finds
Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history.
That’s according to a recent study from Mass General Brigham. Researchers analyzed 4,400 adults between ages 65 and 85 who did not have any signs of cognitive decline, but did have amyloid show up in brain-imaging scans.
The people with the higher amounts of amyloid were more likely to have mothers with symptoms of Alzheimer’s — primarily memory loss, the researchers found.
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Amyloid, a protein that builds up in the brain and forms plaques that affect cognitive function, is one of the hallmarks of Alzheimer’s disease (AD).
The findings were published in JAMA Neurology in June.
Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history, a new study has found. (iStock)
“Our study showed a striking asymmetry in the impact of maternal versus paternal history of dementia on the risk of offsprings’ brain amyloid-beta protein accumulation, with maternal history having a greater impact,” senior corresponding author Hyun-Sik Yang, M.D., a neurologist at Mass General Brigham, told Fox News Digital via email.
“In our study, maternal history of dementia increased their children’s risk of having preclinical AD, while paternal history had less impact.”
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The researchers — a collaborative team from Mass General Brigham, Vanderbilt and Stanford — expected to see similar genetic risks to be passed down by mothers and fathers, Yang noted.
“Our results suggest otherwise, raising intriguing questions about AD genetics and how AD risk is inherited,” he said.
“In our study, maternal history of dementia increased their children’s risk of having preclinical AD, while paternal history had less impact,” a researcher said. (iStock)
The participants in the study had what is referred to as “preclinical Alzheimer’s disease,” Yang noted, which occurs when there is amyloid buildup but no symptoms.
“This stage might represent a unique opportunity to treat AD before it irreversibly destroys the brain,” he said.
The researchers also found a correlation between amyloid buildup and a history of Alzheimer’s on both sides of the family, as well as fathers with early-onset dementia.
“It’s interesting from a genetic perspective to see one sex contributing something the other sex isn’t.”
“If your father had early onset symptoms, that is associated with elevated levels in the offspring,” said Mabel Seto, PhD, first author and a postdoctoral research fellow in the Department of Neurology at the Brigham, in a press release.
“However, it doesn’t matter when your mother started developing symptoms — if she did at all, it’s associated with elevated amyloid.”
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Women are nearly twice as likely to develop Alzheimer’s than men, according to data from the Alzheimer’s Society.
“It’s really interesting from a genetic perspective to see one sex contributing something the other sex isn’t,” Seto said.
Limitations of the study
Courtney Kloske, PhD, director of scientific engagement at the Alzheimer’s Association in Chicago, Illinois, was not involved in the study but shared her insights on the findings.
“This study sheds light on the interplay between genetics and cognition in individuals with a family history of cognitive decline,” Kloske told Fox News Digital in an email.
A protein called amyloid that builds up in the brain and forms plaques — affecting cognitive function — is one of the hallmarks of Alzheimer’s disease. (iStock)
The expert did point out some limitations in the study, which the researchers also acknowledged.
“The authors mention that their findings should be interpreted cautiously,” she said.
One key limitation was that the study participants self-reported their family history, which could introduce some degree of bias or inaccuracy.
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“Additionally, the generally longer lifespan of women compared to men may contribute to the higher observed prevalence of cognitive impairment among women,” Kloske added.
Yang also spoke to this limitation, adding that the study participants were older adults and that the average life expectancy was shorter in their parents’ generation, especially for males.
While having elevated amyloid levels significantly increases the risk of someone eventually having dementia, more research is needed to determine the full impact of family history on the course of Alzheimer’s disease. (AP Newsroom)
“That might have made it even more challenging to assess the actual risk of dementia in their fathers, as they might have passed away before getting to the age when dementia becomes more prevalent,” he said.
Another consideration, according to Kloske, is that the parents in the current study lived in a “different, earlier era” when women were less likely to be in the workforce and had lower levels of education.
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“These trends limit the generalizability of these results,” she said.
Yang also reiterated that none of the study participants had dementia — “we asked about their family history and matched them with the amyloid PET scan results.”
While having elevated amyloid levels significantly increases the risk of someone eventually having dementia, Yang noted, more research is needed to determine the full impact of family history on the course of Alzheimer’s disease.
Women are nearly twice as likely to develop Alzheimer’s than men, according to data from the Alzheimer’s Society. (iStock)
“We think it is important for doctors evaluating dementia patients to gather detailed family history information, including the history of both parents and their age at onset if there was a memory loss or dementia history,” he said.
It is also important to seek out ways to decrease the risk, especially if someone has a family history, according to the researcher.
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“Lifestyle and environmental factors are thought to play a significant role in dementia risk,” Yang said.
“I always tell my patients to focus on a healthy lifestyle, such as a heart-healthy diet, regular physical activity, and a socially and intellectually active lifestyle.”
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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.
But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.
Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date.
The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum.
A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)
The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).
“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.
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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.
Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.
The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)
The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles.
Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.
“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”
Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging.
Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)
However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.
Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.
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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”
The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.
Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)
The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives.
Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be.
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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.
Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.
Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)
Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.
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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.
“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.
Fox News Digital has reached out to the researchers for comment.
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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